Advanced Search
Display options
Filter resources
Text Availability
Article type
Publication date
Species
Language
Sex
Age
Showing 1 to 12 of 3591 entries
Sorted by: Best Match Show Resources per page
Comparative effectiveness of liraglutide in the treatment of type 2 diabetes.

Diabetes, metabolic syndrome and obesity : targets and therapy

Rigato M, Fadini GP.
PMID: 24672252
Diabetes Metab Syndr Obes. 2014 Mar 18;7:107-20. doi: 10.2147/DMSO.S37644. eCollection 2014.

Type 2 diabetes is characterized by a progressive decline in beta cell function, with consequent worsening of glycemic control. The ideal antihyperglycemic treatment should achieve good and sustained glycemic control, with a low risk of hypoglycemia and no weight...

Multiple Factors Related to the Secretion of Glucagon-Like Peptide-1.

International journal of endocrinology

Wang X, Liu H, Chen J, Li Y, Qu S.
PMID: 26366173
Int J Endocrinol. 2015;2015:651757. doi: 10.1155/2015/651757. Epub 2015 Aug 20.

The glucagon-like peptide-1 is secreted by intestinal L cells in response to nutrient ingestion. It regulates the secretion and sensitivity of insulin while suppressing glucagon secretion and decreasing postprandial glucose levels. It also improves beta-cell proliferation and prevents beta-cell...

Recurrent Sleep Fragmentation Induces Insulin and Neuroprotective Mechanisms in Middle-Aged Flies.

Frontiers in aging neuroscience

Williams MJ, Perland E, Eriksson MM, Carlsson J, Erlandsson D, Laan L, Mahebali T, Potter E, Frediksson R, Benedict C, Schiöth HB.
PMID: 27531979
Front Aging Neurosci. 2016 Aug 02;8:180. doi: 10.3389/fnagi.2016.00180. eCollection 2016.

Lack of quality sleep increases central nervous system oxidative stress and impairs removal of neurotoxic soluble metabolites from brain parenchyma. During aging poor sleep quality, caused by sleep fragmentation, increases central nervous system cellular stress. Currently, it is not...

Expression of GLP-1 receptor and CD26 in human thyroid C-cells: The association of thyroid C-cell tumorigenesis with incretin-based medicine.

Oncology letters

Song Y, Zhou M, Cao Y, Qi J, Geng J, Liu X.
PMID: 28454451
Oncol Lett. 2017 Apr;13(4):2684-2690. doi: 10.3892/ol.2017.5752. Epub 2017 Feb 20.

Recent reports have demonstrated that long-term and high dosage treatments with incretin-based medicine, such as hormone glucagon-like peptide-1 (GLP-1) may induce thyroid C-cell pathological changes in rodents, rather than in humans. Doubts regarding the tumorigenic potential of GLP-1 analogues...

Dipeptidyl peptidase-4 levels are increased and partially related to body fat distribution in patients with familial partial lipodystrophy type 2.

Diabetology & metabolic syndrome

Valerio CM, de Almeida JS, Moreira RO, Aguiar LBS, Siciliano PO, Carvalho DP, Godoy-Matos AF.
PMID: 28450900
Diabetol Metab Syndr. 2017 Apr 24;9:26. doi: 10.1186/s13098-017-0226-0. eCollection 2017.

BACKGROUND: Dipeptidyl peptidase-4 (DDP4) is an enzyme responsible for glucagon-like peptide-1 inactivation and plays an important role in glucose metabolism.OBJECTIVE: The aim of this study was to evaluate DPP4 levels in patients with familial partial lipodystrophy type 2 (FPLD2)...

WITHDRAWN: Glucagon-like Peptide-1 Receptor Agonists: A Class Update for Treating Type 2 Diabetes.

Canadian journal of diabetes

Lovshin JA.
PMID: 28392300
Can J Diabetes. 2017 Apr 05; doi: 10.1016/j.jcjd.2017.02.003. Epub 2017 Apr 05.

The Publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/10.1016/j.jcjd.2017.02.003. The duplicate article has therefore been withdrawn. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal.

Weekly glucagon-like peptide-1 receptor agonist albiglutide as monotherapy improves glycemic parameters in Japanese patients with type 2 diabetes mellitus: A randomized, double-blind, placebo-controlled study.

Journal of diabetes investigation

Nino A, Okuda I, Wilson TH, Yue L, Nakajima H, Tsuboi M, Carr MC, Seino Y.
PMID: 28921915
J Diabetes Investig. 2017 Sep 16; doi: 10.1111/jdi.12749. Epub 2017 Sep 16.

AIMS/INTRODUCTION: The present phase 3, randomized, double-blind 24-week study with extension to 1 year assessed the efficacy and safety of albiglutide compared with placebo in Japanese patients with type 2 diabetes mellitus inadequately controlled by diet and exercise with...

The Effect of Tofogliflozin Treatment on Postprandial Glucose and Lipid Metabolism in Japanese Men With Type 2 Diabetes: A Pilot Study.

Journal of clinical medicine research

Kakuda H, Kobayashi J, Sakurai M, Kakuda M, Takekoshi N.
PMID: 28392860
J Clin Med Res. 2017 May;9(5):403-409. doi: 10.14740/jocmr2806w. Epub 2017 Apr 01.

BACKGROUND: Postprandial hyperglycemia and hyperlipidemia are highly related to the development of atherosclerosis. Sodium/glucose cotransporter-2 (SGLT2) inhibitors have attracted attention as a new class of anti-diabetic agents for the treatment of type 2 diabetes. We investigated the effect of...

Liraglutide for weight management: a critical review of the evidence.

Obesity science & practice

Mehta A, Marso SP, Neeland IJ.
PMID: 28392927
Obes Sci Pract. 2017 Mar;3(1):3-14. doi: 10.1002/osp4.84. Epub 2016 Dec 19.

OBJECTIVE: To review the efficacy, safety, and clinical applicability of liraglutide for weight management from phase III clinical trials.METHODS: A search of the English language literature was performed using PubMed search terms: "liraglutide", "glucagon-like peptide-1 receptor agonist", and "randomized...

Experience from Development of Once-Weekly Glucagon-Like Peptide-1 Receptor Agonist (GLP-1 RA) Dulaglutide for Treatment of Type 2 Diabetes Mellitus.

Clinical therapeutics

Milicevic Z.
PMID: 27673601
Clin Ther. 2016 Oct 06;38(10):e1. doi: 10.1016/j.clinthera.2016.07.013.

No abstract available.

Survival and Function of Transplanted Islet Cells on an in Vivo, Vascularized Tissue Engineering Platform in the Rat: A Pilot Study 1.

Cell transplantation

Brown DL, Meagher PJ, Knight KR, Keramidaris E, Romeo-Meeuw R, Penington AJ, Morrison WA.
PMID: 28863745
Cell Transplant. 2006 Apr;15(4):319-324. doi: 10.3727/000000006783981909.

As in vivo tissue engineering of complex tissues and organs progresses, there is a need for an independently vascularized, alterable, and recoverable model. Current models of islet cell transplantation (release into the portal venous system, placement under the renal...

Metastatic VIPoma presenting as an ovarian mass.

International journal of surgery case reports

Mark J, Bush S, Glazer E, Strosberg J, Saglam O, Apte SM.
PMID: 26657531
Int J Surg Case Rep. 2015;17:167-9. doi: 10.1016/j.ijscr.2015.11.006. Epub 2015 Nov 23.

INTRODUCTION: Pancreatic VIPomas are exceedingly rare, with an annual incidence of less than 1 per million. Most VIPomas are metastatic at diagnosis, with the liver being the most common site of spread.PRESENTATION OF CASE: We describe a highly unusual...

Showing 1 to 12 of 3591 entries