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Showing 1 to 8 of 8 entries
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Differing response to antipsychotic therapy in schizophrenia: pharmacogenomic aspects.

Dialogues in clinical neuroscience

Ackenheil M, Weber K.
PMID: 22034253
Dialogues Clin Neurosci. 2004 Mar;6(1):71-7.

Treatment-resistance in schizophrenia remains a public health problem: about 20% to 30% of patients do not respond to antipsychotic therapy. Clozapine has been shown to be effective in about one-third of patients, but the medical risks and weekly blood...

Dendritic spine density changes and homeostatic synaptic scaling: a meta-analysis of animal studies.

Neural regeneration research

Moulin TC, Rayêe D, Schiöth HB.
PMID: 34100421
Neural Regen Res. 2022 Jan;17(1):20-24. doi: 10.4103/1673-5374.314283.

Mechanisms of homeostatic plasticity promote compensatory changes of cellular excitability in response to chronic changes in the network activity. This type of plasticity is essential for the maintenance of brain circuits and is involved in the regulation of neural...

The search for the molecular correlates of sleep and wakefulness.

Sleep medicine reviews

Cirelli C, Tononi G.
PMID: 12531005
Sleep Med Rev. 2001 Oct;5(5):397-408. doi: 10.1053/smrv.2001.0160.

Knowledge of the molecular correlates of sleep and wakefulness is essential if we are to understand the restorative processes occurring during sleep and the cellular mechanisms underlying sleep regulation. In order to determine what molecular changes occur during the...

Correlation of Artemin and GFRα3 With Osteoarthritis Pain: Early Evidence From Naturally Occurring Osteoarthritis-Associated Chronic Pain in Dogs.

Frontiers in neuroscience

Minnema L, Wheeler J, Enomoto M, Pitake S, Mishra SK, Lascelles BDX.
PMID: 32116521
Front Neurosci. 2020 Feb 13;14:77. doi: 10.3389/fnins.2020.00077. eCollection 2020.

Arthritis, including osteoarthritis (OA) and other musculoskeletal-associated pain, is a worldwide problem, however, effective drug options are limited. Several receptors, neurotransmitters, and endogenous mediators have been identified in rodent models, but the relevance of these molecules in disease-associated pain...

A deep dive into UV-based phototherapy: Mechanisms of action and emerging molecular targets in inflammation and cancer.

Pharmacology & therapeutics

Vieyra-Garcia PA, Wolf P.
PMID: 33316286
Pharmacol Ther. 2021 Jun;222:107784. doi: 10.1016/j.pharmthera.2020.107784. Epub 2020 Dec 11.

UV-based phototherapy (including psoralen plus UVA (PUVA), UVB and UVA1) has a long, successful history in the management of numerous cutaneous disorders. Photoresponsive diseases are etiologically diverse, but most involve disturbances in local (and occasionally systemic) inflammatory cells and/or...

Physiological and pharmacological aspects of the vas deferens-an update.

Frontiers in pharmacology

Koslov DS, Andersson KE.
PMID: 23986701
Front Pharmacol. 2013 Aug 22;4:101. doi: 10.3389/fphar.2013.00101. eCollection 2013.

The vas deferens, a muscular conduit conveying spermatozoa from the epididymis to the urethra, has been used as a model tissue for smooth muscle pharmacological and physiological advancements. Many drugs, notably α-adrenergic antagonists, have effects on contractility and thus...

NMDA Receptors and Colitis: Basic Science and Clinical Implications.

Reviews in analgesia

Zhou Q, Nicholas Verne G.
PMID: 20574552
Rev Analg. 2008 Nov 01;10(1):33-43. doi: 10.3727/154296108783994013.

During the last decade, research focusing primarily on alterations in the peripheral and central nervous system has improved our understanding of the pathophysiological mechanisms of chronic visceral pain. These studies have demonstrated significant physiological changes following injury to the...

Innovative Molecular Imaging for Clinical Research, Therapeutic Stratification, and Nosography in Neuroscience.

Frontiers in medicine

Beaurain M, Salabert AS, Ribeiro MJ, Arlicot N, Damier P, Le Jeune F, Demonet JF, Payoux P.
PMID: 31828073
Front Med (Lausanne). 2019 Nov 27;6:268. doi: 10.3389/fmed.2019.00268. eCollection 2019.

Over the past few decades, several radiotracers have been developed for neuroimaging applications, especially in PET. Because of their low steric hindrance, PET radionuclides can be used to label molecules that are small enough to cross the blood brain...

Showing 1 to 8 of 8 entries