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Showing 1 to 12 of 942 entries
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Cyclodextrin-based nanosponges as drug carriers.

Beilstein journal of organic chemistry

Trotta F, Zanetti M, Cavalli R.
PMID: 23243470
Beilstein J Org Chem. 2012;8:2091-9. doi: 10.3762/bjoc.8.235. Epub 2012 Nov 29.

Cyclodextrin-based nanosponges, which are proposed as a new nanosized delivery system, are innovative cross-linked cyclodextrin polymers nanostructured within a three-dimensional network. This type of cyclodextrin polymer can form porous insoluble nanoparticles with a crystalline or amorphous structure and spherical...

Synthesis of polymerized calcium silicate hydrate nanostructures as drug carriers.

Journal of controlled release : official journal of the Controlled Release Society

Wu J, Chen F, Zhao XY, Zhao J, Qi C, Zhu YJ.
PMID: 27005184
J Control Release. 2015 Sep 10;213:e52. doi: 10.1016/j.jconrel.2015.05.085. Epub 2015 Aug 19.

No abstract available.

Chemical and biological assessment of metal organic frameworks (MOFs) in pulmonary cells and in an acute in vivo model: relevance to pulmonary arterial hypertension therapy.

Pulmonary circulation

Mohamed NA, Davies RP, Lickiss PD, Ahmetaj-Shala B, Reed DM, Gashaw HH, Saleem H, Freeman GR, George PM, Wort SJ, Morales-Cano D, Barreira B, Tetley TD, Chester AH, Yacoub MH, Kirkby NS, Moreno L, Mitchell JA.
PMID: 28447910
Pulm Circ. 2017 Jul-Sep;7(3):643-653. doi: 10.1177/2045893217710224. Epub 2017 Jun 27.

Pulmonary arterial hypertension (PAH) is a progressive and debilitating condition. Despite promoting vasodilation, current drugs have a therapeutic window within which they are limited by systemic side effects. Nanomedicine uses nanoparticles to improve drug delivery and/or reduce side effects....

Comparison of drug release from liquid crystalline monoolein dispersions and solid lipid nanoparticles using a flow cytometric technique.

Acta pharmaceutica Sinica. B

Dawoud MZ, Nasr M.
PMID: 27006901
Acta Pharm Sin B. 2016 Mar;6(2):163-9. doi: 10.1016/j.apsb.2016.01.004. Epub 2016 Jan 25.

Colloidal lipid particles such as solid lipid nanoparticles and liquid crystalline nanoparticles have great opportunities as drug carriers especially for lipophilic drugs intended for intravenous administration. In order to evaluate drug release from these nanoparticles and determine their behavior...

Bovine serum albumin nanoparticles as controlled release carrier for local drug delivery to the inner ear.

Nanoscale research letters

Yu Z, Yu M, Zhang Z, Hong G, Xiong Q.
PMID: 25114637
Nanoscale Res Lett. 2014 Jul 09;9(1):343. doi: 10.1186/1556-276X-9-343. eCollection 2014.

Nanoparticles have attracted increasing attention for local drug delivery to the inner ear recently. Bovine serum albumin (BSA) nanoparticles were prepared by desolvation method followed by glutaraldehyde fixation or heat denaturation. The nanoparticles were spherical in shape with an...

Delineating intracellular pharmacokinetics of paclitaxel delivered by PLGA nanoparticles.

Drug delivery and translational research

Li M, Czyszczon EA, Reineke JJ, Brigido M, Borrachero AB.
PMID: 25786375
Drug Deliv Transl Res. 2013 Dec;3(6):551-61. doi: 10.1007/s13346-013-0162-y.

Although many studies have shown that drug delivery and efficacy can be improved by nano-sized drug carriers, we understand little regarding their pharmacokinetics (PK). PK calculations for drugs delivered by carriers are more complex than those for drug-only solutions....

ATRP Synthesis of Sunflower Polymers using Cyclic Multimacroinitiators.

ACS macro letters

Wei H, Wang CE, Tan N, Boydston AJ, Pun SH.
PMID: 26900511
ACS Macro Lett. 2015 Sep 15;4(9):938-941. doi: 10.1021/acsmacrolett.5b00565. Epub 2015 Aug 17.

Polymers with advanced architectures can now be readily and reproducibly synthesized using controlled living polymerization. These materials are attractive as potential drug carriers due to their tunable size, versatile methods of drug incorporation and release, and ease of functionalization...

Supercritical carbon dioxide design strategies: from drug carriers to soft killers.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences

Aguiar-Ricardo A, Bonifácio VD, Casimiro T, Correia VG.
PMID: 26574528
Philos Trans A Math Phys Eng Sci. 2015 Dec 28;373(2057). doi: 10.1098/rsta.2015.0009.

The integrated use of supercritical carbon dioxide (scCO(2)) and micro- and nanotechnologies has enabled new sustainable strategies for the manufacturing of new medications. 'Green' scCO(2)-based methodologies are well suited to improve either the synthesis or materials processing leading to...

Doxorubicin- and cisplatin-loaded nanostructured lipid carriers for breast cancer combination chemotherapy.

Drug development and industrial pharmacy

Di H, Wu H, Gao Y, Li W, Zou D, Dong C.
PMID: 27184819
Drug Dev Ind Pharm. 2016 Dec;42(12):2038-2043. doi: 10.1080/03639045.2016.1190743. Epub 2016 Jun 01.

CONTEXT: Combination anticancer therapy is promising to generate synergistic anticancer effects, to maximize the treatment effect and to overcome multi-drug resistance. Nanostructured lipid carriers (NLCs), composed of solid and liquid lipids, and surfactants are potentially good colloidal drug carriers.OBJECTIVE:...

Synthesis and characterization of dextran coated magnetite nanoparticles for diagnostics and therapy.

BioImpacts : BI

Khalkhali M, Sadighian S, Rostamizadeh K, Khoeini F, Naghibi M, Bayat N, Habibizadeh M, Hamidi M.
PMID: 26457252
Bioimpacts. 2015;5(3):141-50. doi: 10.15171/bi.2015.19. Epub 2015 Jun 30.

INTRODUCTION: Expansion of efficacious theranostic systems is of pivotal significance for medicine and human healthcare. Magnetic nanoparticles (MNPs) are known as drug delivery system and magnetic resonance imaging (MRI) contrast agent. MNPs as drug carriers have attracted significant attention...

Quantum Dot-Loaded Liposomes to Evaluate the Behavior of Drug Carriers after Oral Administration.

Journal of pharmaceutics

Tahara K, Fujimoto S, Fujii F, Tozuka Y, Jin T, Takeuchi H.
PMID: 26555997
J Pharm (Cairo). 2013;2013:848275. doi: 10.1155/2013/848275. Epub 2013 Jul 18.

We have developed submicron-sized liposomes modified with a mucoadhesive polymer to enhance peptide drug absorption after oral administration. Liposomal behavior in the gastrointestinal tract is a critical factor for effective peptide drug delivery. The purpose of this study was...

Exploring polymeric micelles for improved delivery of anticancer agents: recent developments in preclinical studies.

Pharmaceutics

Tan C, Wang Y, Fan W.
PMID: 24300405
Pharmaceutics. 2013 Mar 22;5(1):201-19. doi: 10.3390/pharmaceutics5010201.

As versatile drug delivery systems, polymeric micelles have demonstrated particular strength in solubilizing hydrophobic anticancer drugs while eliminating the use of toxic organic solvents and surfactants. However, the true promise of polymeric micelles as drug carriers for cancer therapy...

Showing 1 to 12 of 942 entries