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The role of the periaqueductal gray in the modulation of pain in males and females: are the anatomy and physiology really that different?

STEM and males

Loyd DR, Murphy AZ.
GSID: I-PmTmT6yCsJ
DR Loyd, AZ Murphy - Neural plasticity, 2009 - psycnet.apa.org

… Remarkably, the majority of these studies were conducted exclusively in males with the … It is well established that morphine administration produces greater antinociception in males …

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Loyd, D. R., & Murphy, A. Z. (2009). The role of the periaqueductal gray in the modulation of pain in males and females: are the anatomy and physiology really that different?. Neural plasticity.
Loyd, Dayna R., and Anne Z. Murphy. "The role of the periaqueductal gray in the modulation of pain in males and females: are the anatomy and physiology really that different?." Neural plasticity (2009).
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Rostral spread of epidural morphine

STEM and males

Camporesi EM.
GSID: f_tCbMeXIVIJ
PR Bromage, EM Camporesi, PA Durant… - …, 1982 - pubmed.ncbi.nlm.nih.gov

… Ten healthy males between 18 and 33 years received 10 mg morphine sulfate intravenously, or by … in the cerebrospinal fluid to reach the brain stem and fourth ventricle by the sixth hour. …

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Bromage, P. R., Camporesi, E. M., Durant, P. A., & Nielsen, C. H. (1982). Rostral spread of epidural morphine. Anesthesiology, 56(6), 431-436.
Bromage, Philip R., et al. "Rostral spread of epidural morphine." Anesthesiology 56.6 (1982): 431-436.
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Addictive drugs and stress trigger similar change in brain cells, animal study finds

community settings

[No authors listed]
GSID: DZfBJVgIAy0J
P Zickler, NNS Writer - NIDA Notes, 2003 - radarcart.boisestate.edu

Researchers injected mice with either saline, an addictive drug (cocaine, amphetamine, morphine, nicotine, or alcohol), or a nonaddictive drug that is active in the brain …

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Zickler, P., & Writer, N. N. S. (2003). Addictive drugs and stress trigger similar change in brain cells, animal study finds. NIDA Notes, 18(5).
Zickler, Patrick, and NIDA NOTES Staff Writer. "Addictive drugs and stress trigger similar change in brain cells, animal study finds." NIDA Notes 18.5 (2003).
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Permanganate of Potassium as an Antidote for Opium and Morphine Poisoning.

British medical journal

Luff AP.
PMID: 20756227
Br Med J. 1896 May 16;1(1846):1193-4. doi: 10.1136/bmj.1.1846.1193.

No abstract available.

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Luff AP. Permanganate of Potassium as an Antidote for Opium and Morphine Poisoning. Br Med J. 1896;1(1846):1193-4doi: 10.1136/bmj.1.1846.1193.
Luff, A. P. (1896). Permanganate of Potassium as an Antidote for Opium and Morphine Poisoning. British medical journal, 1(1846), 1193-4. https://doi.org/10.1136/bmj.1.1846.1193
Luff, A P. "Permanganate of Potassium as an Antidote for Opium and Morphine Poisoning." British medical journal vol. 1,1846 (1896): 1193-4. doi: https://doi.org/10.1136/bmj.1.1846.1193
Luff AP. Permanganate of Potassium as an Antidote for Opium and Morphine Poisoning. Br Med J. 1896 May 16;1(1846):1193-4. doi: 10.1136/bmj.1.1846.1193. PMID: 20756227; PMCID: PMC2406701.
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Improvement of recovery parameters using patient-controlled epidural analgesia after oncological surgery. A prospective, randomized single center study.

Romanian journal of anaesthesia and intensive care

Zgâia AO, Lisencu CI, Rogobete A, Vlad C, Achimaş-Cadariu P, Lazăr G, Muntean M, Ignat F, Ormindean V, Irimie A.
PMID: 28913495
Rom J Anaesth Intensive Care. 2017 Apr;24(1):29-36. doi: 10.21454/rjaic.7518.241.zga.

