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Impact of Erg11 amino acid substitutions identified in Candida auris clade III isolates on triazole drug susceptibility

Louis Stokes Alliances for Minority Participation AND Program Evaluation

[No authors listed]
GSID: s-S0QL5sMacJ
B Williamson, A Wilk, KD Guerrero… - Antimicrobial agents …, 2022 - Am Soc Microbiol

ABSTRACT ERG11 sequencing of 28 Candida auris clade III isolates revealed the presence of concomitant V125A and F126L substitutions. Heterologous expression of Erg11-V125A/F126L in Saccharomyces cerevisiae led to reduced fluconazole and voriconazole susceptibilities. Generation of single substitution gene variants...

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Williamson, B., Wilk, A., Guerrero, K. D., Mikulski, T. D., Elias, T. N., Sawh, I., ... & Healey, K. R. (2022). Impact of Erg11 amino acid substitutions identified in Candida auris clade III isolates on triazole drug susceptibility. Antimicrobial agents and chemotherapy, 66(1), e01624-21.
Williamson, Benjamin, et al. "Impact of Erg11 amino acid substitutions identified in Candida auris clade III isolates on triazole drug susceptibility." Antimicrobial agents and chemotherapy 66.1 (2022): e01624-21.
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Antemortem Diagnosis and Successful Treatment of Pulmonary Candidiasis in a Sun Conure (Aratinga solstitialis).

Journal of avian medicine and surgery

Proença LM, Mayer J, Schnellbacher R, Sanchez S, Huang CT, Brown H, Jiménez D, Stelmach D, Divers SJ.
PMID: 25843470
J Avian Med Surg. 2014 Dec;28(4):316-21. doi: 10.1647/2013-073.

An adult male sun conure (Aratinga solstitialis) was evaluated because of lethargy, ruffled feathers, and decreased appetite. Physical examination revealed hypothermia, dehydration, dyspnea, and crop distention. Results of a complete blood cell count revealed a marked inflammatory leukogram, and...

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Proença LM, Mayer J, Schnellbacher R, et al. Antemortem Diagnosis and Successful Treatment of Pulmonary Candidiasis in a Sun Conure (Aratinga solstitialis). J Avian Med Surg. 2014;28(4):316-21doi: 10.1647/2013-073.
Proença, L. M., Mayer, J., Schnellbacher, R., Sanchez, S., Huang, C. T., Brown, H., Jiménez, D., Stelmach, D., & Divers, S. J. (2014). Antemortem Diagnosis and Successful Treatment of Pulmonary Candidiasis in a Sun Conure (Aratinga solstitialis). Journal of avian medicine and surgery, 28(4), 316-21. https://doi.org/10.1647/2013-073
Proença, Laila M, et al. "Antemortem Diagnosis and Successful Treatment of Pulmonary Candidiasis in a Sun Conure (Aratinga solstitialis)." Journal of avian medicine and surgery vol. 28,4 (2014): 316-21. doi: https://doi.org/10.1647/2013-073
Proença LM, Mayer J, Schnellbacher R, Sanchez S, Huang CT, Brown H, Jiménez D, Stelmach D, Divers SJ. Antemortem Diagnosis and Successful Treatment of Pulmonary Candidiasis in a Sun Conure (Aratinga solstitialis). J Avian Med Surg. 2014 Dec;28(4):316-21. doi: 10.1647/2013-073. PMID: 25843470.
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Fungus ball and emphysematous cystitis secondary to Candida tropicalis: A case report.

Canadian Urological Association journal = Journal de l'Association des urologues du Canada

Wang L, Ji X, Sun GF, Qin YC, Gong MZ, Zhang JX, Li NC, Na YQ.
PMID: 26425243
Can Urol Assoc J. 2015 Sep-Oct;9(9):E683-6. doi: 10.5489/cuaj.3008. Epub 2015 Sep 09.

Fungus ball and fungal emphysematous cystitis are two rare complications of fungal urinary tract infection. A 53-year-old male patient presented with these complications caused by Candida tropicalis simultaneously. The predisposing factors were diabetes mellitus and usage of broad-spectrum antibiotics....

