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Showing 1 to 12 of 9911 entries
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Ethanol potentiates GABA- and glycine-induced chloride currents in chick spinal cord neurons.

Celentano JJ, Gibbs TT, Farb DH.
PMID: 2900060
Brain Res. 1988 Jul 12;455(2):377-80. doi: 10.1016/0006-8993(88)90098-4.

The effects of acute ethanol exposure of chick spinal cord neurons were studied in tissue culture, using whole-cell voltage-clamp techniques. Results indicate that ethanol produces a persistent increase in the sensitivity of spinal neurons to GABA and glycine, with...

N-methyl-D-aspartate receptor antagonists reduce synaptic excitation in the hippocampus.

Hablitz JJ, Langmoen IA.
PMID: 2868075
J Neurosci. 1986 Jan;6(1):102-6.
Free PMC Article

The hypothesis that synaptic excitation in the CA1 region of the hippocampus is mediated in part by N-methyl-D-aspartate (NMDA) receptors was tested using intra- and extracellular recording techniques. Synaptic potentials elicited by stratum radiatum stimulation were examined in individual...

The binding of bombesin and somatostatin and their analogs to human colon cancers.

Radulovic SS, Milovanovic SR, Cai RZ, Schally AV.
PMID: 1352046
Proc Soc Exp Biol Med. 1992 Jul;200(3):394-401. doi: 10.3181/00379727-200-43447.

Specific receptors for bombesin/gastrin-releasing peptide, somatostatin, and EGF were investigated in 15 human colon cancer specimens. Eight of 15 clinical specimens (15%) of colon cancer showed the presence of somatostatin receptors. Octapeptide somatostatin analogs, RC-160 and RC-121, showed 10...

Characterization of the receptor mediating relaxation to substance P in canine middle cerebral artery: no evidence for involvement of substance P in neurogenically mediated relaxation.

Stubbs CM, Waldron GJ, Connor HE, Feniuk W.
PMID: 1380374
Br J Pharmacol. 1992 Apr;105(4):875-80. doi: 10.1111/j.1476-5381.1992.tb09071.x.
Free PMC Article

1. The aim of this study was to characterize the neurokinin receptor which mediates relaxation of dog isolated middle cerebral artery by the use of selective agonists and antagonists and to establish whether substance P is involved in the...

FR 113680: a novel tripeptide substance P antagonist with NK1 receptor selectivity.

Morimoto H, Murai M, Maeda Y, Hagiwara D, Miyake H, Matsuo M, Fujii T.
PMID: 1380378
Br J Pharmacol. 1992 May;106(1):123-6. doi: 10.1111/j.1476-5381.1992.tb14303.x.
Free PMC Article

1. We have discovered a novel tripeptide substance P (SP) antagonist, FR 113680 [N alpha-[N alpha-(N alpha-acetyl-L-threonyl)-N'-formyl-D- tryptophyl]-N-methyl-N-phenylmethyl-L-phenylalaninamide]. In binding experiments, FR 113680 inhibited [3H]-SP binding to guinea-pig lung membranes (NK1) in a competitive manner but had not effect...

Light microscopic radioautographic localization of somatostatin binding sites in the brainstem of the rat.

Moyse E, Beaudet A, Bertherat J, Epelbaum J.
PMID: 1351397
J Chem Neuroanat. 1992 Jan-Feb;5(1):75-84. doi: 10.1016/0891-0618(92)90035-o.

The distribution of somatostatin binding sites was investigated by light microscopic radioautography in the brainstem of the rat following in vitro labeling with 125I-Tyr0-DTrp8-somatostatin14. Moderate to high labeling densities were detected within the superior colliculus, the locus coeruleus and...

Phencyclidine receptor ligands attenuate cortical neuronal injury after N-methyl-D-aspartate exposure or hypoxia.

Goldberg MP, Viseskul V, Choi DW.
PMID: 2838603
J Pharmacol Exp Ther. 1988 Jun;245(3):1081-7.

Phencyclidine (PCP) and related noncompetitive antagonists of N-methyl-D-aspartate (NMDA) receptor neuroexcitation were tested for their ability to attenuate either NMDA- or hypoxia-induced neuronal loss in dissociated cell cultures prepared from mouse neocortex. 10 microM PCP or MK-801 [(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate]...

Effects of the NMDA antagonist 2AP5 on complex spike discharge by hippocampal pyramidal cells.

Abraham WC, Kairiss EW.
PMID: 2899864
Neurosci Lett. 1988 Jun 17;89(1):36-42. doi: 10.1016/0304-3940(88)90477-6.

The N-methyl-D-aspartate receptor antagonist D,L-2-amino-5-phosphonopentanoate (2AP5) was administered intraventricularly to determine its effect on the complex spike firing pattern of spontaneously active hippocampal pyramidal cells recorded in urethane anaesthetized rats. Following 2AP5 delivery, complex spike firing decreased by a...

Is guanylate cyclase activation through the release of nitric oxide or a related compound involved in bradykinin-induced perivascular primary afferent excitation?.

Corrado AP, Ballejo G.
PMID: 1351697
Agents Actions Suppl. 1992;36:238-50.

In dogs under light thiopentobarbital anesthesia, intracarotid injection of bradykinin (BK) causes a dose-dependent "pain response" represented by hyperpnea, bradycardia, vocalization and ipsilateral contraction of the sternocephalic muscle. These events result from the activation of primary afferent nerves located...

The ontogenetic development of neurotensin-like immunoreactivity and neurotensin receptors in the cat striatum.

Goedert M, Hunt SP, Mantyh PW, Emson PC.
PMID: 2988709
Brain Res. 1985 May;352(1):127-31. doi: 10.1016/0165-3806(85)90095-1.

At birth, striatal neurotensin-like immunoreactivity amounted to 10% of the adult values which were reached at the age of 5 weeks. In the caudate nucleus neurotensin-like immunoreactivity presented a patchy distribution throughout development that was in register with Met-enkephalin...

Noradrenergic receptor function and aging: beyond the binding.

Bloom FE.
PMID: 2837672
Neurobiol Aging. 1988 Jan-Feb;9(1):59-60. doi: 10.1016/s0197-4580(88)80022-8.

Quantitative studies of noradrenergic binding sites with aging probably underestimate the functional alterations in this, and other, central synaptic systems. Transmitters like norepinephrine, whose actions are based on amplification and interaction of interneuronal signalling capacity, rely on interactions among...

Tachykinin receptors in the guinea-pig renal pelvis: activation by exogenous and endogenous tachykinins.

Maggi CA, Patacchini R, Eglezos A, Quartara L, Giuliani S, Giachetti A.
PMID: 1384907
Br J Pharmacol. 1992 Sep;107(1):27-33. doi: 10.1111/j.1476-5381.1992.tb14459.x.
Free PMC Article

1. The contractile response to substance P, neurokinin A, selective agonists for the NK1, NK2 and NK3 tachykinin receptors and the activity of receptor-selective antagonists has been investigated in circular muscle strips of the guinea-pig isolated renal pelvis in...

Showing 1 to 12 of 9911 entries