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Showing 1 to 12 of 15567 entries
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Isoproterenol Promotes Rapid Ryanodine Receptor Movement to Bridging Integrator 1 (BIN1)-Organized Dyads.


Fu Y, Shaw SA, Naami R, Vuong CL, Basheer WA, Guo X, Hong T.
PMID: 26733606
Circulation. 2016 Jan 26;133(4):388-97. doi: 10.1161/CIRCULATIONAHA.115.018535. Epub 2016 Jan 05.

BACKGROUND: The key pathophysiology of human acquired heart failure is impaired calcium transient, which is initiated at dyads consisting of ryanodine receptors (RyRs) at sarcoplasmic reticulum apposing CaV1.2 channels at t-tubules. Sympathetic tone regulates myocardial calcium transients through β-adrenergic...

Labetalol Use Is Associated With Increased In-Hospital Infection Compared With Nicardipine Use in Intracerebral Hemorrhage.


Starr JB, Tirschwell DL, Becker KJ.
PMID: 28904237
Stroke. 2017 Oct;48(10):2693-2698. doi: 10.1161/STROKEAHA.117.017230. Epub 2017 Sep 13.

BACKGROUND AND PURPOSE: Increased sympathetic tone causes hypertension after intracerebral hemorrhage, and blood pressure reduction has been studied as a way to decrease hemorrhage growth and improve outcomes. It is unknown if the antihypertensive used to achieve blood pressure...

β1-adrenergic receptor and sphingosine-1-phosphate receptor 1 (S1PR1) reciprocal downregulation influences cardiac hypertrophic response and progression to heart failure: protective role of S1PR1 cardiac gene therapy.


Cannavo A, Rengo G, Liccardo D, Pagano G, Zincarelli C, De Angelis MC, Puglia R, Di Pietro E, Rabinowitz JE, Barone MV, Cirillo P, Trimarco B, Palmer TM, Ferrara N, Koch WJ, Leosco D, Rapacciuolo A.
PMID: 23969695
Circulation. 2013 Oct 08;128(15):1612-22. doi: 10.1161/CIRCULATIONAHA.113.002659. Epub 2013 Aug 22.

BACKGROUND: The sphingosine-1-phosphate receptor 1 (S1PR1) and β1-adrenergic receptor (β1AR) are G-protein-coupled receptors expressed in the heart. These 2 receptors have opposing actions on adenylyl cyclase because of differential G-protein coupling. Importantly, both of these receptors can be regulated...

Enhanced expression of β3-adrenoceptors in cardiac myocytes attenuates neurohormone-induced hypertrophic remodeling through nitric oxide synthase.


Belge C, Hammond J, Dubois-Deruy E, Manoury B, Hamelet J, Beauloye C, Markl A, Pouleur AC, Bertrand L, Esfahani H, Jnaoui K, Götz KR, Nikolaev VO, Vanderper A, Herijgers P, Lobysheva I, Iaccarino G, Hilfiker-Kleiner D, Tavernier G, Langin D, Dessy C, Balligand JL.
PMID: 24190960
Circulation. 2014 Jan 28;129(4):451-62. doi: 10.1161/CIRCULATIONAHA.113.004940. Epub 2013 Nov 04.

BACKGROUND: β1-2-adrenergic receptors (AR) are key regulators of cardiac contractility and remodeling in response to catecholamines. β3-AR expression is enhanced in diseased human myocardium, but its impact on remodeling is unknown.METHODS AND RESULTS: Mice with cardiac myocyte-specific expression of...

The Interaction Between β-3 Adrenergic Receptor and Peroxisome Proliferator-Activated Receptor Gamma Gene Polymorphism to Periodontal Disease in Community-Dwelling Elderly Japanese.

Journal of periodontology

Yoshihara A, Sugita N, Iwasaki M, Wang Y, Miyazaki H, Yoshie H, Nakamura K.
PMID: 25855572
J Periodontol. 2015 Aug;86(8):955-63. doi: 10.1902/jop.2015.140472. Epub 2015 Apr 09.

BACKGROUND: It has been hypothesized that β-3 adrenergic receptor and peroxisome proliferator-activated receptor gamma (PPARγ) might have gene-environmental and gene-gene interactions in periodontal disease. The purpose of this study is to elucidate the interaction between β-3 adrenergic receptor and...

