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Showing 1 to 12 of 42 entries
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Possible modulatory effect of endogenous islet catecholamines on insulin secretion.

BMC endocrine disorders

Borelli MI, Gagliardino JJ.
PMID: 11696250
BMC Endocr Disord. 2001;1(1):1. doi: 10.1186/1472-6823-1-1.

BACKGROUND: The possible participation of endogenous islet catecholamines (CAs) in the control of insulin secretion was tested. METHODS: Glucose-induced insulin secretion was measured in the presence of 3-Iodo-L-Tyrosine (MIT), a specific inhibitor of tyrosine-hydroxylase activity, in fresh and precultured...

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Borelli MI, Gagliardino JJ. Possible modulatory effect of endogenous islet catecholamines on insulin secretion. BMC Endocr Disord. 2001;1(1):1doi: 10.1186/1472-6823-1-1.
Borelli, M. I., & Gagliardino, J. J. (2001). Possible modulatory effect of endogenous islet catecholamines on insulin secretion. BMC endocrine disorders, 1(1), 1. https://doi.org/10.1186/1472-6823-1-1
Borelli, Maria I, and Gagliardino, Juan J. "Possible modulatory effect of endogenous islet catecholamines on insulin secretion." BMC endocrine disorders vol. 1,1 (2001): 1. doi: https://doi.org/10.1186/1472-6823-1-1
Borelli MI, Gagliardino JJ. Possible modulatory effect of endogenous islet catecholamines on insulin secretion. BMC Endocr Disord. 2001;1(1):1. doi: 10.1186/1472-6823-1-1. PMID: 11696250; PMCID: PMC59668.
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Determination of idazoxan in plasma by radioreceptor assay.

Journal of pharmaceutical and biomedical analysis

Lane AC, Nichols JD, Steel ND, Sugden K, Walter DS.
PMID: 16867344
J Pharm Biomed Anal. 1988;6(6):787-92. doi: 10.1016/0731-7085(88)80092-x.

A radioreceptor assay to determine the plasma concentration of idazoxan, a potent, highly selective antagonist for the alpha(2)-adrenoreceptor, is described. The assay is based upon a technique in which plasma extracts containing idazoxan compete with radiolabelled ligand for binding...

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Lane AC, Nichols JD, Steel ND, et al. Determination of idazoxan in plasma by radioreceptor assay. J Pharm Biomed Anal. 1988;6(6):787-92doi: 10.1016/0731-7085(88)80092-x.
Lane, A. C., Nichols, J. D., Steel, N. D., Sugden, K., & Walter, D. S. (1988). Determination of idazoxan in plasma by radioreceptor assay. Journal of pharmaceutical and biomedical analysis, 6(6), 787-92. https://doi.org/10.1016/0731-7085(88)80092-x
Lane, A C, et al. "Determination of idazoxan in plasma by radioreceptor assay." Journal of pharmaceutical and biomedical analysis vol. 6,6 (1988): 787-92. doi: https://doi.org/10.1016/0731-7085(88)80092-x
Lane AC, Nichols JD, Steel ND, Sugden K, Walter DS. Determination of idazoxan in plasma by radioreceptor assay. J Pharm Biomed Anal. 1988;6(6):787-92. doi: 10.1016/0731-7085(88)80092-x. PMID: 16867344.
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Analgesic efficacy of CR4056, a novel imidazoline-2 receptor ligand, in rat models of inflammatory and neuropathic pain.

Journal of pain research

Ferrari F, Fiorentino S, Mennuni L, Garofalo P, Letari O, Mandelli S, Giordani A, Lanza M, Caselli G.
PMID: 21647215
J Pain Res. 2011;4:111-25. doi: 10.2147/JPR.S18353. Epub 2011 Apr 18.

Two decades of investigations have failed to unequivocally clarify the functions and the molecular nature of imidazoline-2 receptors (I2R). However, there is robust pharmacological evidence for the functional modulation of monoamino oxidase (MAO) and other important enzyme activities by...

