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The underestimated N-glycomes of lepidopteran species.

Biochimica et biophysica acta. General subjects

Stanton R, Hykollari A, Eckmair B, Malzl D, Dragosits M, Palmberger D, Wang P, Wilson IB, Paschinger K.
PMID: 28077298
Biochim Biophys Acta Gen Subj. 2017 Apr;1861(4):699-714. doi: 10.1016/j.bbagen.2017.01.009. Epub 2017 Jan 08.

BACKGROUND: Insects are significant to the environment, agriculture, health and biotechnology. Many of these aspects display some relationship to glycosylation, e.g., in case of pathogen binding or production of humanised antibodies; for a long time, it has been considered...

Hyaluronan synthase 1 (HAS1) produces a cytokine-and glucose-inducible, CD44-dependent cell surface coat.

Experimental cell research

Siiskonen H, Kärnä R, Hyttinen JM, Tammi RH, Tammi MI, Rilla K.
PMID: 24099991
Exp Cell Res. 2014 Jan 01;320(1):153-63. doi: 10.1016/j.yexcr.2013.09.021. Epub 2013 Oct 04.

Hyaluronan is a ubiquitous glycosaminoglycan involved in embryonic development, inflammation and cancer. In mammals, three hyaluronan synthase isoenzymes (HAS1-3) inserted in the plasma membrane produce hyaluronan directly on cell surface. The mRNA level and enzymatic activity of HAS1 are...

Synthetic Studies on the Incorporation of .

Molecules (Basel, Switzerland)

Cristófalo AE, Uhrig ML.
PMID: 33401465
Molecules. 2021 Jan 01;26(1). doi: 10.3390/molecules26010180.

Two approaches for the synthesis of the thiodisaccharide β-S-GlcA(1→3)β-S-AllNAc are described here. The target disaccharide was a C-3 epimer and thio-analogue of the hyaluronic acid repetitive unit, tuned with a thiopropargyl anomeric group for further click conjugation. Thus, we...

Improving the thrombin inhibitory activity of glycyrrhizin, a triterpenic saponin, through a molecular simplification of the carbohydrate moiety.

Chemical biology & drug design

de Paula FT, Frauches PQ, Pedebos C, Berger M, Gnoatto SC, Gossmann G, Verli H, Guimarães JA, Graebin CS.
PMID: 23964664
Chem Biol Drug Des. 2013 Dec;82(6):756-60. doi: 10.1111/cbdd.12204. Epub 2013 Oct 25.

Glycyrrhizin, a saponin, and its aglycone glycyrrhetinic acid are natural products found in the Liquorice (Glycyrrhiza glabra L.) root extract. This saponin is known for its in vitro and in vivo thrombin inhibitory activity. The design and synthesis of...

Biosynthesis of the carbohydrate moieties of arabinogalactan proteins by membrane-bound β-glucuronosyltransferases from radish primary roots.


Endo M, Kotake T, Watanabe Y, Kimura K, Tsumuraya Y.
PMID: 24057431
Planta. 2013 Dec;238(6):1157-69. doi: 10.1007/s00425-013-1959-0. Epub 2013 Sep 22.

A membrane fraction from etiolated 6-day-old primary radish roots (Raphanus sativus L. var hortensis) contained β-glucuronosyltransferases (GlcATs) involved in the synthesis of the carbohydrate moieties of arabinogalactan proteins (AGPs). The GlcATs transferred [(14)C]GlcA from UDP-[(14)C]GlcA on to β-(1 →...

Structure and anticoagulant activity of fucosylated glycosaminoglycan degraded by deaminative cleavage.

Carbohydrate polymers

Zhao L, Lai S, Huang R, Wu M, Gao N, Xu L, Qin H, Peng W, Zhao J.
PMID: 24053834
Carbohydr Polym. 2013 Nov 06;98(2):1514-23. doi: 10.1016/j.carbpol.2013.07.063. Epub 2013 Aug 06.

Fucosylated glycosaminoglycans (FGs) are complex glycosaminoglycans that exhibit potent anticoagulant activity. To study the relationship between molecular size and biological activity, oligosaccharides with (2,5)-anhydro-D-talose units at new reducing ends were prepared by hydrazine deacetylation and nitrous acid depolymerization. The...