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Wang L, Ji X, Sun GF, et al. Fungus ball and emphysematous cystitis secondary to Candida tropicalis: A case report. Can Urol Assoc J. 2015;9(9):E683-6doi: 10.5489/cuaj.3008.
Wang, L., Ji, X., Sun, G. F., Qin, Y. C., Gong, M. Z., Zhang, J. X., Li, N. C., & Na, Y. Q. (2015). Fungus ball and emphysematous cystitis secondary to Candida tropicalis: A case report. Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 9(9), E683-6. https://doi.org/10.5489/cuaj.3008
Wang, Lei, et al. "Fungus ball and emphysematous cystitis secondary to Candida tropicalis: A case report." Canadian Urological Association journal = Journal de l'Association des urologues du Canada vol. 9,9 (2015): E683-6. doi: https://doi.org/10.5489/cuaj.3008
Wang L, Ji X, Sun GF, Qin YC, Gong MZ, Zhang JX, Li NC, Na YQ. Fungus ball and emphysematous cystitis secondary to Candida tropicalis: A case report. Can Urol Assoc J. 2015 Sep-Oct;9(9):E683-6. doi: 10.5489/cuaj.3008. Epub 2015 Sep 09. PMID: 26425243; PMCID: PMC4581947.
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Investigation of In Vitro Activity of Five Antifungal Drugs against Dermatophytes Species Isolated from Clinical Samples Using the E-Test Method.

The Eurasian journal of medicine

Aktas AE, Yigit N, Aktas A, Gozubuyuk SG.
PMID: 25610290
Eurasian J Med. 2014 Feb;46(1):26-31. doi: 10.5152/eajm.2014.05.

OBJECTIVE: Dermatomycosis is an infection with fungi related to the skin: glabrous skin, hair and/or nails. Oral treatment of fungal infections in dermatology has become a preferred modality for the management of these very common conditions. Although there are...

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Aktas AE, Yigit N, Aktas A, et al. Investigation of In Vitro Activity of Five Antifungal Drugs against Dermatophytes Species Isolated from Clinical Samples Using the E-Test Method. Eurasian J Med. 2014;46(1):26-31doi: 10.5152/eajm.2014.05.
Aktas, A. E., Yigit, N., Aktas, A., & Gozubuyuk, S. G. (2014). Investigation of In Vitro Activity of Five Antifungal Drugs against Dermatophytes Species Isolated from Clinical Samples Using the E-Test Method. The Eurasian journal of medicine, 46(1), 26-31. https://doi.org/10.5152/eajm.2014.05
Aktas, Ayse Esin, et al. "Investigation of In Vitro Activity of Five Antifungal Drugs against Dermatophytes Species Isolated from Clinical Samples Using the E-Test Method." The Eurasian journal of medicine vol. 46,1 (2014): 26-31. doi: https://doi.org/10.5152/eajm.2014.05
Aktas AE, Yigit N, Aktas A, Gozubuyuk SG. Investigation of In Vitro Activity of Five Antifungal Drugs against Dermatophytes Species Isolated from Clinical Samples Using the E-Test Method. Eurasian J Med. 2014 Feb;46(1):26-31. doi: 10.5152/eajm.2014.05. PMID: 25610290; PMCID: PMC4261438.
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Candidiasis, A Rare Cause of Gastric Perforation: A Case Report and Review of Literature.

Annals of medical and health sciences research

Ukekwe FI, Nwajiobi C, Agbo MO, Ebede SO, Eni AO.
PMID: 26229723
Ann Med Health Sci Res. 2015 Jul-Aug;5(4):314-6. doi: 10.4103/2141-9248.160187.

Fungi are unusually rare causes of gastric perforation, with most cases of gastric perforation occurring as complications of peptic ulcer disease (PUD), nonsteroidal anti-inflammatory drugs (NSAIDs) and gastric neoplasms. Here, we report the case of a 70-year-old Nigerian male...

