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A novel pH-induced thermosensitive hydrogel composed of carboxymethyl chitosan and poloxamer cross-linked by glutaraldehyde for ophthalmic drug delivery.

Carbohydrate polymers

Yu S, Zhang X, Tan G, Tian L, Liu D, Liu Y, Yang X, Pan W.
PMID: 27702506
Carbohydr Polym. 2017 Jan 02;155:208-217. doi: 10.1016/j.carbpol.2016.08.073. Epub 2016 Aug 25.

In this work, a stimuli-responsive three dimensional cross-linked hydrogel system containing carboxymethyl chitosan (CMC) and poloxamer composed of a poly (ethylene oxide)/poly (propylene oxide)/poly (ethylene oxide) (PEO-PPO-PEO) block copolymer was constructed, and its aqueous solution was found to undergo...

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Yu S, Zhang X, Tan G, et al. A novel pH-induced thermosensitive hydrogel composed of carboxymethyl chitosan and poloxamer cross-linked by glutaraldehyde for ophthalmic drug delivery. Carbohydr Polym. 2016;155:208-217doi: 10.1016/j.carbpol.2016.08.073.
Yu, S., Zhang, X., Tan, G., Tian, L., Liu, D., Liu, Y., Yang, X., & Pan, W. (2017). A novel pH-induced thermosensitive hydrogel composed of carboxymethyl chitosan and poloxamer cross-linked by glutaraldehyde for ophthalmic drug delivery. Carbohydrate polymers, 155208-217. https://doi.org/10.1016/j.carbpol.2016.08.073
Yu, Shihui, et al. "A novel pH-induced thermosensitive hydrogel composed of carboxymethyl chitosan and poloxamer cross-linked by glutaraldehyde for ophthalmic drug delivery." Carbohydrate polymers vol. 155 (2017): 208-217. doi: https://doi.org/10.1016/j.carbpol.2016.08.073
Yu S, Zhang X, Tan G, Tian L, Liu D, Liu Y, Yang X, Pan W. A novel pH-induced thermosensitive hydrogel composed of carboxymethyl chitosan and poloxamer cross-linked by glutaraldehyde for ophthalmic drug delivery. Carbohydr Polym. 2017 Jan 02;155:208-217. doi: 10.1016/j.carbpol.2016.08.073. Epub 2016 Aug 25. PMID: 27702506.
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Thermogelling properties of purified poloxamer 407.

Heliyon

Fakhari A, Corcoran M, Schwarz A.
PMID: 28920092
Heliyon. 2017 Aug 30;3(8):e00390. doi: 10.1016/j.heliyon.2017.e00390. eCollection 2017 Aug.

Poloxamers are triblock copolymers with a center block of hydrophobic polypropylene oxide (PPO) flanked by two hydrophilic polyethyleneoxide (PEO) blocks. Among this family of copolymers, poloxamer 407 is a non-ionic surfactant with reversible gelation properties above a particular polymer...

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Fakhari A, Corcoran M, Schwarz A. Thermogelling properties of purified poloxamer 407. Heliyon. 2017;3(8):e00390doi: 10.1016/j.heliyon.2017.e00390.
Fakhari, A., Corcoran, M., & Schwarz, A. (2017). Thermogelling properties of purified poloxamer 407. Heliyon, 3(8), e00390. https://doi.org/10.1016/j.heliyon.2017.e00390
Fakhari, Amir, et al. "Thermogelling properties of purified poloxamer 407." Heliyon vol. 3,8 (2017): e00390. doi: https://doi.org/10.1016/j.heliyon.2017.e00390
Fakhari A, Corcoran M, Schwarz A. Thermogelling properties of purified poloxamer 407. Heliyon. 2017 Aug 30;3(8):e00390. doi: 10.1016/j.heliyon.2017.e00390. eCollection 2017 Aug. PMID: 28920092; PMCID: PMC5576961.
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Clinical Development of a Cytomegalovirus DNA Vaccine: From Product Concept to Pivotal Phase 3 Trial.