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Ferrari F, Fiorentino S, Mennuni L, et al. Analgesic efficacy of CR4056, a novel imidazoline-2 receptor ligand, in rat models of inflammatory and neuropathic pain. J Pain Res. 2011;4:111-25doi: 10.2147/JPR.S18353.
Ferrari, F., Fiorentino, S., Mennuni, L., Garofalo, P., Letari, O., Mandelli, S., Giordani, A., Lanza, M., & Caselli, G. (2011). Analgesic efficacy of CR4056, a novel imidazoline-2 receptor ligand, in rat models of inflammatory and neuropathic pain. Journal of pain research, 4111-25. https://doi.org/10.2147/JPR.S18353
Ferrari, Flora, et al. "Analgesic efficacy of CR4056, a novel imidazoline-2 receptor ligand, in rat models of inflammatory and neuropathic pain." Journal of pain research vol. 4 (2011): 111-25. doi: https://doi.org/10.2147/JPR.S18353
Ferrari F, Fiorentino S, Mennuni L, Garofalo P, Letari O, Mandelli S, Giordani A, Lanza M, Caselli G. Analgesic efficacy of CR4056, a novel imidazoline-2 receptor ligand, in rat models of inflammatory and neuropathic pain. J Pain Res. 2011;4:111-25. doi: 10.2147/JPR.S18353. Epub 2011 Apr 18. PMID: 21647215; PMCID: PMC3100226.
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Stimulation of Alpha-Adrenoceptors Facilitates the Release of Growth Hormone-Releasing Hormone from Rat Hypothalamus in vitro.

Journal of neuroendocrinology

Tsagarakis S, Ge F, Rees LH, Besser GM, Grossman A.
PMID: 19210470
J Neuroendocrinol. 1989 Apr 01;1(2):129-33. doi: 10.1111/j.1365-2826.1989.tb00091.x.

Abstract While extensive evidence suggests that adrenoceptors play an important role in the control of growth hormone in the rat, there are few studies involving the direct measurement of growth hormone-releasing hormone (GHRH). We have therefore developed a radioimmunoassay...

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Tsagarakis S, Ge F, Rees LH, et al. Stimulation of Alpha-Adrenoceptors Facilitates the Release of Growth Hormone-Releasing Hormone from Rat Hypothalamus in vitro. J Neuroendocrinol. 1989;1(2):129-33doi: 10.1111/j.1365-2826.1989.tb00091.x.
Tsagarakis, S., Ge, F., Rees, L. H., Besser, G. M., & Grossman, A. (1989). Stimulation of Alpha-Adrenoceptors Facilitates the Release of Growth Hormone-Releasing Hormone from Rat Hypothalamus in vitro. Journal of neuroendocrinology, 1(2), 129-33. https://doi.org/10.1111/j.1365-2826.1989.tb00091.x
Tsagarakis, S, et al. "Stimulation of Alpha-Adrenoceptors Facilitates the Release of Growth Hormone-Releasing Hormone from Rat Hypothalamus in vitro." Journal of neuroendocrinology vol. 1,2 (1989): 129-33. doi: https://doi.org/10.1111/j.1365-2826.1989.tb00091.x
Tsagarakis S, Ge F, Rees LH, Besser GM, Grossman A. Stimulation of Alpha-Adrenoceptors Facilitates the Release of Growth Hormone-Releasing Hormone from Rat Hypothalamus in vitro. J Neuroendocrinol. 1989 Apr 01;1(2):129-33. doi: 10.1111/j.1365-2826.1989.tb00091.x. PMID: 19210470.
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Acute and chronic idazoxan in normal volunteers: biochemical, physiological and psychological effects.

Journal of psychopharmacology (Oxford, England)

Glue P, Wilson S, Lawson C, Campling GM, Franklin M, Cowen PJ, Nutt DJ.
PMID: 22282849
J Psychopharmacol. 1991 Jan;5(4):396-403. doi: 10.1177/026988119100500434.

The acute and chronic effects of the selective a(2)-antagonist idazoxan were studied in 12 normal volunteers. Plasma 3-methoxy-4-hydroxyphenylethylene glycol (MHPG), blood pressure and psychological responses to oral challenge doses of idazoxan 40 mg were measured twice, on the first...

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Glue P, Wilson S, Lawson C, et al. Acute and chronic idazoxan in normal volunteers: biochemical, physiological and psychological effects. J Psychopharmacol. 1991;5(4):396-403doi: 10.1177/026988119100500434.
Glue, P., Wilson, S., Lawson, C., Campling, G. M., Franklin, M., Cowen, P. J., & Nutt, D. J. (1991). Acute and chronic idazoxan in normal volunteers: biochemical, physiological and psychological effects. Journal of psychopharmacology (Oxford, England), 5(4), 396-403. https://doi.org/10.1177/026988119100500434
Glue, P, et al. "Acute and chronic idazoxan in normal volunteers: biochemical, physiological and psychological effects." Journal of psychopharmacology (Oxford, England) vol. 5,4 (1991): 396-403. doi: https://doi.org/10.1177/026988119100500434
Glue P, Wilson S, Lawson C, Campling GM, Franklin M, Cowen PJ, Nutt DJ. Acute and chronic idazoxan in normal volunteers: biochemical, physiological and psychological effects. J Psychopharmacol. 1991 Jan;5(4):396-403. doi: 10.1177/026988119100500434. PMID: 22282849.
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Specific α2-adrenoreceptor antagonists induce behavioural activation in the rat.