PURPOSE: The aim of this study was to compare patient-controlled epidural analgesia (PCEA) versus conventional opioid intravenous (IV) infusion after gastrointestinal cancer surgery regarding several post-surgery parameters of recovery.METHODS: One hundred and one patients were prospectively randomized to receive...

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Zgâia AO, Lisencu CI, Rogobete A, et al. Improvement of recovery parameters using patient-controlled epidural analgesia after oncological surgery. A prospective, randomized single center study. Rom J Anaesth Intensive Care. 2017;24(1):29-36doi: 10.21454/rjaic.7518.241.zga.
Zgâia, A. O., Lisencu, C. I., Rogobete, A., Vlad, C., Achimaş-Cadariu, P., Lazăr, G., Muntean, M., Ignat, F., Ormindean, V., & Irimie, A. (2017). Improvement of recovery parameters using patient-controlled epidural analgesia after oncological surgery. A prospective, randomized single center study. Romanian journal of anaesthesia and intensive care, 24(1), 29-36. https://doi.org/10.21454/rjaic.7518.241.zga
Zgâia, Armeana Olimpia, et al. "Improvement of recovery parameters using patient-controlled epidural analgesia after oncological surgery. A prospective, randomized single center study." Romanian journal of anaesthesia and intensive care vol. 24,1 (2017): 29-36. doi: https://doi.org/10.21454/rjaic.7518.241.zga
Zgâia AO, Lisencu CI, Rogobete A, Vlad C, Achimaş-Cadariu P, Lazăr G, Muntean M, Ignat F, Ormindean V, Irimie A. Improvement of recovery parameters using patient-controlled epidural analgesia after oncological surgery. A prospective, randomized single center study. Rom J Anaesth Intensive Care. 2017 Apr;24(1):29-36. doi: 10.21454/rjaic.7518.241.zga. PMID: 28913495; PMCID: PMC5555424.
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Interventional treatment for neuropathic pain due to combined cervical radiculopathy and carpal tunnel syndrome: a case report.

Clinical case reports

Vigneri S, Sindaco G, Zanella M, Sette E, Tugnoli V, Pari G.
PMID: 28396759
Clin Case Rep. 2017 Feb 23;5(4):414-418. doi: 10.1002/ccr3.840. eCollection 2017 Apr.

The coexistence of median and cervical nerve root damage might hide a complex pathophysiology. Here, we describe and discuss the case of a patient suffering from numbness and painful tingling of the hand, whose symptoms were effectively treated with...

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Vigneri S, Sindaco G, Zanella M, et al. Interventional treatment for neuropathic pain due to combined cervical radiculopathy and carpal tunnel syndrome: a case report. Clin Case Rep. 2017;5(4):414-418doi: 10.1002/ccr3.840.
Vigneri, S., Sindaco, G., Zanella, M., Sette, E., Tugnoli, V., & Pari, G. (2017). Interventional treatment for neuropathic pain due to combined cervical radiculopathy and carpal tunnel syndrome: a case report. Clinical case reports, 5(4), 414-418. https://doi.org/10.1002/ccr3.840
Vigneri, Simone, et al. "Interventional treatment for neuropathic pain due to combined cervical radiculopathy and carpal tunnel syndrome: a case report." Clinical case reports vol. 5,4 (2017): 414-418. doi: https://doi.org/10.1002/ccr3.840
Vigneri S, Sindaco G, Zanella M, Sette E, Tugnoli V, Pari G. Interventional treatment for neuropathic pain due to combined cervical radiculopathy and carpal tunnel syndrome: a case report. Clin Case Rep. 2017 Feb 23;5(4):414-418. doi: 10.1002/ccr3.840. eCollection 2017 Apr. PMID: 28396759; PMCID: PMC5378831.
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Intrathecal rapamycin attenuates morphine-induced analgesic tolerance and hyperalgesia in rats with neuropathic pain.

Translational perioperative and pain medicine

Xu JT, Sun L, Lutz BM, Bekker A, Tao YX.
PMID: 26339682
Transl Perioper Pain Med. 2015;2(2):27-34.

Repeated and long-term administration of opioids is often accompanied by the initiation of opioid-induced analgesic tolerance and hyperalgesia in chronic pain patients. Our previous studies showed that repeated intrathecal morphine injection activated the mammalian target of rapamycin complex 1...