Vaccines

Smith LR, Wloch MK, Chaplin JA, Gerber M, Rolland AP.
PMID: 26344340
Vaccines (Basel). 2013 Sep 25;1(4):398-414. doi: 10.3390/vaccines1040398.

2013 marks a milestone year for plasmid DNA vaccine development as a first-in-class cytomegalovirus (CMV) DNA vaccine enters pivotal phase 3 testing. This vaccine consists of two plasmids expressing CMV antigens glycoprotein B (gB) and phosphoprotein 65 (pp65) formulated...

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Smith LR, Wloch MK, Chaplin JA, et al. Clinical Development of a Cytomegalovirus DNA Vaccine: From Product Concept to Pivotal Phase 3 Trial. Vaccines (Basel). 2013;1(4):398-414doi: 10.3390/vaccines1040398.
Smith, L. R., Wloch, M. K., Chaplin, J. A., Gerber, M., & Rolland, A. P. (2013). Clinical Development of a Cytomegalovirus DNA Vaccine: From Product Concept to Pivotal Phase 3 Trial. Vaccines, 1(4), 398-414. https://doi.org/10.3390/vaccines1040398
Smith, Larry R, et al. "Clinical Development of a Cytomegalovirus DNA Vaccine: From Product Concept to Pivotal Phase 3 Trial." Vaccines vol. 1,4 (2013): 398-414. doi: https://doi.org/10.3390/vaccines1040398
Smith LR, Wloch MK, Chaplin JA, Gerber M, Rolland AP. Clinical Development of a Cytomegalovirus DNA Vaccine: From Product Concept to Pivotal Phase 3 Trial. Vaccines (Basel). 2013 Sep 25;1(4):398-414. doi: 10.3390/vaccines1040398. PMID: 26344340; PMCID: PMC4494211.
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Combination of lycopene, quercetin and poloxamer 188 alleviates anxiety and depression in 3-nitropropionic acid-induced Huntington's disease in rats.

Journal of intercultural ethnopharmacology

Jain D, Gangshettiwar A.
PMID: 26401371
J Intercult Ethnopharmacol. 2014 Oct-Dec;3(4):186-91. doi: 10.5455/jice.20140903012921. Epub 2014 Sep 12.

AIM: The present study investigates synergistic effect of combination treatment of lycopene, quercetin and poloxamer188 in 3-nitropropionic acid (3-NP)-induced Huntington's disease (HD).MATERIALS AND METHODS: Anxiety and depression were induced in male Wistar rat by intra-peritoneal administration of 3-NP (10...

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Jain D, Gangshettiwar A. Combination of lycopene, quercetin and poloxamer 188 alleviates anxiety and depression in 3-nitropropionic acid-induced Huntington's disease in rats. J Intercult Ethnopharmacol. 2014;3(4):186-91doi: 10.5455/jice.20140903012921.
Jain, D., & Gangshettiwar, A. (2014). Combination of lycopene, quercetin and poloxamer 188 alleviates anxiety and depression in 3-nitropropionic acid-induced Huntington's disease in rats. Journal of intercultural ethnopharmacology, 3(4), 186-91. https://doi.org/10.5455/jice.20140903012921
Jain, Dilpesh, and Gangshettiwar, Arti. "Combination of lycopene, quercetin and poloxamer 188 alleviates anxiety and depression in 3-nitropropionic acid-induced Huntington's disease in rats." Journal of intercultural ethnopharmacology vol. 3,4 (2014): 186-91. doi: https://doi.org/10.5455/jice.20140903012921
Jain D, Gangshettiwar A. Combination of lycopene, quercetin and poloxamer 188 alleviates anxiety and depression in 3-nitropropionic acid-induced Huntington's disease in rats. J Intercult Ethnopharmacol. 2014 Oct-Dec;3(4):186-91. doi: 10.5455/jice.20140903012921. Epub 2014 Sep 12. PMID: 26401371; PMCID: PMC4576812.
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Solid lipid nanoparticle: an efficient carrier for improved ocular permeation of voriconazole.

