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HS-142-1, a Novel Non-peptide Antagonist for Atrial Natriuretic Peptide Receptor, Selectively Inhibits Particulate Guanylyl Cyclase and Lowers Cyclic GMP in LLC-PK1 Cells.

Bioscience, biotechnology, and biochemistry

Tanaka T, Ichimura M, Nakajo S, Snajdar RM, Morishita Y, Sano T, Yamada K, Inagami T, Matsuda Y.
PMID: 27286374
Biosci Biotechnol Biochem. 1992 Jan;56(7):1041-5. doi: 10.1271/bbb.56.1041.

HS-142-1, a novel atrial natriuretic peptide (ANP) antagonist isolated from the culture broth of Aureobasidium sp., selectively inhibits ANP-induced cyclic GMP accumulation in porcine kidney epithelial LLC-PK1 cells. At concentrations from 0.1 to 100 μg/ml (= 2.5 × 10(-8)...

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Tanaka T, Ichimura M, Nakajo S, et al. HS-142-1, a Novel Non-peptide Antagonist for Atrial Natriuretic Peptide Receptor, Selectively Inhibits Particulate Guanylyl Cyclase and Lowers Cyclic GMP in LLC-PK1 Cells. Biosci Biotechnol Biochem. 1992;56(7):1041-5doi: 10.1271/bbb.56.1041.
Tanaka, T., Ichimura, M., Nakajo, S., Snajdar, R. M., Morishita, Y., Sano, T., Yamada, K., Inagami, T., & Matsuda, Y. (1992). HS-142-1, a Novel Non-peptide Antagonist for Atrial Natriuretic Peptide Receptor, Selectively Inhibits Particulate Guanylyl Cyclase and Lowers Cyclic GMP in LLC-PK1 Cells. Bioscience, biotechnology, and biochemistry, 56(7), 1041-5. https://doi.org/10.1271/bbb.56.1041
Tanaka, T, et al. "HS-142-1, a Novel Non-peptide Antagonist for Atrial Natriuretic Peptide Receptor, Selectively Inhibits Particulate Guanylyl Cyclase and Lowers Cyclic GMP in LLC-PK1 Cells." Bioscience, biotechnology, and biochemistry vol. 56,7 (1992): 1041-5. doi: https://doi.org/10.1271/bbb.56.1041
Tanaka T, Ichimura M, Nakajo S, Snajdar RM, Morishita Y, Sano T, Yamada K, Inagami T, Matsuda Y. HS-142-1, a Novel Non-peptide Antagonist for Atrial Natriuretic Peptide Receptor, Selectively Inhibits Particulate Guanylyl Cyclase and Lowers Cyclic GMP in LLC-PK1 Cells. Biosci Biotechnol Biochem. 1992 Jan;56(7):1041-5. doi: 10.1271/bbb.56.1041. PMID: 27286374.
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Increase of high molecular weight adiponectin in hypertensive pregnancy was correlated with brain-type natriuretic peptide stimulation on adipocyte.

Pregnancy hypertension

Naruse K, Yamasaki Y, Tsunemi T, Onogi A, Noguchi T, Sado T, Oi H, Kobayashi H.
PMID: 26009027
Pregnancy Hypertens. 2011 Jul-Oct;1(3):200-5. doi: 10.1016/j.preghy.2011.07.004. Epub 2011 Jul 26.

BACKGROUND: High-molecular weight (HMW)-adiponectin is an active multimer for insulin sensitivity and anti-inflammatory reactions. We compared the ratio of serum total and HMW-adiponectin with brain-type natriuretic peptide (BNP) and other adipocytokines in normal pregnancy and pregnancy-induced hypertension (PIH). Effect...

