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Preliminary estimates of the virtually safe dose for tumors obtained from the maximum tolerated dose.

Gaylor DW.
PMID: 2717786
Regul Toxicol Pharmacol. 1989 Apr;9(2):101-8. doi: 10.1016/0273-2300(89)90028-7.

The purpose of this paper was to examine the correlation between the maximum tolerated dose (MTD) and the low-dose estimate of the virtually safe dose (VSD) for animal carcinogens. Chronic bioassay results from the National Cancer Institute/National Toxicology Program...

A note on the role of background tumor incidence in risk assessment for carcinogens.

Kodell RL, Chen JJ, Gaylor DW.
PMID: 2717789
Regul Toxicol Pharmacol. 1989 Apr;9(2):141-6. doi: 10.1016/0273-2300(89)90031-7.

The extrapolation of animal bioassay data to humans for the purpose of estimating risk from food additives, drugs, pesticides, etc. is still the primary approach to carcinogenic risk assessment. When the extrapolation is based on tumor data with high...

Screening the potential risks of toxic substances using a multimedia compartment model: estimation of human exposure.

McKone TE, Layton DW.
PMID: 3809615
Regul Toxicol Pharmacol. 1986 Dec;6(4):359-80. doi: 10.1016/0273-2300(86)90004-8.

Managing environmental health risks requires the assessment of environmental fate, exposure, and health risk of an ever-increasing list of contaminants. The magnitude of this list precludes an experimental evaluation of each contaminant. For this reason, computer models are being...

Workshop on New Approaches in Extrapolation Procedures and Standard Setting for Noncarcinogenic Substances in Human Exposure. May 2 and 3, 1988, Bilthoven, The Netherlands. Proceedings.

[No authors listed]
PMID: 3222478
Regul Toxicol Pharmacol. 1988 Dec;8(4):381-492.

No abstract available.

Policy principles for utilizing science in decision-making on chronic health issues.

Hoerger F, Plaut JA, Stevenson DE.
PMID: 3222489
Regul Toxicol Pharmacol. 1988 Dec;8(4):487-92. doi: 10.1016/0273-2300(88)90048-7.

Scientific advances will continue to contribute to our understanding of latent chronic diseases related to chemical exposure. Regulatory agencies must deal with a complex matrix of emerging scientific information, a diversity of potential risk situations, and a variety of...

The evaluation of negative epidemiologic studies: the importance of all available evidence in risk characterization.

Buffler PA.
PMID: 2667035
Regul Toxicol Pharmacol. 1989 Feb;9(1):34-43. doi: 10.1016/0273-2300(89)90043-3.

The importance of publishing and utilizing all available epidemiologic evidence in risk assessment is recognized. This recognition includes the findings from negative epidemiologic studies, described as well designed and executed studies where the hypothesized association with an adverse health...

Risk assessment: the convergence of science and the law.

Young FE.
PMID: 3615957
Regul Toxicol Pharmacol. 1987 Jun;7(2):179-84. doi: 10.1016/0273-2300(87)90028-6.

No abstract available.

Exposures to carcinogens and consequences of listing of carcinogens in the Swedish working environment.

Holm L, Holmberg B.
PMID: 3615958
Regul Toxicol Pharmacol. 1987 Jun;7(2):185-99. doi: 10.1016/0273-2300(87)90029-8.

No abstract available.

Biological nitrogen fixation: recent advances and future prospects.

Ausubel FM.
PMID: 3704206
Regul Toxicol Pharmacol. 1986 Mar;6(1):1-10. doi: 10.1016/0273-2300(86)90035-8.

Current research on nitrogen fixation is basic to finding the knowledge needed for agriculture research in the future. Genetic engineering is the best approach to increase biological nitrogen fixation and recent developments hold promise for this technology. This concept...

Estimates of the risk of bladder tumor promotion by saccharin in rats.

Gaylor DW, Kadlubar FF, West RW.
PMID: 3222487
Regul Toxicol Pharmacol. 1988 Dec;8(4):467-70. doi: 10.1016/0273-2300(88)90046-3.

Tumor data from an initiation-promotion bioassay in rats are used to illustrate how urinary bladder tumor risk estimates can be modified to reflect tumor promotion by saccharin. Assuming equal carcinogenic potency in humans and rats, the estimated human risk...

Reference dose (RfD): description and use in health risk assessments.

Barnes DG, Dourson M.
PMID: 3222488
Regul Toxicol Pharmacol. 1988 Dec;8(4):471-86. doi: 10.1016/0273-2300(88)90047-5.

For many years the concept of the "acceptable daily intake" has served the toxicological and regulatory fields quite well. However, as approaches to assessing the health significance of exposures to noncarcinogenic substances receive greater scrutiny, some difficulties with this...

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) in the environment: human health risk estimation and its application to the Seveso case as an example.

di Domenico A, Zapponi GA.
PMID: 3775083
Regul Toxicol Pharmacol. 1986 Sep;6(3):248-60. doi: 10.1016/0273-2300(86)90016-4.

Findings from selected dose-response experimental studies on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) carcinogenic action in rodents were utilized for low-dose lifetime cancer risk estimation in man. The Weibull, Armitage-Doll, and linearized Armitage-Doll mathematical models were employed in this work. Conversion factors, based...

Showing 1 to 12 of 4648 entries