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Ukekwe FI, Nwajiobi C, Agbo MO, et al. Candidiasis, A Rare Cause of Gastric Perforation: A Case Report and Review of Literature. Ann Med Health Sci Res. 2015;5(4):314-6doi: 10.4103/2141-9248.160187.
Ukekwe, F. I., Nwajiobi, C., Agbo, M. O., Ebede, S. O., & Eni, A. O. (2015). Candidiasis, A Rare Cause of Gastric Perforation: A Case Report and Review of Literature. Annals of medical and health sciences research, 5(4), 314-6. https://doi.org/10.4103/2141-9248.160187
Ukekwe, F I, et al. "Candidiasis, A Rare Cause of Gastric Perforation: A Case Report and Review of Literature." Annals of medical and health sciences research vol. 5,4 (2015): 314-6. doi: https://doi.org/10.4103/2141-9248.160187
Ukekwe FI, Nwajiobi C, Agbo MO, Ebede SO, Eni AO. Candidiasis, A Rare Cause of Gastric Perforation: A Case Report and Review of Literature. Ann Med Health Sci Res. 2015 Jul-Aug;5(4):314-6. doi: 10.4103/2141-9248.160187. PMID: 26229723; PMCID: PMC4512127.
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Coccidioidomycosis Masquerading as Eosinophilic Ascites.

Case reports in gastrointestinal medicine

Alavi K, Atla PR, Haq T, Sheikh MY.
PMID: 26266062
Case Rep Gastrointest Med. 2015;2015:891910. doi: 10.1155/2015/891910. Epub 2015 Jul 21.

Endemic to the southwestern parts of the United States, coccidioidomycosis, also known as "Valley Fever," is a common fungal infection that primarily affects the lungs in both acute and chronic forms. Disseminated coccidioidomycosis is the most severe but very...

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Alavi K, Atla PR, Haq T, et al. Coccidioidomycosis Masquerading as Eosinophilic Ascites. Case Rep Gastrointest Med. 2015;2015:891910doi: 10.1155/2015/891910.
Alavi, K., Atla, P. R., Haq, T., & Sheikh, M. Y. (2015). Coccidioidomycosis Masquerading as Eosinophilic Ascites. Case reports in gastrointestinal medicine, 2015891910. https://doi.org/10.1155/2015/891910
Alavi, Kourosh, et al. "Coccidioidomycosis Masquerading as Eosinophilic Ascites." Case reports in gastrointestinal medicine vol. 2015 (2015): 891910. doi: https://doi.org/10.1155/2015/891910
Alavi K, Atla PR, Haq T, Sheikh MY. Coccidioidomycosis Masquerading as Eosinophilic Ascites. Case Rep Gastrointest Med. 2015;2015:891910. doi: 10.1155/2015/891910. Epub 2015 Jul 21. PMID: 26266062; PMCID: PMC4523687.
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Incidence and outcome of documented fungal endocarditis.

International cardiovascular research journal

Badiee P, Amirghofran AA, Ghazi Nour M, Shafa M, Nemati MH.
PMID: 25614858
Int Cardiovasc Res J. 2014 Dec;8(4):152-5. Epub 2014 Dec 01.

BACKGROUND: Fungal endocarditis, the most severe form of infective endocarditis, is characterized by excessive mortality and morbidity.OBJECTIVES: The present study aimed to analyze the characteristics of fungal endocarditis to improve the management of these patients.MATERIALS AND METHODS: In this...

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Badiee P, Amirghofran AA, Ghazi Nour M, et al. Incidence and outcome of documented fungal endocarditis. Int Cardiovasc Res J. 2014;8(4):152-5
Badiee, P., Amirghofran, A. A., Ghazi Nour, M., Shafa, M., & Nemati, M. H. (2014). Incidence and outcome of documented fungal endocarditis. International cardiovascular research journal, 8(4), 152-5.
Badiee, Parisa, et al. "Incidence and outcome of documented fungal endocarditis." International cardiovascular research journal vol. 8,4 (2014): 152-5.
Badiee P, Amirghofran AA, Ghazi Nour M, Shafa M, Nemati MH. Incidence and outcome of documented fungal endocarditis. Int Cardiovasc Res J. 2014 Dec;8(4):152-5. Epub 2014 Dec 01. PMID: 25614858; PMCID: PMC4302502.
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Antifungal agent utilization evaluation in hospitalized neutropenic cancer patients at a large teaching hospital.

