Advanced Search
Display options
Filter resources
Text Availability
Article type
Publication date
Species
Language
Sex
Age
Showing 1 to 12 of 107 entries
Sorted by: Best Match Show Resources per page
A comparative study of methyldopa and labetalol in the treatment of hypertension.

British journal of clinical pharmacology

Sanders GL, Davies DM, Gales GM, Rao JG, Rawlins MD, Routledge PA.
PMID: 26635157
Br J Clin Pharmacol. 1979 Apr;8:149S-51S. doi: 10.1111/j.1365-2125.1979.tb04771.x.

1 Twenty patients with essential hypertension completed a double-blind, dose-tritrated, cross-over comparison of methyldopa and labetalol. 2 Average lying BPs (systolic/diastolic) were reduced by 28/15 mmHg with methyldopa and by 23/15 mmHg with labetalol. 3 Average standing BPs (systolic/diastolic)...

Use of labetalol and methyldopa in pregnancy-induced hypertension.

British journal of clinical pharmacology

Lamming GD, Symonds EB.
PMID: 26635170
Br J Clin Pharmacol. 1979 Apr;8:217S-22S. doi: 10.1111/j.1365-2125.1979.tb04784.x.

1 Nineteen pregnant patients whose mean arterial pressure (MAP) was persistently greater than or equal to 103.3 mmHg were given labetalol or methyldopa. 2 Singificant falls (P less than 0.001) in BP only occurred in the group treated with...

Autoimmune-like drug-induced liver injury: a review and update for the clinician.

Expert opinion on drug metabolism & toxicology

Stine JG, Northup PG.
PMID: 27402321
Expert Opin Drug Metab Toxicol. 2016 Nov;12(11):1291-1301. doi: 10.1080/17425255.2016.1211110. Epub 2016 Jul 21.

INTRODUCTION: Autoimmune-like drug-induced liver injury (DI-AIH) is a rare but serious event with a growing body of scientific evidence and a fair degree of uncertainty. Areas covered: This review covers the definition, pathophysiology, treatment and patient-centered outcomes of DI-AIH...

Antihypertensive drug prescription pattern before and during pregnancy in France.

Pregnancy hypertension

Duhalde V, Delarue C, Lacroix I, Suarez C, Bourrel R, Montastruc JL, Damase-Michel C.
PMID: 26104501
Pregnancy Hypertens. 2011 Apr;1(2):185-9. doi: 10.1016/j.preghy.2011.01.001. Epub 2011 Feb 01.

OBJECTIVE: This study provides firsthand information on antihypertensive prescriptions before and during pregnancy in France.METHODS: The study, on 23,898 women, was carried out using data from the French Health Insurance System.RESULTS: Before and during pregnancy, 1.1% and 5.1% of...

NTP Toxicology and Carcinogenesis Studies of alpha-Methyldopa Sesquihydrate (CAS No. 41372-08-1) in F344/N Rats and B6C3F1 Mice (Feed Studies).

National Toxicology Program technical report series

[No authors listed]
PMID: 12704436
Natl Toxicol Program Tech Rep Ser. 1989 Mar;348:1-184.

a-Methyldopa sesquihydrate is used in the treatment of hypertension; over 20 million prescriptions are written annually for a -methyldopa or a-methyldopa sesquihydrate in the United States. a-Methyldopa sesquihydrate (USP grade, greater than 99% pure) was selected for study because...

A sensitive and selective spectrophotometric estimation of catechol derivatives in pharmaceutical preparations.

Talanta

Nagaraja P, Vasantha RA, Sunitha KR.
PMID: 18968454
Talanta. 2001 Dec 24;55(6):1039-46. doi: 10.1016/s0039-9140(01)00438-6.

A sensitive and simple spectrophotometric method for the estimation of catechol and its derivatives like dopamine hydrochloride (DPH), levodopa (LDP), methyldopa (MDP) and adrenaline hydrochloride (ADH) in both pure form and in pharmaceutical formulation, is described. The method is...

Methyldopa-induced thrombocytopenia.

Canadian Medical Association journal

Ten Pas A, de Leeuw NK, Stacey CH.
PMID: 20328626
Can Med Assoc J. 1966 Aug 13;95(7):322.

No abstract available.

Therapeutic interventions and adjustments in the management of Parkinson disease: role of combined carbidopa/levodopa/entacapone (Stalevo).

Neuropsychiatric disease and treatment

Solla P, Cannas A, Marrosu F, Marrosu MG.
PMID: 20856911
Neuropsychiatr Dis Treat. 2010 Sep 07;6:483-90. doi: 10.2147/ndt.s5190.

Parkinson disease (PD) is a neurodegenerative disorder characterized by 3 cardinal motor symptoms: resting tremor, rigidity, and bradykinesia. Since its introduction 40 years ago, levodopa has represented the gold standard for dopaminergic stimulation therapy in patients with PD. Levodopa...

The absorption and metabolism of a standard oral dose of levodopa in patients with Parkinsonism.

British journal of clinical pharmacology

Bergmann S, Curzon G, Friedel J, Godwin-Austen RB, Marsden CD, Parkes JD.
PMID: 22454921
Br J Clin Pharmacol. 1974 Oct;1(5):417-24. doi: 10.1111/j.1365-2125.1974.tb00280.x.

1 The metabolism of a standard oral dose of levodopa was studied in forty-two patients with Parkinsonism. Plasma levodopa and 3-o-methyldopa concentrations were estimated at intervals for 8 h after ingestion and the concentration of homovanillic acid (HVA) in...

A new spectrophotometric method for the determination of methyldopa.

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

Gadkariem EA, Ibrahim KE, Kamil NA, Haga ME, El-Obeid HA.
PMID: 23960712
Saudi Pharm J. 2009 Oct;17(4):289-93. doi: 10.1016/j.jsps.2009.10.005. Epub 2009 Nov 10.

A new, simple and low cost spectrophotometric method for the determination of methyldopa in pharmaceutical preparations was developed. The method was based on the coupling of methyldopa with 2,6-dichloroquinone-4-chlorimide (DCQ). The absorbance maximum (λ max) of the resulted colored...

Comparison of atenolol (tenormin) and methyldopa (a multicentre study in general practice).

Proceedings of the Royal Society of Medicine

Basker MA.
PMID: 20919337
Proc R Soc Med. 1977;70:19-20.

No abstract available.

Adverse drug reactions in high-risk pregnant women: A prospective study.

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

de Oliveira-Filho AD, Vieira AES, da Silva RC, Neves SJF, Gama TAB, Lima RV, Oliveira WR, de Gonçalves Dias JM.
PMID: 29158717
Saudi Pharm J. 2017 Nov;25(7):1073-1077. doi: 10.1016/j.jsps.2017.01.005. Epub 2017 Feb 02.

BACKGROUND: Because pregnant women are often excluded from clinical trials, there is still very limited information about the risk and safety of prescription drugs during pregnancy.OBJECTIVE: We aimed to determine the prevalence of Adverse Drug Reactions (ADRs) in high-risk...

Showing 1 to 12 of 107 entries