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Diclofenac, a nonsteroidal anti-inflammatory drug, is an antagonist of human TRPM3 isoforms.

Pharmacology research & perspectives

Suzuki H, Sasaki E, Nakagawa A, Muraki Y, Hatano N, Muraki K.
PMID: 27433342
Pharmacol Res Perspect. 2016 Apr 07;4(3):e00232. doi: 10.1002/prp2.232. eCollection 2016 Jun.

The effects of diclofenac (Dic), an acetic acid derivative-type nonsteroidal anti-inflammatory drug, were examined on the function of transient receptor potential (TRP) melastatin (TRPM) 3 (TRPM3) in human embryonic kidney 293 cell-line (HEK293) cells with recombinant human TRPM3 isoforms...

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Suzuki H, Sasaki E, Nakagawa A, et al. Diclofenac, a nonsteroidal anti-inflammatory drug, is an antagonist of human TRPM3 isoforms. Pharmacol Res Perspect. 2016;4(3):e00232doi: 10.1002/prp2.232.
Suzuki, H., Sasaki, E., Nakagawa, A., Muraki, Y., Hatano, N., & Muraki, K. (2016). Diclofenac, a nonsteroidal anti-inflammatory drug, is an antagonist of human TRPM3 isoforms. Pharmacology research & perspectives, 4(3), e00232. https://doi.org/10.1002/prp2.232
Suzuki, Hiroka, et al. "Diclofenac, a nonsteroidal anti-inflammatory drug, is an antagonist of human TRPM3 isoforms." Pharmacology research & perspectives vol. 4,3 (2016): e00232. doi: https://doi.org/10.1002/prp2.232
Suzuki H, Sasaki E, Nakagawa A, Muraki Y, Hatano N, Muraki K. Diclofenac, a nonsteroidal anti-inflammatory drug, is an antagonist of human TRPM3 isoforms. Pharmacol Res Perspect. 2016 Apr 07;4(3):e00232. doi: 10.1002/prp2.232. eCollection 2016 Jun. PMID: 27433342; PMCID: PMC4876142.
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Imperatorin derivative OW1 inhibits the upregulation of TGF-β and MMP-2 in renovascular hypertension-induced cardiac remodeling.

Experimental and therapeutic medicine

Zhou N, Zhu Y, Zhang P, Zhang YU, Zhou M, Wang T, He L.
PMID: 27168797
Exp Ther Med. 2016 May;11(5):1748-1754. doi: 10.3892/etm.2016.3172. Epub 2016 Mar 15.

Chronic hypertension induces vascular and cardiac remodeling. OW1 is a novel imperatorin derivative that was previously reported to inhibit vascular remodeling and improve kidney function affected by hypertension. In the present study, the effect of OW1 on the cardiac...

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Zhou N, Zhu Y, Zhang P, et al. Imperatorin derivative OW1 inhibits the upregulation of TGF-β and MMP-2 in renovascular hypertension-induced cardiac remodeling. Exp Ther Med. 2016;11(5):1748-1754doi: 10.3892/etm.2016.3172.
Zhou, N., Zhu, Y., Zhang, P., Zhang, Y. U., Zhou, M., Wang, T., & He, L. (2016). Imperatorin derivative OW1 inhibits the upregulation of TGF-β and MMP-2 in renovascular hypertension-induced cardiac remodeling. Experimental and therapeutic medicine, 11(5), 1748-1754. https://doi.org/10.3892/etm.2016.3172
Zhou, Nan, et al. "Imperatorin derivative OW1 inhibits the upregulation of TGF-β and MMP-2 in renovascular hypertension-induced cardiac remodeling." Experimental and therapeutic medicine vol. 11,5 (2016): 1748-1754. doi: https://doi.org/10.3892/etm.2016.3172
Zhou N, Zhu Y, Zhang P, Zhang YU, Zhou M, Wang T, He L. Imperatorin derivative OW1 inhibits the upregulation of TGF-β and MMP-2 in renovascular hypertension-induced cardiac remodeling. Exp Ther Med. 2016 May;11(5):1748-1754. doi: 10.3892/etm.2016.3172. Epub 2016 Mar 15. PMID: 27168797; PMCID: PMC4840669.
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The Novel Development of an Experimental Model of Dihydropyridine Calcium Channel Blocker Poisoning using Intravenous Amlodipine.

International journal of cardiovascular research

Jang D, Donovan S, Bania T, Nelson L, Hoffman R, Chu J.
PMID: 24416727
Int J Cardiovasc Res. 2013 Mar 29;2(2):1000121.

