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Showing 1 to 12 of 54 entries
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What Should the Cardiologist know about Lamin Disease?.

Arrhythmia & electrophysiology review

Charron P, Arbustini E, Bonne G.
PMID: 26835025
Arrhythm Electrophysiol Rev. 2012 Sep;1(1):22-28. doi: 10.15420/aer.2012.1.22.

Lamins are intermediate filament proteins able to polymerise and form an organised meshwork underlying the inner nuclear membrane in most differentiated somatic cells. Mutations in the LMNA gene, which encodes the two major lamin A and C isoforms, cause...

Keratin function and regulation in tissue homeostasis and pathogenesis.

Biomolecular concepts

Roth W, Hatzfeld M, Friedrich M, Thiering S, Magin TM.
PMID: 25436530
Biomol Concepts. 2012 Apr;3(2):161-73. doi: 10.1515/bmc.2011.060.

Abstract Epithelial tissues act as hubs in metabolism and communication and protect the organism against dehydration, infections, pharmacological and physical stress. Keratin intermediate filament proteins are well established as major cytoskeletal players in maintaining epithelial integrity. More recently, an...

Cytokeratin-19 associated with apoptosis and chemosensitivity in human cervical cancer cells.

Apoptosis : an international journal on programmed cell death

Yuan CC, Huang HC, Tsai LC, Ng HT, Huang TS.
PMID: 14646570
Apoptosis. 1997;2(1):101-5. doi: 10.1023/a:1026448027870.

Cytokeratins are one group of intermediate filament proteins responsible for the integrity of cell structure, and have been recently reported to play a role in conferring a drug resistance phenotype. MAb Cx-99 is a monoclonal antibody exhibiting the specificity...

How protein materials balance strength, robustness, and adaptability.

HFSP journal

Buehler MJ, Yung YC.
PMID: 20676305
HFSP J. 2010 Feb;4(1):26-40. doi: 10.2976/1.3267779. Epub 2010 Jan 14.

Proteins form the basis of a wide range of biological materials such as hair, skin, bone, spider silk, or cells, which play an important role in providing key functions to biological systems. The focus of this article is to...

Expression of intermediate filament proteins by normal and transformed mouse epidermal-keratinocytes in culture.

International journal of oncology

Caulin C, Gandarillas A, Scholl F, Quintanilla M.
PMID: 21573564
Int J Oncol. 1993 Mar;2(3):373-9. doi: 10.3892/ijo.2.3.373.

The aberrant expression of embryonic simple epithelial keratins K8 and K18 has been previously detected in chemically-induced mouse skin carcinomas and in cultured epidermal keratinocytes containing H-ras oncogenes. In this study, we report that cell lines derived from benign...

Predisposition to apoptosis in keratin 8-null liver is related to inactivation of NF-κB and SAPKs but not decreased c-Flip.

Biology open

Lee J, Jang KH, Kim H, Lim Y, Kim S, Yoon HN, Chung IK, Roth J, Ku NO.
PMID: 23862017
Biol Open. 2013 May 29;2(7):695-702. doi: 10.1242/bio.20134606. Print 2013 Jul 15.

Keratin 8 and 18 (K8/K18) are major intermediate filament proteins of liver hepatocytes. They provide mechanical and nonmechanical stability, thereby protecting cells from stress. Hence, K8-null mice are highly sensitive to Fas-mediated liver cell apoptosis. However, the role of...

Cyclic olefin copolymer as an X-ray compatible material for microfluidic devices.

Lab on a chip

Denz M, Brehm G, Hémonnot CYJ, Spears H, Wittmeier A, Cassini C, Saldanha O, Perego E, Diaz A, Burghammer M, Köster S.
PMID: 29210424
Lab Chip. 2017 Dec 19;18(1):171-178. doi: 10.1039/c7lc00824d.

The combination of microfluidics and X-ray methods attracts a lot of attention from researchers as it brings together the high controllability of microfluidic sample environments and the small length scales probed by X-rays. In particular, the fields of biophysics...

Prognostic Values of Vimentin Expression and Its Clinicopathological Significance in Non-Small Cell Lung Cancer: A Meta-Analysis of Observational Studies with 4118 Cases.

PloS one

Ye Z, Zhang X, Luo Y, Li S, Huang L, Li Z, Li P, Chen G.
PMID: 27657690
PLoS One. 2016 Sep 22;11(9):e0163162. doi: 10.1371/journal.pone.0163162. eCollection 2016.

BACKGROUND: Vimentin is a member of the intermediate filament proteins and a canonical marker of the epithelial-mesenchymal transition (EMT), which is pivotal in tumorigenesis, metastasis and invasion in non-small cell lung cancer (NSCLC). The current meta-analysis aimed to investigate...

Alterations in keratins and associated proteins during 4- Nitroquinoline-1-oxide induced rat oral carcinogenesis.

Journal of carcinogenesis

Kanojia D, Sawant SS, Borges AM, Ingle AD, Vaidya MM.
PMID: 23233820
J Carcinog. 2012;11:14. doi: 10.4103/1477-3163.100861. Epub 2012 Sep 13.

BACKGROUND: Oral squamous cell carcinoma (OSCC) is the sixth largest group of malignancies globally and the single largest group of malignancies in the Indian subcontinent. Despite the advances in treatment and therapeutic modalities the five year survival rate of...

Differential expression of nuclear lamin subtypes in the neural cells of the adult rat cerebral cortex.

IBRO reports

Takamori Y, Hirahara Y, Wakabayashi T, Mori T, Koike T, Kataoka Y, Tamura Y, Kurebayashi S, Kurokawa K, Yamada H.
PMID: 30505974
IBRO Rep. 2018 Nov 05;5:99-109. doi: 10.1016/j.ibror.2018.11.001. eCollection 2018 Dec.

Lamins are type V intermediate filament proteins that are located beneath the inner nuclear membrane. In mammalian somatic cells, LMNB1 and LMNB2 encode somatic lamins B1 and B2, respectively, and the LMNA gene is alternatively spliced to generate somatic...

A detailed mapping of the readily accessible disulphide bonds in the cortex of wool fibres.

Proteins

Plowman JE, Miller RE, Thomas A, Grosvenor AJ, Harland DP, Deb-Choudhury S.
PMID: 33550642
Proteins. 2021 Jun;89(6):708-720. doi: 10.1002/prot.26053. Epub 2021 Feb 22.

Trichocyte keratin intermediate filament proteins (keratins) and keratin associated proteins (KAPs) differ from their epithelial equivalents by having significantly more cysteine residues. Interactions between these cysteine residues within a mammalian fiber, and the putative regular organization of interactions are...

Reactive astrocytes as treatment targets in Alzheimer's disease-Systematic review of studies using the APPswePS1dE9 mouse model.

Glia

Smit T, Deshayes NAC, Borchelt DR, Kamphuis W, Middeldorp J, Hol EM.
PMID: 33634529
Glia. 2021 Aug;69(8):1852-1881. doi: 10.1002/glia.23981. Epub 2021 Feb 25.

Astrocytes regulate synaptic communication and are essential for proper brain functioning. In Alzheimer's disease (AD) astrocytes become reactive, which is characterized by an increased expression of intermediate filament proteins and cellular hypertrophy. Reactive astrocytes are found in close association...

Showing 1 to 12 of 54 entries