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Showing 1 to 12 of 483 entries
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Investigation of In Vitro Activity of Five Antifungal Drugs against Dermatophytes Species Isolated from Clinical Samples Using the E-Test Method.

The Eurasian journal of medicine

Aktas AE, Yigit N, Aktas A, Gozubuyuk SG.
PMID: 25610290
Eurasian J Med. 2014 Feb;46(1):26-31. doi: 10.5152/eajm.2014.05.

OBJECTIVE: Dermatomycosis is an infection with fungi related to the skin: glabrous skin, hair and/or nails. Oral treatment of fungal infections in dermatology has become a preferred modality for the management of these very common conditions. Although there are...

Pathogen distribution and drug resistance in a burn ward: a three-year retrospective analysis of a single center in China.

International journal of clinical and experimental medicine

Cen H, Wu Z, Wang F, Han C.
PMID: 26770555
Int J Clin Exp Med. 2015 Oct 15;8(10):19188-99. eCollection 2015.

To investigate the spread of multiple-resistant strain in a burn ward to inform clinical administration of antibiotic drugs, burn wound treatment and decision-making for infection control. A 3-year retrospective analysis was conducted. Specimens from wounds, blood, catheter, sputum, urine...

Detection of dermatophytes in healthy companion dogs and cats in eastern India.

Iranian journal of veterinary research

Debnath C, Mitra T, Kumar A, Samanta I.
PMID: 27656224
Iran J Vet Res. 2016;17(1):20-4.

In recent times increasing occurrence of dermatophytosis, especially among the school children in eastern India was evidenced along with increased tendency of keeping companion animals such as dogs and cats. This study was undertaken to detect the occurrence of...

Evacetrapib: in vitro and clinical disposition, metabolism, excretion, and assessment of drug interaction potential with strong CYP3A and CYP2C8 inhibitors.

Pharmacology research & perspectives

Cannady EA, Wang MD, Friedrich S, Rehmel JL, Yi P, Small DS, Zhang W, Suico JG.
PMID: 26516590
Pharmacol Res Perspect. 2015 Oct;3(5):e00179. doi: 10.1002/prp2.179. Epub 2015 Oct 12.

Evacetrapib is an investigational cholesteryl ester transfer protein inhibitor (CETPi) for reduction of risk of major adverse cardiovascular events in patients with high-risk vascular disease. Understanding evacetrapib disposition, metabolism, and the potential for drug-drug interactions (DDI) may help guide...

Cyclosporine/ketoconazole reduces treatment costs for nephrotic syndrome.

Indian journal of nephrology

Iyengar A, Kamath N, Phadke KD, Bitzan M.
PMID: 24339519
Indian J Nephrol. 2013 Nov;23(6):419-23. doi: 10.4103/0971-4065.120338.

Cyclosporine A (CyA) is an effective agent for the treatment of glucocorticoid-dependent idiopathic nephrotic syndrome (GCDNS), but costs are prohibitive in resource-poor societies. The objectives of this study were to evaluate the efficacy and safety of reducing the dose...

Long-term outcome of ketoconazole and tacrolimus co-administration in kidney transplant patients.

World journal of nephrology

Khan E, Killackey M, Kumbala D, LaGuardia H, Liu YJ, Qin HZ, Alper B, Paramesh A, Buell J, Zhang R.
PMID: 25332902
World J Nephrol. 2014 Aug 06;3(3):107-13. doi: 10.5527/wjn.v3.i3.107.

AIM: To study the long-term outcome of ketoconazole and tacrolimus combination in kidney transplant recipients.METHODS: From 2006 to 2010, ketoconazole was given in 199 patients and was continued for at least 1 year or until graft failure (Group 1),...

Evaluation of 4β-Hydroxycholesterol as a Clinical Biomarker of CYP3A4 Drug Interactions Using a Bayesian Mechanism-Based Pharmacometric Model.