Cooperation of binding sites at the hydrophilic domain of cell-surface sulfatase Sulf1 allows for dynamic interaction of the enzyme with its substrate heparan sulfate.

Biochimica et biophysica acta

Milz F, Harder A, Neuhaus P, Breitkreuz-Korff O, Walhorn V, Lübke T, Anselmetti D, Dierks T.
PMID: 23891937
Biochim Biophys Acta. 2013 Nov;1830(11):5287-98. doi: 10.1016/j.bbagen.2013.07.014. Epub 2013 Jul 25.

BACKGROUND: Sulf1 is a cell-surface sulfatase removing internal 6-O-sulfate groups from heparan sulfate (HS) chains. Thereby it modulates the activity of HS-dependent growth factors. For HS interaction Sulf1 employs a unique hydrophilic domain (HD).METHODS: Affinity-chromatography, AFM-single-molecule force spectroscopy (SMFS)...

Role of glucuronidated 25-hydroxyvitamin D on colon gene expression in mice.

American journal of physiology. Gastrointestinal and liver physiology

Reynolds CJ, Koszewski NJ, Horst RL, Beitz DC, Goff JP.
PMID: 32628073
Am J Physiol Gastrointest Liver Physiol. 2020 Aug 01;319(2):G253-G260. doi: 10.1152/ajpgi.00355.2019. Epub 2020 Jul 06.

25-Hydroxyvitamin D

SAR11 lipid renovation in response to phosphate starvation.

Proceedings of the National Academy of Sciences of the United States of America

Carini P, Van Mooy BA, Thrash JC, White A, Zhao Y, Campbell EO, Fredricks HF, Giovannoni SJ.
PMID: 26056292
Proc Natl Acad Sci U S A. 2015 Jun 23;112(25):7767-72. doi: 10.1073/pnas.1505034112. Epub 2015 Jun 08.

Phytoplankton inhabiting oligotrophic ocean gyres actively reduce their phosphorus demand by replacing polar membrane phospholipids with those lacking phosphorus. Although the synthesis of nonphosphorus lipids is well documented in some heterotrophic bacterial lineages, phosphorus-free lipid synthesis in oligotrophic marine...

Polysaccharides with immunomodulating properties from the bark of Parkia biglobosa.

Carbohydrate polymers

Zou YF, Zhang BZ, Inngjerdingen KT, Barsett H, Diallo D, Michaelsen TE, El-Zoubair E, Paulsen BS.
PMID: 24299798
Carbohydr Polym. 2014 Jan 30;101:457-63. doi: 10.1016/j.carbpol.2013.09.082. Epub 2013 Sep 30.

The bark of Parkia biglobosa is used in traditional medicine to cure a wide range of illnesses. Polysaccharides were extracted from the bark with 50% ethanol-water, 50°C and 100°C water, and seven active fractions obtained by anion exchange chromatography...

A novel acetyl xylan esterase enabling complete deacetylation of substituted xylans.

Biotechnology for biofuels

Razeq FM, Jurak E, Stogios PJ, Yan R, Tenkanen M, Kabel MA, Wang W, Master ER.
PMID: 29588659
Biotechnol Biofuels. 2018 Mar 22;11:74. doi: 10.1186/s13068-018-1074-3. eCollection 2018.

BACKGROUND: Acetylated 4-RESULTS: An unclassified carbohydrate esterase (FjoAcXE) was identified as a protein of unknown function from a polysaccharide utilization locus (PUL) otherwise comprising carbohydrate-active enzyme families known to target xylan. FjoAcXE was shown to efficiently release acetyl groups...

A comparison of bioactive aqueous extracts and polysaccharide fractions from roots of wild and cultivated Cochlospermum tinctorium A. Rich.


Tvete Inngjerdingen K, Ballo N, Zhang BZ, Malterud KE, Michaelsen TE, Diallo D, Paulsen BS.
PMID: 23582214
Phytochemistry. 2013 Sep;93:136-43. doi: 10.1016/j.phytochem.2013.03.012. Epub 2013 Apr 09.

In Malian traditional medicine the roots of Cochlospermum tinctorium are used in the treatment of gastric ulcer, but extending harvesting is causing a growing concern of a dramatic reduction in the wild plant population. In the present study cultivation...

Showing 1 to 12 of 12575 entries