BACKGROUND: Cardiovascular drug poisoning remains a leading cause of fatality. Within this class, calcium channel blockers (CCBs) account for the majority of deaths. CCBs are typically categorized as dihydropyridines (i.e. amlodipine or nifedipine) versus the non-dihydropyridine (i.e. verapamil and...

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Jang D, Donovan S, Bania T, et al. The Novel Development of an Experimental Model of Dihydropyridine Calcium Channel Blocker Poisoning using Intravenous Amlodipine. Int J Cardiovasc Res. 2013;2(2):1000121
Jang, D., Donovan, S., Bania, T., Nelson, L., Hoffman, R., & Chu, J. (2013). The Novel Development of an Experimental Model of Dihydropyridine Calcium Channel Blocker Poisoning using Intravenous Amlodipine. International journal of cardiovascular research, 2(2), 1000121.
Jang, David, et al. "The Novel Development of an Experimental Model of Dihydropyridine Calcium Channel Blocker Poisoning using Intravenous Amlodipine." International journal of cardiovascular research vol. 2,2 (2013): 1000121.
Jang D, Donovan S, Bania T, Nelson L, Hoffman R, Chu J. The Novel Development of an Experimental Model of Dihydropyridine Calcium Channel Blocker Poisoning using Intravenous Amlodipine. Int J Cardiovasc Res. 2013 Mar 29;2(2):1000121. PMID: 24416727; PMCID: PMC3886834.
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Spontaneous electrical activity of cultured interstitial cells of cajal from mouse urinary bladder.

The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology

Kim SO, Jeong HS, Jang S, Wu MJ, Park JK, Jiao HY, Jun JY, Park JS.
PMID: 24381503
Korean J Physiol Pharmacol. 2013 Dec;17(6):531-6. doi: 10.4196/kjpp.2013.17.6.531. Epub 2013 Dec 16.

Interstitial cells of Cajal (ICCs) from the urinary bladder regulate detrusor smooth muscle activities. We cultured ICCs from the urinary bladder of mice and performed patch clamp and intracellular Ca(2+) ([Ca(2+)]i) imaging to investigate whether cultured ICCs can be...

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Kim SO, Jeong HS, Jang S, et al. Spontaneous electrical activity of cultured interstitial cells of cajal from mouse urinary bladder. Korean J Physiol Pharmacol. 2013;17(6):531-6doi: 10.4196/kjpp.2013.17.6.531.
Kim, S. O., Jeong, H. S., Jang, S., Wu, M. J., Park, J. K., Jiao, H. Y., Jun, J. Y., & Park, J. S. (2013). Spontaneous electrical activity of cultured interstitial cells of cajal from mouse urinary bladder. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 17(6), 531-6. https://doi.org/10.4196/kjpp.2013.17.6.531
Kim, Sun-Ouck, et al. "Spontaneous electrical activity of cultured interstitial cells of cajal from mouse urinary bladder." The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology vol. 17,6 (2013): 531-6. doi: https://doi.org/10.4196/kjpp.2013.17.6.531
Kim SO, Jeong HS, Jang S, Wu MJ, Park JK, Jiao HY, Jun JY, Park JS. Spontaneous electrical activity of cultured interstitial cells of cajal from mouse urinary bladder. Korean J Physiol Pharmacol. 2013 Dec;17(6):531-6. doi: 10.4196/kjpp.2013.17.6.531. Epub 2013 Dec 16. PMID: 24381503; PMCID: PMC3874441.
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Antihypertensive drug prescription pattern before and during pregnancy in France.

Pregnancy hypertension

Duhalde V, Delarue C, Lacroix I, Suarez C, Bourrel R, Montastruc JL, Damase-Michel C.
PMID: 26104501
Pregnancy Hypertens. 2011 Apr;1(2):185-9. doi: 10.1016/j.preghy.2011.01.001. Epub 2011 Feb 01.

OBJECTIVE: This study provides firsthand information on antihypertensive prescriptions before and during pregnancy in France.METHODS: The study, on 23,898 women, was carried out using data from the French Health Insurance System.RESULTS: Before and during pregnancy, 1.1% and 5.1% of...