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Xu JT, Sun L, Lutz BM, et al. Intrathecal rapamycin attenuates morphine-induced analgesic tolerance and hyperalgesia in rats with neuropathic pain. Transl Perioper Pain Med. 2015;2(2):27-34
Xu, J. T., Sun, L., Lutz, B. M., Bekker, A., & Tao, Y. X. (2015). Intrathecal rapamycin attenuates morphine-induced analgesic tolerance and hyperalgesia in rats with neuropathic pain. Translational perioperative and pain medicine, 2(2), 27-34.
Xu, Ji-Tian, et al. "Intrathecal rapamycin attenuates morphine-induced analgesic tolerance and hyperalgesia in rats with neuropathic pain." Translational perioperative and pain medicine vol. 2,2 (2015): 27-34.
Xu JT, Sun L, Lutz BM, Bekker A, Tao YX. Intrathecal rapamycin attenuates morphine-induced analgesic tolerance and hyperalgesia in rats with neuropathic pain. Transl Perioper Pain Med. 2015;2(2):27-34. PMID: 26339682; PMCID: PMC4556423.
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A randomized, double-blind study of hydromorphone hydrochloride extended-release tablets versus oxycodone hydrochloride extended-release tablets for cancer pain: efficacy and safety in Japanese cancer patients (EXHEAL: a Phase III study of EXtended-release HydromorphonE for cAncer pain reLief).

Journal of pain research

Inoue S, Saito Y, Tsuneto S, Aruga E, Ide A, Kakurai Y.
PMID: 28860850
J Pain Res. 2017 Aug 18;10:1953-1962. doi: 10.2147/JPR.S136937. eCollection 2017.

BACKGROUND: In Japan, there are limited options for switching opioid analgesics. Hydromorphone is an opioid analgesic that is routinely used instead of morphine for cancer pain; however, it is not yet available in Japan. The aim of this study...

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Inoue S, Saito Y, Tsuneto S, et al. A randomized, double-blind study of hydromorphone hydrochloride extended-release tablets versus oxycodone hydrochloride extended-release tablets for cancer pain: efficacy and safety in Japanese cancer patients (EXHEAL: a Phase III study of EXtended-release HydromorphonE for cAncer pain reLief). J Pain Res. 2017;10:1953-1962doi: 10.2147/JPR.S136937.
Inoue, S., Saito, Y., Tsuneto, S., Aruga, E., Ide, A., & Kakurai, Y. (2017). A randomized, double-blind study of hydromorphone hydrochloride extended-release tablets versus oxycodone hydrochloride extended-release tablets for cancer pain: efficacy and safety in Japanese cancer patients (EXHEAL: a Phase III study of EXtended-release HydromorphonE for cAncer pain reLief). Journal of pain research, 101953-1962. https://doi.org/10.2147/JPR.S136937
Inoue, Satoshi, et al. "A randomized, double-blind study of hydromorphone hydrochloride extended-release tablets versus oxycodone hydrochloride extended-release tablets for cancer pain: efficacy and safety in Japanese cancer patients (EXHEAL: a Phase III study of EXtended-release HydromorphonE for cAncer pain reLief)." Journal of pain research vol. 10 (2017): 1953-1962. doi: https://doi.org/10.2147/JPR.S136937
Inoue S, Saito Y, Tsuneto S, Aruga E, Ide A, Kakurai Y. A randomized, double-blind study of hydromorphone hydrochloride extended-release tablets versus oxycodone hydrochloride extended-release tablets for cancer pain: efficacy and safety in Japanese cancer patients (EXHEAL: a Phase III study of EXtended-release HydromorphonE for cAncer pain reLief). J Pain Res. 2017 Aug 18;10:1953-1962. doi: 10.2147/JPR.S136937. eCollection 2017. PMID: 28860850; PMCID: PMC5571837.
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Can intravenous acetaminophen reduce the needs to more opioids to control pain in intubated patients?.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

Mahshidfar B, Sameti A, Abbasi S, Farsi D, Mofidi M, Hafezimoghadam P, Rahimzadeh P, Rezai M.
PMID: 27630458
Indian J Crit Care Med. 2016 Aug;20(8):465-8. doi: 10.4103/0972-5229.188197.

