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Showing 1 to 12 of 14 entries
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Intrinsic immunity against retrotransposons by APOBEC cytidine deaminases.

Frontiers in microbiology

Koito A, Ikeda T.
PMID: 23431045
Front Microbiol. 2013 Feb 20;4:28. doi: 10.3389/fmicb.2013.00028. eCollection 2013.

Over 40% of the human genome is recognizable as having been derived from ancient retroelements, transported by an intracellular copy-and-paste process involving an RNA intermediate, with an additional few percent classified as DNA transposable elements. Endogenous retroviruses are long...

Harnessing CRISPR-Cas system diversity for gene editing technologies.

Journal of biomedical research

Mckay A, Burgio G.
PMID: 33797415
J Biomed Res. 2021 Mar 26;35(2):91-106. doi: 10.7555/JBR.35.20200184.

The discovery and utilization of RNA-guided surveillance complexes, such as CRISPR-Cas9, for sequence-specific DNA or RNA cleavage, has revolutionised the process of gene modification or knockdown. To optimise the use of this technology, an exploratory race has ensued to...

Frontiers in microbiology

Ding Q, Tan KS.
PMID: 29018421
Front Microbiol. 2017 Sep 26;8:1842. doi: 10.3389/fmicb.2017.01842. eCollection 2017.

No abstract available.

Foldback intercoil DNA and the mechanism of DNA transposition.

Genomics & informatics

Kim BD.
PMID: 25317106
Genomics Inform. 2014 Sep;12(3):80-6. doi: 10.5808/GI.2014.12.3.80. Epub 2014 Sep 30.

Foldback intercoil (FBI) DNA is formed by the folding back at one point of a non-helical parallel track of double-stranded DNA at as sharp as 180° and the intertwining of two double helixes within each other's major groove to...

Genetics and epigenetics in flower pigmentation associated with transposable elements in morning glories.

Advances in biophysics

Iida S, Morita Y, Choi JD, Park KI, Hoshino A.
PMID: 15476897
Adv Biophys. 2004;38:141-159.

Among the genus Ipomoea, three morning glories, I. nil the Japanese morning glory), I. purpurea (the common morning glory), and I. tricolor, were domesticated well for floricultural plants, and many spontaneous mutants displaying various flower pigmentation patterns were isolated....

Driving DNA transposition by lentiviral protein transduction.

Mobile genetic elements

Cai Y, Mikkelsen JG.
PMID: 25057443
Mob Genet Elements. 2014 Jun 23;4:e29591. doi: 10.4161/mge.29591. eCollection 2014.

Gene vectors derived from DNA transposable elements have become powerful molecular tools in biomedical research and are slowly moving into the clinic as carriers of therapeutic genes. Conventional uses of DNA transposon-based gene vehicles rely on the intracellular production...

piRNA: A promising biomarker in early detection of gastrointestinal cancer.

Pathology, research and practice

Ameli Mojarad M, Ameli Mojarad M, Shojaee B, Nazemalhosseini-Mojarad E.
PMID: 34998210
Pathol Res Pract. 2021 Dec 30;230:153757. doi: 10.1016/j.prp.2021.153757. Epub 2021 Dec 30.

Gastrointestinal (GI) cancer has become the primary concern of today's society due to its aggressive nature and poor prognosis. PIWI-interacting RNAs (piRNAs), a subgroup of non-coding RNAs, are mainly expressed in the germline and have emerged as a critical...

piRNA: A promising biomarker in early detection of gastrointestinal cancer.

Pathology, research and practice

Ameli Mojarad M, Ameli Mojarad M, Shojaee B, Nazemalhosseini-Mojarad E.
PMID: 34998210
Pathol Res Pract. 2021 Dec 30;230:153757. doi: 10.1016/j.prp.2021.153757. Epub 2021 Dec 30.

Gastrointestinal (GI) cancer has become the primary concern of today's society due to its aggressive nature and poor prognosis. PIWI-interacting RNAs (piRNAs), a subgroup of non-coding RNAs, are mainly expressed in the germline and have emerged as a critical...

piRNA: A promising biomarker in early detection of gastrointestinal cancer.

Pathology, research and practice

Ameli Mojarad M, Ameli Mojarad M, Shojaee B, Nazemalhosseini-Mojarad E.
PMID: 34998210
Pathol Res Pract. 2021 Dec 30;230:153757. doi: 10.1016/j.prp.2021.153757. Epub 2021 Dec 30.

Gastrointestinal (GI) cancer has become the primary concern of today's society due to its aggressive nature and poor prognosis. PIWI-interacting RNAs (piRNAs), a subgroup of non-coding RNAs, are mainly expressed in the germline and have emerged as a critical...

Transposable elements and genome size variations in plants.

Genomics & informatics

Lee SI, Kim NS.
PMID: 25317107
Genomics Inform. 2014 Sep;12(3):87-97. doi: 10.5808/GI.2014.12.3.87. Epub 2014 Sep 30.

Although the number of protein-coding genes is not highly variable between plant taxa, the DNA content in their genomes is highly variable, by as much as 2,056-fold from a 1C amount of 0.0648 pg to 132.5 pg. The mean...

Transposable Elements: No More 'Junk DNA'.

Genomics & informatics

Kim YJ, Lee J, Han K.
PMID: 23346034
Genomics Inform. 2012 Dec;10(4):226-33. doi: 10.5808/GI.2012.10.4.226. Epub 2012 Dec 31.

Since the advent of whole-genome sequencing, transposable elements (TEs), just thought to be 'junk' DNA, have been noticed because of their numerous copies in various eukaryotic genomes. Many studies about TEs have been conducted to discover their functions in...

Mobilization of DNA transposable elements from lentiviral vectors.

Mobile genetic elements

Bak RO, Mikkelsen JG.
PMID: 22016863
Mob Genet Elements. 2011 Jul;1(2):139-144. doi: 10.4161/mge.1.2.17062. Epub 2011 Jul 01.

With the Sleeping Beauty (SB) DNA transposon, a reconstructed Tc1/mariner element, as the driving force, DNA transposable elements have emerged as new gene delivery vectors with therapeutic potential. The bipartite transposon vector system consists of a transposon vector carrying...

Showing 1 to 12 of 14 entries