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Showing 1 to 12 of 91 entries
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Examining the predictive accuracy of the novel 3D N-linear algebraic molecular codifications on benchmark datasets.

Journal of cheminformatics

García-Jacas CR, Contreras-Torres E, Marrero-Ponce Y, Pupo-Meriño M, Barigye SJ, Cabrera-Leyva L.
PMID: 26925168
J Cheminform. 2016 Feb 25;8:10. doi: 10.1186/s13321-016-0122-x. eCollection 2016.

BACKGROUND: Recently, novel 3D alignment-free molecular descriptors (also known as QuBiLS-MIDAS) based on two-linear, three-linear and four-linear algebraic forms have been introduced. These descriptors codify chemical information for relations between two, three and four atoms by using several (dis-)similarity...

The effects of increasing PGE2 on translocation of labeled albumin into rat brain.

Research in pharmaceutical sciences

Messripour M, Mesripour A, Mashayekhie FJ.
PMID: 26487895
Res Pharm Sci. 2015 Mar-Apr;10(2):177-81.

Under pathophysiological conditions, infiltration of leukocyte plays a key role in the progression of the neuroinflammatory reaction in the CNS. Prostaglandin E2 (PGE2) is known to accumulate at lesion sites of the post-ischemic brain. Although post-ischemic treatments with cyclooxygenase-2...

Potential of prescription registries to capture individual-level use of aspirin and other nonsteroidal anti-inflammatory drugs in Denmark: trends in utilization 1999-2012.

Clinical epidemiology

Schmidt M, Hallas J, Friis S.
PMID: 24872722
Clin Epidemiol. 2014 May 12;6:155-68. doi: 10.2147/CLEP.S59156. eCollection 2014.

BACKGROUND: Due to over-the-counter availability, no consensus exists on whether adequate information on nonsteroidal anti-inflammatory drug (NSAID) use can be obtained from prescription registries.OBJECTIVES: To examine utilization of aspirin and nonaspirin NSAIDs in Denmark between 1999 and 2012 and...

Consensus on the Prevention, Screening, Early Diagnosis and Treatment of Colorectal Tumors in China: Chinese Society of Gastroenterology, October 14-15, 2011, Shanghai, China.

Gastrointestinal tumors

Fang JY, Zheng S, Jiang B, Lai MD, Fang DC, Han Y, Sheng QJ, Li JN, Chen YX, Gao QY.
PMID: 26672726
Gastrointest Tumors. 2014 Jun;1(2):53-75. doi: 10.1159/000362585. Epub 2014 May 09.

BACKGROUND: Colorectal cancer (CRC) is steadily increasing in China. Colorectal adenoma (CRA) is the most important precancerous disease of CRC. Screening for colorectal tumors can aid early diagnosis. Advances in endoscopic mucosal resection and endoscopic submucosal dissection can aid...

Design, Synthesis and Biological Evaluation of New 1, 4-Dihydropyridine (DHP) Derivatives as Selective Cyclooxygenase-2 Inhibitors.

Iranian journal of pharmaceutical research : IJPR

Sabakhi I, Topuzyan V, Hajimahdi Z, Daraei B, Arefi H, Zarghi A.
PMID: 26664375
Iran J Pharm Res. 2015;14(4):1087-93.

As a continuous research for discovery of new COX-2 inhibitors, chemical synthesis, in vitro biological activity and molecular docking study of a new group of 1, 4-dihydropyridine (DHP) derivatives were presented. Novel synthesized compounds possessing a COX-2 SO2Me pharmacophore...

Delayed Effect of Acupuncture Treatment in OA of the Knee: A Blinded, Randomized, Controlled Trial.

Evidence-based complementary and alternative medicine : eCAM

Miller E, Maimon Y, Rosenblatt Y, Mendler A, Hasner A, Barad A, Amir H, Dekel S, Lev-Ari S.
PMID: 19124552
Evid Based Complement Alternat Med. 2011;2011:792975. doi: 10.1093/ecam/nen080. Epub 2010 Oct 20.

To assess the efficacy in providing improved function and pain relief by administering 8 weeks of acupuncture as adjunctive therapy to standard care in elderly patients with OA of the knee. This randomized, controlled, blinded trial was conducted on...

There may be a way to say "NO" to gastric injury associated with the combined use of aspirin and cyclooxygenase-2 inhibitors.

Canadian journal of gastroenterology = Journal canadien de gastroenterologie

Williams JJ, Beck PL.
PMID: 15565212
Can J Gastroenterol. 2004 Nov;18(11):697-8. doi: 10.1155/2004/841412.

No abstract available.

Recent advances in elucidating pain mechanisms.

Current opinion in anaesthesiology

Vadivelu N, Sinatra R.
PMID: 16534290
Curr Opin Anaesthesiol. 2005 Oct;18(5):540-7. doi: 10.1097/01.aco.0000183109.27297.75.

PURPOSE OF REVIEW: The purpose of this review is to highlight the important recent advances in this fast developing field of pain mechanisms. It is now recognized that acute tissue and neural injuries can result in nociceptor sensitization (primary...

Cost-effectiveness of replacing NSAIDs with coxibs: diclofenac and celecoxib in rheumatoid arthritis.

Expert review of pharmacoeconomics & outcomes research

Kristiansen IS, Kvien TK.
PMID: 19807415
Expert Rev Pharmacoecon Outcomes Res. 2002 Jun;2(3):229-41. doi: 10.1586/14737167.2.3.229.

Cyclooxygenase-2 inhibitors exhibit the same effectiveness on rheumatic symptoms as nonsteroidal anti-inflammatory drugs, have fewer gastrointestinal side effects, but a higher price. Based on cost and healthcare utilization in Norway, this paper explores what factors are most important for...

Lumiracoxib, a highly selective COX-2 inhibitor.

Expert review of clinical immunology

Jeger RV, Greenberg JD, Ramanathan K, Farkouh ME.
PMID: 20477653
Expert Rev Clin Immunol. 2005 May;1(1):37-45. doi: 10.1586/1744666X.1.1.37.

Lumiracoxib Prexige, Novartis AG) is a highly selective inhibitor of cyclooxygenase-2 that has been approved in 22 countries including the UK for analgesic therapy in chronic and acute pain. For patients with osteoarthritis, the recommended initial dose is 100...

The effect of a cyclooxygenase 2 inhibitor on early degenerated human nucleus pulposus explants.

Global spine journal

van Dijk B, Potier E, Licht R, Creemers L, Ito K.
PMID: 24494179
Global Spine J. 2014 Feb;4(1):33-40. doi: 10.1055/s-0033-1359724. Epub 2013 Oct 23.

Study Design Preclinical in vitro culture of human degenerated nucleus pulposus (NP) tissue. Objective Cyclooxygenase 2 inhibitors (e.g., celecoxib) inhibit prostaglandin E2 (PGE2) production, and they have been shown to upregulate regeneration of articular cartilage. In this study, we...

Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors.

ACS medicinal chemistry letters

Radwan MF, Dalby KN, Kaoud TS.
PMID: 25221653
ACS Med Chem Lett. 2014 Jun 23;5(9):983-8. doi: 10.1021/ml500156v. eCollection 2014 Sep 11.

Improving the gastrointestinal safety profile of nonsteroidal anti-inflammatory drugs (NSAIDs) is an important goal. Herein, we report two strategies, using the nonacidic propyphenazone structure, with potential to overcome the side effects of NSAIDs. Propyphenazone was employed to temporarily mask...

Showing 1 to 12 of 91 entries