Drug development and industrial pharmacy

Kumar R, Sinha VR.
PMID: 27143048
Drug Dev Ind Pharm. 2016 Dec;42(12):1956-1967. doi: 10.1080/03639045.2016.1185437. Epub 2016 May 20.

This research focuses on the fabrication and evaluation of solid lipid nanoparticles (SLNs) for improved ocular delivery of voriconazole (VCZ). Compritol and palmitic acid were selected as lipid carriers based on drug solubility and partitioning behavior. Poloxamer and soya...

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Kumar R, Sinha VR. Solid lipid nanoparticle: an efficient carrier for improved ocular permeation of voriconazole. Drug Dev Ind Pharm. 2016;42(12):1956-1967doi: 10.1080/03639045.2016.1185437.
Kumar, R., & Sinha, V. R. (2016). Solid lipid nanoparticle: an efficient carrier for improved ocular permeation of voriconazole. Drug development and industrial pharmacy, 42(12), 1956-1967. https://doi.org/10.1080/03639045.2016.1185437
Kumar, Rakesh, and Sinha, Vivek Ranjan. "Solid lipid nanoparticle: an efficient carrier for improved ocular permeation of voriconazole." Drug development and industrial pharmacy vol. 42,12 (2016): 1956-1967. doi: https://doi.org/10.1080/03639045.2016.1185437
Kumar R, Sinha VR. Solid lipid nanoparticle: an efficient carrier for improved ocular permeation of voriconazole. Drug Dev Ind Pharm. 2016 Dec;42(12):1956-1967. doi: 10.1080/03639045.2016.1185437. Epub 2016 May 20. PMID: 27143048.
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Encapsulation of Vitamin A Palmitate in Nanostructured Lipid Carrier (NLC)-Effect of Surfactant Concentration on the Formulation Properties.

Advanced pharmaceutical bulletin

Pezeshki A, Ghanbarzadeh B, Mohammadi M, Fathollahi I, Hamishehkar H.
PMID: 25671190
Adv Pharm Bull. 2014 Dec;4:563-8. doi: 10.5681/apb.2014.083. Epub 2014 Dec 31.

PURPOSE: Nanostructured lipid carrier (NLC) is a useful delivery system with high capacity for bioactive loading, and suitable stability for fortification of foods and beverages. The objective of the present work is to prepare vitamin A palmitate (vitA)-loaded NLC...

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Pezeshki A, Ghanbarzadeh B, Mohammadi M, et al. Encapsulation of Vitamin A Palmitate in Nanostructured Lipid Carrier (NLC)-Effect of Surfactant Concentration on the Formulation Properties. Adv Pharm Bull. 2014;4:563-8doi: 10.5681/apb.2014.083.
Pezeshki, A., Ghanbarzadeh, B., Mohammadi, M., Fathollahi, I., & Hamishehkar, H. (2014). Encapsulation of Vitamin A Palmitate in Nanostructured Lipid Carrier (NLC)-Effect of Surfactant Concentration on the Formulation Properties. Advanced pharmaceutical bulletin, 4563-8. https://doi.org/10.5681/apb.2014.083
Pezeshki, Akram, et al. "Encapsulation of Vitamin A Palmitate in Nanostructured Lipid Carrier (NLC)-Effect of Surfactant Concentration on the Formulation Properties." Advanced pharmaceutical bulletin vol. 4 (2014): 563-8. doi: https://doi.org/10.5681/apb.2014.083
Pezeshki A, Ghanbarzadeh B, Mohammadi M, Fathollahi I, Hamishehkar H. Encapsulation of Vitamin A Palmitate in Nanostructured Lipid Carrier (NLC)-Effect of Surfactant Concentration on the Formulation Properties. Adv Pharm Bull. 2014 Dec;4:563-8. doi: 10.5681/apb.2014.083. Epub 2014 Dec 31. PMID: 25671190; PMCID: PMC4312406.
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Artemisia arborescens L essential oil-loaded solid lipid nanoparticles for potential agricultural application: Preparation and characterization.

