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Showing 1 to 12 of 882 entries
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Design, synthesis and anticonvulsant activity of some new 6,8-halo-substituted-2h-[1,2,4]triazino[5,6-b]indole-3(5h)-one/-thione and 6,8-halo-substituted 5-methyl-2h-[1,2,4]triazino[5,6-b]indol-3(5h)-one/-thione.

EXCLI journal

Kumar R, Singh T, Singh H, Jain S, Roy RK.
PMID: 26417257
EXCLI J. 2014 Mar 10;13:225-40. eCollection 2014.

A new series of 6,8-halo-substituted-2H-[1,2,4]triazino[5,6-b]indole-3(5H)-one/-thione and 6,8-halo-substituted 5-methyl-2H-[1,2,4]triazino[5,6-b]indol-3(5H)-one/-thione (5a-5l) were designed and synthesized keeping in view of the structural requirement of pharmacophore. The above compounds were characterized by thin layer chromatography and spectral analysis. Anticonvulsant activity of the synthesized...

Life-threatening bradyarrhythmia with oral phenytoin overdose.

Journal of pharmacology & pharmacotherapeutics

Srinivasan G, Wyawahare M, Mathen PG, Subrahmanyam DK.
PMID: 26312007
J Pharmacol Pharmacother. 2015 Jul-Sep;6(3):179-81. doi: 10.4103/0976-500X.162017.

We report a case of a 41-year-old lady, who developed severe hypotension and sinus bradycardia, following oral consumption of 20 g of phenytoin and 500 mg of glibenclamide. She required high dose of inotropes and a temporary transvenous pacer...

Controversies in contraception for women with epilepsy.

Annals of Indian Academy of Neurology

Thomas SV.
PMID: 26425002
Ann Indian Acad Neurol. 2015 Jul-Sep;18(3):278-83. doi: 10.4103/0972-2327.162261.

Contraception is an important choice that offers autonomy to women with regard to prevention of unintended pregnancies. There is wide variation in the contraceptive practices between continents, countries, and societies. The medical eligibility for contraception for sexually active women...

Morphological Pattern of Cutaneous Adverse Drug Reactions due to Antiepileptic Drugs in Eastern India.

Journal of clinical and diagnostic research : JCDR

Singh PK, Kumar MK, Kumar D, Kumar P.
PMID: 25738068
J Clin Diagn Res. 2015 Jan;9(1):WC01-3. doi: 10.7860/JCDR/2015/11701.5419. Epub 2015 Jan 01.

INTRODUCTION: Cutaneous manifestations of adverse drug reactions are a common occurrence and need to be differentiated from other causes of similar manifestations. Antiepileptic drugs (AED) usually are responsible for severe cutaneous adverse drug reactions (CADR) like Stevens-Johnson Syndrome/Toxic epidermal...

Neuroprotection for acute optic neuritis-Can it work?.

Multiple sclerosis and related disorders

Raftopoulos RE, Kapoor R.
PMID: 25877841
Mult Scler Relat Disord. 2013 Oct;2(4):307-11. doi: 10.1016/j.msard.2013.02.001. Epub 2013 Mar 13.

Optic neuritis is a common manifestation of MS and the acute inflammatory lesion in the optic nerve resembles demyelinating plaques elsewhere in the CNS. As with other MS relapses, treatment with corticosteroids has little or no impact on the...

Should we do early and frequent charcoal hemoperfusion in phenytoin toxicity?.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

Sahoo JN, Gurjar M.
PMID: 27076716
Indian J Crit Care Med. 2016 Feb;20(2):123-5. doi: 10.4103/0972-5229.175936.

Phenytoin toxicity or adverse drug reaction is common due to its narrow therapeutic window. Mild and moderate toxicity require supportive care and enteral activated charcoal. In severe toxicity, charcoal hemoperfusion (CHP) have been shown to decrease serum phenytoin half-life...

The comparison of anti-seizure and tocolytic effects of phenytoin and magnesium sulphate in the treatment of eclampsia and preeclampsia: A randomised clinical trial.

Iranian journal of neurology

Khooshideh M, Ghaffarpour M, Bitarafan S.
PMID: 29114367
Iran J Neurol. 2017 Jul 06;16(3):125-129.

No abstract available.

Kaposi's Varicelliform Eruption in Phenytoin-Induced Erythroderma.

Indian dermatology online journal

Naveen KN, Bhandary DJ, Chandan MD, Athaniker SB.
PMID: 28584772
Indian Dermatol Online J. 2017 May-Jun;8(3):231-232. doi: 10.4103/idoj.IDOJ_220_16.

No abstract available.

Release of(14)C-adenine derivatives from cerebral cortical slices: Effect of phenytoin and phenobarbital.

Neurochemical research

Lewin E, Bleck V.
PMID: 24271574
Neurochem Res. 1976 Aug;1(4):429-35. doi: 10.1007/BF00966234.

Both ouabain, 0.1 mM, and veratridine, 0.05 mM, increased the release of(14)C-labeled compounds from rat cortical slices prelabeled with(14)C-adenine and incubated in vitro. The increment in radioactivity released by both depolarizing agents was almost entirely a result of increases...

Posterior reversible encephalopathy syndrome-an under recognized manifestation of Chronic Kidney Disease.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

Kute VB, Trivedi HL, Shah PR, Gumber MR, Patel HV, Vanikar AV.
PMID: 24339647
Indian J Crit Care Med. 2013 Sep;17(5):318-20. doi: 10.4103/0972-5229.120329.

First Report of the Indian Chronic Kidney Disease (CKD) Registry showed that patient with CKD in India more frequently presented in Stage V. Many patients have uncontrolled hypertension and uremia due to noncompliance or non affordability of renal replacement...

Risk factors for seizures and antiepileptic drug-associated adverse effects in high-grade glioma patients: A multicentre, retrospective study in Hong Kong.

Surgical practice

Woo PY, Chan DT, Chan KY, Wong WK, Po YC, Kwok JC, Poon WS.
PMID: 26097495
Surg Pract. 2015 Feb;19(1):2-8. doi: 10.1111/1744-1633.12102. Epub 2015 Jan 11.

AIM: The aim of this present study was to determine the frequency, as well as risk factors, for seizures and antiepileptic drug (AED)-associated adverse effects among high-grade glioma (HGG) patients.PATIENTS AND METHODS: A multicentre, retrospective study of adult Chinese...

One Polymorph and Various Morphologies of Phenytoin at a Silica Surface Due to Preparation Kinetics.

Crystal growth & design

Ehmann HM, Baumgartner R, Reischl D, Roblegg E, Zimmer A, Resel R, Werzer O.
PMID: 25593545
Cryst Growth Des. 2015 Jan 07;15(1):326-332. doi: 10.1021/cg501391j. Epub 2014 Nov 25.

The preparation of solid crystalline films at surfaces is of great interest in a variety of fields. Within this work the preparation of pharmaceutically relevant thin films containing the active pharmaceutical ingredient phenytoin is demonstrated. The preparation techniques applied...

Showing 1 to 12 of 882 entries