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NTP Toxicology and Carcinogenesis Studies of Oxazepam (CAS No. 604-75-1) in F344/N Rats (Feed Studies).

National Toxicology Program technical report series

[No authors listed]
PMID: 12579205
Natl Toxicol Program Tech Rep Ser. 1998 Oct;468:1-189.

Oxazepam and related benzodiazepine drugs are used in the treatment of anxiety. All benzodiazepines currently in use share a number of effects, including sedation, hypnosis, decreased anxiety, muscle relaxation, amnesia, and anticonvulsant activity. Oxazepam and four other benzodiazepines (chlordiazepoxide,...

Therapy of unspecific tinnitus without organic cause.

GMS health technology assessment

Frank W, Konta B, Seiler G.
PMID: 21289968
GMS Health Technol Assess. 2006 Aug 30;2:Doc17.

INTRODUCTION: There is a variety of medical and non-medical therapies in practice, which were not evaluated regarding its effectiveness by any systematic evidence oriented investigation. A number of therapies of medical and non-medical type try to treat the different...

Levels of Rat Brain mRna Encoding the Beta 1,2,3 and Gamma 2 Subunits of the Gaba-a Receptor Are Unchanged By Flurazepam Treatment: O'Donovan MC, Buckland PR and McGuffin P Dept. of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, CF4 4XN.

Journal of psychopharmacology (Oxford, England)

[No authors listed]
PMID: 22291310
J Psychopharmacol. 1992 Jan;6(1):129. doi: 10.1177/026988119200600182.

No abstract available.

Muscle relaxants for pain management in rheumatoid arthritis.

The Cochrane database of systematic reviews

Richards BL, Whittle SL, Buchbinder R.
PMID: 22258993
Cochrane Database Syst Rev. 2012 Jan 18;1:CD008922. doi: 10.1002/14651858.CD008922.pub2.

BACKGROUND: Pain management is a high priority for patients with rheumatoid arthritis (RA). Muscle relaxants include drugs that reduce muscle spasm (for example benzodiazepines such as diazepam (Valium), alprazolam (Xanax), lorazepam (Ativan) and non-benzodiazepines such as metaxalone (Skelaxin) or...

Effects of benzodiazepines, antidepressants and opioids on driving: a systematic review and meta-analysis of epidemiological and experimental evidence.

Drug safety

Dassanayake T, Michie P, Carter G, Jones A.
PMID: 21247221
Drug Saf. 2011 Feb 01;34(2):125-56. doi: 10.2165/11539050-000000000-00000.

BACKGROUND: Many individuals in the community are prescribed psychoactive drugs with sedative effects. These drugs may affect their daily functions, of which automobile driving is a major component.OBJECTIVE: To examine the association of three classes of commonly used psychoactive...

Role of giant depolarizing potentials in shaping synaptic currents in the developing hippocampus.

Critical reviews in neurobiology

Mohajerani MH, Cherubini E.
PMID: 17725505
Crit Rev Neurobiol. 2006;18(1):13-23. doi: 10.1615/critrevneurobiol.v18.i1-2.30.

Early in development, network activity in the hippocampus is characterized by giant depolarizing potentials (GDPs). These potentials consist of recurrent membrane depolarizations with superimposed fast action potentials separated by quiescent intervals. They are generated by the interplay of glutamate...

Pharmacological properties of GABAA receptors containing gamma1 subunits.

Molecular pharmacology

Khom S, Baburin I, Timin EN, Hohaus A, Sieghart W, Hering S.
PMID: 16272224
Mol Pharmacol. 2006 Feb;69(2):640-9. doi: 10.1124/mol.105.017236. Epub 2005 Nov 04.

GABA(A) receptors composed of alpha(1), beta(2), gamma(1) subunits are expressed in only a few areas of the brain and thus represent interesting drug targets. The pharmacological properties of this receptor subtype, however, are largely unknown. In the present study,...

Review of Safety and Efficacy of Sleep Medicines in Older Adults.

Clinical therapeutics

Schroeck JL, Ford J, Conway EL, Kurtzhalts KE, Gee ME, Vollmer KA, Mergenhagen KA.
PMID: 27751669
Clin Ther. 2016 Nov;38(11):2340-2372. doi: 10.1016/j.clinthera.2016.09.010. Epub 2016 Oct 15.

PURPOSE: Insomnia is problematic for older adults. After behavioral modifications fail to show adequate response, pharmacologic options are used. The pharmacokinetics of agents used to treat insomnia may be altered. This review focuses on the safety and efficacy of...

Benzodiazepines and synaptic processing in the spatial domain within the cat's primary somatosensory cortex.

Canadian journal of physiology and pharmacology

Oka JI, Hicks TP.
PMID: 1975221
Can J Physiol Pharmacol. 1990 Aug;68(8):1025-40. doi: 10.1139/y90-156.

In the primary somatosensory cortex of cats, the size of the receptive fields (RFs) of cutaneously responsive neurones is under the control of gamma-aminobutyric acid (GABA) mediated inhibition when the cells are situated in rapidly adapting (RA) background regions....

Benzodiazepines inhibit thyrotropin (TSH)-releasing hormone-induced TSH and growth hormone release from perifused rat pituitaries.


Roussel JP, Astier H, Tapia-Arancibia L.
PMID: 3023014
Endocrinology. 1986 Dec;119(6):2519-26. doi: 10.1210/endo-119-6-2519.

The perifusion technique was used to investigate the action of diazepam (DZ), a benzodiazepine molecule known to compete for TRH receptor binding in rat pituitary, on TRH-induced TSH and GH release. The release kinetics for the two hormones from...

Site-specific enhancement of gamma-aminobutyric acid-mediated inhibition of neural activity by ethanol in the rat medial septal area.

The Journal of pharmacology and experimental therapeutics

Givens BS, Breese GR.
PMID: 2166794
J Pharmacol Exp Ther. 1990 Aug;254(2):528-38.
Free PMC Article

Because of uncertainty concerning the interaction of ethanol with gamma-aminobutyric acid (GABA) receptor-mediated events, the present work was designed to investigate the effect of ethanol on GABA transmission in the rat septal area using behavioral and electrophysiological techniques. Microinjection...

Positive allosteric activation of GABAA receptors bi-directionally modulates hippocampal glutamate plasticity and behaviour.

Biochemical Society transactions

Shen G, Mohamed MS, Das P, Tietz EI.
PMID: 19909283
Biochem Soc Trans. 2009 Dec;37:1394-8. doi: 10.1042/BST0371394.

Long-term BZ (benzodiazepine) anxiolytic therapy increases the risk of physical dependence manifested as withdrawal anxiety. BZ-induced potentiation of GABA(A)R (gamma-aminobutyric acid type-A receptor) function by 1-week oral administration of FZP (flurazepam) bi-directionally modulates excitatory glutamatergic synaptic transmission in hippocampal...

Showing 1 to 12 of 1140 entries