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Showing 1 to 12 of 846 entries
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Gastrodin Inhibits Store-Operated Ca.

Frontiers in pharmacology

Zheng C, Lo CY, Meng Z, Li Z, Zhong M, Zhang P, Lu J, Yang Z, Yan F, Zhang Y, Huang Y, Yao X.
PMID: 28487655
Front Pharmacol. 2017 Apr 25;8:222. doi: 10.3389/fphar.2017.00222. eCollection 2017.

Cardiac hypertrophy is a major risk factor for heart failure, which are among the leading causes of human death. Gastrodin is a small molecule that has been used clinically to treat neurological and vascular diseases for many years without...

Vasorelaxing and antihypertensive activities of synthesized peptides derived from computer-aided simulation of pepsin hydrolysis of yam dioscorin.

Botanical studies

Lin YS, Lu YL, Wang GJ, Liang HJ, Hou WC.
PMID: 28510941
Bot Stud. 2014 Dec;55(1):49. doi: 10.1186/s40529-014-0049-3. Epub 2014 Jun 07.

BACKGROUND: We reported that yam dioscorin and its peptic hydrolysates exhibited ACE inhibition and antihypertensive effects on SHRs, however, the active peptides are not really isolated until now. Using ACE inhibitory screenings, two penta-peptides, KTCGY and KRIHF, were selected...

The vasodilatory action of telmisartan on isolated mesenteric artery rings from rats.

Iranian journal of basic medical sciences

Chen XP, Qian LR.
PMID: 26730331
Iran J Basic Med Sci. 2015 Oct;18(10):974-8.

OBJECTIVES: Angiotensin II type 1 receptor blockers (ARBs) represent one of the widely used antihypertensive agents. In addition to anti-hypertension effect, some ARBs also show other molecular effects such as activating peroxisome proliferator-activated receptor-γ and so on. Here we...

Protective effect of sitagliptin and rosuvastatin combination on vascular endothelial dysfunction in type-2 diabetes.

Indian journal of pharmaceutical sciences

Nade VS, Kawale LA, Patel KM.
PMID: 25767324
Indian J Pharm Sci. 2015 Jan-Feb;77(1):96-102. doi: 10.4103/0250-474x.151604.

The present investigation aimed to evaluate the protective effects of sitagliptin, glimepiride, rosuvastatin and their combinations on oxidative stress and endothelial dysfunction in the aortic tissues in fructose-fed type-2 diabetic rats. Sitagliptin (20 mg/kg, p.o.), glimepiride (2 mg/kg, p.o.),...

Maternal age effects on myometrial expression of contractile proteins, uterine gene expression, and contractile activity during labor in the rat.

Physiological reports

Elmes M, Szyszka A, Pauliat C, Clifford B, Daniel Z, Cheng Z, Wathes C, McMullen S.
PMID: 25876907
Physiol Rep. 2015 Apr;3(4). doi: 10.14814/phy2.12305.

Advanced maternal age of first time pregnant mothers is associated with prolonged and dysfunctional labor and significant risk of emergency cesarean section. We investigated the influence of maternal age on myometrial contractility, expression of contractile associated proteins (CAPs), and...

A new rodent model of cerebral hyperperfusion.

International journal of clinical and experimental medicine

Jia B, Zhao L, Xiao W, Cai B, Wang TL, Li DG.
PMID: 26770334
Int J Clin Exp Med. 2015 Oct 15;8(10):17441-50. eCollection 2015.

BACKGROUND: Most studies of hyperperfusion and hyperperfusion syndrome after carotid endarterectomy or carotid stenting are based on clinical observation or meta-analyses in patients, whereas there is little corresponding fundamental research since proper animal model that can reproduce phenotype stably...

Comparing prophylactic effect of phenylephrine and ephedrine on hypotension during spinal anesthesia for hip fracture surgery.

Advanced biomedical research

Abbasivash R, Sane S, Golmohammadi M, Shokuhi S, Toosi FD.
PMID: 27995106
Adv Biomed Res. 2016 Oct 26;5:167. doi: 10.4103/2277-9175.190943. eCollection 2016.

BACKGROUND: Spinal anesthesia is an accepted technique in hip fracture surgery and prevention of this complication by sympathomimetic agents is of potential clinical significance. The aim of this study is to compare the effect of prophylactic phenylephrine versus ephedrine...

Causes and management of small pupil in patients with cataract.

Oman journal of ophthalmology

Halkiadakis I, Chatziralli I, Drakos E, Katzakis M, Skouriotis S, Patsea E, Mitropoulos P, Kandarakis A.
PMID: 29118499
Oman J Ophthalmol. 2017 Sep-Dec;10(3):220-224. doi: 10.4103/ojo.OJO_102_2016.

BACKGROUND: The purpose of the study was to present the causes and management of small pupil (

Antihypertensive Effects of Hydroalcoholic Extract of .

Iranian journal of medical sciences

Haydari MR, Panjeshahin MR, Mashghoolozekr E, Nekooeian AA.
PMID: 28533575
Iran J Med Sci. 2017 May;42(3):266-274.

BACKGROUND: Hawthorn species decreases blood pressure and relaxes precontracted vessels. This study aimed at examining the antihypertensive effect and related mechanisms of hydroalcoholic extract of METHODS: Six groups of male Sprague-Dawley rats, each containing 6 to 8 rats, were...

Horner Syndrome Following Thyroid Surgery: The Clinical and Pharmacological Presentations.

Journal of ophthalmic & vision research

Giannaccare G, Gizzi C, Fresina M.
PMID: 27994816
J Ophthalmic Vis Res. 2016 Oct-Dec;11(4):442-444. doi: 10.4103/2008-322X.194146.

PURPOSE: To report the clinical and pharmacological findings of a patient with iatrogenic Horner syndrome (HS) which occurred after thyroid surgery.CASE REPORT: A 29-year-old man was referred to our emergency ward due to anisocoria and unilateral eyelid ptosis reported...

Vasopressin use in critically ill cirrhosis patients with catecholamine-resistant septic shock: The CVICU cohort.

World journal of hepatology

Myc LA, Stine JG, Chakrapani R, Kadl A, Argo CK.
PMID: 28144392
World J Hepatol. 2017 Jan 18;9(2):106-113. doi: 10.4254/wjh.v9.i2.106.

AIM: To examine patient-centered outcomes with vasopressin (AVP) use in patients with cirrhosis with catecholamine-refractory septic shock.METHODS: We conducted a single center, retrospective cohort study enrolling adult patients with cirrhosis treated for catecholamine-resistant septic shock in the intensive care...

Thermal decomposition of thonzonium bromide.

Pharmaceutical research

Chafetz L, Greenough RC, Frank J.
PMID: 24271714
Pharm Res. 1986 Oct;3(5):298-301. doi: 10.1023/A:1016367503669.

Thonzonium bromide, a quaternary ammonium compound used as a surface active agent in a phenylephrine nasal solution, gave a gas chromatographic peak which was proportional in height and area to its concentration. Quaternary ammonium salts are nonvolatile and polar,...

Showing 1 to 12 of 846 entries