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Showing 1 to 12 of 23 entries
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Rapid Reduction in Use of Antidiabetic Medication after Laparoscopic Sleeve Gastrectomy: The Newfoundland and Labrador Bariatric Surgery Cohort (BaSCo) Study.

The Canadian journal of hospital pharmacy

Dillon C, Peddle J, Twells L, Lester K, Midodzi W, Manning K, Murphy R, Pace D, Smith C, Boone D, Gregory D.
PMID: 25964682
Can J Hosp Pharm. 2015 Mar-Apr;68(2):113-20. doi: 10.4212/cjhp.v68i2.1436.

BACKGROUND: Patients who have undergone bariatric surgery generally need fewer medications as they experience improvement in, or even resolution of, various medical conditions, including type 2 diabetes mellitus, hypertension, and dyslipidemia. Published data on changes in medication use after...

[Secondary prevention in acute myocardial infarction].

Acta medica portuguesa

Ferreira R, Ferreira D, Correia MJ, De Sá ME, De Sousa JV, Sousa JV, Tavares MG.
PMID: 11475986
Acta Med Port. 2001 Mar-Apr;14(2):149-69.

Myocardial infarction is still one of the main causes of mortality and morbidity in Western countries. The advances made in the last 30 years have made it possible to reduce mortality significantly (which is currently below two digits) as...

Assessing the adherence to and the therapeutic effectiveness of hypolipidemic agents in a population of patients in Brazil: a retrospective cohort study.

Pharmacy practice

Cunico C, Picheth G, Correr CJ, Scartezini M.
PMID: 25035713
Pharm Pract (Granada). 2014 Apr;12(2):378. doi: 10.4321/s1886-36552014000200002. Epub 2014 Mar 15.

OBJECTIVE: to evaluate the relation between patient adherence and therapeutic effectiveness of hypolipidemic agents in clinical practice.METHODS: A retrospective cohort study of 417 patients using hypolipidemic drugs (simvastatin, atorvastatin) between 2003 and 2010 was performed. The population studied consists...

A comparative clinical study of hypolipidemic efficacy of Amla (Emblica officinalis) with 3-hydroxy-3-methylglutaryl-coenzyme-A reductase inhibitor simvastatin.

Indian journal of pharmacology

Gopa B, Bhatt J, Hemavathi KG.
PMID: 22529483
Indian J Pharmacol. 2012 Mar;44(2):238-42. doi: 10.4103/0253-7613.93857.

OBJECTIVES: To evaluate the efficacy of Amla in patients with type II hyperlipidemia and compare its hypolipidemic effects with those of simvastatin.MATERIALS AND METHODS: Sixty type II hyperlipidemic patients of both sexes with plasma total cholesterol and low density...

Hypolipidemic activity of amine-borane aducts of cyclohexylamine and toluidine in rodents.

Metal-based drugs

Burnham BS, Chen SY, Sood A, Spielvogel BF, Hall IH.
PMID: 18472769
Met Based Drugs. 1995;2(4):221-32. doi: 10.1155/MBD.1995.221.

The amine-borane adducts of cyclohexylamine and toluidine were observed to be potent hypolipidemic agents in mice, I.P. and rats orally at 8 mg/kg/day lowering both serum cholesterol and triglyceride levels after 14-16 days. These compounds were able to lower...

The hypolipidemic activity of furoic Acid and furylacrylic Acid derivatives in rodents.

Pharmaceutical research

Hall IH, Williams WL, Rhyne KA, Knowles M.
PMID: 24272843
Pharm Res. 1985 Sep;2(5):233-8. doi: 10.1023/A:1016368912659.

2-Furoic acid, 3-furoic acid, 3,4-furan dicarboxylic acid and furyl-acrylic acid were evaluated for hypolipidemic activity in mice and rats. 2-Furoic acid was the most potent agent of the four tested, lowering serum cholesterol levels 41 % and serum triglyceride...

Hypolipidemic Agents of Phthalimide Derivatives 6. Effects of Aromatic vs. Non-Aromatic Imides.

Pharmaceutical research

Chapman JM, Wyrick SD, Maguire JH, Cocolas GH, Hall IH.
PMID: 24277360
Pharm Res. 1984 Nov;1(6):267-9. doi: 10.1023/A:1016346018962.

A number of substituted phthalimide, 1, 8-naphthalimide, succinimide and glutarimide derivatives demonstrated significant hypolipidemic activity at 20 mg/kg/ day, I.P. after 16 days dosing. The N-(n-pentyl) succinimide proved to be the most potent analogue of the new compounds, lowering...

Statin-Associated Myopathy: Emphasis on Mechanisms and Targeted Therapy.

International journal of molecular sciences

Vinci P, Panizon E, Tosoni LM, Cerrato C, Pellicori F, Mearelli F, Biasinutto C, Fiotti N, Di Girolamo FG, Biolo G.
PMID: 34769118
Int J Mol Sci. 2021 Oct 28;22(21). doi: 10.3390/ijms222111687.

Hyperlipidemia is a major risk factor for cardiovascular morbidity and mortality. Statins are the first-choice therapy for dyslipidemias and are considered the cornerstone of atherosclerotic cardiovascular disease (ASCVD) in both primary and secondary prevention. Despite the statin-therapy-mediated positive effects...

The Hypolipidemic and Anti-Inflammatory Activity of Boronated Aromatic Amino Acids in CF(1) Male Mice.

Metal-based drugs

Miller MC, Sood A, Spielvogel BF, Hall IH.
PMID: 18475910
Met Based Drugs. 1999;6(6):337-44. doi: 10.1155/MBD.1999.337.

The boronated aromatic amino acids were shown to be potent hypolipidemic agents in mice lowering both serum cholesterol and triglycerides after 16 days. Selective compounds were as effective as the clinical standards. Furthermore, the compounds were effective anti-inflammatory agents...

The hypolipidemic activity of heterocyclic thiosemicarbazones, thioureas and their metal complexes in sprague dawley male rats.

Metal-based drugs

Hall IH, Chen SY, Barnes BJ, West DX.
PMID: 18472903
Met Based Drugs. 1999;6(3):143-7. doi: 10.1155/MBD.1999.143.

Heterocyclic thiosemicarbazones, thioureas and their copper, nickel, and cobalt complexes were shown to be potent hypolipidemic agents in male Sprague Dawley rats at 8 mg/kg/day, orally. These agents lowered the activity of rat hepatic rate limiting enzymes for the...

Different adipose depots: their role in the development of metabolic syndrome and mitochondrial response to hypolipidemic agents.

Journal of obesity

Bjørndal B, Burri L, Staalesen V, Skorve J, Berge RK.
PMID: 21403826
J Obes. 2011;2011:490650. doi: 10.1155/2011/490650. Epub 2011 Feb 15.

Adipose tissue metabolism is closely linked to insulin resistance, and differential fat distributions are associated with disorders like hypertension, diabetes, and cardiovascular disease. Adipose tissues vary in their impact on metabolic risk due to diverse gene expression profiles, leading...

Statins and Fibrates for Diabetic Retinopathy: Protocol for a Systematic Review.

JMIR research protocols

Mozetic V, Freitas CG, Riera R.
PMID: 28228373
JMIR Res Protoc. 2017 Feb 22;6(2):e30. doi: 10.2196/resprot.6650.

BACKGROUND: Diabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus, and more than 75% of patients who have had diabetes for more than 20 years will have some degree of DR. This disease is highly destructive to...

Showing 1 to 12 of 23 entries