Journal of psychopharmacology (Oxford, England)

Dickinson SL, Gadie B, Tulloch IF.
PMID: 22282933
J Psychopharmacol. 1990 Jan;4(2):90-9. doi: 10.1177/026988119000400207.

The behavioural effects of the specific and selective α(2)-adrenoreceptor antagonists, idazoxan, efaroxan and RX811059, have been investigated in the rat. All three drugs induced periods of behavioural activation characterized by increased locomotion and exploration (rearing and hole dipping). However,...

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Dickinson SL, Gadie B, Tulloch IF. Specific α2-adrenoreceptor antagonists induce behavioural activation in the rat. J Psychopharmacol. 1990;4(2):90-9doi: 10.1177/026988119000400207.
Dickinson, S. L., Gadie, B., & Tulloch, I. F. (1990). Specific α2-adrenoreceptor antagonists induce behavioural activation in the rat. Journal of psychopharmacology (Oxford, England), 4(2), 90-9. https://doi.org/10.1177/026988119000400207
Dickinson, S L, et al. "Specific α2-adrenoreceptor antagonists induce behavioural activation in the rat." Journal of psychopharmacology (Oxford, England) vol. 4,2 (1990): 90-9. doi: https://doi.org/10.1177/026988119000400207
Dickinson SL, Gadie B, Tulloch IF. Specific α2-adrenoreceptor antagonists induce behavioural activation in the rat. J Psychopharmacol. 1990 Jan;4(2):90-9. doi: 10.1177/026988119000400207. PMID: 22282933.
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Estradiol regulates the number of ?(1) but not ? or ?(2) noradrenergic receptors in hypothalamus of female rats.

Neurochemistry international

Etgen AM, Karkanias GB.
PMID: 20504534
Neurochem Int. 1990;16(1):1-9. doi: 10.1016/0197-0186(90)90117-c.

Present experiments examined whether previously observed hormone-dependent differences in norepinephrine-stimulated cAMP accumulation in hypothalamic and preoptic area slices are attributable to differences in noradrenergic receptor number or binding affinity. When compared to ovariectomized controls, hypothalamic and preoptic area membranes...

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Etgen AM, Karkanias GB. Estradiol regulates the number of ?(1) but not ? or ?(2) noradrenergic receptors in hypothalamus of female rats. Neurochem Int. 1990;16(1):1-9doi: 10.1016/0197-0186(90)90117-c.
Etgen, A. M., & Karkanias, G. B. (1990). Estradiol regulates the number of ?(1) but not ? or ?(2) noradrenergic receptors in hypothalamus of female rats. Neurochemistry international, 16(1), 1-9. https://doi.org/10.1016/0197-0186(90)90117-c
Etgen, A M, and Karkanias, G B. "Estradiol regulates the number of ?(1) but not ? or ?(2) noradrenergic receptors in hypothalamus of female rats." Neurochemistry international vol. 16,1 (1990): 1-9. doi: https://doi.org/10.1016/0197-0186(90)90117-c
Etgen AM, Karkanias GB. Estradiol regulates the number of ?(1) but not ? or ?(2) noradrenergic receptors in hypothalamus of female rats. Neurochem Int. 1990;16(1):1-9. doi: 10.1016/0197-0186(90)90117-c. PMID: 20504534.
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Identification of ?(2) adrenergic receptors in human frontal cortex membranes by binding of [(3)H]RX 821002, the 2-methoxy analog of [(3)H]idazoxan.

Neurochemistry international

Vauquelin G, De Vos H, De Backer JP, Ebinger G.
PMID: 20504656
Neurochem Int. 1990;17(4):537-46. doi: 10.1016/0197-0186(90)90041-q.

The antagonist [(3)H]idazoxan binds with comparable affinity to ?(2) adrenergic receptors and to phentolamine-displaceable non-stereoselective sites in human frontal cortex membranes. In contrast, idazoxan analogs possessing alkyl and alkoxy substituents at the 2-position of the benzodioxan moiety (i.e. RX...