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Duhalde V, Delarue C, Lacroix I, et al. Antihypertensive drug prescription pattern before and during pregnancy in France. Pregnancy Hypertens. 2011;1(2):185-9doi: 10.1016/j.preghy.2011.01.001.
Duhalde, V., Delarue, C., Lacroix, I., Suarez, C., Bourrel, R., Montastruc, J. L., & Damase-Michel, C. (2011). Antihypertensive drug prescription pattern before and during pregnancy in France. Pregnancy hypertension, 1(2), 185-9. https://doi.org/10.1016/j.preghy.2011.01.001
Duhalde, Veronique, et al. "Antihypertensive drug prescription pattern before and during pregnancy in France." Pregnancy hypertension vol. 1,2 (2011): 185-9. doi: https://doi.org/10.1016/j.preghy.2011.01.001
Duhalde V, Delarue C, Lacroix I, Suarez C, Bourrel R, Montastruc JL, Damase-Michel C. Antihypertensive drug prescription pattern before and during pregnancy in France. Pregnancy Hypertens. 2011 Apr;1(2):185-9. doi: 10.1016/j.preghy.2011.01.001. Epub 2011 Feb 01. PMID: 26104501.
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In vitro inhibitory effects of plumbagin, the promising antimalarial candidate, on human cytochrome P450 enzymes.

Asian Pacific journal of tropical medicine

Sumsakul W, Chaijaroenkul W, Na-Bangchang K.
PMID: 26614990
Asian Pac J Trop Med. 2015 Nov;8(11):914-918. doi: 10.1016/j.apjtm.2015.10.016. Epub 2015 Oct 09.

OBJECTIVE: To investigate the propensity of plumbagin to inhibit the three isoforms of human cytochrome P450 (CYP), i.e., CYP1A2, CYP2C19, and CYP3A4 using human liver microsomes in vitro.METHODS: Inhibitory effects of plumbagin on the three human CYP isoforms were...

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Sumsakul W, Chaijaroenkul W, Na-Bangchang K. In vitro inhibitory effects of plumbagin, the promising antimalarial candidate, on human cytochrome P450 enzymes. Asian Pac J Trop Med. 2015;8(11):914-918doi: 10.1016/j.apjtm.2015.10.016.
Sumsakul, W., Chaijaroenkul, W., & Na-Bangchang, K. (2015). In vitro inhibitory effects of plumbagin, the promising antimalarial candidate, on human cytochrome P450 enzymes. Asian Pacific journal of tropical medicine, 8(11), 914-918. https://doi.org/10.1016/j.apjtm.2015.10.016
Sumsakul, Wiriyaporn, et al. "In vitro inhibitory effects of plumbagin, the promising antimalarial candidate, on human cytochrome P450 enzymes." Asian Pacific journal of tropical medicine vol. 8,11 (2015): 914-918. doi: https://doi.org/10.1016/j.apjtm.2015.10.016
Sumsakul W, Chaijaroenkul W, Na-Bangchang K. In vitro inhibitory effects of plumbagin, the promising antimalarial candidate, on human cytochrome P450 enzymes. Asian Pac J Trop Med. 2015 Nov;8(11):914-918. doi: 10.1016/j.apjtm.2015.10.016. Epub 2015 Oct 09. PMID: 26614990.
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New mechanisms of antiplatelet activity of nifedipine, an L-type calcium channel blocker.

BioMedicine

Chou TC.
PMID: 25520937
Biomedicine (Taipei). 2014;4:24. doi: 10.7603/s40681-014-0024-z. Epub 2014 Nov 18.

Platelet hyperactivity often occursd in hypertensive patients and is a key factor in the development of cardiovascular diseases including thrombosis and atherosclerosis. Nifedipine, an L-type calcium channel blocker, is widely used for hypertension and coronary heart disease therapy. In...

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Chou TC. New mechanisms of antiplatelet activity of nifedipine, an L-type calcium channel blocker. Biomedicine (Taipei). 2014;4:24doi: 10.7603/s40681-014-0024-z.
Chou, T. C. (2014). New mechanisms of antiplatelet activity of nifedipine, an L-type calcium channel blocker. BioMedicine, 424. https://doi.org/10.7603/s40681-014-0024-z
Chou, Tz-Chong. "New mechanisms of antiplatelet activity of nifedipine, an L-type calcium channel blocker." BioMedicine vol. 4 (2014): 24. doi: https://doi.org/10.7603/s40681-014-0024-z
Chou TC. New mechanisms of antiplatelet activity of nifedipine, an L-type calcium channel blocker. Biomedicine (Taipei). 2014;4:24. doi: 10.7603/s40681-014-0024-z. Epub 2014 Nov 18. PMID: 25520937; PMCID: PMC4265014.
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Cortex phellodendri Extract Relaxes Airway Smooth Muscle.

