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Showing 1 to 12 of 107 entries
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Serotonin and Dopamine Have Opposite Effects on Phototaxis in Larvae of the Bryozoan Bugula neritina.

The Biological bulletin

Pires A, Woollacott RM.
PMID: 28581842
Biol Bull. 1997 Jun;192(3):399-409. doi: 10.2307/1542749.

Adult colonies of the bryozoan Bugula neritina release short-term anenteric larvae that initially are strongly photopositive. Over the course of several hours larvae lose their initial photopositivity and either become photonegative or alternate between positive and negative phototaxis. We...

Differential Effects of Oxycodone, Hydrocodone, and Morphine on Activation Levels of Signaling Molecules.

Pain medicine (Malden, Mass.)

Emery MA, Bates ML, Wellman PJ, Eitan S.
PMID: 26349634
Pain Med. 2016 May 01;17(5):908-914. doi: 10.1111/pme.12918. Epub 2015 Sep 09.

BACKGROUND: Opioids alter the responses of D2-like dopamine receptors (D2DRs), known to be involved in the pathology of addiction and other mental illnesses. Importantly, our recent results demonstrated that various opioids differentially modulate the behavioral responses of D2DRs.OBJECTIVE: To...

Dissociation of the effects of amphetamine and quinpirole on dopamine release in the nucleus accumbens following behavioural sensitization: an ex vivo voltammetric study.

Behavioural pharmacology

Muscat R, Patel J, Trout SJ, Wieczorek W, Kruk ZL.
PMID: 11224210
Behav Pharmacol. 1993;4(4):411-418.

Behavioural sensitization to the locomotor stimulant effect of (+)-amphetamine or quinpirole was induced in rats by intermittent drug administration. Once established, endogenous dopamine release (DA) was measured in slices containing nucleus accumbens using fast cyclic voltammetry. DA release induced...

Changes of dopamine-sensitive cyclic AMP-generating system in the rat hippocampus as a function of age.

Archives of gerontology and geriatrics

Amenta F, Cavallotti C, de Michele M, Ricci A, Vega JA.
PMID: 15374503
Arch Gerontol Geriatr. 1990 May-Jun;10(3):279-85. doi: 10.1016/0167-4943(90)90029-6.

The dopamine (DA) D(1) and D(2) receptors coupled to the 3',5'-cyclic adenosine monophosphate (cAMP)-generating system were studied in membrane particles of the dorsal hippocampus in 3 (considered to be young), 12 (considered to be adult) and 24 (considered to...

Repeated treatment with antidepressant drugs and/or electroconvulsive shock (ECS) does not affect the quinpirole-induced elevation of the serum corticosterone concentration in rats.

Journal of psychopharmacology (Oxford, England)

Przegalinski E, Budziszewska B, Blaszczynska E.
PMID: 22281848
J Psychopharmacol. 1990 Jan;4(4):198-203. doi: 10.1177/026988119000400403.

The selective dopamine D2 receptor agonist quinpirole (0.03-1 mg/kg intra peritoneally) increased dose-dependently the serum corticosterone level in rats. The effect of the maximum dose of quinpirole (0.3 mg/kg intraperitoneally) was antagonized in a dose- dependent manner by the...

GFAP expression induced by dopamine D(2) receptor agonists in the rat pituitary intermediate lobe.

Endocrine

Sands SA, Chronwall BM.
PMID: 21153289
Endocrine. 1996 Feb;4(1):35-42. doi: 10.1007/BF02738872.

This study was conducted to determine if intermediate lobe glial-like cells are affected by compounds that regulate melanotrope biosynthetic activity via the dopamine D(2) receptor. Glial-like cells were stellate, and expressed glial fibrillary acidic protein (GFAP) and vimentin in...

Animal models of obsessive compulsive disorder: recent findings and future directions.

Expert opinion on drug discovery

Hoffman KL.
PMID: 22650979
Expert Opin Drug Discov. 2011 Jul;6(7):725-37. doi: 10.1517/17460441.2011.577772. Epub 2011 Jun 02.

INTRODUCTION: Obsessive compulsive disorder (OCD) is a debilitating condition with limited treatment options. OCD is heterogeneous with respect to the content of obsessions and compulsions and their underlying motivation, among other characteristics. Animal models have provided important insights into...

Effect of chronic treatment with NNC 756, a new D-1 receptor antagonist, or raclopride, a D-2 receptor antagonist, in drug-naive Cebus monkeys: dystonia, dyskinesia and D-1/D-2 supersensitivity.

Journal of psychopharmacology (Oxford, England)

Gerlach J, Hansen L.
PMID: 22290999
J Psychopharmacol. 1993 Jan;7(4):355-64. doi: 10.1177/026988119300700407.

When given subcutaneously in gradually increasing doses, up to 1 mg/kg, NNC 756, a dopamine (DA) D-1 antagonist, failed to produce dystonia in eight drug-naive Cebus monkeys. In contrast, raclopride, a DA D-2 antagonist, produced dystonia at low doses...

Potentiation of licking in rats by stimulation of both D-1 and D-2 dopamine receptors.

Journal of psychopharmacology (Oxford, England)

Zarrindast MR, Roushan-Zamir F, Amir-Rahmat F, Moslehi M.
PMID: 22291386
J Psychopharmacol. 1992 Jan;6(3):395-8. doi: 10.1177/026988119200600309.

Apomorphine-induced licking in rats was assessed by recording the total number of licks by direct observation. Apomorphine induced licking dose dependently. The maximum response was obtained by 0.5 mg/kg of the drug and 30 min after drug administration. Pre-treatment...

MPTP-Induced Dopamine Depletion in Basolateral Amygdala .

Frontiers in molecular neuroscience

Zhang T, Chen T, Chen P, Zhang B, Hong J, Chen L.
PMID: 28824377
Front Mol Neurosci. 2017 Aug 07;10:247. doi: 10.3389/fnmol.2017.00247. eCollection 2017.

Anxiety disorders commonly occur in Parkinson's disease. Using field potential recording and patch-clamp recording, we evaluated influence of MPTP-reduced dopaminergic afferent in basolateral amygdala (BLA), a main region for affective regulation, on excitatory-inhibitory circuits and synaptic plasticity. Field excitatory...

Relief of neuropathic pain by cell-specific manipulation of nucleus accumbens dopamine D1- and D2-receptor-expressing neurons.

Molecular brain

Sato D, Narita M, Hamada Y, Mori T, Tanaka K, Tamura H, Yamanaka A, Matsui R, Watanabe D, Suda Y, Senba E, Watanabe M, Navratilova E, Porreca F, Kuzumaki N, Narita M.
PMID: 34991655
Mol Brain. 2022 Jan 06;15(1):10. doi: 10.1186/s13041-021-00896-2.

Emerging evidence suggests that the mesolimbic dopaminergic network plays a role in the modulation of pain. As chronic pain conditions are associated with hypodopaminergic tone in the nucleus accumbens (NAc), we evaluated the effects of increasing signaling at dopamine...

Characterization of the discriminative stimulus effect of quinpirole: Further evidence for functional interaction between central dopamine D.

Pharmacology, biochemistry, and behavior

Mori T, Yamashita K, Takahashi K, Mano S, Sato D, Narita M.
PMID: 34919902
Pharmacol Biochem Behav. 2021 Dec 14;213:173314. doi: 10.1016/j.pbb.2021.173314. Epub 2021 Dec 14.

Dysfunction of the central dopamine D

Showing 1 to 12 of 107 entries