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Sympathetic stimulation-evoked overflow of norepinephrine and neuropeptide Y from the heart.

Circulation research

Warner MR, Senanayake PD, Ferrario CM, Levy MN.
PMID: 1776971
Circ Res. 1991 Aug;69(2):455-65. doi: 10.1161/01.res.69.2.455.

Neuropeptide Y (NPY) and norepinephrine are released together on sympathetic activation. To compare the time courses of NPY and norepinephrine washout from cardiac tissues, we measured the overflow of NPY-like immunoreactivity (NPY-LI) and norepinephrine in coronary sinus blood before,...

Sinus and atrioventricular nodal distribution of sympathetic fibers that contain neuropeptide Y.

Circulation research

Warner MR, Levy MN.
PMID: 2397577
Circ Res. 1990 Sep;67(3):713-21. doi: 10.1161/01.res.67.3.713.

Neuropeptide Y and norepinephrine are localized in sympathetic nerve terminals throughout the heart. We sought to determine the functional distribution of the neuropeptide Y-containing sympathetic fibers to the sinus and atrioventricular (AV) nodal regions. We recorded cycle length, AV...

Inhibition of cardiac vagal effects by neurally released and exogenous neuropeptide Y.

Circulation research

Warner MR, Levy MN.
PMID: 2582589
Circ Res. 1989 Dec;65(6):1536-46. doi: 10.1161/01.res.65.6.1536.

Neuropeptide Y (NPY) attenuates vagal effects on cardiac cycle length, presumably by inhibiting the release of acetylcholine from vagal nerve endings. We sought to determine if NPY inhibited the vagal effects on atrioventricular (AV) interval and atrial contraction in...

Circulating neuropeptide Y in dog plasma consists of multiple peptide fragments.


deS Senanayake P, Warner MR, Brosnihan KB, Levy MN, Ferrario CM.
PMID: 1283629
Peptides. 1992 Nov-Dec;13(6):1165-73. doi: 10.1016/0196-9781(92)90024-w.

Neuropeptide Y-like immunoreactivity (NPY-LI) in dog plasma was characterized and quantified using three extraction methods (Sep-Pak:acetonitrile, HCl:ethanol, and ethanol). Sep-Pak extraction yields the best recovery and preserves the integrity of the peptide. Oxidized NPY is not generated during blood...

Mechanisms of denervation supersensitivity in regionally denervated canine hearts.

The American journal of physiology

Warner MR, Wisler PL, Hodges TD, Watanabe AM, Zipes DP.
PMID: 8384424
Am J Physiol. 1993 Mar;264(3):H815-20. doi: 10.1152/ajpheart.1993.264.3.H815.

Mechanisms responsible for "denervation supersensitivity" in regionally denervated canine hearts were examined by measuring beta-adrenergic receptor density and affinity and the density of the alpha-subunit of the stimulatory G protein (Gs alpha). Sympathetic denervation was produced by applying an...

Sympathetic stimulation and norepinephrine infusion modulate extracellular potassium concentration during acute myocardial ischemia.

Circulation research

Warner MR, Kroeker TS, Zipes DP.
PMID: 1394871
Circ Res. 1992 Nov;71(5):1078-87. doi: 10.1161/01.res.71.5.1078.

The purpose of this study was to investigate whether sympathetic stimulation modulated the rise in extracellular K+ concentration ([K+]o) evoked by acute myocardial ischemia. In 35 alpha-chloralose-anesthetized dogs, we measured changes in [K+]o during acute myocardial ischemia in the...

Showing 1 to 6 of 6 entries