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Showing 1 to 12 of 65592 entries
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The Bio-Persistence of Reversible Inflammatory, Histological Changes and Metabolic Profile Alterations in Rat Livers after Silver/Gold Nanorod Administration.

Nanomaterials (Basel, Switzerland)

Liu Y, Wen H, Wu X, Wu M, Liu L, Wang J, Huo G, Lyu J, Xie L, Dan M.
PMID: 34685095
Nanomaterials (Basel). 2021 Oct 09;11(10). doi: 10.3390/nano11102656.

As a widely applied nanomaterial, silver nanomaterials (AgNMs) have increased public concern about their potential adverse biological effects. However, there are few related researches on the long-term toxicity, especially on the reversibility of AgNMs in vivo. In the current...

Pharmacokinetic effects of proton pump inhibitors on the novel PARP inhibitor fluzoparib: a single-arm, fixed-sequence trial in male healthy volunteers.

Investigational new drugs

Li L, Xiang YX, Yang GP, Zhang XF, Yang XY, Yang S, Huang J.
PMID: 33420642
Invest New Drugs. 2021 Jun;39(3):796-802. doi: 10.1007/s10637-020-01034-w. Epub 2021 Jan 09.

Purpose To assess the pharmacokinetic (PK) effect of proton pump inhibitors on the novel poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitor fluzoparib, and observe the safety of its co-administration with omeprazole. Patients and methods Sixteen male healthy volunteers (HVs) were enrolled...

Roles of ROS and cell cycle arrest in the genotoxicity induced by gold nanorod core/silver shell nanostructure.

Nanoscale research letters

Wang D, Dan M, Ji Y, Wu X, Wang X, Wen H.
PMID: 33284367
Nanoscale Res Lett. 2020 Dec 07;15(1):224. doi: 10.1186/s11671-020-03455-1.

To understand the genotoxicity induced in the liver by silver nanoparticles (AgNPs) and silver ions, an engineered gold nanorod core/silver shell nanostructure ([email protected] NR) and humanized hepatocyte HepaRG cells were used in this study. The involvement of oxidative stress...

Metabolizable Near-Infrared-II Nanoprobes for Dynamic Imaging of Deep-Seated Tumor-Associated Macrophages in Pancreatic Cancer.

ACS nano

Luo X, Hu D, Gao D, Wang Y, Chen X, Liu X, Zheng H, Sun M, Sheng Z.
PMID: 34060821
ACS Nano. 2021 Jun 22;15(6):10010-10024. doi: 10.1021/acsnano.1c01608. Epub 2021 Jun 01.

Tumor-associated macrophages (TAMs) play a crucial part in cancer evolution. Dynamic imaging of TAMs is of great significance for treatment outcome evaluation and precision tumor therapy. Currently, most fluorescence nanoprobes tend to accumulate in the liver and are difficult...

Are the optimum pharmaceutical preparations used for the second-line eradication therapy for helicobacter pylori infection in Japan? - a discussion from a simulation for the amount of antibiotics in stomach based on the data of dissolution studies -.

Journal of basic and clinical pharmacy

Kubodera M, Tokumura T, Machida Y.
PMID: 24825995
J Basic Clin Pharm. 2010 Sep;1(4):255-61. Epub 2010 Nov 15.

The purpose of this study was to evaluate whether the optimum preparations are used for the second-line eradication therapy for Helicobacter pylori (H. pylori) infection in Japan. In the therapy, commercial tablets, which have 250 mg of amoxicillin (AMX)...

Sponge particulates for biomedical applications: Biofunctionalization, multi-drug shielding, and theranostic applications.

Biomaterials

Zhang H, Jin Y, Chi C, Han G, Jiang W, Wang Z, Cheng H, Zhang C, Wang G, Sun C, Chen Y, Xi Y, Liu M, Gao X, Lin X, Lv L, Zhou J, Ding Y.
PMID: 33894401
Biomaterials. 2021 Jun;273:120824. doi: 10.1016/j.biomaterials.2021.120824. Epub 2021 Apr 15.

Sponge particulates have attracted enormous attention in biomedical applications for superior properties, including large porosity, elastic deformation, capillary action, and three-dimensional (3D) reaction environment. Especially, the tiny porous structures make sponge particulates a promising platform for drug delivery, tissue...

[Efficacy trial of the antimicrobial preservation of pharmaceutical preparations. 3d joint report of the Committee for Laboratories and Official Services for the Control of Drugs and the Section of Industrial Pharmacists--International Pharmacy Federation, June 1979].

Pharmaceutica acta Helvetiae

[No authors listed]
PMID: 395540
Pharm Acta Helv. 1979;54(12):370-9.

No abstract available.

Development and application of a validated stability-indicating high-performance liquid chromatographic method using photodiode array detection for simultaneous determination of granisetron, methylparaben, propylparaben, sodium benzoate, and their main degradation products in oral pharmaceutical preparations.

Journal of AOAC International

Hewala I, El-Fatatry H, Emam E, Mabrouk M.
PMID: 22165009
J AOAC Int. 2011 Sep-Oct;94(5):1447-60. doi: 10.5740/jaoacint.10-129.

A simple, rapid, and sensitive RP-HPLC method using photodiode array detection was developed and validated for the simultaneous determination of granisetron hydrochloride, 1-methyl-1H-indazole-3-carboxylic acid (the main degradation product of granisetron), sodium benzoate, methylparaben, propylparaben, and 4-hydroxybenzoic acid (the main...

[The pH-endoradio transmitter: a method for studying the decomposition of gastric juice resistant enteric-coated pharmaceutical preparations in the intestine. 2. Decomposition time of gastric juice resistant enteric-coated hard gelain capsules].

Arzneimittel-Forschung

Eckert T, Rothgang G, Seidel R.
PMID: 5696018
Arzneimittelforschung. 1968 Mar;18(3):372-3.

No abstract available.

The control of injections and other pharmaceutical preparations by means of U.V. spectrophotometry as a standard analytical tool. IV. Differences and correspondences in the U.V. absorption spectra of pharmaceuticals with isolated (phenyl) chromophores.

Pharmaceutisch weekblad

van der POL H, REKKER RF.
PMID: 14433723
Pharm Weekbl. 1959 Dec 12;94:813-6.

No abstract available.

Potential antioxidant properties and hepatoprotective effects of Juniperus phoenicea berries against CCl.

Asian Pacific journal of tropical medicine

Laouar A, Klibet F, Bourogaa E, Benamara A, Boumendjel A, Chefrour A, Messarah M.
PMID: 28442109
Asian Pac J Trop Med. 2017 Mar;10(3):263-269. doi: 10.1016/j.apjtm.2017.03.005. Epub 2017 Mar 07.

OBJECTIVE: To investigate the antioxidant and hepatoprotective properties of Juniperus phoenicea (J. phoenicea) berries against CClMETHODS: Hepatotoxicity was induced in albino Wistar rats by single dose of CClRESULTS: Obtained results revealed that administration of CClCONCLUSIONS: The results of the...

Reversed phase ion pair chromatography with an adsorbing stationary phase and a hydrophobic quaternary ammonium ion in the mobile phase. Part II: quantitative analysis of multi-component analgesic pharmaceutical preparations.

Acta pharmaceutica Suecica

Tilly Melin A, Askemark Y.
PMID: 539439
Acta Pharm Suec. 1979;16(5):289-98.

No abstract available.

Showing 1 to 12 of 65592 entries