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Prediction of treatment response to ¹³¹I therapy by diffuse hepatic uptake intensity on post-therapy whole-body scan in patients with distant metastases of differentiated thyroid cancer.

Annals of nuclear medicine

Jun S, Lee JJ, Park SH, Kim TY, Kim WB, Shong YK, Ryu JS.
PMID: 25980591
Ann Nucl Med. 2015 Aug;29(7):603-12. doi: 10.1007/s12149-015-0983-5. Epub 2015 May 17.

OBJECTIVE: A diffuse hepatic uptake (DHU) on radioiodine whole-body scans (WBS) after (131)I therapy is caused by (131)I-labeled iodoproteins, particularly (131)I-labeled thyroglobulin (Tg). We hypothesized that the DHU intensity after (131)I therapy might correlate with subsequent serum Tg reduction,...

Thyroglobulin biosynthesis in "cold" and "hot" nodules in the human thyroid gland.

The Journal of clinical endocrinology and metabolism

Monaco F, Monaco G, Andreoli M.
PMID: 1159044
J Clin Endocrinol Metab. 1975 Aug;41(2):253-9. doi: 10.1210/jcem-41-2-253.

Studies on "cold" and "hot" nodules from human thyroid gland have been carried out to investigate thyroglobulin biosynthesis and to correlate carbohydrates incorporation and thyroid hormone formation in thyroglobulin. The aim of the investigation was to ascertain the role...

Transformation of normal follicles into thyrotropin-refractory "cold" follicles in the aging mouse thyroid gland.


Studer H, Forster R, Conti A, Kohler H, Haeberli A, Engler H.
PMID: 744040
Endocrinology. 1978 May;102(5):1576-86. doi: 10.1210/endo-102-5-1576.

Autoradiographs of thyroid glands of aging mice demonstrate the gradual appearance of "cold" follicles which fail to iodinate the intraluminar iodoproteins even after intense exogeneous or endogeneous TSH stimulation. "Cold" follicles first appear at the age of 5 months....

Age-related failure of endocytosis may be the pathogenetic mechanism responsible for "cold" follicle formation in the aging mouse thyroid.


Gerber H, Peter HJ, Studer H.
PMID: 3569110
Endocrinology. 1987 May;120(5):1758-64. doi: 10.1210/endo-120-5-1758.

With advancing age, 60-80% of the follicles of the mouse thyroid gland turn "cold", i.e. they lose their normal capacity to iodinate thyroglobulin (Tgb). Cold follicles are morphologically characterized by their large size, by deeply periodic acid-Schiff-stained colloid and...

Action of iodoproteins on the thyroid and metamorphosis of amphibians (rana temporaria) biometric and histological study.

Bulletin d'histologie appliquee et de technique microscopique

PMID: 18886019
Bull Histol Appl Tech Microsc. 1948 Jul-Aug;25(7):123-36.

No abstract available.

Familial goitre with partial iodine organification defect, lack of thyroglobulin, and high levels of thyroid peroxidase.

Clinical endocrinology

Niepomniszcze H, Medeiros-Neto GA, Refetoff S, Degroot LJ, Fang VS.
PMID: 844215
Clin Endocrinol (Oxf). 1977 Jan;6(1):27-39. doi: 10.1111/j.1365-2265.1977.tb01993.x.

From a sibship of three sisters having congenital goitre and normal hearing, two had impairment of organification of iodine. S1 (4 years old) had goitre since birth, euthyroidism, and a negative perchlorate test. S2 (15 years old) and S3...

[The 12S, 19S and 27S thyroid iodoproteins in various mammals and their physiological significance].

Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles

Salvatore G, Sena L, Covelli I, Salvatore M.
PMID: 4954279
C R Acad Hebd Seances Acad Sci D. 1965 Jun 09;260(23):6227-9.

No abstract available.

A study of the thyroglobulin, thyroidal protease and iodoproteins in two congenital goitrous cretins.

The American journal of medicine

Pittman CS, Pittman JA.
PMID: 4158767
Am J Med. 1966 Jan;40(1):49-57. doi: 10.1016/0002-9343(66)90186-0.

No abstract available.

Labeled metabolites appearing in human serum after 125I-triiodothyronine (T3) administration: a quantitative reappraisal.

Metabolism: clinical and experimental

Zucchelli GC, Pilo A, Giannessi D, Bianchi R, Cazzuola F, Molea N.
PMID: 7432167
Metabolism. 1980 Oct;29(11):1031-6. doi: 10.1016/0026-0495(80)90212-7.

The appearance in human serum of labeled iodothyronines arising from 3,5,3'-triiodothyronine (T3) catabolism was measured after bolus administration of 125I-T3. The use of column chromatography made it possible to separate in the plasma samples iodoproteins, iodide, T3 and a...

Thyroid function and thyrotropin levels in rabbits immunized to produce antibodies against thyroid hormones.

International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology

Joseph LJ, Desai KB, Patel MC, Mehta MN, Ganatra RD.
PMID: 2444567
Int J Rad Appl Instrum B. 1987;14(5):511-4. doi: 10.1016/0883-2897(87)90119-x.

Various parameters of thyroid function were studied in 27 rabbits, out of which 10 were immunized to produce antibodies against triiodothyronine (T3), 9 against thyroxine (T4) and 8 were normals. Estimations of T3, T4, Free T4 (FT4) and thyrotropin...

Freeze fracture morphology of thyroid tight junctions in goats with different thyrotropin stimulation.


van Uigen AJ, van Dijk JE, Koch CA, de Vijlder JJ.
PMID: 4006860
Endocrinology. 1985 Jul;117(1):114-8. doi: 10.1210/endo-117-1-114.

In the thyroid follicles and blood of goats with congenital hypothyroidism and goiter, abnormal iodoproteins (e.g. iodoalbumin) are found. To study the mechanism involved in the passage of these proteins between the follicles and the blood, the morphology of...

Labelled amino acids in plasma of patients with thyrotoxicosis and thyroid cancer after radioiodine treatment.

Endocrinologia experimentalis

Bednár J, Nĕmec J, Soutorová M, Neradilová M, Pohunková D, Zamrazil V, Vána S, Havelka J, Röhling S.
PMID: 316382
Endocrinol Exp. 1979 Mar;13(1):53-63.

The levels of total organically bound 131I, per cent of labelled iodoproteins, total labelled iodinated amino acids and a percentage of individual iodinated amino acids (thin-layer chromatography) were measured in serum of 84 patients with thyroid cancer and of...

Showing 1 to 12 of 624 entries