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beta(1)- and beta(2)-Adrenoceptor antagonist activity of a series of para-substituted N-isopropylphenoxypropanolamines.

European journal of medicinal chemistry

Louis SN, Nero TL, Iakovidis D, Colagrande FM, Jackman GP, Louis WJ.
PMID: 10889317
Eur J Med Chem. 1999 Nov 01;34(11):919-937. doi: 10.1016/s0223-5234(99)00114-2.

To further explore the structure-activity relationships of beta-adrenoceptor (beta-AR) antagonists, a series of 25 para-substituted N-isopropylphenoxy-propanolamines were synthesised, nine of which are new compounds. All have been examined for their ability to antagonise beta(1)-ARs in rat atria and beta(2)-ARs...

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