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Showing 1 to 12 of 152 entries
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Animal Models of Cancer-Associated Hypercalcemia.

Veterinary sciences

Kohart NA, Elshafae SM, Breitbach JT, Rosol TJ.
PMID: 29056680
Vet Sci. 2017 Apr 13;4(2). doi: 10.3390/vetsci4020021.

Cancer-associated hypercalcemia (CAH) is a frequently-occurring paraneoplastic syndrome that contributes to substantial patient morbidity and occurs in both humans and animals. Patients with CAH are often characterized by markedly elevated serum calcium concentrations that result in a range of...

Type I saikosaponins a and d inhibit osteoclastogenesis in bone marrow-derived macrophages and osteolytic activity of metastatic breast cancer cells.

Evidence-based complementary and alternative medicine : eCAM

Shin JE, Kim HJ, Kim KR, Lee SK, Park J, Kim H, Park KK, Chung WY.
PMID: 25892999
Evid Based Complement Alternat Med. 2015;2015:582437. doi: 10.1155/2015/582437. Epub 2015 Mar 29.

Many osteopenic disorders, including a postmenopausal osteoporosis and lytic bone metastasis in breast and prostate cancers, are linked with a hyperosteoclast activity due to increased receptor activator of nuclear factor kappa-B ligand (RANKL) expression in osteoblastic/stromal cells. Therefore, inhibition...

On the evolution of development.

Trends in developmental biology

Torday JS.
PMID: 25729239
Trends Dev Biol. 2014;8:17-37.

Perhaps development is more than just morphogenesis. We now recognize that the conceptus expresses epigenetic marks that heritably affect it phenotypically, indicating that the offspring are to some degree genetically autonomous, and that ontogeny and phylogeny may coordinately determine...

Proprotein-Processing Endoprotease Furin and its Substrate Parathyroid Hormone-Related Protein Are Coexpressed in Insulinoma Cells.

Endocrine pathology

Sawada Y, Kameya T, Aizama T, Izumi T, Takeuchi T.
PMID: 12114655
Endocr Pathol. 2000;11(1):31-39. doi: 10.1385/ep:11:1:31.

Parathyroid hormone-related protein (PTHrP) is frequently produced in pancreatic endocrine tumors. PTHrP is synthesized as the precursor pro-PTHrP and undergoes a series of posttranslational processing reactions, among which cleavage of a 12 amino acid sequence from its precursor is...

Coherent expression chromosome cluster analysis reveals differential regulatory functions of amino-terminal and distal parathyroid hormone-related protein domains in prostate carcinoma.

Journal of biomedicine & biotechnology

Tsigelny I, Burton DW, Sharikov Y, Hastings RH, Deftos LJ.
PMID: 16489268
J Biomed Biotechnol. 2005;2005(4):353-63. doi: 10.1155/JBB.2005.353.

Parathyroid hormone-related protein (PTHrP) has a number of cancer-related actions. While best known for causing hypercalcemia of malignancy, it also has effects on cancer cell growth, apoptosis, and angiogenesis. Studying the actions of PTHrP in human cancer is complicated...

Postpartum hypercalcemia secondary to a neuroendocrine tumor of pancreas; a case report and review of literature.

Iranian journal of medical sciences

Ghazi AA, Boustani I, Amouzegar A, Attarian H, Pourafkari M, Gashti HN, Sabetian T, Tirgari F, Ghazi S, Kovacs K.
PMID: 23358529
Iran J Med Sci. 2011 Sep;36(3):217-21.

Parathyroid hormone-related protein producing pancreatic neuroendocrine tumors have been infrequently reported. Herein, we report a case of an Iranian woman who had such a tumor during pregnancy, and gave birth to a female neonate with esophago-tracheal fistula and imperforated...

Severe Hypercalcaemia - Chronic Tophaceous Gout as the Responsible Cause?.

European endocrinology

Rodríguez-Gutiérrez R, Zapata-Rivera MA, Rodriguez-Velver KV, Lavalle-Gonzalez FJ, Gonzalez-Gonzalez JG, Villarreal-Perez JZ.
PMID: 29632580
Eur Endocrinol. 2015 Aug;11(2):102-104. doi: 10.17925/EE.2015.11.02.102. Epub 2015 Aug 19.

The association of chronic tophaceous gout with severe hypercalcaemia is exceptional. In this case, a 42-year old man with a long-standing history of gout arrived at the emergency room with altered mental status. Laboratory work up revealed a uric...

Calcitriol-mediated hypercalcemia in a patient with bilateral adrenal non-Hodgkin's B-cell lymphoma case report.

Journal of community hospital internal medicine perspectives

Abaroa-Salvatierra A, Shaikh B, Deshmukh M, Alweis R, Patel A.
PMID: 27124160
J Community Hosp Intern Med Perspect. 2016 Apr 25;6(2):30381. doi: 10.3402/jchimp.v6.30381. eCollection 2016.

Calcitriol-mediated hypercalcemia is a frequent manifestation of hematological malignancies. However, there are a few reports of cases presenting with increased angiotensin-converting enzyme (ACE) level, which suggests a possible mechanism similar to that of granulomatous diseases. We present a patient...

The Roles of Epithelial-to-Mesenchymal Transition (EMT) and Mesenchymal-to-Epithelial Transition (MET) in Breast Cancer Bone Metastasis: Potential Targets for Prevention and Treatment.

Journal of clinical medicine

Demirkan B.
PMID: 26237148
J Clin Med. 2013 Nov 22;2(4):264-82. doi: 10.3390/jcm2040264.

Many studies have revealed molecular connections between breast and bone. Genes, important in the control of bone remodeling, such as receptor activator of nuclear kappa (RANK), receptor activator of nuclear kappa ligand (RANKL), vitamin D, bone sialoprotein (BSP), osteopontin...

Profile of Abaloparatide and Its Potential in the Treatment of Postmenopausal Osteoporosis.

Cureus

Tella SH, Kommalapati A, Correa R.
PMID: 28680788
Cureus. 2017 May 31;9(5):e1300. doi: 10.7759/cureus.1300.

Abaloparatide (previously known as BA058) is a synthetic 34-amino acid peptide and novel selective activator of parathyroid hormone receptor 1 (PTHR1) currently under development as a new anabolic agent in the management of osteoporosis. This paper reviews the profile...

Expression of parathyroid hormone related protein (PTHRP) in ameloblastomas.

Journal of clinical and experimental dentistry

Zeballos R, Bologna-Molina R, Pereira-Prado V, Villarroel-Dorrego M.
PMID: 29670736
J Clin Exp Dent. 2018 Feb 01;10(2):e172-e176. doi: 10.4317/jced.54222. eCollection 2018 Feb.

BACKGROUND: Presence of parathyroid hormone related protein (PTHrP) might suggest that ameloblastomas recapitulate features of the enamel epithelium and induce bone resorption, which would facilitate their growth and local invasion. The aim of this study was to determine the...

The effect of nitro-oleic versus losartan in diabetic nephropathy: modulation of parathyroid hormone-related protein.

Folia morphologica

Mohammed AS, Sadek NB, Eshra MA, Khowailed EAH, Rashed LA, Aboulhoda BE.
PMID: 30009367
Folia Morphol (Warsz). 2019;78(1):79-90. doi: 10.5603/FM.a2018.0057. Epub 2018 Jul 16.

BACKGROUND: Parathyroid hormone-related protein (PTHrP) involvement in the mechanisms related to angiotensin II (AngII)-induced renal injury has become an emerging concern. The current study was thus designed to compare the possible preventive and therapeutic effect of AngII antagonists, losartan...

Showing 1 to 12 of 152 entries