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TC21/RRas2 regulates glycoprotein VI-FcRγ-mediated platelet activation and thrombus stability.

Journal of thrombosis and haemostasis : JTH

Janapati S, Wurtzel J, Dangelmaier C, Manne BK, Bhavanasi D, Kostyak JC, Kim S, Holinstat M, Kunapuli SP, Goldfinger LE.
PMID: 29883056
J Thromb Haemost. 2018 Jun 08; doi: 10.1111/jth.14197. Epub 2018 Jun 08.

Essentials RAS proteins are expressed in platelets but their functions are largely uncharacterized. TC21/RRas2 is required for glycoprotein VI-induced platelet responses and for thrombus stability in vivo. TC21 regulates platelet aggregation by control of αSUMMARY: Background Many RAS family...

Showing 1 to 1 of 1 entries