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Showing 1 to 8 of 8 entries
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State of the art in intravesical therapy for lower urinary tract symptoms.

Reviews in urology

Kaufman J, Tyagi V, Anthony M, Chancellor MB, Tyagi P.
PMID: 21234261
Rev Urol. 2010;12(4):e181-9.

Intravesical therapy is the routine first-line treatment for effectively delaying or preventing the recurrence of bladder cancer. This route of drug administration has also shown tremendous promise in the treatment of interstitial cystitis/painful bladder syndrome (IC/PBS) and potentially overactive...

Subcutaneous implants for long-acting drug therapy in laboratory animals may generate unintended drug reservoirs.

Journal of pharmacy & bioallied sciences

Guarnieri M, Tyler BM, Detolla L, Zhao M, Kobrin B.
PMID: 24459402
J Pharm Bioallied Sci. 2014 Jan;6(1):38-42. doi: 10.4103/0975-7406.124315.

BACKGROUND: Long-acting therapy in laboratory animals offers advantages over the current practice of 2-3 daily drug injections. Yet little is known about the disintegration of biodegradable drug implants in rodents.OBJECTIVE: Compare bioavailability of buprenorphine with the biodegradation of lipid-encapsulated...

Laser-Activated Drug Implant for Controlled Release to the Posterior Segment of the Eye.

ACS applied bio materials

He X, Yuan Z, Gaeke S, Kao WW, Li SK, Miller D, Williams B, Park YC.
PMID: 35014495
ACS Appl Bio Mater. 2021 Feb 15;4(2):1461-1469. doi: 10.1021/acsabm.0c01334. Epub 2021 Jan 22.

To treat chronic posterior eye diseases, frequent intravitreal injections or sustained-release drug implants are the current standard of care. Sustained-release drug implants often involve burst release of the drugs and the dosage from the implants cannot be controlled after...

Size-Exclusive Nanoporous Biodegradable PLGA Capsules for Drug Delivery Implants and In Vivo Stability in the Posterior Segment.

ACS applied bio materials

He X, Yuan Z, Kao W, Miller D, Li SK, Park YC.
PMID: 35021661
ACS Appl Bio Mater. 2020 Mar 16;3(3):1722-1729. doi: 10.1021/acsabm.0c00027. Epub 2020 Feb 25.

The current standard of care for posterior segment eye diseases, such as neovascular age-related macular degeneration, diabetic macular edema, is frequent intravitreal injections or sustained-release drug implants. Intravitreal injections have a low incidence of serious complications such as retinal...

Safety, Quality, and Acceptability of Contraceptive Subdermal Implant Provision by Community Health Extension Workers Versus Nurses and Midwives in Nigeria: Protocol for a Quasi-Experimental, Noninferiority Study.

JMIR research protocols

Reiss K, Penfold S, Alabi O, Ali M, Hopkins K, Ngo TD, Odogwu K, Douthwaite M, Ezire O, Udoh U, Effiom E, Munroe ES.
PMID: 29500162
JMIR Res Protoc. 2018 Mar 02;7(3):e67. doi: 10.2196/resprot.8721.

BACKGROUND: As part of its Family Planning 2020 commitment, the Nigerian government is aiming for a contraceptive prevalence rate of 36% by 2018, and in 2014, approved a policy to allow community health extension workers (CHEWs), in addition to...

Biobased Ionic Liquids as Multitalented Materials in Lipidic Drug Implants.

Pharmaceutics

Júlio A, Sultane A, Viana AS, Mota JP, Santos de Almeida T.
PMID: 34452124
Pharmaceutics. 2021 Jul 28;13(8). doi: 10.3390/pharmaceutics13081163.

Lipidic implants are valuable controlled delivery systems that present good biocompatibility and are useful for long-lasting therapies. However, these promising systems can present inflexible drug release profiles that limit their performance. Thus, finding new materials to overcome this drawback...

Subcutaneous Implants of Buprenorphine-Cholesterol-Triglyceride Powder in Mice.

Journal of veterinary medicine

DeTolla L, Sanchez R, Khan E, Tyler B, Guarnieri M.
PMID: 26464927
J Vet Med. 2014;2014:365673. doi: 10.1155/2014/365673. Epub 2014 Nov 27.

Subcutaneous drug implants are convenient systems for the long-term delivery of drugs in animals. Lipid carriers are logical tools because they generally allow for higher doses and low toxicity. The present study used an US Food and Drug Administration...

Drug Implants of Hydrogels via Collective Behavior of Microgel Colloids for On-Demand Cancer Therapy.

ACS applied bio materials

Wang Y, Wang L, Yan M, Feng L, Dong S, Hao J.
PMID: 35026926
ACS Appl Bio Mater. 2019 Apr 15;2(4):1531-1541. doi: 10.1021/acsabm.8b00823. Epub 2019 Mar 07.

In nature, the collective behaviors such as the growth of bacteria and the cooperation of insects possess great superiority and can create functional materials through diversified interactions for accomplishing complex tasks that cannot be performed by a single unit....

Showing 1 to 8 of 8 entries