Drug, healthcare and patient safety

Vazin A, Davarpanah MA, Ghalesoltani S.
PMID: 26064070
Drug Healthc Patient Saf. 2015 Jun 01;7:97-102. doi: 10.2147/DHPS.S80762. eCollection 2015.

To evaluate pattern of using of three antifungal drugs: fluconazole, amphotericin B and voriconazole, at the hematology-oncology and bone marrow transplant wards of one large teaching hospital. In a prospective cross-sectional study, we evaluated the appropriateness of using antifungal...

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Vazin A, Davarpanah MA, Ghalesoltani S. Antifungal agent utilization evaluation in hospitalized neutropenic cancer patients at a large teaching hospital. Drug Healthc Patient Saf. 2015;7:97-102doi: 10.2147/DHPS.S80762.
Vazin, A., Davarpanah, M. A., & Ghalesoltani, S. (2015). Antifungal agent utilization evaluation in hospitalized neutropenic cancer patients at a large teaching hospital. Drug, healthcare and patient safety, 797-102. https://doi.org/10.2147/DHPS.S80762
Vazin, Afsaneh, et al. "Antifungal agent utilization evaluation in hospitalized neutropenic cancer patients at a large teaching hospital." Drug, healthcare and patient safety vol. 7 (2015): 97-102. doi: https://doi.org/10.2147/DHPS.S80762
Vazin A, Davarpanah MA, Ghalesoltani S. Antifungal agent utilization evaluation in hospitalized neutropenic cancer patients at a large teaching hospital. Drug Healthc Patient Saf. 2015 Jun 01;7:97-102. doi: 10.2147/DHPS.S80762. eCollection 2015. PMID: 26064070; PMCID: PMC4457220.
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Pathogen distribution and drug resistance in a burn ward: a three-year retrospective analysis of a single center in China.

International journal of clinical and experimental medicine

Cen H, Wu Z, Wang F, Han C.
PMID: 26770555
Int J Clin Exp Med. 2015 Oct 15;8(10):19188-99. eCollection 2015.

To investigate the spread of multiple-resistant strain in a burn ward to inform clinical administration of antibiotic drugs, burn wound treatment and decision-making for infection control. A 3-year retrospective analysis was conducted. Specimens from wounds, blood, catheter, sputum, urine...

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Cen H, Wu Z, Wang F, et al. Pathogen distribution and drug resistance in a burn ward: a three-year retrospective analysis of a single center in China. Int J Clin Exp Med. 2015;8(10):19188-99
Cen, H., Wu, Z., Wang, F., & Han, C. (2015). Pathogen distribution and drug resistance in a burn ward: a three-year retrospective analysis of a single center in China. International journal of clinical and experimental medicine, 8(10), 19188-99.
Cen, Hanghui, et al. "Pathogen distribution and drug resistance in a burn ward: a three-year retrospective analysis of a single center in China." International journal of clinical and experimental medicine vol. 8,10 (2015): 19188-99.
Cen H, Wu Z, Wang F, Han C. Pathogen distribution and drug resistance in a burn ward: a three-year retrospective analysis of a single center in China. Int J Clin Exp Med. 2015 Oct 15;8(10):19188-99. eCollection 2015. PMID: 26770555; PMCID: PMC4694455.
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Type of Antifungals: Does it Matter in Empirical Treatment of Otomycosis?.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

Navaneethan N, YaadhavaKrishnan RP.
PMID: 25621236
Indian J Otolaryngol Head Neck Surg. 2015 Mar;67(1):64-7. doi: 10.1007/s12070-014-0780-9. Epub 2014 Oct 04.

To evaluate the efficacy of clotrimazole, miconazole and fluconazole in empirical treatment of otomycosis in our tertiary care hospital and to appraise possible better outcome in otomycosis. Two hundred and ninety five patients who presented with clinical otomycosis at...

