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Showing 1 to 12 of 994 entries
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Effect of tissue inhibitor of metalloproteinases 3 on DLK1 shedding in cultured human pre-adipocytes and implications for adipose tissue remodelling.

Lancet (London, England)

Fenech M, Gavrilovic J, Turner J.
PMID: 26312857
Lancet. 2015 Feb 26;385:S35. doi: 10.1016/S0140-6736(15)60350-6.

BACKGROUND: Metabolically unhealthy obesity is associated with adipose tissue inflammation and increased risk of type 2 diabetes. Dysfunctional adipose tissue remodelling has been implicated in development of metabolically unhealthy obesity, but the pathogenesis remains poorly characterised. We hypothesised that...

Role of interleukin-1 and its antagonism of hepatic stellate cell proliferation and liver fibrosis in the Abcb4(-/-) mouse model.

World journal of hepatology

Reiter FP, Wimmer R, Wottke L, Artmann R, Nagel JM, Carranza MO, Mayr D, Rust C, Fickert P, Trauner M, Gerbes AL, Hohenester S, Denk GU.
PMID: 27004088
World J Hepatol. 2016 Mar 18;8(8):401-10. doi: 10.4254/wjh.v8.i8.401.

AIM: To study the interleukin-1 (IL-1) pathway as a therapeutic target for liver fibrosis in vitro and in vivo using the ATP-binding cassette transporter b4(-/-) (Abcb4(-/-)) mouse model.METHODS: Female and male Abcb4(-/-) mice from 6 to 13 mo of...

Quantitative analyses of myelofibrosis by determining hydroxyproline.

Stem cell investigation

Zhao W, Ho WT, Zhao ZJ.
PMID: 27358870
Stem Cell Investig. 2015 Jan 26;2:2. doi: 10.3978/j.issn.2306-9759.2015.01.02. eCollection 2015.

BACKGROUND: Myeloproliferative neoplasms (MPNs) are blood malignancies manifested in increased production of red blood cells, white blood cells, and/or platelets. Myelofibrosis is a subtype of MPNs characterized by the formation of scar-like tissues in the bone marrow due to...

Pulsed low-intensity ultrasound increases proliferation and extracelluar matrix production by human dermal fibroblasts in three-dimensional culture.

Journal of tissue engineering

Bohari SP, Grover LM, Hukins DW.
PMID: 26668710
J Tissue Eng. 2015 Nov 19;6:2041731415615777. doi: 10.1177/2041731415615777. eCollection 2015.

This study evaluated the effect of pulsed low-intensity ultrasound on cell proliferation, collagen production and glycosaminoglycan deposition by human dermal fibroblasts encapsulated in alginate. Hoechst 33258 assay for cell number, hydroxyproline assay for collagen content, dimethylmethylene blue assay for...

Facile construction of pyrrolo[1,2-b]isoquinolin-10(5H)-ones via a redox-amination-aromatization-Friedel-Crafts acylation cascade reaction and discovery of novel topoisomerase inhibitors.

Chemical communications (Cambridge, England)

Wu S, Liu N, Dong G, Ma L, Wang S, Shi W, Fang K, Chen S, Li J, Zhang W, Sheng C, Wang W.
PMID: 27400278
Chem Commun (Camb). 2016 Jul 21;52(61):9593-6. doi: 10.1039/c6cc03071h.

An efficient redox-amination-aromatization-Friedel-Crafts acylation cascade process from trans-4-hydroxyproline and 2-formylbenzoic acids has been developed for the synthesis of pyrrolo[1,2-b]isoquinolin-10(5H)-ones. Compound 3h was identified as a new potent dual topoisomerase I/II inhibitor.

Studies on wound healing potential of polyherbal formulation using in vitro and in vivo assays.

Journal of Ayurveda and integrative medicine

Talekar YP, Apte KG, Paygude SV, Tondare PR, Parab PB.
PMID: 28601354
J Ayurveda Integr Med. 2017 Apr - Jun;8(2):73-81. doi: 10.1016/j.jaim.2016.11.007. Epub 2017 Jun 07.

