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Showing 1 to 11 of 11 entries
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iRNA-PseU: Identifying RNA pseudouridine sites.

Molecular therapy. Nucleic acids

Chen W, Tang H, Ye J, Lin H, Chou KC.
PMID: 28427142
Mol Ther Nucleic Acids. 2016;5:e332. doi: 10.1038/mtna.2016.37.

As the most abundant RNA modification, pseudouridine plays important roles in many biological processes. Occurring at the uridine site and catalyzed by pseudouridine synthase, the modification has been observed in nearly all kinds of RNA, including transfer RNA, messenger...

Riboswitches as Potential Targets for the Development of Anti-Biofilm Drugs.

Current topics in medicinal chemistry

Reyes-Darias JA, Krell T.
PMID: 28403796
Curr Top Med Chem. 2017 Apr 07; doi: 10.2174/1568026617666170407163517. Epub 2017 Apr 07.

In nature, bacteria can exist as single motile cells or as sessile cellular community, known as microbial biofilms. Bacteria within biofilms are embedded in a self-produced extracellular matrix that makes them more resistant to antibiotic treatment and responses of...

Biological Properties of Milk-Derived Extracellular Vesicles and Their Physiological Functions in Infant.

Frontiers in cell and developmental biology

Jiang X, You L, Zhang Z, Cui X, Zhong H, Sun X, Ji C, Chi X.
PMID: 34249944
Front Cell Dev Biol. 2021 Jun 25;9:693534. doi: 10.3389/fcell.2021.693534. eCollection 2021.

Extracellular vesicles (EVs) are released by all cells under pathological and physiological conditions. EVs harbor various biomolecules, including protein, lipid, non-coding RNA, messenger RNA, and DNA. In 2007, mRNA and microRNA (miRNA) carried by EVs were found to have...

Prognostic roles of the expression of sphingosine-1-phosphate metabolism enzymes in non-small cell lung cancer.

Translational lung cancer research

Wang Y, Shen Y, Sun X, Hong TL, Huang LS, Zhong M.
PMID: 31737503
Transl Lung Cancer Res. 2019 Oct;8(5):674-681. doi: 10.21037/tlcr.2019.10.04.

BACKGROUND: Sphingosine-1-phosphate (S1P), a bioactive lipid, is generally increased in human non-small cell lung cancer (NSCLC). Evidence has shown that the levels of enzymes in S1P metabolism were associated with clinical outcomes in patients with NSCLC. Nevertheless, the roles...

At the Intersection of Biomaterials and Gene Therapy: Progress in Non-viral Delivery of Nucleic Acids.

Frontiers in bioengineering and biotechnology

Uludag H, Ubeda A, Ansari A.
PMID: 31214586
Front Bioeng Biotechnol. 2019 Jun 04;7:131. doi: 10.3389/fbioe.2019.00131. eCollection 2019.

Biomaterials play a critical role in technologies intended to deliver therapeutic agents in clinical settings. Recent explosion of our understanding of how cells utilize nucleic acids has garnered excitement to develop a range of older (e.g., antisense oligonucleotides, plasmid...

Non-radioactive organization and transcript analysis of the ATPase subunit 6 gene region in the mitochondrial genome from fertile and sterile (CMS) forms of wheat and triticale.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik

Pfeil U, van der Kuip H, Hesemann CU.
PMID: 24185931
Theor Appl Genet. 1994 May;88(2):231-5. doi: 10.1007/BF00225902.

In sterile triticale forms [with cytoplasmic male-sterile (CMS)-inducing timopheevi cytoplasm], fertile orms (with normal cytoplasm) and the corresponding wheat cross parents mitochondrial DNA (mtDNA) and RNA (messenger mtRNA) were characterized using total DNA and RNA material for Southern and...

Alterations in micro RNA-messenger RNA (miRNA-mRNA) Coupled Signaling Networks in Sporadic Alzheimer's Disease (AD) Hippocampal CA1.

Journal of Alzheimer's disease & Parkinsonism

Jaber V, Zhao Y, Lukiw WJ.
PMID: 29051843
J Alzheimers Dis Parkinsonism. 2017 Apr;7(2). doi: 10.4172/2161-0460.1000312. Epub 2017 Mar 10.

RNA sequencing, DNA microfluidic array, LED-Northern, Western immunoassay and bioinformatics analysis have uncovered a small family of up-regulated human brain enriched microRNAs (miRNAs) and down-regulated messenger RNAs (mRNAs) in short post-mortem interval (PMI) sporadic Alzheimer's disease (AD) brain. At...

Competing endogenous RNA screening based on long noncoding RNA-messenger RNA co-expression profile in Hepatitis B virus-associated hepatocarcinogenesis.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

Wen Q, Wang D, Yang Y, Chen X, Pan X, Han Q, Deng Y, Li X, Chen X, Yan J, Zhou J.
PMID: 32188210
J Tradit Chin Med. 2017 Aug;37(4):510-521.

OBJECTIVE: To profile the liver cancer specific long noncoding RNAs (lncRNAs) and competing endogenous RNA (ceRNA) networks of Hepatitis B virus (HBV)-associated hepatocarcinogensis (HCG) and to examine the effect of compound K on the expression of identified ceRNA networks.METHODS:...

Identification of stemness and differentially expressed genes in human cementum-derived cells.

Journal of periodontal & implant science

Lee E, Kim YS, Lee YM, Kim WK, Lee YK, Kim SH.
PMID: 34713994
J Periodontal Implant Sci. 2021 Oct;51(5):329-341. doi: 10.5051/jpis.2102600130.

PURPOSE: Periodontal treatment aims at complete regeneration of the periodontium, and developing strategies for periodontal regeneration requires a deep understanding of the tissues composing the periodontium. In the present study, the stemness characteristics and gene expression profiles of cementum-derived...

Specific Modified mRNA Translation System.

Circulation

Magadum A, Kurian AA, Chepurko E, Sassi Y, Hajjar RJ, Zangi L.
PMID: 33347328
Circulation. 2020 Dec 22;142(25):2485-2488. doi: 10.1161/CIRCULATIONAHA.120.047211. Epub 2020 Dec 21.

No abstract available.

Automated immunohistochemical assessment ability to evaluate estrogen and progesterone receptor status compared with quantitative reverse transcription-polymerase chain reaction in breast carcinoma patients.

Journal of pathology and translational medicine

Jeon T, Kim A, Kim C.
PMID: 33260290
J Pathol Transl Med. 2021 Jan;55(1):33-42. doi: 10.4132/jptm.2020.09.29. Epub 2020 Dec 03.

BACKGROUND: This study aimed to investigate the capability of an automated immunohistochemical (IHC) evaluation of hormonal receptor status in breast cancer patients compared to a well-validated quantitative reverse transcription-polymerase chain reaction (RT-qPCR) method.METHODS: This study included 93 invasive breast...

Showing 1 to 11 of 11 entries