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Navaneethan N, YaadhavaKrishnan RP. Type of Antifungals: Does it Matter in Empirical Treatment of Otomycosis?. Indian J Otolaryngol Head Neck Surg. 2014;67(1):64-7doi: 10.1007/s12070-014-0780-9.
Navaneethan, N., & YaadhavaKrishnan, R. P. (2015). Type of Antifungals: Does it Matter in Empirical Treatment of Otomycosis?. Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India, 67(1), 64-7. https://doi.org/10.1007/s12070-014-0780-9
Navaneethan, Nagendran, and YaadhavaKrishnan, Raj Prakash Dharmapuri. "Type of Antifungals: Does it Matter in Empirical Treatment of Otomycosis?." Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India vol. 67,1 (2015): 64-7. doi: https://doi.org/10.1007/s12070-014-0780-9
Navaneethan N, YaadhavaKrishnan RP. Type of Antifungals: Does it Matter in Empirical Treatment of Otomycosis?. Indian J Otolaryngol Head Neck Surg. 2015 Mar;67(1):64-7. doi: 10.1007/s12070-014-0780-9. Epub 2014 Oct 04. PMID: 25621236; PMCID: PMC4298570.
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Bis-pyrimidine acetamides: design, synthesis and biological evaluation.

Chemistry Central journal

Kumar S, Lim SM, Ramasamy K, Vasudevan M, Shah SAA, Narasimhan B.
PMID: 29086907
Chem Cent J. 2017 Aug 08;11(1):80. doi: 10.1186/s13065-017-0312-2.

BACKGROUND: In the past few years, increased resistance of microorganisms towards antimicrobial agents become a serious health problem, so there is a need for the discovery of new antimicrobial agents. On the other hand, bis-pyrimidines possess various types of...

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Kumar S, Lim SM, Ramasamy K, et al. Bis-pyrimidine acetamides: design, synthesis and biological evaluation. Chem Cent J. 2017;11(1):80doi: 10.1186/s13065-017-0312-2.
Kumar, S., Lim, S. M., Ramasamy, K., Vasudevan, M., Shah, S. A. A., & Narasimhan, B. (2017). Bis-pyrimidine acetamides: design, synthesis and biological evaluation. Chemistry Central journal, 11(1), 80. https://doi.org/10.1186/s13065-017-0312-2
Kumar, Sanjiv, et al. "Bis-pyrimidine acetamides: design, synthesis and biological evaluation." Chemistry Central journal vol. 11,1 (2017): 80. doi: https://doi.org/10.1186/s13065-017-0312-2
Kumar S, Lim SM, Ramasamy K, Vasudevan M, Shah SAA, Narasimhan B. Bis-pyrimidine acetamides: design, synthesis and biological evaluation. Chem Cent J. 2017 Aug 08;11(1):80. doi: 10.1186/s13065-017-0312-2. PMID: 29086907; PMCID: PMC5548699.
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Synthesis, characterization, and in vitro activity against .

Nanotechnology, science and applications

Gómez-Sequeda N, Torres R, Ortiz C.
PMID: 28572725
Nanotechnol Sci Appl. 2017 May 16;10:95-104. doi: 10.2147/NSA.S96018. eCollection 2017.

In this study, nanoparticles (NPs) of poly(lactic-co-glycolic acid) (PLGA) loaded with fluconazole (FLZ) and FLZ-NPs coated with the cationic polymer polyethylenimine (PEI) (FLZ-NP-PEI) were synthetized in order to improve antimycotic activity against four strains of

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Gómez-Sequeda N, Torres R, Ortiz C. Synthesis, characterization, and in vitro activity against . Nanotechnol Sci Appl. 2017;10:95-104doi: 10.2147/NSA.S96018.
Gómez-Sequeda, N., Torres, R., & Ortiz, C. (2017). Synthesis, characterization, and in vitro activity against . Nanotechnology, science and applications, 1095-104. https://doi.org/10.2147/NSA.S96018
Gómez-Sequeda, Nicolás, et al. "Synthesis, characterization, and in vitro activity against ." Nanotechnology, science and applications vol. 10 (2017): 95-104. doi: https://doi.org/10.2147/NSA.S96018
Gómez-Sequeda N, Torres R, Ortiz C. Synthesis, characterization, and in vitro activity against . Nanotechnol Sci Appl. 2017 May 16;10:95-104. doi: 10.2147/NSA.S96018. eCollection 2017. PMID: 28572725; PMCID: PMC5441665.
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Showing 1 to 12 of 1338 entries