AIMS: To evaluate the effect of intravenous (IV) acetaminophen on reducing the need for morphine sulfate in intubated patients admitted to the Intensive Care Unit (ICU).SETTINGS AND DESIGN: Current study was done as a clinical trial on the patients...

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Mahshidfar B, Sameti A, Abbasi S, et al. Can intravenous acetaminophen reduce the needs to more opioids to control pain in intubated patients?. Indian J Crit Care Med. 2016;20(8):465-8doi: 10.4103/0972-5229.188197.
Mahshidfar, B., Sameti, A., Abbasi, S., Farsi, D., Mofidi, M., Hafezimoghadam, P., Rahimzadeh, P., & Rezai, M. (2016). Can intravenous acetaminophen reduce the needs to more opioids to control pain in intubated patients?. Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine, 20(8), 465-8. https://doi.org/10.4103/0972-5229.188197
Mahshidfar, Babak, et al. "Can intravenous acetaminophen reduce the needs to more opioids to control pain in intubated patients?." Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine vol. 20,8 (2016): 465-8. doi: https://doi.org/10.4103/0972-5229.188197
Mahshidfar B, Sameti A, Abbasi S, Farsi D, Mofidi M, Hafezimoghadam P, Rahimzadeh P, Rezai M. Can intravenous acetaminophen reduce the needs to more opioids to control pain in intubated patients?. Indian J Crit Care Med. 2016 Aug;20(8):465-8. doi: 10.4103/0972-5229.188197. PMID: 27630458; PMCID: PMC4994126.
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Comparison of anesthetic management and outcomes of robot-assisted versus open radical cystectomy.

Journal of robotic surgery

Trentman TL, Fassett SL, McGirr D, Anderson B, Chang YH, Nateras RN, Castle EP, Rosenfeld DM.
PMID: 27000923
J Robot Surg. 2013 Sep;7(3):273-9. doi: 10.1007/s11701-012-0379-7. Epub 2012 Sep 22.

Robot-assisted cystectomy surgery may be advantageous for patients. The purpose of this study was to compare anesthetic management and outcomes in patients undergoing robot-assisted versus open radical cystectomy. In a retrospective review of 256 cystectomy procedures, procedure duration, blood...

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Trentman TL, Fassett SL, McGirr D, et al. Comparison of anesthetic management and outcomes of robot-assisted versus open radical cystectomy. J Robot Surg. 2012;7(3):273-9doi: 10.1007/s11701-012-0379-7.
Trentman, T. L., Fassett, S. L., McGirr, D., Anderson, B., Chang, Y. H., Nateras, R. N., Castle, E. P., & Rosenfeld, D. M. (2013). Comparison of anesthetic management and outcomes of robot-assisted versus open radical cystectomy. Journal of robotic surgery, 7(3), 273-9. https://doi.org/10.1007/s11701-012-0379-7
Trentman, Terrence L, et al. "Comparison of anesthetic management and outcomes of robot-assisted versus open radical cystectomy." Journal of robotic surgery vol. 7,3 (2013): 273-9. doi: https://doi.org/10.1007/s11701-012-0379-7
Trentman TL, Fassett SL, McGirr D, Anderson B, Chang YH, Nateras RN, Castle EP, Rosenfeld DM. Comparison of anesthetic management and outcomes of robot-assisted versus open radical cystectomy. J Robot Surg. 2013 Sep;7(3):273-9. doi: 10.1007/s11701-012-0379-7. Epub 2012 Sep 22. PMID: 27000923.
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Analgesic effect of paracetamol combined with low-dose morphine versus morphine alone on patients with biliary colic: a double blind, randomized controlled trial.

World journal of emergency medicine

Farnia MR, Babaei R, Shirani F, Momeni M, Hajimaghsoudi M, Vahidi E, Saeedi M.
PMID: 27006734
World J Emerg Med. 2016;7(1):25-9. doi: 10.5847/wjem.j.1920-8642.2016.01.004.

