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Critical importance of appropriate fixation conditions for faithful imaging of receptor microclusters.

Biology open

Stanly TA, Fritzsche M, Banerji S, García E, Bernardino de la Serna J, Jackson DG, Eggeling C.
PMID: 27464671
Biol Open. 2016 Sep 15;5(9):1343-50. doi: 10.1242/bio.019943.

Receptor clustering is known to trigger signalling events that contribute to critical changes in cellular functions. Faithful imaging of such clusters by means of fluorescence microscopy relies on the application of adequate cell fixation methods prior to immunolabelling in...

Hyaluronan-CD44 Interactions in Cancer: Paradoxes and Possibilities.

Clinical cancer research : an official journal of the American Association for Cancer Research

Toole BP.
PMID: 20008845
Clin Cancer Res. 2009 Dec 15;15(24):7462-7468. doi: 10.1158/1078-0432.CCR-09-0479.

Hyaluronan is a prominent component of the micro-environment in most malignant tumors and can be prognostic for tumor progression. Extensive experimental evidence in animal models implicates hyaluronan interactions in tumor growth and metastasis, but it is also evident that...

Differential synthesis and binding of hyaluronan by human breast cancer cell lines.

Oncology reports

Heldin P, Delatorre M, Ytterberg D, Bergh J.
PMID: 21594498
Oncol Rep. 1996 Nov;3(6):1011-6. doi: 10.3892/or.3.6.1011.

In the present study we investigated a panel of human breast cancer cell lines which were sensitive or resistant to the cytotoxic drug doxorubicin, for their abilities to synthesize and bind hyaluronan. We found that MDA-231 and HS-578T cells...

Showing 1 to 3 of 3 entries