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Showing 1 to 12 of 24 entries
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Synthesis, Structure Activity Relationship Studies and Pharmacological Evaluation of 2-Phenyl-3-(Substituted Phenyl)-3H-Quinazolin-4-ones as Serotonin 5-HT(2) Antagonists.

Indian journal of pharmaceutical sciences

Sati N, Kumar S, Rawat MS.
PMID: 20502582
Indian J Pharm Sci. 2009 Sep;71(5):572-5. doi: 10.4103/0250-474X.58185.

Benzoyl chloride was added to the solution of anthranilic acid in pyridine to afford crude 2-phenyl-benzo[d][1, 3] oxazin-4-one (1). To the solution of compound 1 in dry toluene, various substituted anilines were added and the mixture refluxed for 8...

5-HT3 and 5-HT4 antagonists inhibit peristaltic contractions in guinea-pig distal colon by mechanisms independent of endogenous 5-HT.

Frontiers in neuroscience

Sia TC, Whiting M, Kyloh M, Nicholas SJ, Oliver J, Brookes SJ, Dinning PG, Wattchow DA, Spencer NJ.
PMID: 23935564
Front Neurosci. 2013 Aug 05;7:136. doi: 10.3389/fnins.2013.00136. eCollection 2013.

Recent studies have shown that endogenous serotonin is not required for colonic peristalsis in vitro, nor gastrointestinal (GI) transit in vivo. However, antagonists of 5-Hydroxytryptamine (5-HT) receptors can inhibit peristalsis and GI-transit in mammals, including humans. This raises the...

The role of neurokinin-1 (substance P) antagonists in the prevention of postoperative nausea and vomiting.

Journal of anaesthesiology, clinical pharmacology

Okafor D, Kaye AD, Kaye RJ, Urman RD.
PMID: 29416232
J Anaesthesiol Clin Pharmacol. 2017 Oct-Dec;33(4):441-445. doi: 10.4103/0970-9185.222511.

Postoperative nausea and vomiting (PONV) can be very debilitating for surgical patients, and effective management reduces potential morbidity, aiding in patient satisfaction, and minimizing the need for unintended hospital stays. Risk factors include female sex, nonsmoker, and having a...

Cyclohexylamine, an active compound from .

BioMedicine

Chen YF, Wang YW, Chen IS, Tsai HY.
PMID: 33854916
Biomedicine (Taipei). 2020 Jun 05;10(2):12-22. doi: 10.37796/2211-8039.1025. eCollection 2020.

METHODS: Male S.D. rats weighting between 200 g to 250 g were used. The epididymal portion of vas deferens was isolated and was added with various concentrations of serotonin, serotonin antagonists and CHA.RESULTS: Serotonin elicited dose-dependent (1 × 10CONCLUSIONS:...

Guidelines for the prevention of migraine.

Neurosciences (Riyadh, Saudi Arabia)

Deleu D, Hanssens Y.
PMID: 24276654
Neurosciences (Riyadh). 2000 Jan;5(1):7-12.

Treatment of migraine has traditionally been divided into managing acute attacks and prophylactic treatment. Treatment of acute migraine has been the subject of many research papers and review articles in recent literature partly at the cost of prophylactic treatment,...

Antinociceptive role of neurotensin receptor 1 in rats with chemotherapy-induced peripheral neuropathy.

The Korean journal of pain

Yin M, Kim YO, Choi JI, Jeong S, Yang SH, Bae HB, Yoon MH.
PMID: 32989196
Korean J Pain. 2020 Oct 01;33(4):318-325. doi: 10.3344/kjp.2020.33.4.318.

BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is a major side effect of anti-cancer drugs. Neurotensin receptors (NTSRs) are widely distributed within the pain circuits in the central nervous system. The purpose of this study was to determine the role of...

Management of severe arterial hypertension associated with serotonin syndrome: a case report analysis based on systematic review techniques.

Therapeutic advances in psychopharmacology

Ott M, Mannchen JK, Jamshidi F, Werneke U.
PMID: 30886699
Ther Adv Psychopharmacol. 2019 Mar 11;9:2045125318818814. doi: 10.1177/2045125318818814. eCollection 2019.

Serotonin syndrome is thought to arise from serotonin excess. In many cases, symptoms are mild and self-limiting. But serotonin syndrome can become life threatening, when neuromuscular hyperexcitability spins out of control. Uncontainable neuromuscular hyperexcitability may lead to cardiovascular complications,...

Potential of combined thromboxane A2 and serotonin antagonists to prevent the development of unstable angina and acute myocardial infarction.

Texas Heart Institute journal

Willerson JT, Buja LM.
PMID: 15227166
Tex Heart Inst J. 1990;17(3):157-64.

We have previously speculated that the abrupt conversion from chronic stable angina to unstable angina and the subsequent progression to acute myocardial infarction may result from myocardial ischemia caused by progressive platelet aggregation and dynamic coronary vasoconstriction. In turn,...

Advances in medical treatment of Cushing's disease.

Expert review of endocrinology & metabolism

Arnaldi G, Cardinaletti M, Boscaro M.
PMID: 30290469
Expert Rev Endocrinol Metab. 2007 Nov;2(6):735-743. doi: 10.1586/17446651.2.6.735.

It is well known that transphenoidal surgery is the first line of treatment for Cushing's disease (CD). In case of recurrence, pituitary irradiation or adrenalectomy are usually performed; however, the morbidity due to these procedures is not negligible. For...

Newest Drugs for Chronic Unexplained Nausea and Vomiting.

Current treatment options in gastroenterology

Hasler WL.
PMID: 27726068
Curr Treat Options Gastroenterol. 2016 Dec;14(4):371-385. doi: 10.1007/s11938-016-0110-2.

OPINION STATEMENT: Chronic unexplained nausea and vomiting (CUNV) refers to a symptom complex defined by nausea and/or vomiting with normal diagnostic testing, including anatomic assessments (including upper endoscopy) and measures of upper gut function (e.g., gastric emptying testing). Nausea...

Effects of serotonin and serotonin antagonists on chick embryogenesis.

Wilhelm Roux's archives of developmental biology

Palén K, Thörneby L, Emanuelsson H.
PMID: 28304924
Wilehm Roux Arch Dev Biol. 1979 Mar;187(1):89-103. doi: 10.1007/BF00848170.

Serotonin and some selected substances known to interfere with its formation (diethyldithiocarbamate) and function (Catron

Cost-effectiveness of antiemetics use during cancer chemotherapy.

Expert review of pharmacoeconomics & outcomes research

Lachaine J, Crott R.
PMID: 19807374
Expert Rev Pharmacoecon Outcomes Res. 2003 Jun;3(3):263-72. doi: 10.1586/14737167.3.3.263.

Emesis is a major obstacle to cancer chemotherapy. Patients indicate that nausea and vomiting are a substantial concern when receiving chemotherapy. In recent years, newer antiemetics, serotonin antagonists, have been commercialized. Other agents, particularly the neurokin-1 antagonists, are in...

Showing 1 to 12 of 24 entries