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The antifertility action of alpha-chlorohydrin: enzyme inhibition by alpha-chlorohydrin phosphate.


Mashford PM, Jones AR.
PMID: 738390
Experientia. 1978 Oct 15;34(10):1267-8. doi: 10.1007/BF01981408.

Preparations of the enzymes glyceraldehyde-3-phosphate dehydrogenase and triosephosphate isomerase are shown to be inhibited by alpha-chlorohydrin phosphate (II) in a competitive and non-competitive manner, respectively. alpha-Chlorohydrin (I), glycidol and epi-chlorohydrin have no inhibitory activities suggesting that their antifertility actions...

Hormonally exacerbated hereditary angioedema.

The Australasian journal of dermatology

Yip J, Cunliffe WJ.
PMID: 1445091
Australas J Dermatol. 1992;33(1):35-8. doi: 10.1111/j.1440-0960.1992.tb00050.x.

Hereditary angioedema is a rare disorder which is associated with an inherited deficiency of the inhibitor of the activated first component of complement. Genetic transmission occurs in an autosomal dominant manner. Affected patients are heterozygotes, and their deficiency is...

Retroviruses: new viral infections in man.

The Pediatric infectious disease journal

Salahuddin SZ, Markham PD.
PMID: 2899867
Pediatr Infect Dis J. 1988 May;7(5):S107-19.

No abstract available.

Interaction between anticoagulants and contraceptives: an unsuspected finding.

British medical journal

de Teresa E, Vera A, Ortigosa J, Pulpon LA, Arus AP, de Artaza M.
PMID: 519402
Br Med J. 1979 Nov 17;2(6200):1260-1. doi: 10.1136/bmj.2.6200.1260.
Free PMC Article

To assess the effects of oral contraceptives on anticoagulant treatment the prothrombin times of 12 patients were measured while they were taking both drugs simultaneously and while they were taking only anticoagulants. The mean prothrombin time ratio was significantly...

Distribution of a seminal plasma-associated protein kinase inhibitor in normal, oligozoospermic, and vasectomized men.

Biology of reproduction

Pliego JF, Van-Arsdalen K, Kopf GS.
PMID: 3015272
Biol Reprod. 1986 Jun;34(5):885-93. doi: 10.1095/biolreprod34.5.885.

Human sperm-free seminal plasma contains an inhibitor, which is protein in nature, of the histone kinase present in seminal plasma. Since protein kinase inhibitors have been observed to be present in spermatozoa, the objective of the present study was...

Indomethacin in low concentration potentiates the actions of some spasmogens on the isolated oestrous rat uterus.

The Journal of pharmacy and pharmacology

Sharma JN, Zeitlin IJ.
PMID: 17703
J Pharm Pharmacol. 1977 May;29(5):316-7. doi: 10.1111/j.2042-7158.1977.tb11324.x.

No abstract available.

Mechanism-based inactivation of human liver microsomal cytochrome P-450 IIIA4 by gestodene.

Chemical research in toxicology

Guengerich FP.
PMID: 2133086
Chem Res Toxicol. 1990 Jul-Aug;3(4):363-71. doi: 10.1021/tx00016a015.

A series of 17 alpha-acetylenic steroids was examined with regard to ability to inactivate human liver microsomal cytochrome P-450 (P-450) IIA4, an enzyme involved in the oxidation of a number of drugs, carcinogens, and steroids, including estrogens and progestogens....

[Prophylactic use of prostaglandin synthesis inhibitors in connection with IUD insertion].

Ugeskrift for laeger

Jensen HH, Blaabjerg J, Lyndrup J.
PMID: 9846090
Ugeskr Laeger. 1998 Nov 23;160(48):6958-61.

In a double-blind, randomized, placebo-controlled study conducted at a contraception clinic, 55 women (three nulliparous) were given either ibuprofen 600 mg or placebo 1-4 hours prior to insertion of IUD, 4-6 hours after insertion of IUD and the following...

Decrease in human plasma gravidin levels after medical abortion.


Wilson T, Thong KJ, Howie PW.
PMID: 7809383
Prostaglandins. 1994 Sep;48(3):175-85. doi: 10.1016/0090-6980(94)90017-5.

The aim of this study was to determine if loss of pregnancy is associated with a decrease in plasma levels of gravidin, a phospholipase inhibitor thought to maintain pregnancy. Blood was taken from 28 women in the first trimester...

Protein-Templated Formation of an Inhibitor of the Blood Coagulation Factor Xa through a Background-Free Amidation Reaction.

Angewandte Chemie (International ed. in English)

Jaegle M, Steinmetzer T, Rademann J.
PMID: 28199769
Angew Chem Int Ed Engl. 2017 Mar 20;56(13):3718-3722. doi: 10.1002/anie.201611547. Epub 2017 Feb 15.

Protein-templated reactions enable the target-guided formation of protein ligands from reactive fragments, ideally with no background reaction. Herein, we investigate the templated formation of amides. A nucleophilic fragment that binds to the coagulation factor Xa was incubated with the...

C-Disaccharides of Ketoses.

Chemistry (Weinheim an der Bergstrasse, Germany)

Streicher H, Geyer A, Schmidt RR.
PMID: 29178224
Chemistry. 1996 May;2(5):502-510. doi: 10.1002/chem.19960020508.

Reaction of gluconolactone 2 with allylmagnesium bromide at low temperatures afforded ketopyranose 3, which could easily be converted into open-chain ketoses (R)-6 and (S)-6. Their reaction with lithioacetylide 9 afforded propargylic alcohol derivatives (R)-10 and (S)-10, which could not...

A manganese-salen complex as dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.

International journal of biological macromolecules

Zhu MR, Zhou J, Jin Y, Gao LH, Li L, Yang JR, Lu CM, Zhao QH, Xie MJ.
PMID: 30171949
Int J Biol Macromol. 2018 Dec;120:1232-1239. doi: 10.1016/j.ijbiomac.2018.08.089. Epub 2018 Aug 29.

A manganese Schiff base complex with N,N'-1,2-phenylenediamine-bis(salicyladimine) was synthesized and characterized by X-ray crystallography. This complex was administered intragastrically to alloxan-diabetic mice 3 weeks. In vivo tests showed that the complex significantly lowered serum glucose levels in alloxan-diabetic mice...

Showing 1 to 12 of 152175 entries