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Clinical pharmacokinetics and pharmacodynamics of mycophenolate in solid organ transplant recipients.

Clinical pharmacokinetics

Staatz CE, Tett SE.
PMID: 17201457
Clin Pharmacokinet. 2007;46(1):13-58. doi: 10.2165/00003088-200746010-00002.

This review aims to provide an extensive overview of the literature on the clinical pharmacokinetics of mycophenolate in solid organ transplantation and a briefer summary of current pharmacodynamic information. Strategies are suggested for further optimisation of mycophenolate therapy and...

Ontogeny of P2-purinoceptors in the longitudinal muscle and muscularis mucosae of the rat isolated duodenum.

British journal of pharmacology

Brownhill VR, Hourani SM, Kitchen I.
PMID: 9313929
Br J Pharmacol. 1997 Sep;122(2):225-32. doi: 10.1038/sj.bjp.0701375.
Free PMC Article

1. The ontogeny of P2-purinoceptors in the longitudinal muscle and the muscularis mucosae of the rat isolated duodenum was investigated by use of functional assays in tissues from neonatal animals. The degradation of purinoceptor agonists by the rat duodenum...

In vitro effects of mycophenolic acid on the nucleotide pool and on the expression of adhesion molecules of human umbilical vein endothelial cells.

Clinica chimica acta; international journal of clinical chemistry

Raab M, Daxecker H, Karimi A, Markovic S, Cichna M, Markl P, Müller MM.
PMID: 11485760
Clin Chim Acta. 2001 Aug 01;310(1):89-98. doi: 10.1016/s0009-8981(01)00527-7.

The immunosuppressive drug mycophenolate mofetil (MMF) and its active metabolite mycophenolic acid (MPA) selectively inhibit inosine 5'-monophosphate dehydrogenase (IMPDH), and therefore interfere with cellular guanine nucleotide biosynthesis. IMPDH is additionally involved in the synthesis of membrane glycoproteins, some of...

Interaction of purine nucleotides with inert paramagnetic Cr(III) probes evaluated by NMR relaxation effects. Molecular mechanics calculations on Cr(III) and Co(III) polyphosphate complexes.

Journal of biomolecular structure & dynamics

Cini R, Giorgi G, Laschi F, Rossi C, Marzilli LG.
PMID: 2310520
J Biomol Struct Dyn. 1990 Feb;7(4):859-78. doi: 10.1080/07391102.1990.10508529.

The 1H NMR relaxation effects produced by paramagnetic Cr(III) complexes on nucleoside 5'-mono- and -triphosphates in D2O solution at pH' = 3 were measured. The paramagnetic probes were [Cr(III)(H2O)6]3+, [Cr(III)(H2O)3(HATP)], [Cr(III)(H2O)3(HCTP)] and [Cr(III)(H2O)3(UTP)-, while the matrix nucleotides (0.1 M)...

Enzymes involved in purine metabolism--a review of histochemical localization and functional implications.

Histology and histopathology

Moriwaki Y, Yamamoto T, Higashino K.
PMID: 10506947
Histol Histopathol. 1999 Oct;14(4):1321-40. doi: 10.14670/HH-14.1321.

Many enzymes are involved in the biosynthesis, interconversion, and degradation of purine compounds. The exact function of these enzymes is still unknown, but they seem to play important roles other than in purine metabolism. To elucidate their functional roles,...

Tricarboxylic acid cycle intermediate pool size: functional importance for oxidative metabolism in exercising human skeletal muscle.

Sports medicine (Auckland, N.Z.)

Bowtell JL, Marwood S, Bruce M, Constantin-Teodosiu D, Greenhaff PL.
PMID: 18027994
Sports Med. 2007;37(12):1071-88. doi: 10.2165/00007256-200737120-00005.

The tricarboxylic acid (TCA) cycle is the major final common pathway for oxidation of carbohydrates, lipids and some amino acids, which produces reducing equivalents in the form of nicotinamide adenine dinucleotide and flavin adenine dinucleotide that result in production...

