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Showing 1 to 12 of 25 entries
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Synthesis of 19-Trideuterated ent-Testosterone and the GABA(A) Receptor Potentiators ent-Androsterone and ent-Etiocholanolone.

Journal of labelled compounds & radiopharmaceuticals

Komarapuri S, Krishnan K, Covey DF.
PMID: 19122784
J Labelled Comp Radiopharm. 2008 Nov;51(14):430-434. doi: 10.1002/jlcr.1558.

19-Trideuteromethyl enantiomers of androgens namely ent-testosterone, ent-androsterone and ent-etiocholanolone were prepared by total synthesis. The isotope labeling at the carbon-19 angular methyl group was achieved by using deuterated methyl iodide (99.5% d(3)) for introduction of C-19 before closure of...

Steroids and steroid glucuronides in the ovarian fluid of the African catfish,Clarias gariepinus, between ovulation and oviposition.

Fish physiology and biochemistry

Schoonen WG, Granneman JC, Lambert JG.
PMID: 24226975
Fish Physiol Biochem. 1989 Mar;6(2):91-112. doi: 10.1007/BF01875482.

As part of a series of experiments concerning a possible pheromonal function of steroids and steroid glucuronides excreted by the sex organs of the African catfish,Clarias gariepinus, qualitative and quantitative studies, using GCMS, were carried out to examine the...

Effects of androgen and progestin on the proliferation and differentiation of osteoblasts.

Experimental and therapeutic medicine

Wu X, Zhang M.
PMID: 30542427
Exp Ther Med. 2018 Dec;16(6):4722-4728. doi: 10.3892/etm.2018.6772. Epub 2018 Sep 19.

Osteoporosis is liable to affect patients with gonadal hormone deficiency, and a supplement of androgens may be used to increase bone density of patients with osteoporosis. Since the androgens currently used may cause severe side effects, it is useful...

NMR-based plasma metabolic profiling in patients with unstable angina.

Iranian journal of basic medical sciences

PouralijanAmiri M, Khoshkam M, Madadi R, Kamali K, Faghanzadeh Ganji G, Salek R, Ramazani A.
PMID: 32440317
Iran J Basic Med Sci. 2020 Mar;23(3):311-320. doi: 10.22038/IJBMS.2020.39979.9475.

OBJECTIVES: Unstable angina (UA) is a form of the acute coronary syndrome (ACS) that affects more than a third of the population before age 70. Due to the limitations of diagnostic tests, appropriate identification of UA is difficult. In...

5α-reductase inhibitors: Evaluation of their potential confounding effect on GC-C-IRMS doping analysis.

Drug testing and analysis

Iannella L, Colamonici C, Curcio D, Botrè F, de la Torre X.
PMID: 34318592
Drug Test Anal. 2021 Jul 27; doi: 10.1002/dta.3134. Epub 2021 Jul 27.

5α-reductase inhibitors (5-ARIs) are considered by the World Anti-doping Agency as potential confounding factors in evaluating the athlete steroid profile, since they may interfere with the urinary excretion of several diagnostic compounds. We herein investigated 5α-reductase inhibitors from a...

Serum concentration of mineralocorticoids, glucocorticoids, and sex steroids in peripartum bitches.

Domestic animal endocrinology

Milani C, Rota A, Olsson U, Paganotto A, Holst BS.
PMID: 32980594
Domest Anim Endocrinol. 2021 Jan;74:106558. doi: 10.1016/j.domaniend.2020.106558. Epub 2020 Sep 04.

The aim of the work was to describe the profile of steroid hormones in the peripartum period of the bitch. Twenty-five healthy pregnant bitches presented for pregnancy monitoring and parturition assistance were included in the study. A blood sample...

Urinary Steroid Profile in Elite Female Athletes in Relation to Serum Androgens and in Comparison With Untrained Controls.

Frontiers in physiology

Eklund E, Andersson A, Ekström L, Hirschberg AL.
PMID: 34526910
Front Physiol. 2021 Aug 30;12:702305. doi: 10.3389/fphys.2021.702305. eCollection 2021.

INTRODUCTION: In female athletes, the interpretation of doping tests is complex due to hormonal variations during the menstrual cycle and hormonal contraceptive use, both influencing the urinary steroid profile. Exercise is suggested to affect circulating steroid hormone levels, and...

Studies on steroid fever: I. Production of leukocyte pyrogen in vitro by etiocholanolone.

The Journal of clinical investigation

Bodel P, Dillard M.
PMID: 16695933
J Clin Invest. 1968 Jan;47(1):107-17. doi: 10.1172/JCI105701.

When a serum-buffer solution of etiocholanolone is incubated with human blood leukocytes in vitro, a pyrogen is released. Like endogenous pyrogen of leukocyte origin, this pyrogen produces prompt monophasic fevers in rabbits, does not induce fever tolerance when given...

Plasma profiles of fourteen ovarian steroids before, during and after ovulation in African catfish,Clarias gariepinus, determined by gas chromatography and mass spectrometry.

Fish physiology and biochemistry

van Dam GH, Schoonen WG, Lambert JG, van Oordt PG.
PMID: 24226974
Fish Physiol Biochem. 1989 Mar;6(2):79-89. doi: 10.1007/BF01875481.

The plasma concentrations of fourteen ovarian steroids were measured in postvitellogenic African catfish,Clarias gariepinus, which had been injected with pimozide and LHRHa. Postvitellogenesis persisted for at least four hours after pimozide and LHRHa administration. During this stage a limited...

Altered levels of circulating GABAergic 5α/β-reduced pregnane and androstane steroids in schizophrenic men.

Hormone molecular biology and clinical investigation

Bicikova M, Hill M, Ripova D, Mohr P.
PMID: 25961259
Horm Mol Biol Clin Investig. 2011 May 01;6(2):227-30. doi: 10.1515/HMBCI.2010.083.

The role of GABAergic pathways in the pathophysiology of schizophrenia is generally accepted. Therefore, the information concerning alterations of the steroid metabolome associated with the disease and/or its treatment is of interest with regard to the pathophysiology of the...

Sensitive detection of testosterone and testosterone prohormone administrations based on urinary concentrations and carbon isotope ratios of androsterone and etiocholanolone.

Drug testing and analysis

Piper T, Haenelt N, Fusshöller G, Geyer H, Thevis M.
PMID: 34648228
Drug Test Anal. 2021 Oct 14; doi: 10.1002/dta.3168. Epub 2021 Oct 14.

The testing strategy for the detection of testosterone (T) or T-prohormones is based on the longitudinal evaluation of urinary steroid concentrations accompanied by subsequent isotope ratio mass spectrometry (IRMS)-based confirmation of samples showing atypical concentrations or concentration ratios. In...

Comparison of the Glucocorticoid Concentrations between Three Species of .

Animals : an open access journal from MDPI

Volfova M, Machovcova Z, Voslarova E, Bedanova I, Vecerek V.
PMID: 32532091
Animals (Basel). 2020 Jun 10;10(6). doi: 10.3390/ani10061013.

We compared the glucocorticoid concentrations in response to various types of potential stressors present during standard operation of a temporary housing facility between three species, namely, ring-tailed lemurs, collared brown lemurs and white-headed lemurs. The levels of faecal glucocorticoid...

Showing 1 to 12 of 25 entries