AAPS PharmSciTech

Lai F, Wissing SA, Müller RH, Fadda AM.
PMID: 28290017
AAPS PharmSciTech. 2006 Mar;7(1):E10. doi: 10.1208/pt070102. Epub 2017 Mar 08.

The aim of this study was to formulate a new delivery system for ecological pesticides by the incorporation of Artemisia arborescens L essential oil into solid lipid nanoparticles (SLN). Two different SLN formulations were prepared following the high-pressure homogenization...

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Lai F, Wissing SA, Müller RH, et al. Artemisia arborescens L essential oil-loaded solid lipid nanoparticles for potential agricultural application: Preparation and characterization. AAPS PharmSciTech. 2017;7(1):E10doi: 10.1208/pt070102.
Lai, F., Wissing, S. A., Müller, R. H., & Fadda, A. M. (2006). Artemisia arborescens L essential oil-loaded solid lipid nanoparticles for potential agricultural application: Preparation and characterization. AAPS PharmSciTech, 7(1), E10. https://doi.org/10.1208/pt070102
Lai, Francesco, et al. "Artemisia arborescens L essential oil-loaded solid lipid nanoparticles for potential agricultural application: Preparation and characterization." AAPS PharmSciTech vol. 7,1 (2006): E10. doi: https://doi.org/10.1208/pt070102
Lai F, Wissing SA, Müller RH, Fadda AM. Artemisia arborescens L essential oil-loaded solid lipid nanoparticles for potential agricultural application: Preparation and characterization. AAPS PharmSciTech. 2006 Mar;7(1):E10. doi: 10.1208/pt070102. Epub 2017 Mar 08. PMID: 28290017.
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Formulation, Characterisation, and in Vitro Skin Diffusion of Nanostructured Lipid Carriers for Deoxyarbutin Compared to a Nanoemulsion and Conventional Cream.

Scientia pharmaceutica

Tofani RP, Sumirtapura YC, Darijanto ST.
PMID: 28656942
Sci Pharm. 2016 Jul 20;84(4):634-645. doi: 10.3390/scipharm84040634.

The long-term use of topical hydroquinone as an anti-hyperpigmentation treatment has well-known, unwanted effects. Deoxyarbutin (4-[(tetrahydro-2H-pyran-2-yl)oxy]phenol) is a relatively new tyrosinase inhibitor, with stronger inhibitory potency than hydroquinone, that exhibited decreased cytotoxicity against melanocytes and other cells. This study...

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Tofani RP, Sumirtapura YC, Darijanto ST. Formulation, Characterisation, and in Vitro Skin Diffusion of Nanostructured Lipid Carriers for Deoxyarbutin Compared to a Nanoemulsion and Conventional Cream. Sci Pharm. 2016;84(4):634-645doi: 10.3390/scipharm84040634.
Tofani, R. P., Sumirtapura, Y. C., & Darijanto, S. T. (2016). Formulation, Characterisation, and in Vitro Skin Diffusion of Nanostructured Lipid Carriers for Deoxyarbutin Compared to a Nanoemulsion and Conventional Cream. Scientia pharmaceutica, 84(4), 634-645. https://doi.org/10.3390/scipharm84040634
Tofani, Rendra P, et al. "Formulation, Characterisation, and in Vitro Skin Diffusion of Nanostructured Lipid Carriers for Deoxyarbutin Compared to a Nanoemulsion and Conventional Cream." Scientia pharmaceutica vol. 84,4 (2016): 634-645. doi: https://doi.org/10.3390/scipharm84040634
Tofani RP, Sumirtapura YC, Darijanto ST. Formulation, Characterisation, and in Vitro Skin Diffusion of Nanostructured Lipid Carriers for Deoxyarbutin Compared to a Nanoemulsion and Conventional Cream. Sci Pharm. 2016 Jul 20;84(4):634-645. doi: 10.3390/scipharm84040634. PMID: 28656942; PMCID: PMC5198023.
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Evaluation of the methylene blue addition in binary polymeric systems composed by poloxamer 407 and Carbopol 934P using quality by design: rheological, textural, and mucoadhesive analysis.

