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Showing 1 to 12 of 3919 entries
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Protective effect of Korean Red Ginseng against glucocorticoid-induced osteoporosis in vitro and in vivo.

Journal of ginseng research

Kim J, Lee H, Kang KS, Chun KH, Hwang GS.
PMID: 25535476
J Ginseng Res. 2015 Jan;39(1):46-53. doi: 10.1016/j.jgr.2014.06.001. Epub 2014 Jul 09.

BACKGROUND: Glucocorticoids (GCs) are commonly used in many chemotherapeutic protocols and play an important role in the normal regulation of bone remodeling. However, the prolonged use of GCs results in osteoporosis, which is partially due to apoptosis of osteoblasts...

Complete resistance after maximal dose of rocuronium.

Journal of pharmacology & pharmacotherapeutics

Capuano A, Sullo MG, Rafaniello C, Sportiello L, Fusco P, De Vizia M, Ferraro F.
PMID: 26312006
J Pharmacol Pharmacother. 2015 Jul-Sep;6(3):175-8. doi: 10.4103/0976-500X.162012.

Rocuronium is a non-depolarizing neuromuscular blocking agent (NDNMBA), employed in the clinic as an adjunct to general anesthesia to facilitate tracheal intubation rapid sequence, and to provide skeletal muscle relaxation during surgery. Many cases of resistance to neuromuscular blocking...

Divergent transcriptional activation by glucocorticoids in mouse and human macrophages.

Lancet (London, England)

Jubb A, Young R, Bickmore W, Hume D.
PMID: 26312876
Lancet. 2015 Feb 26;385:S54. doi: 10.1016/S0140-6736(15)60369-5.

BACKGROUND: Innate immune cells are major targets of glucocorticoids as anti-inflammatory therapies. Glucocorticoids are metabolic hormones that provide natural feedback regulation of immune function. They are widely prescribed, but use is restricted by side-effects. Much of our knowledge about...

Comparison of Pioglitazone and Metformin Efficacy against Glucocorticoid Induced Atherosclerosis and Hepatic Steatosis in Insulin Resistant Rats.

Journal of clinical and diagnostic research : JCDR

Nayak IMN, Narendar K, M PA, Jamadar MG, Kumar VH.
PMID: 28892924
J Clin Diagn Res. 2017 Jul;11(7):FC06-FC10. doi: 10.7860/JCDR/2017/28418.10193. Epub 2017 Jul 01.

INTRODUCTION: Insulin Resistance is a major cause of Atherosclerosis (AS) and Non Alcoholic Fatty Liver Disease (NAFLD). These lipid alterations in blood vessels and liver may progress to cardiovascular abnormalities and cirrhosis respectively. Drugs like pioglitazone (PIO) and metformin...

Major osteoporotic fragility fractures: Risk factor updates and societal impact.

World journal of orthopedics

Pisani P, Renna MD, Conversano F, Casciaro E, Di Paola M, Quarta E, Muratore M, Casciaro S.
PMID: 27004165
World J Orthop. 2016 Mar 18;7(3):171-81. doi: 10.5312/wjo.v7.i3.171. eCollection 2016 Mar 18.

Osteoporosis is a silent disease without any evidence of disease until a fracture occurs. Approximately 200 million people in the world are affected by osteoporosis and 8.9 million fractures occur each year worldwide. Fractures of the hip are a...

Pyoderma gangrenosum in an abdominal surgical site: a case report.

Surgical case reports

Ogata K, Takamori H, Ikuta Y, Tanaka H, Ozaki N, Hayashi H, Ogawa K, Doi K.
PMID: 26943446
Surg Case Rep. 2015 Dec;1(1):122. doi: 10.1186/s40792-015-0124-3. Epub 2015 Dec 09.

Pyoderma gangrenosum (PG) is an uncommon, ulcerative skin disease that is often associated with systemic diseases. Herein, we report a development of PG in a surgical site after cholecystectomy that was difficult to discriminate from surgical site infection. The...