Evidence-based complementary and alternative medicine : eCAM

Jiang QJ, Chen W, Dan H, Tan L, Zhu H, Yang G, Shen J, Peng YB, Zhao P, Xue L, Yu MF, Ma L, Si XT, Wang Z, Dai J, Qin G, Zou C, Liu QH.
PMID: 27239213
Evid Based Complement Alternat Med. 2016;2016:8703239. doi: 10.1155/2016/8703239. Epub 2016 Apr 27.

Cortex phellodendri is used to reduce fever and remove dampness and toxin. Berberine is an active ingredient of C. phellodendri. Berberine from Argemone ochroleuca can relax airway smooth muscle (ASM); however, whether the nonberberine component of C. phellodendri has...

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Jiang QJ, Chen W, Dan H, et al. Cortex phellodendri Extract Relaxes Airway Smooth Muscle. Evid Based Complement Alternat Med. 2016;2016:8703239doi: 10.1155/2016/8703239.
Jiang, Q. J., Chen, W., Dan, H., Tan, L., Zhu, H., Yang, G., Shen, J., Peng, Y. B., Zhao, P., Xue, L., Yu, M. F., Ma, L., Si, X. T., Wang, Z., Dai, J., Qin, G., Zou, C., & Liu, Q. H. (2016). Cortex phellodendri Extract Relaxes Airway Smooth Muscle. Evidence-based complementary and alternative medicine : eCAM, 20168703239. https://doi.org/10.1155/2016/8703239
Jiang, Qiu-Ju, et al. "Cortex phellodendri Extract Relaxes Airway Smooth Muscle." Evidence-based complementary and alternative medicine : eCAM vol. 2016 (2016): 8703239. doi: https://doi.org/10.1155/2016/8703239
Jiang QJ, Chen W, Dan H, Tan L, Zhu H, Yang G, Shen J, Peng YB, Zhao P, Xue L, Yu MF, Ma L, Si XT, Wang Z, Dai J, Qin G, Zou C, Liu QH. Cortex phellodendri Extract Relaxes Airway Smooth Muscle. Evid Based Complement Alternat Med. 2016;2016:8703239. doi: 10.1155/2016/8703239. Epub 2016 Apr 27. PMID: 27239213; PMCID: PMC4863113.
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Autonomic hyperreflexia after spinal cord injury managed successfully with intravenous lidocaine: a case report.

Patient safety in surgery

Leão P, Figueiredo P.
PMID: 26985238
Patient Saf Surg. 2016 Mar 15;10:10. doi: 10.1186/s13037-016-0098-5. eCollection 2016.

BACKGROUND: Some paraplegic patients may wish undergo some surgical procedures, like urological procedures, without anesthesia. However, these patients can develop autonomic hyperreflexia if cystoscopy is performed without anesthesia.CASE PRESENTATION: We present a case of severe autonomic hyperreflexia in a...

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Leão P, Figueiredo P. Autonomic hyperreflexia after spinal cord injury managed successfully with intravenous lidocaine: a case report. Patient Saf Surg. 2016;10:10doi: 10.1186/s13037-016-0098-5.
Leão, P., & Figueiredo, P. (2016). Autonomic hyperreflexia after spinal cord injury managed successfully with intravenous lidocaine: a case report. Patient safety in surgery, 1010. https://doi.org/10.1186/s13037-016-0098-5
Leão, Pedro, and Figueiredo, Paulo. "Autonomic hyperreflexia after spinal cord injury managed successfully with intravenous lidocaine: a case report." Patient safety in surgery vol. 10 (2016): 10. doi: https://doi.org/10.1186/s13037-016-0098-5
Leão P, Figueiredo P. Autonomic hyperreflexia after spinal cord injury managed successfully with intravenous lidocaine: a case report. Patient Saf Surg. 2016 Mar 15;10:10. doi: 10.1186/s13037-016-0098-5. eCollection 2016. PMID: 26985238; PMCID: PMC4793543.
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Drug-Induced Acute Interstitial Nephritis with Nifedipine.

Case reports in nephrology

Golbin L, Dolley-Hitze T, Lorcy N, Rioux-Leclercq N, Vigneau C.
PMID: 26955492
Case Rep Nephrol. 2016;2016:1971465. doi: 10.1155/2016/1971465. Epub 2016 Feb 03.

Background. Acute interstitial nephritis (AIN) is a frequent cause of Acute Kidney Injury (AKI). Drug hypersensitivity is the most common etiology and the list of drugs that can induce AIN is not exhaustive yet. Case Report. Here, we describe...