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Vauquelin G, De Vos H, De Backer JP, et al. Identification of ?(2) adrenergic receptors in human frontal cortex membranes by binding of [(3)H]RX 821002, the 2-methoxy analog of [(3)H]idazoxan. Neurochem Int. 1990;17(4):537-46doi: 10.1016/0197-0186(90)90041-q.
Vauquelin, G., De Vos, H., De Backer, J. P., & Ebinger, G. (1990). Identification of ?(2) adrenergic receptors in human frontal cortex membranes by binding of [(3)H]RX 821002, the 2-methoxy analog of [(3)H]idazoxan. Neurochemistry international, 17(4), 537-46. https://doi.org/10.1016/0197-0186(90)90041-q
Vauquelin, G, et al. "Identification of ?(2) adrenergic receptors in human frontal cortex membranes by binding of [(3)H]RX 821002, the 2-methoxy analog of [(3)H]idazoxan." Neurochemistry international vol. 17,4 (1990): 537-46. doi: https://doi.org/10.1016/0197-0186(90)90041-q
Vauquelin G, De Vos H, De Backer JP, Ebinger G. Identification of ?(2) adrenergic receptors in human frontal cortex membranes by binding of [(3)H]RX 821002, the 2-methoxy analog of [(3)H]idazoxan. Neurochem Int. 1990;17(4):537-46. doi: 10.1016/0197-0186(90)90041-q. PMID: 20504656.
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The efficacy of combination treatment of gabapentin and electro-acupuncture on paclitaxel-induced neuropathic pain.

The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology

Kim MJ, Lee JH, Jang JU, Quan FS, Kim SK, Kim W.
PMID: 29200909
Korean J Physiol Pharmacol. 2017 Nov;21(6):657-666. doi: 10.4196/kjpp.2017.21.6.657. Epub 2017 Oct 30.

Paclitaxel, a chemotherapeutic drug, induces severe peripheral neuropathy. Gabapentin (GBT) is a first line agent used to treat neuropathic pain, and its effect is mediated by spinal noradrenergic and muscarinic cholinergic receptors. Electro-acupuncture (EA) is used for treating various...

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Kim MJ, Lee JH, Jang JU, et al. The efficacy of combination treatment of gabapentin and electro-acupuncture on paclitaxel-induced neuropathic pain. Korean J Physiol Pharmacol. 2017;21(6):657-666doi: 10.4196/kjpp.2017.21.6.657.
Kim, M. J., Lee, J. H., Jang, J. U., Quan, F. S., Kim, S. K., & Kim, W. (2017). The efficacy of combination treatment of gabapentin and electro-acupuncture on paclitaxel-induced neuropathic pain. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 21(6), 657-666. https://doi.org/10.4196/kjpp.2017.21.6.657
Kim, Min Joon, et al. "The efficacy of combination treatment of gabapentin and electro-acupuncture on paclitaxel-induced neuropathic pain." The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology vol. 21,6 (2017): 657-666. doi: https://doi.org/10.4196/kjpp.2017.21.6.657
Kim MJ, Lee JH, Jang JU, Quan FS, Kim SK, Kim W. The efficacy of combination treatment of gabapentin and electro-acupuncture on paclitaxel-induced neuropathic pain. Korean J Physiol Pharmacol. 2017 Nov;21(6):657-666. doi: 10.4196/kjpp.2017.21.6.657. Epub 2017 Oct 30. PMID: 29200909; PMCID: PMC5709483.
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Alpha1-adrenergic antagonists block 6-nitrodopamine contractions on the rat isolated epididymal vas deferens.

European journal of pharmacology

Britto-Júnior J, Ribeiro A, Ximenes L, Lima AT, Jacintho FF, Fregonesi A, Mónica FZ, Antunes E, De Nucci G.
PMID: 34951979
Eur J Pharmacol. 2021 Dec 21;174716. doi: 10.1016/j.ejphar.2021.174716. Epub 2021 Dec 21.

6-nitrodopamine (6-ND) is released from rat isolated vas deferens and modulates electrical-field stimulation (EFS) contractions of the rat isolated epididymal vas deferens (RIEVD) via a specific receptor which is blocked by tricyclic antidepressants. Here, the effects of selective α