Vanadate Impedes Adipogenesis in Mesenchymal Stem Cells Derived from Different Depots within Bone.

Frontiers in endocrinology

Jacobs FA, Sadie-Van Gijsen H, van de Vyver M, Ferris WF.
PMID: 27536268
Front Endocrinol (Lausanne). 2016 Aug 03;7:108. doi: 10.3389/fendo.2016.00108. eCollection 2016.

Glucocorticoid-induced osteoporosis (GIO) is associated with an increase in bone marrow adiposity, which skews the differentiation of mesenchymal stem cell (MSC) progenitors away from osteoblastogenesis and toward adipogenesis. We have previously found that vanadate, a non-specific protein tyrosine phosphatase...

Prematurity and programming: contribution of neonatal Intensive Care Unit interventions.

Journal of developmental origins of health and disease

Kalhan SC, Wilson-Costello D.
PMID: 25054678
J Dev Orig Health Dis. 2013 Apr;4(2):121-33. doi: 10.1017/S204017441200061X.

Contemporary clinical practice for the care of the prematurely born babies has markedly improved their rates of survival so that most of these babies are expected to grow up to live a healthy functional life. Since the clinical follow-up...

Chronic Inflammatory Demyelinating Polyneuropathy Following Anti-TNF-α Therapy With Infliximab for Crohn's Disease.

ACG case reports journal

Kamel AY, Concepcion O, Schlachterman A, Glover S, Forsmark CY.
PMID: 27144200
ACG Case Rep J. 2016 Apr 15;3(3):187-9. doi: 10.14309/crj.2016.45. eCollection 2016 Apr.

We present a 29-year-old male with Crohn's disease who developed chronic inflammatory demyelinating polyneuropathy (CIDP) related to infliximab therapy. He developed lower extremity weakness and dysesthesia 3 weeks after a fourth infliximab dose. Laboratory examination revealed an elevated cerebrospinal...

Parachute Jumping Induces More Sympathetic Activation Than Cortisol Secretion in First-Time Parachutists.

Asian journal of sports medicine

Messina G, Chieffi S, Viggiano A, Tafuri D, Cibelli G, Valenzano A, Triggiani AI, Messina A, De Luca V, Monda M.
PMID: 27217924
Asian J Sports Med. 2016 Mar 08;7(1):e26841. doi: 10.5812/asjsm.26841. eCollection 2016 Mar.

BACKGROUND: The word "stress" describes the status of the body affected by external or internal forces, or "stressors", threatening to alter its dynamic balance or homeostasis. The adaptive changes which occur in reply to stressors are either behavioral or...

Oral Calcidiol Is More Effective Than Cholecalciferol Supplementation to Reach Adequate 25(OH)D Levels in Patients with Autoimmune Diseases Chronically Treated with Low Doses of Glucocorticoids: A "Real-Life" Study.

Journal of osteoporosis

Ortego-Jurado M, Callejas-Rubio JL, Ríos-Fernández R, González-Moreno J, González Ramírez AR, González-Gay MA, Ortego-Centeno N.
PMID: 26124976
J Osteoporos. 2015;2015:729451. doi: 10.1155/2015/729451. Epub 2015 Jun 01.

Glucocorticoids (GCs) are the cornerstone of the therapy in many autoimmune and inflammatory diseases. However, it is well known that their use is a double edged sword, as their beneficial effects are associated almost universally with unwanted effects, as,...

Cushing's Syndrome Secondary to Adulterated Complementary and Alternative Medicine.

Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia

Sazlina S, Zaiton A.
PMID: 25606172
Malays Fam Physician. 2009 Aug 31;4(2):94-7. eCollection 2009.

This is a case of a 65 year old lady who presented with Cushing's syndrome secondary to ingestion of a complementary and alternative medicine that has been adulterated with exogenous glucocorticoids. In a clinical consultation, it is important to...

Showing 1 to 12 of 3919 entries