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Showing 1 to 12 of 69 entries
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Protecting Mammalian Hair Cells from Aminoglycoside-Toxicity: Assessing Phenoxybenzamine's Potential.

Frontiers in cellular neuroscience

Majumder P, Moore PA, Richardson GP, Gale JE.
PMID: 28503132
Front Cell Neurosci. 2017 Apr 18;11:94. doi: 10.3389/fncel.2017.00094. eCollection 2017.

Aminoglycosides (AGs) are widely used antibiotics because of their low cost and high efficacy against gram-negative bacterial infection. However, AGs are ototoxic, causing the death of sensory hair cells in the inner ear. Strategies aimed at developing or discovering...

Improvement of preoperative management in patients with adrenal pheochromocytoma.

International journal of clinical and experimental medicine

Li J, Yang CH.
PMID: 25664068
Int J Clin Exp Med. 2014 Dec 15;7(12):5541-6. eCollection 2014.

OBJECTIVE: To investigate methods for improving the preoperative management of patients with pheochromocytoma.METHODS: We collected 155 cases diagnosed as adrenal pheochromocytoma and with hypertension. During preoperative preparation, 85 patients had antihypertensive therapy by using the selective α1-blocker doxazosin controlled-release...

Bioassay of phenoxybenzamine hydrochloride for possible carcinogenicity.

National Cancer Institute carcinogenesis technical report series

[No authors listed]
PMID: 12830225
Natl Cancer Inst Carcinog Tech Rep Ser. 1978;72:1-107.

A bioassay of phenoxybenzamine hydrochloride for possible carcinogenicity was conducted by administering the test chemical by intraperitoneal injection to Sprague-Dawley rats and B6C3F1 mice. Groups of 35 rats of each sex were administered phenoxybenzamine hydrochloride at one of two...

An excitatory action of adrenaline, noradrenaline, and 5-hydroxytryptamine on the spinal cord.

The Journal of physiology

E Silva MR, Sproull DH.
PMID: 16992231
J Physiol. 1966 Jul;185(2):445-54. doi: 10.1113/jphysiol.1966.sp007995.

1. Fasciculation was produced in the trapezius and sternomastoid muscles of anaesthetized cats by adrenaline, noradrenaline and 5-hydroxytryptamine (5-HT) put into the cisterna magna. Isoprenaline, similarly applied, was ineffective.2. Each of the three active amines was without effect when...

Secondary amenorrhoea due to pheochromocytoma: a case report.

Cases journal

Wakil A, Atkin S.
PMID: 18620585
Cases J. 2008 Jul 11;1(1):30. doi: 10.1186/1757-1626-1-30.

INTRODUCTION: Pheochromocytoma is a chromaffin cell catecholamine-secreting tumour originating from the adrenal medulla.CASE PRESENTATION: We report here an unusual presentation of pheochromocytoma with secondary amenorrhoea and its resolution after medical treatment with the alpha adrenergic blocker, Phenoxybenzamine.CONCLUSION: Pheochromocytoma is...

Correlation of changes in pineal gland cAMP metabolism with light-mediated decrease in N-acetyltransferase activity.

Neurochemistry international

Alphs L, Miller LP, Lovenberg W.
PMID: 20487929
Neurochem Int. 1983;5(1):101-6. doi: 10.1016/0197-0186(83)90015-3.

The present study investigated the correlation between the light-mediated decrease in rat pineal N-acetyltransferase (NAT) observed in vivo and changes in cAMP metabolism. While exposing dark-adapted rats to light for short time periods (0-10 min) resulted in a rapid...

Osthole Improves Spatial Memory Deficits in Rats via Hippocampal α 1-Adrenergic and D 1 /D 2 Receptors.

Evidence-based complementary and alternative medicine : eCAM

Lin LW, Kuo YH, Hseu YC, Tsai CW, Hsieh MT, Chen SC, Wu CR.
PMID: 23533468
Evid Based Complement Alternat Med. 2013;2013:273682. doi: 10.1155/2013/273682. Epub 2013 Feb 26.

The present study evaluated the effect of osthole, an active ingredient isolated from Cnidium monnieri L. Cusson, on spatial memory deficits caused by central neurotoxins using the Morris water maze in rats. The involvement of catecholaminergic receptors on the...

Cement-augmented dorsal instrumentation of the spine as a safe adjunct to the multimodal management of metastatic pheochromocytoma: a case report.

Patient safety in surgery

Rittirsch D, Battegay E, Zimmerli LU, Baulig W, Spahn DR, Ossendorf C, Wanner GA, Simmen HP, Werner CM.
PMID: 22222147
Patient Saf Surg. 2012 Jan 05;6(1):1. doi: 10.1186/1754-9493-6-1.

Malignant pheochromocytoma is a neuroendocrine tumor that originates from chromaffin tissue. Although osseous metastases are common, metastatic dissemination to the spine rarely occurs.Five years after primary diagnosis of extra-adrenal, abdominal pheochromocytoma and laparoscopic extirpation, a 53-year old patient presented...

Preoperative risk factors for massive blood loss in adrenalectomy for pheochromocytoma.

Oncotarget

Liu H, Li B, Yu X, Huang Y.
PMID: 29108378
Oncotarget. 2017 Aug 22;8(45):79964-79970. doi: 10.18632/oncotarget.20396. eCollection 2017 Oct 03.

BACKGROUND: This retrospective analysis of patients who underwent adrenalectomy for pheochromocytoma aimed to determine preoperative risk factors for intraoperative massive blood loss. Preoperative identification of patients at high-risk of massive blood loss may be helpful in anesthesia management and...

Effect of prazosin on feline recurrent urethral obstruction.

Journal of feline medicine and surgery

Hanson KR, Rudloff E, Yuan L, Mochel JP, Linklater AK.
PMID: 33749375
J Feline Med Surg. 2021 Dec;23(12):1176-1182. doi: 10.1177/1098612X211001283. Epub 2021 Mar 22.

OBJECTIVES: The aim of this study was to determine if male cats treated with 7 days of prazosin following relief of urethral obstruction (UO) experienced decreased rates of recurrent urethral obstruction (rUO) within 30 days vs those treated with...

Colonic Pseudo-obstruction as a Rare Complication of Pheochromocytoma.

European journal of case reports in internal medicine

So KW, Tsui HL, Tsang KH.
PMID: 33869102
Eur J Case Rep Intern Med. 2021 Mar 26;8(3):002421. doi: 10.12890/2021_002421. eCollection 2021.

Colonic pseudo-obstruction is characterized by dilatation of the colon without a structural lesion causing the obstruction. It usually involves the caecum and right side of the colon and is commonly observed in patients with severe illness or after surgery;...

A Predictive Nomogram for Red Blood Cell Transfusion in Pheochromocytoma Surgery: A Study on Improving the Preoperative Management of Pheochromocytoma.

Frontiers in endocrinology

Guo Y, You L, Hu H, Tong A, Zhang X, Yan L, Zhang S.
PMID: 33790869
Front Endocrinol (Lausanne). 2021 Mar 11;12:647610. doi: 10.3389/fendo.2021.647610. eCollection 2021.

PURPOSE: Surgery is the major treatment option for pheochromocytoma but carries potential risks, including hemorrhage and hemodynamic instability. Even with laparoscopic adrenalectomy, intraoperative blood transfusion happens from time to time, but few studies have investigated risk factors. For the...

Showing 1 to 12 of 69 entries