Impact of the β-1 adrenergic receptor polymorphism on tolerability and efficacy of bisoprolol therapy in Korean heart failure patients: association between β adrenergic receptor polymorphism and bisoprolol therapy in heart failure (ABBA) study.

The Korean journal of internal medicine

Lee HY, Chung WJ, Jeon HK, Seo HS, Choi DJ, Jeon ES, Kim JJ, Shin JH, Kang SM, Lim SC, Baek SH.
PMID: 26879662
Korean J Intern Med. 2016 Mar;31(2):277-87. doi: 10.3904/kjim.2015.043. Epub 2016 Feb 16.

BACKGROUND/AIMS: We evaluated the association between coding region variants of adrenergic receptor genes and therapeutic effect in patients with congestive heart failure (CHF).METHODS: One hundred patients with stable CHF (left ventricular ejection fraction [LVEF] < 45%) were enrolled. Enrolled...

Nucleoside Diphosphate Kinase-C Suppresses cAMP Formation in Human Heart Failure.


Abu-Taha IH, Heijman J, Hippe HJ, Wolf NM, El-Armouche A, Nikolaev VO, Schäfer M, Würtz CM, Neef S, Voigt N, Baczkó I, Varró A, Müller M, Meder B, Katus HA, Spiger K, Vettel C, Lehmann LH, Backs J, Skolnik EY, Lutz S, Dobrev D, Wieland T.
PMID: 27927712
Circulation. 2017 Feb 28;135(9):881-897. doi: 10.1161/CIRCULATIONAHA.116.022852. Epub 2016 Dec 07.

BACKGROUND: Chronic heart failure (HF) is associated with altered signal transduction via β-adrenoceptors and G proteins and with reduced cAMP formation. Nucleoside diphosphate kinases (NDPKs) are enriched at the plasma membrane of patients with end-stage HF, but the functional...

Molecular biology of adrenergic receptors.

Journal of hypertension

Strasser RH, Ihl-Vahl R, Marquetant R.
PMID: 1320069
J Hypertens. 1992 Jun;10(6):501-6. doi: 10.1097/00004872-199206000-00001.

No abstract available.

Desmethylimipramine attenuates cocaine withdrawal in rats.


Markou A, Hauger RL, Koob GF.
PMID: 1365631
Psychopharmacology (Berl). 1992;109(3):305-14. doi: 10.1007/BF02245878.

Depression and anhedonia are two major symptoms of cocaine withdrawal in humans. Hence, pharmacological treatments effective in depression might also alleviate the symptoms of cocaine withdrawal. In the present study, the effects of acute and repeated administration of a...

Dihydrotestosterone decreases beta-adrenergic receptor binding in the fetal rabbit lung.

American journal of perinatology

Moawad AH, River LP, River JM.
PMID: 2838034
Am J Perinatol. 1988 Jul;5(3):283-5. doi: 10.1055/s-2007-999704.

Tritium-labeled dihydroalprenolol was used to quantify the beta-adrenergic receptor sites in day 30 fetal rabbit lung tissue. Each of the fetuses of New Zealand White rabbits on day 28 of gestation was injected with dihydrotestosterone (2.0 micrograms) in one...

Alterations in norepinephrine content and beta adrenoceptor regulation in myocardium bordering aneurysm in human heart: their possible role in the genesis of ventricular tachycardia.

European journal of clinical investigation

Bevilacqua M, Norbiato G, Vago T, Meroni R, Dagani R, Raggi U, Frigeni G, Santoli C.
PMID: 3015633
Eur J Clin Invest. 1986 Apr;16(2):163-8. doi: 10.1111/j.1365-2362.1986.tb01324.x.

On the assumption that alterations in the adrenergic system may play a role in generating ventricular tachycardia in patients with myocardial post-infarction apical aneurysm, we evaluated norepinephrine concentration, number and affinity of both beta 1 and beta 2 adrenoceptors...

Somatostatin: a metabolic regulator.

Life sciences

Dileepan KN, Wagle SR.
PMID: 2867445
Life Sci. 1985 Dec 23;37(25):2335-43. doi: 10.1016/0024-3205(85)90100-6.

Somatostatin, the hypothalamic release-inhibiting factor, has been found to stimulate gluconeogenesis in rat kidney cortical slices. Stimulation by somatostatin was linear and dose-dependent. Other bioactive peptides such as cholecystokinin, gastrointestinal peptide, secretin, neurotensin, vasoactive intestinal peptide, pancreatic polypeptide, beta...

Showing 1 to 12 of 15567 entries