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Golbin L, Dolley-Hitze T, Lorcy N, et al. Drug-Induced Acute Interstitial Nephritis with Nifedipine. Case Rep Nephrol. 2016;2016:1971465doi: 10.1155/2016/1971465.
Golbin, L., Dolley-Hitze, T., Lorcy, N., Rioux-Leclercq, N., & Vigneau, C. (2016). Drug-Induced Acute Interstitial Nephritis with Nifedipine. Case reports in nephrology, 20161971465. https://doi.org/10.1155/2016/1971465
Golbin, Léonard, et al. "Drug-Induced Acute Interstitial Nephritis with Nifedipine." Case reports in nephrology vol. 2016 (2016): 1971465. doi: https://doi.org/10.1155/2016/1971465
Golbin L, Dolley-Hitze T, Lorcy N, Rioux-Leclercq N, Vigneau C. Drug-Induced Acute Interstitial Nephritis with Nifedipine. Case Rep Nephrol. 2016;2016:1971465. doi: 10.1155/2016/1971465. Epub 2016 Feb 03. PMID: 26955492; PMCID: PMC4756134.
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IP3R and RyR calcium channels are involved in neonatal rat cardiac myocyte hypertrophy induced by tumor necrosis factor-α.

American journal of translational research

Wang GJ, Guo LY, Wang HX, Yao YS.
PMID: 28337264
Am J Transl Res. 2017 Feb 15;9(2):343-354. eCollection 2017.

To investigate which calcium channels are involved in cardiac myocyte hypertrophy induced by TNF-α, cultured cardiomyocytes were treated with 100 μg/L TNF-α. In addition, three different calcium channel blockers (2-APB, ryanodine and nifedipine) were used, and the effects of...

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Wang GJ, Guo LY, Wang HX, et al. IP3R and RyR calcium channels are involved in neonatal rat cardiac myocyte hypertrophy induced by tumor necrosis factor-α. Am J Transl Res. 2017;9(2):343-354
Wang, G. J., Guo, L. Y., Wang, H. X., & Yao, Y. S. (2017). IP3R and RyR calcium channels are involved in neonatal rat cardiac myocyte hypertrophy induced by tumor necrosis factor-α. American journal of translational research, 9(2), 343-354.
Wang, Gui-Jun, et al. "IP3R and RyR calcium channels are involved in neonatal rat cardiac myocyte hypertrophy induced by tumor necrosis factor-α." American journal of translational research vol. 9,2 (2017): 343-354.
Wang GJ, Guo LY, Wang HX, Yao YS. IP3R and RyR calcium channels are involved in neonatal rat cardiac myocyte hypertrophy induced by tumor necrosis factor-α. Am J Transl Res. 2017 Feb 15;9(2):343-354. eCollection 2017. PMID: 28337264; PMCID: PMC5340671.
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Effect of azithromycin on gingival overgrowth induced by cyclosporine A + nifedipine combination therapy: A morphometric analysis in rats.

Journal of Indian Society of Periodontology

Ratre MS, Mehta DS.
PMID: 28298821
J Indian Soc Periodontol. 2016 Jul-Aug;20(4):396-401. doi: 10.4103/0972-124X.194271.

BACKGROUND: Drug-induced gingival overgrowth (DIGO) is a well-known adverse effect of cyclosporine A (CsA) and nifedipine (Nf) therapy. The aim of the present morphometric study was to evaluate the effect of azithromycin (Azi) on the combined GO in rats...

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Ratre MS, Mehta DS. Effect of azithromycin on gingival overgrowth induced by cyclosporine A + nifedipine combination therapy: A morphometric analysis in rats. J Indian Soc Periodontol. 2016;20(4):396-401doi: 10.4103/0972-124X.194271.
Ratre, M. S., & Mehta, D. S. (2016). Effect of azithromycin on gingival overgrowth induced by cyclosporine A + nifedipine combination therapy: A morphometric analysis in rats. Journal of Indian Society of Periodontology, 20(4), 396-401. https://doi.org/10.4103/0972-124X.194271
Ratre, Madhu Singh, and Mehta, Dhoom Singh. "Effect of azithromycin on gingival overgrowth induced by cyclosporine A + nifedipine combination therapy: A morphometric analysis in rats." Journal of Indian Society of Periodontology vol. 20,4 (2016): 396-401. doi: https://doi.org/10.4103/0972-124X.194271
Ratre MS, Mehta DS. Effect of azithromycin on gingival overgrowth induced by cyclosporine A + nifedipine combination therapy: A morphometric analysis in rats. J Indian Soc Periodontol. 2016 Jul-Aug;20(4):396-401. doi: 10.4103/0972-124X.194271. PMID: 28298821; PMCID: PMC5341314.
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