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Showing 1 to 12 of 199 entries
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Autoimmune-like drug-induced liver injury: a review and update for the clinician.

Expert opinion on drug metabolism & toxicology

Stine JG, Northup PG.
PMID: 27402321
Expert Opin Drug Metab Toxicol. 2016 Nov;12(11):1291-1301. doi: 10.1080/17425255.2016.1211110. Epub 2016 Jul 21.

INTRODUCTION: Autoimmune-like drug-induced liver injury (DI-AIH) is a rare but serious event with a growing body of scientific evidence and a fair degree of uncertainty. Areas covered: This review covers the definition, pathophysiology, treatment and patient-centered outcomes of DI-AIH...

Communication Strategies Must Be Tailored to a Medication's Targeted Population: Lessons from the Case of BiDil.

American health & drug benefits

Hawkins-Taylor C, Carlson AM.
PMID: 24991371
Am Health Drug Benefits. 2013 Sep;6(7):401-12.

BACKGROUND: The American population's diversity continues to grow, and its racial and ethnic mixes are changing. The US healthcare system must confront this changing reality. The introduction of isosorbide dinitrate/hydralazine hydrochloride (BiDil) to the US marketplace was a move...

Modifying the Interagency Emergency Health Kit to include treatment for non-communicable diseases in natural disasters and complex emergencies.

BMJ global health

Tonelli M, Wiebe N, Nadler B, Darzi A, Rasheed S.
PMID: 28588970
BMJ Glob Health. 2016 Oct 20;1(3):e000128. doi: 10.1136/bmjgh-2016-000128. eCollection 2016.

The Interagency Emergency Health Kit (IEHK) provides a standard package of medicines and simple medical devices for aid agencies to use in emergencies such as disasters and armed conflicts. Despite the increasing burden of non-communicable diseases (NCDs) in such...

Brain Angiotensin II Type 1 Receptor Blockade Improves Dairy Blood Pressure Variability via Sympathoinhibition in Hypertensive Rats.

International journal of hypertension

Kishi T, Hirooka Y, Sunagawa K.
PMID: 25918643
Int J Hypertens. 2015;2015:759629. doi: 10.1155/2015/759629. Epub 2015 Mar 30.

Abnormal blood pressure (BP) elevation in early morning is known to cause cardiovascular events. Previous studies have suggested that one of the reasons in abnormal dairy BP variability is sympathoexcitation. We have demonstrated that brain angiotensin II type 1...

Simultaneous Estimation of Hydrochlorothiazide, Hydralazine Hydrochloride, and Reserpine Using PCA, NAS, and NAS-PCA.

Scientia pharmaceutica

Sharma C, Badyal PN, Rawal RK.
PMID: 26839841
Sci Pharm. 2015 Jun 22;83(4):599-610. doi: 10.3797/scipharm.1505-03. Print 2015.

In this study, new and feasible UV-visible spectrophotometric and multivariate spectrophotometric methods were described for the simultaneous determination of hydrochlorothiazide (HCTZ), hydralazine hydrochloride (H.HCl), and reserpine (RES) in combined pharmaceutical tablets. Methanol was used as a solvent for analysis...

Ticagrelor-induced pneumonitis and subsequent pulmonary hemorrhage; drug rash with eosinophilia due to boceprevir; hepatitis C reactivation after starting infliximab; hydralazine-associated immune glomerulonephritis; fluoroquinolones and retinal detachment.

Hospital pharmacy

Mancano MA.
PMID: 24958965
Hosp Pharm. 2014 Jun;49(6):498-501. doi: 10.1310/hpj4906-498.

The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), discuss methods of prevention, and promote reporting of ADRs to the US Food and Drug Administration's (FDA's) MedWatch program (800-FDA-1088). If you have reported...

Induction of Tet3-dependent Epigenetic Remodeling by Low-dose Hydralazine Attenuates Progression of Chronic Kidney Disease.

EBioMedicine

Tampe B, Tampe D, Zeisberg EM, Müller GA, Bechtel-Walz W, Koziolek M, Kalluri R, Zeisberg M.
PMID: 25717475
EBioMedicine. 2015 Jan;2(1):19-36. doi: 10.1016/j.ebiom.2014.11.005.

Progression of chronic kidney disease remains a principal problem in clinical nephrology and there is a pressing need for novel therapeutics and biomarkers. Aberrant promoter CpG island methylation and subsequent transcriptional silencing of specific genes have emerged as contributors...

Left Ventricular Hypertrophy.

Current treatment options in cardiovascular medicine

Liebson PR.
PMID: 11096487
Curr Treat Options Cardiovasc Med. 1999 Oct;1(3):219-230. doi: 10.1007/s11936-999-0038-0.

The presence of left ventricular hypertrophy (LVH) as a treatable entity is of particular importance in patients with primary hypertension. Because LVH is associated with a strong risk of adverse clinical events (eg, heart failure, ischemic events, and cardiovascular...

Hydrochlorothiazide Increases Efferent Glomerular Arteriolar Resistance in Spontaneously Hypertensive Rats.

Journal of cardiovascular pharmacology and therapeutics

Komatsu K, Numabe A, Ono Y, Frohlich ED.
PMID: 10684400
J Cardiovasc Pharmacol Ther. 1996 Jan;1(1):57-64. doi: 10.1177/107424849600100109.

BACKGROUND: Micropuncture studies were performed to determine the intrarenal hemodynamic effects of two conventional antihypertensive agents, hydrochlorothiazide (HCTZ) and hydralazine (HYDR) alone and in combination. METHODS AND RESULTS: Male spontaneously hypertensive and normotensive Wistar Kyoto rats (19 weeks old)...

Treatment of Older Patients With CHF Associated With Normal LVEF.

The American journal of geriatric cardiology

Aronow WS.
PMID: 11416478
Am J Geriatr Cardiol. 1998 Nov;7(6):27-31.

CHF with a normal LVEF should be treated with a low salt diet, cautious use of loop diuretics, and à -blockers. If CHF persists despite the use of diuretics and à -blockers, ACE inhibitors should be administered. If the...

Hypertension in the critically ill patient.

Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

Santhi R, Worthley LI.
PMID: 16573454
Crit Care Resusc. 2003 Mar;5(1):24-42.

OBJECTIVE: To review the management of persistent hypertension and hypertensive crisis in the critically ill patient.DATA SOURCES: A review of articles reported on hypertension and the critically ill patient.SUMMARY OF REVIEW: Hypertension is defined as a basal systolic blood...

The use of 2,3-dichloro-5,6-dicyano-p-benzoquinone for the spectrophotometric determination of some cardiovascular drugs.

Talanta

Issa AS, Mahrous MS, Salam MA, Soliman N.
PMID: 18964385
Talanta. 1987 Jul;34(7):670-2. doi: 10.1016/0039-9140(87)80087-5.

Some basic cardiovascular drugs containing secondary or tertiary amino groups are determined spectrophotometrically. The method is simple and sensitive; it is based on the interaction of the drugs, as n-electron donors, with 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) as a pi-acceptor. The highly...

Showing 1 to 12 of 199 entries