Drug development and industrial pharmacy

Junqueira MV, Borghi-Pangoni FB, Ferreira SB, Bruschi ML.
PMID: 27161762
Drug Dev Ind Pharm. 2016 Dec;42(12):2009-2019. doi: 10.1080/03639045.2016.1188111. Epub 2016 Jun 01.

This study describes the investigation about the physicochemical behavior of methylene blue (Mb) addition to systems containing poloxamer 407 (Polox), Carbopol 934P (Carb), intended to be locally used by photodynamic therapy. A factorial design 2

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Junqueira MV, Borghi-Pangoni FB, Ferreira SB, et al. Evaluation of the methylene blue addition in binary polymeric systems composed by poloxamer 407 and Carbopol 934P using quality by design: rheological, textural, and mucoadhesive analysis. Drug Dev Ind Pharm. 2016;42(12):2009-2019doi: 10.1080/03639045.2016.1188111.
Junqueira, M. V., Borghi-Pangoni, F. B., Ferreira, S. B., & Bruschi, M. L. (2016). Evaluation of the methylene blue addition in binary polymeric systems composed by poloxamer 407 and Carbopol 934P using quality by design: rheological, textural, and mucoadhesive analysis. Drug development and industrial pharmacy, 42(12), 2009-2019. https://doi.org/10.1080/03639045.2016.1188111
Junqueira, Mariana Volpato, et al. "Evaluation of the methylene blue addition in binary polymeric systems composed by poloxamer 407 and Carbopol 934P using quality by design: rheological, textural, and mucoadhesive analysis." Drug development and industrial pharmacy vol. 42,12 (2016): 2009-2019. doi: https://doi.org/10.1080/03639045.2016.1188111
Junqueira MV, Borghi-Pangoni FB, Ferreira SB, Bruschi ML. Evaluation of the methylene blue addition in binary polymeric systems composed by poloxamer 407 and Carbopol 934P using quality by design: rheological, textural, and mucoadhesive analysis. Drug Dev Ind Pharm. 2016 Dec;42(12):2009-2019. doi: 10.1080/03639045.2016.1188111. Epub 2016 Jun 01. PMID: 27161762.
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Formulation and evaluation of periodontal in situ gel.

International journal of pharmaceutical investigation

Garala K, Joshi P, Shah M, Ramkishan A, Patel J.
PMID: 23799203
Int J Pharm Investig. 2013 Jan;3(1):29-41. doi: 10.4103/2230-973X.108961.

BACKGROUND: The present study was aimed to develop and optimize in situ gel for the treatment of periodontal disease.MATERIALS AND METHODS: Temperature-sensitive in situ gel containing 0.1% w/v Chlorhexidine hydrochloride was formulated by cold method using different polymers. Preliminary...

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Garala K, Joshi P, Shah M, et al. Formulation and evaluation of periodontal in situ gel. Int J Pharm Investig. 2013;3(1):29-41doi: 10.4103/2230-973X.108961.
Garala, K., Joshi, P., Shah, M., Ramkishan, A., & Patel, J. (2013). Formulation and evaluation of periodontal in situ gel. International journal of pharmaceutical investigation, 3(1), 29-41. https://doi.org/10.4103/2230-973X.108961
Garala, Kevin, et al. "Formulation and evaluation of periodontal in situ gel." International journal of pharmaceutical investigation vol. 3,1 (2013): 29-41. doi: https://doi.org/10.4103/2230-973X.108961
Garala K, Joshi P, Shah M, Ramkishan A, Patel J. Formulation and evaluation of periodontal in situ gel. Int J Pharm Investig. 2013 Jan;3(1):29-41. doi: 10.4103/2230-973X.108961. PMID: 23799203; PMCID: PMC3687234.
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Enhanced ex vivo intestinal absorption of olmesartan medoxomil nanosuspension: Preparation by combinative technology.

