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Showing 1 to 12 of 1226 entries
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Correction to GPR103 Antagonists Demonstrating Anorexigenic Activity in Vivo: Design and Development of Pyrrolo[2,3-c]pyridines That Mimic the C-Terminal Arg-Phe Motif of QRFP26.

Journal of medicinal chemistry

Georgsson J, Bergström F, Nordqvist A, Watson MJ, Blundell CD, Johansson MJ, Petersson AU, Yuan ZQ, Zhou Y, Kristensson L, Kakol-Palm D, Tyrchan C, Wellner E, Bauer U, Brodin P, Svensson Henriksson A.
PMID: 25875054
J Med Chem. 2015 May 14;58(9):4086. doi: 10.1021/acs.jmedchem.5b00479. Epub 2015 Apr 15.

No abstract available.

Synthesis of Indolizine Derivatives by Pd-Catalyzed Oxidative Carbonylation.

Organic letters

Xu T, Alper H.
PMID: 26331787
Org Lett. 2015 Sep 18;17(18):4526-9. doi: 10.1021/acs.orglett.5b02220. Epub 2015 Sep 02.

An efficient synthesis of indolizine derivatives by palladium-catalyzed oxidative carbonylation of propargylic pyridines has been developed. The reaction can be conducted at room temperature and under 3 bar of CO in the presence of Pd2(dba)3 or Pd/C. The catalyst...

Evidence that phospholipase C is involved in the antitumour action of NSC768313, a new thieno[2,3-b]pyridine derivative.

Cancer cell international

Reynisson J, Jaiswal JK, Barker D, D'mello SA, Denny WA, Baguley BC, Leung EY.
PMID: 26966420
Cancer Cell Int. 2016 Mar 10;16:18. doi: 10.1186/s12935-016-0293-6. eCollection 2016.

BACKGROUND: The thieno[2,3-b]pyridines were discovered by virtual high throughput screening as potential inhibitors of phospholipase C (PLC) isoforms and showed potent growth inhibitory effects in National Cancer Institute's human tumour cell line panel (NCI60). The mechanism of the anti-proliferative...

Regio- and Stereoselective Domino Synthesis of Oxazolo Fused Pyridoindoles and Benzofurooxazolo Pyridines from ortho-Alkynylarylaldehydes.

The Journal of organic chemistry

Pal S, Choudhary D, Jainth M, Kumar S, Tiwari RK, Verma AK.
PMID: 27626809
J Org Chem. 2016 Oct 07;81(19):9356-9371. doi: 10.1021/acs.joc.6b02062. Epub 2016 Sep 26.

An environmentally benign Au(III)-catalyzed regio- and stereoselective domino synthesis of oxazolo fused pyridoindoles 7a-v and benzofurooxazolo pyridines 8a-n by the reaction of o-alkynylaldehydes 4a-t and 5a-k with (S)-phenylglycinol 6a and (R)-phenylglycinol 6b under mild reaction conditions using water as...

Access to Imidazo[1,2-a]pyridines via Annulation of α-Keto Vinyl Azides and 2-Aminopyridines.

Organic letters

Adiyala PR, Mani GS, Nanubolu JB, Shekar KC, Maurya RA.
PMID: 26308984
Org Lett. 2015 Sep 04;17(17):4308-11. doi: 10.1021/acs.orglett.5b02124. Epub 2015 Aug 26.

A novel strategy for the synthesis of imidazo[1,2-a]pyridines via efficient catalyst/metal-free annulations of α-keto vinyl azides and 2-aminopyridines is described. Several imidazo[1,2-a]pyridines were synthesized from readily available vinyl azides and 2-aminopyridines and obtained in highly pure form by simply...

High-Temperature Continuous-Flow Zincations of Functionalized Arenes and Heteroarenes Using (Cy2N)2Zn·2LiCl.

Organic letters

Becker MR, Knochel P.
PMID: 26942552
Org Lett. 2016 Mar 18;18(6):1462-5. doi: 10.1021/acs.orglett.6b00408. Epub 2016 Mar 04.