BACKGROUND: The use of herbal plant extracts in wound healing is known through decades, but it is necessary to provide scientific data through reverse pharmacology.OBJECTIVE: The aim of the present study is to find the mechanism behind the healing...

Adipose tissue-derived stem cells ameliorates dermal fibrosis in a mouse model of scleroderma.

Asian Pacific journal of tropical medicine

Chen W, Xia ZK, Zhang MH, Ding GC, Zhang XY, Wang ZX, Yang RY.
PMID: 28107865
Asian Pac J Trop Med. 2017 Jan;10(1):52-56. doi: 10.1016/j.apjtm.2016.10.005. Epub 2016 Nov 09.

OBJECTIVE: To investigate the therapeutic potential of adipose-derived stem cells (ADSCs) for limited cutaneous scleroderma (LS) in mouse models.METHODS: ADSCs were isolated from pathogen-free female C57BL/6 mice and LS was induced in wild type (WT) C57BL/6 mice via daily...

Chemoselective O-acylation of hydroxyamino acids and amino alcohols under acidic reaction conditions: History, scope and applications.

Beilstein journal of organic chemistry

Kristensen TE.
PMID: 25977719
Beilstein J Org Chem. 2015 Apr 08;11:446-68. doi: 10.3762/bjoc.11.51. eCollection 2015.

Amino acids, whether natural, semisynthetic or synthetic, are among the most important and useful chiral building blocks available for organic chemical synthesis. In principle, they can function as inexpensive, chiral and densely functionalized starting materials. On the other hand,...

Fibroblast growth factor 18 increases the trophic effects of bone marrow mesenchymal stem cells on chondrocytes isolated from late stage osteoarthritic patients.

Stem cells international

Zhang Z, Wang Y, Li M, Li J, Wu J.
PMID: 25544847
Stem Cells Int. 2014;2014:125683. doi: 10.1155/2014/125683. Epub 2014 Dec 03.

Coculture of mesenchymal stem cells with chondrocytes increases production of cartilaginous matrix. Chondrocytes isolated from late stage osteoarthritic patients usually lost their phenotype of producing cartilaginous matrix. Fibroblast growth factor 18 is believed to redifferentiate OA chondrocyte into functionally...

Effects of Shenqi Neijin powder on activation and apoptosis of hepatic stellate cells in rats with hepatic fibrosis.

International journal of clinical and experimental medicine

Xie H, Hou W, Yang Y, Yu Y, Wang F, Mao J.
PMID: 25932155
Int J Clin Exp Med. 2015 Jan 09;8(2):2226-32. eCollection 2015.

Traditional herbal medicine is usually administrated according to experiences and practices. We aimed to investigate the anti-fibrotic effects of Shenqi Neijin powder (SQNJP) in hepatic fibrosis rats induced by carbon tetrachloride (CCl4). A total of 32 rats were divided...

Simvastatin improves incisional wound healing in a rat model: an experimental study.

Wounds : a compendium of clinical research and practice

Derici H, Yaman I, Kara C, Kamer E, Diniz G, Ortac R.
PMID: 25874542
Wounds. 2012 Jul;24(7):195-200.

UNLABELLED:  This study investigated the effect of simvastatin on the heal- ing process of abdominal wall wounds in rats.METHODS: The study was performed with adult female Wistar-Albino rats. Control group (n = 20) rats were fed standard laboratory...

Glycoprotein conformation in plant cell walls : Circular dichroism reveals a polyproline II structure.

Planta

Homer RB, Roberts K.
PMID: 24318062
Planta. 1979 Jan;146(2):217-22. doi: 10.1007/BF00388235.

The major structural glycoprotein of the cell wall of Chlamydomonas reinhardii has a protein core, at least 50% of which is in the unusual polyproline II conformation. This has been demonstrated by examining the circular dichroism of the cell...

Showing 1 to 12 of 994 entries