BACKGROUND: Numerous drugs have been proposed to alleviate pain in patients with biliary colic, especially opioids, but still there is a tendency to use less narcotics because of their side effects and the unwillingness of some patients. The present...

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Farnia MR, Babaei R, Shirani F, et al. Analgesic effect of paracetamol combined with low-dose morphine versus morphine alone on patients with biliary colic: a double blind, randomized controlled trial. World J Emerg Med. 2016;7(1):25-9doi: 10.5847/wjem.j.1920-8642.2016.01.004.
Farnia, M. R., Babaei, R., Shirani, F., Momeni, M., Hajimaghsoudi, M., Vahidi, E., & Saeedi, M. (2016). Analgesic effect of paracetamol combined with low-dose morphine versus morphine alone on patients with biliary colic: a double blind, randomized controlled trial. World journal of emergency medicine, 7(1), 25-9. https://doi.org/10.5847/wjem.j.1920-8642.2016.01.004
Farnia, Mohammad Reza, et al. "Analgesic effect of paracetamol combined with low-dose morphine versus morphine alone on patients with biliary colic: a double blind, randomized controlled trial." World journal of emergency medicine vol. 7,1 (2016): 25-9. doi: https://doi.org/10.5847/wjem.j.1920-8642.2016.01.004
Farnia MR, Babaei R, Shirani F, Momeni M, Hajimaghsoudi M, Vahidi E, Saeedi M. Analgesic effect of paracetamol combined with low-dose morphine versus morphine alone on patients with biliary colic: a double blind, randomized controlled trial. World J Emerg Med. 2016;7(1):25-9. doi: 10.5847/wjem.j.1920-8642.2016.01.004. PMID: 27006734; PMCID: PMC4786494.
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Poster 427 Pharmacodynamic Effects From a Category 3 Intranasal Human Abuse Potential Study of an Abuse-Deterrent, Extended-Release Morphine Product Candidate in Nondependent, Recreational Opioid Users.

PM & R : the journal of injury, function, and rehabilitation

Webster LR, Smith MD, Lawler J, Lindhardt K, Dayno JM.
PMID: 27673177
PM R. 2016 Sep;8(9):S300-S301. doi: 10.1016/j.pmrj.2016.07.352. Epub 2016 Sep 24.

No abstract available.

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Webster LR, Smith MD, Lawler J, et al. Poster 427 Pharmacodynamic Effects From a Category 3 Intranasal Human Abuse Potential Study of an Abuse-Deterrent, Extended-Release Morphine Product Candidate in Nondependent, Recreational Opioid Users. PM R. 2016;8(9):S300-S301doi: 10.1016/j.pmrj.2016.07.352.
Webster, L. R., Smith, M. D., Lawler, J., Lindhardt, K., & Dayno, J. M. (2016). Poster 427 Pharmacodynamic Effects From a Category 3 Intranasal Human Abuse Potential Study of an Abuse-Deterrent, Extended-Release Morphine Product Candidate in Nondependent, Recreational Opioid Users. PM & R : the journal of injury, function, and rehabilitation, 8(9), S300-S301. https://doi.org/10.1016/j.pmrj.2016.07.352
Webster, Lynn R, et al. "Poster 427 Pharmacodynamic Effects From a Category 3 Intranasal Human Abuse Potential Study of an Abuse-Deterrent, Extended-Release Morphine Product Candidate in Nondependent, Recreational Opioid Users." PM & R : the journal of injury, function, and rehabilitation vol. 8,9 (2016): S300-S301. doi: https://doi.org/10.1016/j.pmrj.2016.07.352
Webster LR, Smith MD, Lawler J, Lindhardt K, Dayno JM. Poster 427 Pharmacodynamic Effects From a Category 3 Intranasal Human Abuse Potential Study of an Abuse-Deterrent, Extended-Release Morphine Product Candidate in Nondependent, Recreational Opioid Users. PM R. 2016 Sep;8(9):S300-S301. doi: 10.1016/j.pmrj.2016.07.352. Epub 2016 Sep 24. PMID: 27673177.
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Showing 1 to 12 of 4540 entries