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Showing 1 to 12 of 395 entries
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Depressant effects of Agastache mexicana methanol extract and one of major metabolites tilianin.

Asian Pacific journal of tropical medicine

González-Trujano ME, Ponce-Muñoz H, Hidalgo-Figueroa S, Navarrete-Vázquez G, Estrada-Soto S.
PMID: 25902158
Asian Pac J Trop Med. 2015 Mar;8(3):185-90. doi: 10.1016/S1995-7645(14)60312-6.

OBJECTIVE: To determine the depressant-like effects and the possible mechanism of action of tilianin isolated from active methanol extract of Agastache mexicana (A. mexicana). Also, to establish the pharmacophoric requirements of tilianin, as a possible ligand of GABAA/BZD receptor,...

Ameliorative effect of vitamin E on trichloroethylene-induced nephrotoxicity in rats.

Journal of nephropathology

Heydari M, Ahmadizadeh M, Ahmadi Angali K.
PMID: 28975097
J Nephropathol. 2017 Jul;6(3):168-173. doi: 10.15171/jnp.2017.29. Epub 2016 Dec 20.

BACKGROUND: 1,1,2-Trichloroethylene (TCE) is an important organic solvent which is widespread in the environment. Work place exposure to TCE has been associated adverse effects in many organs including kidney. Vitamin E is an antioxidant that can overcome oxidative stress.OBJECTIVES:...

Effects of biogenic amines and intravenous anesthetics on the activity of rat locus coeruleus neurons in vitro.

Journal of anesthesia

Ohta Y, Yamamura T, Santos Alojado E, Kemmotsu O.
PMID: 28921147
J Anesth. 1994 Jun;8(2):213-218. doi: 10.1007/BF02514716.

To examine the effects of biogenic amines and clinically relevant concentrations of intravenous anesthetics on neuronal activities, the authors analyzed both spontaneous and evoked activities of neurons in the nucleus locus coeruleus (LC)in vitro using a single unit recording...

Hypnotic effect of Coriandrum sativum, Ziziphus jujuba, Lavandula angustifolia and Melissa officinalis extracts in mice.

Research in pharmaceutical sciences

Hajhashemi V, Safaei A.
PMID: 26779267
Res Pharm Sci. 2015 Nov-Dec;10(6):477-84.

The aim of the present study was to evaluate hypnotic effect of Coriandrum sativum, Ziziphus jujuba, Lavandula angustifolia and Melissa officinalis hydroalcoholic extracts in mice to select the most effective ones for a combination formula. Three doses of the...

Simvastatin attenuates chromium-induced nephrotoxicity in rats.

Journal of nephropathology

Goodarzi Z, Karami E, Ahmadizadeh M.
PMID: 28042547
J Nephropathol. 2017 Jan;6(1):5-9. doi: 10.15171/jnp.2017.02. Epub 2016 Aug 09.

BACKGROUND: Hexavalent Chromium (Cr (VI)) compounds are extremely toxic and have been demonstrated to induce nephrotoxicity associated with oxidative stress in humans and animals. The wide environmental distribution of these agents lead to an increase interest of preventive effects...

Complications during the management of pediatric refractory status epilepticus with benzodiazepine and pentobarbital infusions.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

Patten W, Naqvi SZ, Raszynski A, Totapally BR.
PMID: 25983434
Indian J Crit Care Med. 2015 May;19(5):275-7. doi: 10.4103/0972-5229.156476.

The objective of this retrospective study was to evaluate complications in the management of refractory status epilepticus (RSE) treated with benzodiazepine and pentobarbital infusions. Of 28 children with RSE, eleven (39%) were treated with a pentobarbital infusion after failure...

Propylene Glycol Toxicity in Adolescent with Refractory Myoclonic Status Epilepticus.

Case reports in pediatrics

Bjur KA, Cannon BC, Fine AL, Ritter MJ, Schueler KE, Nemergut ME.
PMID: 28331645
Case Rep Pediatr. 2017;2017:2979486. doi: 10.1155/2017/2979486. Epub 2017 Feb 26.

Propylene glycol (PG) is a solvent commonly used in medications that, while benign at low doses, may cause toxicity in adults and children at high doses. We describe a case and the physiologic sequelae of propylene glycol toxicity manifested...

Attempts to establish phencyclidine and cocaine discrimination without error.

Behavioural pharmacology

McMillan DE, Hardwick WC.
PMID: 11224081
Behav Pharmacol. 1991 Nov;2(4):379-389.

An attempt was made to train pigeons to discriminate phencyclidine (PCP) from saline using a three-key color-tracking procedure under which birds were trained under a second order schedule [FR10 (FR5)] "without errors." Training without errors was done by not...

Effects of drugs on two-lever single-alternation performance in rats and mice(2).

Behavioural pharmacology

Donald JM, McMillan DE.
PMID: 11175440
Behav Pharmacol. 1990;1(6):541-544.

The effects of d-amphetamine, chlorpromazine and pentobarbital on single alternation were compared in mice and rats. Chlorpromazine and d-amphetamine produced dose-related decreases in both accuracy and rate of responding with no differences in species sensitivity. Pentobarbital also produced dose-dependent...

Participation of Galaninergic Neurotransmission at the Paraventricular Hypothalamic Nucleus in the Suppression of Baroreceptor Reflex Response by Locus ceruleus in the Rat.

Journal of biomedical science

Yang NC, Chan SH, Chan JY.
PMID: 11725139
J Biomed Sci. 1997 Mar-Jun;4(2):91-97. doi: 10.1007/BF02255599.

We evaluated the potential participation of galanin (GAL) at the paraventricular nucleus of hypothalamus (PVN) in the suppression of baroreceptor reflex (BRR) response by locus ceruleus (LC), using adult male Sprague-Dawley rats anesthetized with pentobarbital sodium. Microinjection of GAL...

Effects of food deprivation and satiation on sensitivity to the discriminative-stimulus effects of pentobarbital in pigeons and morphine in rats.

Behavioural pharmacology

Li M, Garner HR, Wessinger WD, McMillan DE.
PMID: 11224375
Behav Pharmacol. 1995 Nov;6(7):724-731.

Food deprivation can produce a substantial increase in the self-administration of drugs of abuse, suggesting that food deprivation increases their reinforcing properties. This finding has been replicated with a wide variety of reinforcing drugs. The present experiments examined the...

Tolerance and cross-tolerance to the response rate-decreasing effects of µ opioids in morphine-maintained squirrel monkeys.

Behavioural pharmacology

Hughes CE, Picker MJ, Dykstra LA.
PMID: 11224380
Behav Pharmacol. 1995 Dec;6(8):776-784.

The purpose of the present experiment was to assess the degree of tolerance and cross-tolerance to the response rate-decreasing effects of opioids with different degrees of intrinsic efficacy at the mu receptor. The mu opioids included buprenorphine, etorphine, l-methadone,...

Showing 1 to 12 of 395 entries