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Showing 1 to 12 of 325 entries
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Molecular recognition of gangliosides and their potential for cancer immunotherapies.

Frontiers in immunology

Krengel U, Bousquet PA.
PMID: 25101077
Front Immunol. 2014 Jul 21;5:325. doi: 10.3389/fimmu.2014.00325. eCollection 2014.

Gangliosides are sialic-acid-containing glycosphingolipids expressed on all vertebrate cells. They are primarily positioned in the plasma membrane with the ceramide part anchored in the membrane and the glycan part exposed on the surface of the cell. These lipids have...

Preface: Studies on Understanding and Anti-Tumor Agents of Reproductive Cancer Cells.

Current pharmaceutical biotechnology

Kim CH.
PMID: 28884656
Curr Pharm Biotechnol. 2017;18(1):2-6. doi: 10.2174/138920101801170113222330.

No abstract available.

Guillain-Barré syndrome.

Expert review of neurotherapeutics

Wakerley BR, Yuki N.
PMID: 26154996
Expert Rev Neurother. 2015;15(8):847-9. doi: 10.1586/14737175.2015.1065732. Epub 2015 Jul 08.

Over the past three decades much has been elucidated about the pathogenesis and clinical manifestations of Guillain-Barré syndrome, the most common cause of acute flaccid paralysis worldwide. Cross-reactivity between surface epitopes on the bacterium Campylobacter jejuni and peripheral nerve...

APP Function and Lipids: A Bidirectional Link.

Frontiers in molecular neuroscience

Grimm MO, Mett J, Grimm HS, Hartmann T.
PMID: 28344547
Front Mol Neurosci. 2017 Mar 10;10:63. doi: 10.3389/fnmol.2017.00063. eCollection 2017.

Extracellular neuritic plaques, composed of aggregated amyloid-β (Aβ) peptides, are one of the major histopathological hallmarks of Alzheimer's disease (AD), a progressive, irreversible neurodegenerative disorder and the most common cause of dementia in the elderly. One of the most...

Sialic acid utilization by Cronobacter sakazakii.

Microbial informatics and experimentation

Joseph S, Hariri S, Masood N, Forsythe S.
PMID: 23706082
Microb Inform Exp. 2013 May 24;3(1):3. doi: 10.1186/2042-5783-3-3.

BACKGROUND: The Cronobacter genus is composed of seven species, and can cause infections in all age groups. Of particular concern is C. sakazakii, as this species is strongly associated with severe and often fatal cases of necrotizing enterocolitis and...

Ganglioside biochemistry.

ISRN biochemistry

Kolter T.
PMID: 25969757
ISRN Biochem. 2012 Dec 19;2012:506160. doi: 10.5402/2012/506160. eCollection 2012.

Gangliosides are sialic acid-containing glycosphingolipids. They occur especially on the cellular surfaces of neuronal cells, where they form a complex pattern, but are also found in many other cell types. The paper provides a general overview on their structures,...

Changes in ganglioside profile in chick embryo retina: Studies on tissue and cell cultures.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience

Landa CA, Moscona AA.
PMID: 24874496
Int J Dev Neurosci. 1985;3(1):77-88. doi: 10.1016/0736-5748(85)90022-X.

The developmental profile of gangliosides in the neural retina of the chick embryo is characterized by a progressive decrease in the concentration of GD3 complex from a high level on day 6; by a continuous increase in GD1a concentration;...

Guillain-Barré syndrome: pathogenesis, diagnosis, treatment and prognosis.

Nature reviews. Neurology

van den Berg B, Walgaard C, Drenthen J, Fokke C, Jacobs BC, van Doorn PA.
PMID: 25023340
Nat Rev Neurol. 2014 Aug;10(8):469-82. doi: 10.1038/nrneurol.2014.121. Epub 2014 Jul 15.

Guillain-Barré syndrome (GBS) is a potentially life-threatening postinfectious disease characterized by rapidly progressive, symmetrical weakness of the extremities. About 25% of patients develop respiratory insufficiency and many show signs of autonomic dysfunction. Diagnosis can usually be made on clinical...

The effect of exogenous gangliosides on neurons in culture: A morphometric analysis.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience

Massarelli R, Ferret B, Gorio A, Durand M, Dreyfus H.
PMID: 24874859
Int J Dev Neurosci. 1985;3(4):341-8. doi: 10.1016/0736-5748(85)90067-X.

Cultures of isolated neurons have been treated with a purified preparation of gangliosides (10(-5)M and 10(-9)M) added to the cell growth medium at the 3rd day in culture and a morphometric analysis of the cells was performed with an...

High-throughput imaging method for direct assessment of GM1 ganglioside levels in mammalian cells.

Data in brief

Acosta W, Martin R, Radin DN, Cramer CL.
PMID: 26958633
Data Brief. 2016 Feb 03;6:1016-22. doi: 10.1016/j.dib.2016.01.027. eCollection 2016 Mar.

GM1-gangliosidosis is an inherited autosomal recessive disorder caused by mutations in the gene GLB1, which encodes acid β-galactosidase (β-gal). The lack of activity in this lysosomal enzyme leads to accumulation of GM1 gangliosides (GM1) in cells. We have developed...

Increase of gangliosides in atherosclerotic human aortas.

Lipids

Breckenridge WC, Halloran JL, Kovacs K, Silver MD.
PMID: 27521075
Lipids. 1975 Apr;10(4):256-9. doi: 10.1007/BF02532490.

Preparations of human thoracic aortas containing intima and media were obtained post-mortem, and gangliosides were isolated by standard techniques. The quantity of ganglioside sialic acid, as assayed by gas liquid chromatography, was lowest in normal aortas (33±9 nmoles N-acetyl...

GM1 ganglioside administration protects spinal neurons after glutamate excitotoxicity.

Restorative neurology and neuroscience

Vorwerk CK, Bonheur J, Kreutz MR, Dreyer EB, Laev H.
PMID: 12671270
Restor Neurol Neurosci. 1999;14(1):47-51.

Injury of the nervous system initiates a cascade of signal transduction including a rise in extracellular glutamate which leads to subsequent secondary neuronal loss. Excitotoxicity is known to play a crucial role in cell death spinal cord trauma. Gangliosides,...

Showing 1 to 12 of 325 entries