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Showing 1 to 12 of 1375 entries
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Improved protocol and data analysis for accelerated shelf-life estimation of solid dosage forms

program design

[No authors listed]
GSID: CbsLLYcymIIJ
KC Waterman, AJ Carella, MJ Gumkowski… - Pharmaceutical …, 2007 - Springer

Purpose To propose and test a new accelerated aging protocol for solid-state, small molecule pharmaceuticals which provides faster predictions for drug substance and drug …

Role of drug absorption in the pharmacokinetics of therapeutic interventions for stroke

Stem education interventions

Conrado DJ, Gonzalez D.
GSID: jK3cVc-0N7gJ
DJ Conrado, D Gonzalez… - Annals of the New York …, 2010 - Wiley Online Library

Absorption is a critical component of the pharmacokinetics for solid dosage forms administered orally. Many barriers must be overcome in order for a drug molecule to reach its effect site. To effectively address each of these barriers, drug‐specific properties,...

The physical and chemical problems inherent in the formulation of dosage forms for new pharmaceuticals. II.

American journal of pharmacy and the sciences supporting public health

Macek TJ.
PMID: 5951741
Am J Pharm Sci Support Public Health. 1966 Jan-Feb;138(1):22-41.

No abstract available.

An Algorithm to Identify Compounded Non-Sterile Products that Can Be Formulated on a Commercial Scale or Imported to Promote Safer Medication Use in Children.

Pharmacy (Basel, Switzerland)

Bhatt-Mehta V, MacArthur RB, Löbenberg R, Cies JJ, Cernak I, Ii RHP.
PMID: 28975916
Pharmacy (Basel). 2015 Nov 11;3(4):284-294. doi: 10.3390/pharmacy3040284.

The lack of commercially-available pediatric drug products and dosage forms is well-known. A group of clinicians and scientists with a common interest in pediatric drug development and medicines-use systems developed a practical framework for identifying a list of active...

To study the influence of different grades of Ethylcellulose ether derivative polymer Ethocel® and co-excipient on drug release profile of controlled release matrix tablet of acarbose.

Pakistan journal of pharmaceutical sciences

Mehsud S, Rauf M, Obaidullah -, Khan KA, Khan GM.
PMID: 26687743
Pak J Pharm Sci. 2015 Nov;28(6):2259-65.

The aim of the study presented is to formulate and evaluate Acarbose controlled release matrix tablets by means of different grades of polymer Ethocel and different co-excipients with the intention to see their effects on drug release profile during...

Muscle Injury After Intramuscular Administration of Diclofenac: A Case Report Supported by Magnetic Resonance Imaging.

Drug safety - case reports

Probst M, Kühn JP, Modeß C, Scheuch E, Seidlitz A, Hosten N, Siegmund W, Weitschies W.
PMID: 28343290
Drug Saf Case Rep. 2017 Dec;4(1):7. doi: 10.1007/s40800-017-0049-9.

Intramuscular injection of diclofenac is still frequently practiced, although there is ample evidence that the risk of local tissue intolerability is highly underestimated. The aim of this study was to evaluate local toxicity in a patient using magnetic resonance...

Role of Components in the Formation of Self-microemulsifying Drug Delivery Systems.

Indian journal of pharmaceutical sciences

Gurram AK, Deshpande PB, Kar SS, Nayak UY, Udupa N, Reddy MS.
PMID: 26180269
Indian J Pharm Sci. 2015 May-Jun;77(3):249-57. doi: 10.4103/0250-474x.159596.

Pharmaceutical research is focused in designing novel drug delivery systems to improve the bioavailability of poorly water soluble drugs. Self-microemulsifying drug delivery systems, one among the lipid-based dosage forms were proven to be promising in improving the oral bioavailability...

A randomized controlled trial to compare the effects of liquid versus powdered recombinant human growth hormone in treating patients with severe burns.

Biomedical reports

Chen G, Shao H, Pan X.
PMID: 27123246
Biomed Rep. 2016 May;4(5):551-556. doi: 10.3892/br.2016.635. Epub 2016 Mar 22.

Recombinant human growth hormone (rhGH) promotes protein utilization and synthesis, and is widely used as a therapy to treat severe burns. The present randomized controlled trial evaluated the effects of different forms of rhGH on patients with severe burns....

Sustained release Curcumin loaded Solid Lipid Nanoparticles.

Advanced pharmaceutical bulletin

Jourghanian P, Ghaffari S, Ardjmand M, Haghighat S, Mohammadnejad M.
PMID: 27123413
Adv Pharm Bull. 2016 Mar;6(1):17-21. doi: 10.15171/apb.2016.004. Epub 2016 Mar 17.

PURPOSE: curcumin is poorly water soluble drug with low bioavailability. Use of lipid systems in lipophilic substances increases solubility and bioavailability of poorly soluble drugs. The aim of this study was to prepare curcumin loaded Solid Lipid Nanoparticles (SLNs)...

The effect of density on the gastric emptying of single- and multiple-unit dosage forms.

Pharmaceutical research

Davis SS, Stockwell AF, Taylor MJ, Hardy JG, Whalley DR, Wilson CG, Bechgaard H, Christensen FN.
PMID: 24271583
Pharm Res. 1986 Aug;3(4):208-13. doi: 10.1023/A:1016334629169.

The gastric emptying of pellets and single units of different densities has been followed in healthy subjects using the technique of gamma scintigraphy. The gastric emptying of the light pellets was affected by their buoyancy in the upper part...

Use of the Charge Transfer Reactions for the Spectrophotometric Determination of Risperidone in Pure and in Dosage Forms.

Journal of pharmaceutics

Deepakumari HN, Revanasiddappa HD.
PMID: 26555994
J Pharm (Cairo). 2013;2013:792186. doi: 10.1155/2013/792186. Epub 2012 Nov 26.

The aim of study was to develop and validate two simple, sensitive, and extraction-free spectrophotometric methods for the estimation of risperidone in both pure and pharmaceutical preparations. They are based on the charge transfer complexation reactions between risperidone (RSP)...

Recently Investigated Natural Gums and Mucilages as Pharmaceutical Excipients: An Overview.

Journal of pharmaceutics

Choudhary PD, Pawar HA.
PMID: 26556189
J Pharm (Cairo). 2014;2014:204849. doi: 10.1155/2014/204849. Epub 2014 Apr 07.

Due to advances in drug delivery technology, currently, excipients are included in novel dosage forms to fulfil specific functions and in some cases they directly or indirectly influence the extent and/or rate of drug release and drug absorption. Recent...

Showing 1 to 12 of 1375 entries