Current and experimental treatments of Parkinson disease: A guide for neuroscientists.

Journal of neurochemistry

Oertel W, Schulz JB.
PMID: 27577098
J Neurochem. 2016 Oct;139:325-337. doi: 10.1111/jnc.13750. Epub 2016 Aug 30.

Over a period of more than 50 years, the symptomatic treatment of the motor symptoms of Parkinson disease (PD) has been optimized using pharmacotherapy, deep brain stimulation, and physiotherapy. The arsenal of pharmacotherapies includes L-Dopa, several dopamine agonists, inhibitors...

Purine in bronchoalveolar lavage fluid as a marker of ventilation-induced lung injury.

Critical care medicine

Verbrugge SJ, de Jong JW, Keijzer E, Vazquez de Anda G, Lachmann B.
PMID: 10321669
Crit Care Med. 1999 Apr;27(4):779-83. doi: 10.1097/00003246-199904000-00035.

OBJECTIVE: To investigate in a rat model of ventilation-induced lung injury whether metabolic changes in the lung are reflected by an increased purine concentration (adenosine, inosine, hypoxanthine, xanthine, and urate; an index of adenosine-triphosphate breakdown) of the bronchoalveolar lavage...

First Report of Soybean dwarf virus (Genus Luteovirus) Infecting Faba Bean and Clover in Germany.

Plant disease

Abraham AD, Menzel W, Vetten HJ, Saucke H.
PMID: 30780466
Plant Dis. 2007 Aug;91(8):1059. doi: 10.1094/PDIS-91-8-1059B.

In 2003, leaf samples from faba bean plants (Vicia faba L.) showing slight growth reductions and yellowing symptoms were collected in a field near Hebenshausen, Hesse, Germany. Some of these samples did not react in triple-antibody sandwich enzyme-linked immunosorbent...

A blinded, randomized clinical trial of mycophenolate mofetil for the prevention of acute rejection in cadaveric renal transplantation. The Tricontinental Mycophenolate Mofetil Renal Transplantation Study Group.


[No authors listed]
PMID: 8623181
Transplantation. 1996 Apr 15;61(7):1029-37.

Mycopehenolate mofetil (MMF) is a powerful immunosuppressant that inhibits the proliferation of T and B lymphocytes by blocking the enzyme inosine monophosphate dehydrogenase. MMF has been shown to prevent acute graft rejection in animal experiments and may have an...

Mizoribine for the treatment of lupus nephritis in children and adolescents.

Clinical nephrology

Tanaka H, Tsugawa K, Tsuruga K, Suzuki K, Nakahata T, Ito E, Waga S.
PMID: 15630899
Clin Nephrol. 2004 Dec;62(6):412-7. doi: 10.5414/cnp62412.

AIM: The optimal treatment for lupus nephritis in the pubertal age group is still unclear. We therefore retrospectively evaluated the efficacy and safety of mizoribine (MZR), a novel selective inhibitor of inosine monophosphatase dehydrogenase, developed in Japan for the...

Relationship between circulating tumor-associated autoantibodies and clinical outcomes in advanced-stage NSCLC patients receiving PD-1/-L1 directed immune checkpoint inhibition.

Journal of immunological methods

Tarhoni I, Wakefield CJ, Kollipara R, Fidler MJ, Batus M, Bonomi P, Borgia JA.
PMID: 33434603
J Immunol Methods. 2021 Mar;490:112956. doi: 10.1016/j.jim.2021.112956. Epub 2021 Jan 09.

BACKGROUND: Durable tumor regressions are observed in a subset of advanced-stage non-small cell lung cancer (NSCLC) patients receiving PD-1/-L1 targeted immune checkpoint inhibitors (or 'immunotherapy') alone or in combination with chemotherapy. However, the majority of advanced NSCLC patients receiving...

Showing 1 to 12 of 9375 entries