The treatment of sensitive arenes and heteroarenes with the zinc bis-amide (Cy2N)2Zn·2LiCl (0.55 equiv), prepared in quantitative yield by the reaction of Cy2NLi with ZnCl2, leads under flow conditions to a fast zincation within 10 min at temperatures between...

Corrigendum: Adjuvanted influenza-H1N1 vaccination reveals lymphoid signatures of age-dependent early responses and of clinical adverse events.

Nature immunology

Sobolev O, Binda E, O'Farrell S, Lorenc A, Pradines J, Huang Y, Duffner J, Schulz R, Cason J, Zambon M, Malim MH, Peakman M, Cope A, Capila I, Kaundinya GV, Hayday AC.
PMID: 27002849
Nat Immunol. 2016 Apr;17(4):469. doi: 10.1038/ni0416-469b.

No abstract available.

A novel symmetric TTF-pyridyl thiolato zinc complex: synthesis, characterization and crystal structure analysis.

Dalton transactions (Cambridge, England : 2003)

Okuno R, Yamaguchi M, Fujiwara H.
PMID: 28345714
Dalton Trans. 2017 Apr 11;46(15):4912-4916. doi: 10.1039/c7dt00468k.

We report the first preparation of a symmetric tetrathiafulvalene (TTF)-pyridyl thiolato zinc(ii) complex in which two TTF parts connect to the central zinc atom through pyridines and thiolates. We also discuss the crystal structure analysis and physical properties of...

Calcium Hydride Catalyzed Highly 1,2-Selective Pyridine Hydrosilylation.

Chemistry (Weinheim an der Bergstrasse, Germany)

Intemann J, Bauer H, Pahl J, Maron L, Harder S.
PMID: 26120024
Chemistry. 2015 Aug 03;21(32):11452-61. doi: 10.1002/chem.201501072. Epub 2015 Jun 26.

Reaction of the calcium hydride complex (DIPPnacnac-CaH⋅THF)2 with pyridine is much faster and selective than that of the corresponding magnesium hydride complex (DIPPnacnac = [(2,6-iPr2 C6 H3 )NC(Me)]2 CH). With a range of pyridine, picoline and quinoline substrates, exclusive...

Three closely related 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridines: synthesis, molecular conformations and hydrogen bonding in zero, one and two dimensions.

Acta crystallographica. Section C, Structural chemistry

Sagar BK, Harsha KB, Yathirajan HS, Rangappa KS, Rathore RS, Glidewell C.
PMID: 28257028
Acta Crystallogr C Struct Chem. 2017 Mar 01;73:298-304. doi: 10.1107/S205322961700273X. Epub 2017 Feb 23.

In each of 1-(4-fluorophenyl)-5-methylsulfonyl-3-[4-(trifluoromethyl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine, C

Electrocatalytic intramolecular oxidative annulation of N-aryl enamines into substituted indoles mediated by iodides.

Chemical communications (Cambridge, England)

Tang S, Gao X, Lei A.
PMID: 28261710
Chem Commun (Camb). 2017 Mar 16;53(23):3354-3356. doi: 10.1039/c7cc00410a.

An electrocatalytic reaction protocol is developed for achieving intramolecular dehydrogenative annulation of N-aryl enamines. It offers a simple and efficient way for the synthesis of indoles in an undivided cell. Good to excellent yields are obtained under oxidant-free and...

Why vertically π-expanded imidazo[1,2-a]pyridines are weak fluorescence emitters: experimental and computational studies.

Physical chemistry chemical physics : PCCP

Banasiewicz M, Deperasińska I, Makarewicz A, Firmansyah D, Gryko DT, Kozankiewicz B.
PMID: 25746202
Phys Chem Chem Phys. 2015 Apr 14;17(14):8945-50. doi: 10.1039/c5cp00216h. Epub 2015 Mar 09.

Photophysics of π-expanded analogs of imidazo[1,2-a]pyridine, a well-known heterocyclic compound, has been experimentally and theoretically studied. Two regioisomeric systems differing only in the arrangement of the benzene ring have shown different optical properties (electronic transition energies, fluorescence quantum yields...

Showing 1 to 12 of 1226 entries