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HIV-1 group O integrase displays lower susceptibility to raltegravir and has a different mutational pathway for resistance than HIV-1 group M.

Journal of the International AIDS Society

Depatureaux A, Mesplède T, Quashie P, Oliveira M, Moisi D, Brenner B, Wainberg M.
PMID: 25397483
J Int AIDS Soc. 2014 Nov 02;17(4):19738. doi: 10.7448/IAS.17.4.19738. eCollection 2014.

INTRODUCTION: HIV-1 group O (HIV-O) is a rare HIV-1 variant characterized by a high number of polymorphisms, especially in the integrase gene, e.g. positions L74I, S153A, G163Q and T206S. As HIV-O integrase enzymes have not previously been studied, our...

Cellular Immune Response Induced by DNA Immunization of Mice with Drug Resistant Integrases of HIV-1 Clade A Offers Partial Protection against Growth and Metastatic Activity of Integrase-Expressing Adenocarcinoma Cells.


Isaguliants M, Krotova O, Petkov S, Jansons J, Bayurova E, Mezale D, Fridrihsone I, Kilpelainen A, Podschwadt P, Agapkina Y, Smirnova O, Kostic L, Saleem M, Latyshev O, Eliseeva O, Malkova A, Gorodnicheva T, Wahren B, Gordeychuk I, Starodubova E, Latanova A.
PMID: 34199989
Microorganisms. 2021 Jun 04;9(6). doi: 10.3390/microorganisms9061219.

Therapeutic DNA-vaccination against drug-resistant HIV-1 may hinder emergence and spread of drug-resistant HIV-1, allowing for longer successful antiretroviral treatment (ART) up-to relief of ART. We designed DNA-vaccines against drug-resistant HIV-1 based on consensus clade A integrase (IN) resistant to...

A novel approach for T7 bacteriophage genome integration of exogenous DNA.

Journal of biological engineering

Liu Y, Huang H, Wang H, Zhang Y.
PMID: 31988659
J Biol Eng. 2020 Jan 16;14:2. doi: 10.1186/s13036-019-0224-x. eCollection 2020.

BACKGROUND: The comparatively small genome, well elucidated functional genomics and rapid life cycle confer T7 bacteriophage with great advantages for bio-application. Genetic manipulation of T7 genome plays a key role in T7 related applications. As one of the important...

Comparative genomic analysis of clinical and environmental Vibrio vulnificus isolates revealed biotype 3 evolutionary relationships.

Frontiers in microbiology

Koton Y, Gordon M, Chalifa-Caspi V, Bisharat N.
PMID: 25642229
Front Microbiol. 2015 Jan 15;5:803. doi: 10.3389/fmicb.2014.00803. eCollection 2014.

In 1996 a common-source outbreak of severe soft tissue and bloodstream infections erupted among Israeli fish farmers and fish consumers due to changes in fish marketing policies. The causative pathogen was a new strain of Vibrio vulnificus, named biotype...

Plant centromeric retrotransposons: a structural and cytogenetic perspective.

Mobile DNA

Neumann P, Navrátilová A, Koblížková A, Kejnovský E, Hřibová E, Hobza R, Widmer A, Doležel J, Macas J.
PMID: 21371312
Mob DNA. 2011 Mar 03;2(1):4. doi: 10.1186/1759-8753-2-4.

BACKGROUND: The centromeric and pericentromeric regions of plant chromosomes are colonized by Ty3/gypsy retrotransposons, which, on the basis of their reverse transcriptase sequences, form the chromovirus CRM clade. Despite their potential importance for centromere evolution and function, they have...

CagA status & genetic characterization of metronidazole resistant strains of H. pylori from: A region at high risk of gastric cancer.

Pakistan journal of medical sciences

Yue JY, Yue J, Wang MY, Song WC, Gao XZ.
PMID: 25097521
Pak J Med Sci. 2014 Jul;30(4):804-8. doi: 10.12669/pjms.304.4840.

OBJECTIVE: The aim of study was to determine relationship between cagA and genetic characterization of metronidazole (MTZ) resistant H. pylori strains from a region at high risk of gastric cancer.METHODS: 172 H. pylori strains were isolated from the patients...

Virus and Potential Host Microbes from Viral-Enriched Metagenomic Characterization in the High-Altitude Wetland, Salar de Huasco, Chile.


Eissler Y, Dorador C, Kieft B, Molina V, Hengst M.
PMID: 32698305
Microorganisms. 2020 Jul 20;8(7). doi: 10.3390/microorganisms8071077.

Salar de Huasco is a wetland in the Andes mountains, located 3800 m above sea level at the Chilean Altiplano. Here we present a study aimed at characterizing the viral fraction and the microbial communities through metagenomic analysis. Two...

Characterization of Five Podoviridae Phages Infecting Citrobacter freundii.

Frontiers in microbiology

Hamdi S, Rousseau GM, Labrie SJ, Kourda RS, Tremblay DM, Moineau S, Slama KB.
PMID: 27446058
Front Microbiol. 2016 Jun 29;7:1023. doi: 10.3389/fmicb.2016.01023. eCollection 2016.

Citrobacter freundii causes opportunistic infections in humans and animals, which are becoming difficult to treat due to increased antibiotic resistance. The aim of this study was to explore phages as potential antimicrobial agents against this opportunistic pathogen. We isolated...

Predicted Cellular Interactors of the Endogenous Retrovirus-K Integrase Enzyme.


Benoit I, Brownell S, Douville RN.
PMID: 34361946
Microorganisms. 2021 Jul 14;9(7). doi: 10.3390/microorganisms9071509.

Integrase (IN) enzymes are found in all retroviruses and are crucial in the retroviral integration process. Many studies have revealed how exogenous IN enzymes, such as the human immunodeficiency virus (HIV) IN, contribute to altered cellular function. However, the...

New Insights into the Classification and Integration Specificity of Streptococcus Integrative Conjugative Elements through Extensive Genome Exploration.

Frontiers in microbiology

Ambroset C, Coluzzi C, Guédon G, Devignes MD, Loux V, Lacroix T, Payot S, Leblond-Bourget N.
PMID: 26779141
Front Microbiol. 2016 Jan 06;6:1483. doi: 10.3389/fmicb.2015.01483. eCollection 2015.

Recent genome analyses suggest that integrative and conjugative elements (ICEs) are widespread in bacterial genomes and therefore play an essential role in horizontal transfer. However, only a few of these elements are precisely characterized and correctly delineated within sequenced...

Retroviral DNA Transposition: Themes and Variations.

Microbiology spectrum

Skalka AM.
PMID: 25844274
Microbiol Spectr. 2014 Dec;2(5):MDNA300052014. doi: 10.1128/microbiolspec.MDNA3-0005-2014.

Retroviruses and LTR retrotransposons are transposable elements that encapsidate the RNAs that are intermediates in the transposition of DNA copies of their genomes (proviruses), from one cell (or one locus) to another. Mechanistic similarities in DNA transposase enzymes and...

Genomic comparison of invasive and rare non-invasive strains reveals Porphyromonas gingivalis genetic polymorphisms.

Journal of oral microbiology

Dolgilevich S, Rafferty B, Luchinskaya D, Kozarov E.
PMID: 21541093
J Oral Microbiol. 2011 Mar 09;3. doi: 10.3402/jom.v3i0.5764.

BACKGROUND: Porphyromonas gingivalis strains are shown to invade human cells in vitro with different invasion efficiencies, varying by up to three orders of magnitude.OBJECTIVE: We tested the hypothesis that invasion-associated interstrain genomic polymorphisms are present in P. gingivalis and...

Showing 1 to 12 of 60 entries