CPT: pharmacometrics & systems pharmacology

Leil TA, Kasichayanula S, Boulton DW, LaCreta F.
PMID: 24964282
CPT Pharmacometrics Syst Pharmacol. 2014 Jun 25;3:e120. doi: 10.1038/psp.2014.18.

A Bayesian mechanism-based pharmacokinetic/pharmacodynamic model of cytochrome P450 3A4 (CYP3A4) activity was developed based on a clinical study of the effects of ketoconazole and rifampin on midazolam exposure and plasma 4β-hydroxycholesterol (4βHC) concentrations. Simulations from the model demonstrated that...

Cushing's Disease Presented by Reversible Dilated Cardiomyopathy.

Case reports in cardiology

Aydoğan Bİ, Gerede DM, Canpolat AG, Erdoğan MF.
PMID: 26649206
Case Rep Cardiol. 2015;2015:980897. doi: 10.1155/2015/980897. Epub 2015 Nov 16.

Introduction. Dilated cardiomyopathy is rarely reported among CS patients especially without hypertension and left ventricular hypertrophy. Materials and Methods. We hereby report a Cushing's syndrome case presenting with dilated cardiomyopathy. Results. A 48-year-old female patient was admitted to our...

Pre-mRNA splicing is modulated by antifungal drugs in the filamentous fungus Neurospora crassa.

FEBS open bio

Mendes NS, Silva PM, Silva-Rocha R, Martinez-Rossi NM, Rossi A.
PMID: 27239448
FEBS Open Bio. 2016 Mar 14;6(4):358-68. doi: 10.1002/2211-5463.12047. eCollection 2016 Apr.

For this study, we sought to identify pre-mRNA processing events modulated by changes in extracellular pH, inorganic phosphate, and antifungal drugs. We examined genes with at least four putative introns whose transcriptional level responded to these effectors. We showed...

In vitro inhibitory effects of plumbagin, the promising antimalarial candidate, on human cytochrome P450 enzymes.

Asian Pacific journal of tropical medicine

Sumsakul W, Chaijaroenkul W, Na-Bangchang K.
PMID: 26614990
Asian Pac J Trop Med. 2015 Nov;8(11):914-918. doi: 10.1016/j.apjtm.2015.10.016. Epub 2015 Oct 09.

OBJECTIVE: To investigate the propensity of plumbagin to inhibit the three isoforms of human cytochrome P450 (CYP), i.e., CYP1A2, CYP2C19, and CYP3A4 using human liver microsomes in vitro.METHODS: Inhibitory effects of plumbagin on the three human CYP isoforms were...

Vitamin D3 May Ameliorate the Ketoconazole Induced Adrenal Injury: Histological and Immunohistochemical Studies on Albino Rats.

Acta histochemica et cytochemica

Khalil MS.
PMID: 26379312
Acta Histochem Cytochem. 2015 Aug 27;48(4):103-13. doi: 10.1267/ahc.14062. Epub 2015 Aug 20.

Ketoconazole (KZ) is used widely for treating the superficial, systemic fungal activities and hyperandrogenemic states. Its uses are limited by its deleterious effect on histological structure and function of the adrenal cortex. This study investigates whether vitamin D3 supplement...

Fluconazole and acetazolamide in the treatment of ectopic Cushing's syndrome with severe metabolic alkalosis.

Endocrinology, diabetes & metabolism case reports

Schwetz V, Aberer F, Stiegler C, R Pieber T, Obermayer-Pietsch B, Pilz S.
PMID: 26380091
Endocrinol Diabetes Metab Case Rep. 2015;2015:150027. doi: 10.1530/EDM-15-0027. Epub 2015 May 21.

UNLABELLED: Cushing's syndrome (CS) due to ectopic ACTH production accounts for about 10% of all types of CS and is frequently associated with metabolic alkalosis. Treatment of CS involves surgical resection and/or medical therapy to control hypercortisolism. We present...

Showing 1 to 12 of 483 entries