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

Attari Z, Bhandari A, Jagadish PC, Lewis S.
PMID: 26903769
Saudi Pharm J. 2016 Jan;24(1):57-63. doi: 10.1016/j.jsps.2015.03.008. Epub 2015 Mar 20.

The purpose of this study was to develop nanosuspension based on combinative technology to enhance the intestinal absorption of Olmesartan medoxomil (OLM), a potent antihypertensive agent with limited oral bioavailability. Two combinative approaches were employed and then characterized. In...

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Attari Z, Bhandari A, Jagadish PC, et al. Enhanced ex vivo intestinal absorption of olmesartan medoxomil nanosuspension: Preparation by combinative technology. Saudi Pharm J. 2015;24(1):57-63doi: 10.1016/j.jsps.2015.03.008.
Attari, Z., Bhandari, A., Jagadish, P. C., & Lewis, S. (2016). Enhanced ex vivo intestinal absorption of olmesartan medoxomil nanosuspension: Preparation by combinative technology. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 24(1), 57-63. https://doi.org/10.1016/j.jsps.2015.03.008
Attari, Zenab, et al. "Enhanced ex vivo intestinal absorption of olmesartan medoxomil nanosuspension: Preparation by combinative technology." Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society vol. 24,1 (2016): 57-63. doi: https://doi.org/10.1016/j.jsps.2015.03.008
Attari Z, Bhandari A, Jagadish PC, Lewis S. Enhanced ex vivo intestinal absorption of olmesartan medoxomil nanosuspension: Preparation by combinative technology. Saudi Pharm J. 2016 Jan;24(1):57-63. doi: 10.1016/j.jsps.2015.03.008. Epub 2015 Mar 20. PMID: 26903769; PMCID: PMC4720021.
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Dual agents loaded polymeric nanoparticle: Effect of process variables.

International journal of pharmaceutical investigation

Sharma D, Philip G, Gabrani R, Ali J, Dang S.
PMID: 26258057
Int J Pharm Investig. 2015 Jul-Sep;5(3):155-60. doi: 10.4103/2230-973X.160853.

AIM AND OBJECTIVES: In the present investigation dual agents i.e., hesperidin and diazepam loaded polymeric nanoparticles (NPs) were formulated by nanoprecipitation method and optimized using three-level factorial design.METHODS: The developed NPs were optimized keeping poly (lactic-co-glycolic) acid (PLGA), poloxamer...

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Sharma D, Philip G, Gabrani R, et al. Dual agents loaded polymeric nanoparticle: Effect of process variables. Int J Pharm Investig. 2015;5(3):155-60doi: 10.4103/2230-973X.160853.
Sharma, D., Philip, G., Gabrani, R., Ali, J., & Dang, S. (2015). Dual agents loaded polymeric nanoparticle: Effect of process variables. International journal of pharmaceutical investigation, 5(3), 155-60. https://doi.org/10.4103/2230-973X.160853
Sharma, Deepak, et al. "Dual agents loaded polymeric nanoparticle: Effect of process variables." International journal of pharmaceutical investigation vol. 5,3 (2015): 155-60. doi: https://doi.org/10.4103/2230-973X.160853
Sharma D, Philip G, Gabrani R, Ali J, Dang S. Dual agents loaded polymeric nanoparticle: Effect of process variables. Int J Pharm Investig. 2015 Jul-Sep;5(3):155-60. doi: 10.4103/2230-973X.160853. PMID: 26258057; PMCID: PMC4522865.
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Showing 1 to 12 of 425 entries