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Britto-Júnior J, Ribeiro A, Ximenes L, et al. Alpha1-adrenergic antagonists block 6-nitrodopamine contractions on the rat isolated epididymal vas deferens. Eur J Pharmacol. 2021;174716doi: 10.1016/j.ejphar.2021.174716.
Britto-Júnior, J., Ribeiro, A., Ximenes, L., Lima, A. T., Jacintho, F. F., Fregonesi, A., Mónica, F. Z., Antunes, E., & De Nucci, G. (2021). Alpha1-adrenergic antagonists block 6-nitrodopamine contractions on the rat isolated epididymal vas deferens. European journal of pharmacology, 174716. https://doi.org/10.1016/j.ejphar.2021.174716
Britto-Júnior, José, et al. "Alpha1-adrenergic antagonists block 6-nitrodopamine contractions on the rat isolated epididymal vas deferens." European journal of pharmacology vol. (2021): 174716. doi: https://doi.org/10.1016/j.ejphar.2021.174716
Britto-Júnior J, Ribeiro A, Ximenes L, Lima AT, Jacintho FF, Fregonesi A, Mónica FZ, Antunes E, De Nucci G. Alpha1-adrenergic antagonists block 6-nitrodopamine contractions on the rat isolated epididymal vas deferens. Eur J Pharmacol. 2021 Dec 21;174716. doi: 10.1016/j.ejphar.2021.174716. Epub 2021 Dec 21. PMID: 34951979.
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Suppression of osteoclastogenesis via α2-adrenergic receptors.

Biomedical reports

Hamajima K, Hamamura K, Chen A, Yokota H, Mori H, Yo S, Kondo H, Tanaka K, Ishizuka K, Kodama D, Hirai T, Miyazawa K, Goto S, Togari A.
PMID: 29725523
Biomed Rep. 2018 May;8(5):407-416. doi: 10.3892/br.2018.1075. Epub 2018 Mar 09.

The sympathetic nervous system is known to regulate osteoclast development. However, the involvement of α2-adrenergic receptors (α2-ARs) in osteoclastogenesis is not well understood. In the present study, their potential role in osteoclastogenesis was investigated. Guanabenz, clonidine and xylazine were...

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Hamajima K, Hamamura K, Chen A, et al. Suppression of osteoclastogenesis via α2-adrenergic receptors. Biomed Rep. 2018;8(5):407-416doi: 10.3892/br.2018.1075.
Hamajima, K., Hamamura, K., Chen, A., Yokota, H., Mori, H., Yo, S., Kondo, H., Tanaka, K., Ishizuka, K., Kodama, D., Hirai, T., Miyazawa, K., Goto, S., & Togari, A. (2018). Suppression of osteoclastogenesis via α2-adrenergic receptors. Biomedical reports, 8(5), 407-416. https://doi.org/10.3892/br.2018.1075
Hamajima, Kosuke, et al. "Suppression of osteoclastogenesis via α2-adrenergic receptors." Biomedical reports vol. 8,5 (2018): 407-416. doi: https://doi.org/10.3892/br.2018.1075
Hamajima K, Hamamura K, Chen A, Yokota H, Mori H, Yo S, Kondo H, Tanaka K, Ishizuka K, Kodama D, Hirai T, Miyazawa K, Goto S, Togari A. Suppression of osteoclastogenesis via α2-adrenergic receptors. Biomed Rep. 2018 May;8(5):407-416. doi: 10.3892/br.2018.1075. Epub 2018 Mar 09. PMID: 29725523; PMCID: PMC5920467.
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Discriminative stimulus produced by the imidazoline I2 site ligand, 2 -BFI.

Journal of psychopharmacology (Oxford, England)

Jordan S, Jackson HC, Nutt DJ, Handley SL.
PMID: 22302973
J Psychopharmacol. 1996 Jan;10(4):273-8. doi: 10.1177/026988119601000403.

2-(2-Benzofuranyl)-2-imidazoline, RX801077 (2-BFI) which has high affinity for imidazoline I(2) binding sites and very low aflinity for α(2)-adrenoceptors, has been investigated for its ability to produce a discriminative stimulus (cue) in drug-discrimination studies in rats since the existence of...

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Jordan S, Jackson HC, Nutt DJ, et al. Discriminative stimulus produced by the imidazoline I2 site ligand, 2 -BFI. J Psychopharmacol. 1996;10(4):273-8doi: 10.1177/026988119601000403.
Jordan, S., Jackson, H. C., Nutt, D. J., & Handley, S. L. (1996). Discriminative stimulus produced by the imidazoline I2 site ligand, 2 -BFI. Journal of psychopharmacology (Oxford, England), 10(4), 273-8. https://doi.org/10.1177/026988119601000403
Jordan, S, et al. "Discriminative stimulus produced by the imidazoline I2 site ligand, 2 -BFI." Journal of psychopharmacology (Oxford, England) vol. 10,4 (1996): 273-8. doi: https://doi.org/10.1177/026988119601000403
Jordan S, Jackson HC, Nutt DJ, Handley SL. Discriminative stimulus produced by the imidazoline I2 site ligand, 2 -BFI. J Psychopharmacol. 1996 Jan;10(4):273-8. doi: 10.1177/026988119601000403. PMID: 22302973.
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Showing 1 to 12 of 42 entries