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Naruse K, Yamasaki Y, Tsunemi T, et al. Increase of high molecular weight adiponectin in hypertensive pregnancy was correlated with brain-type natriuretic peptide stimulation on adipocyte. Pregnancy Hypertens. 2011;1(3):200-5doi: 10.1016/j.preghy.2011.07.004.
Naruse, K., Yamasaki, Y., Tsunemi, T., Onogi, A., Noguchi, T., Sado, T., Oi, H., & Kobayashi, H. (2011). Increase of high molecular weight adiponectin in hypertensive pregnancy was correlated with brain-type natriuretic peptide stimulation on adipocyte. Pregnancy hypertension, 1(3), 200-5. https://doi.org/10.1016/j.preghy.2011.07.004
Naruse, Katsuhiko, et al. "Increase of high molecular weight adiponectin in hypertensive pregnancy was correlated with brain-type natriuretic peptide stimulation on adipocyte." Pregnancy hypertension vol. 1,3 (2011): 200-5. doi: https://doi.org/10.1016/j.preghy.2011.07.004
Naruse K, Yamasaki Y, Tsunemi T, Onogi A, Noguchi T, Sado T, Oi H, Kobayashi H. Increase of high molecular weight adiponectin in hypertensive pregnancy was correlated with brain-type natriuretic peptide stimulation on adipocyte. Pregnancy Hypertens. 2011 Jul-Oct;1(3):200-5. doi: 10.1016/j.preghy.2011.07.004. Epub 2011 Jul 26. PMID: 26009027.
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PDE9A is expressed in the inner retina and contributes to the normal shape of the photopic ERG waveform.

Frontiers in molecular neuroscience

Dhingra A, Tummala SR, Lyubarsky A, Vardi N.
PMID: 25018695
Front Mol Neurosci. 2014 Jun 27;7:60. doi: 10.3389/fnmol.2014.00060. eCollection 2014.

The ubiquitous second messenger cGMP is synthesized by guanylyl cyclase and hydrolyzed by phosphodiesterase (PDE). cGMP mediates numerous signaling pathways in multiple tissues. In the retina, cGMP regulates signaling in nearly every cell class including photoreceptors, bipolar cells, amacrine...

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Dhingra A, Tummala SR, Lyubarsky A, et al. PDE9A is expressed in the inner retina and contributes to the normal shape of the photopic ERG waveform. Front Mol Neurosci. 2014;7:60doi: 10.3389/fnmol.2014.00060.
Dhingra, A., Tummala, S. R., Lyubarsky, A., & Vardi, N. (2014). PDE9A is expressed in the inner retina and contributes to the normal shape of the photopic ERG waveform. Frontiers in molecular neuroscience, 760. https://doi.org/10.3389/fnmol.2014.00060
Dhingra, Anuradha, et al. "PDE9A is expressed in the inner retina and contributes to the normal shape of the photopic ERG waveform." Frontiers in molecular neuroscience vol. 7 (2014): 60. doi: https://doi.org/10.3389/fnmol.2014.00060
Dhingra A, Tummala SR, Lyubarsky A, Vardi N. PDE9A is expressed in the inner retina and contributes to the normal shape of the photopic ERG waveform. Front Mol Neurosci. 2014 Jun 27;7:60. doi: 10.3389/fnmol.2014.00060. eCollection 2014. PMID: 25018695; PMCID: PMC4073215.
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Corrigendum to: Ilk conditional deletion in adult animals increases cyclic GMP-dependent vasorelaxation.

Cardiovascular research

[No authors listed]
PMID: 26906921
Cardiovasc Res. 2016 Mar 01;109(3):408. doi: 10.1093/cvr/cvv278.

[Cardiovasc Res 2013; 99 (3):535–544] The authors wish to acknowledge the following funding information which was omitted from the above article: This work was supported by Health Institute Carlos III (PI1000612) cofunded with FEDER funds. The authors apologise for...

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Corrigendum to: Ilk conditional deletion in adult animals increases cyclic GMP-dependent vasorelaxation. Cardiovasc Res. 2016;109(3):408doi: 10.1093/cvr/cvv278.
(2016). Corrigendum to: Ilk conditional deletion in adult animals increases cyclic GMP-dependent vasorelaxation. Cardiovascular research, 109(3), 408. https://doi.org/10.1093/cvr/cvv278
"Corrigendum to: Ilk conditional deletion in adult animals increases cyclic GMP-dependent vasorelaxation." Cardiovascular research vol. 109,3 (2016): 408. doi: https://doi.org/10.1093/cvr/cvv278
Corrigendum to: Ilk conditional deletion in adult animals increases cyclic GMP-dependent vasorelaxation. Cardiovasc Res. 2016 Mar 01;109(3):408. doi: 10.1093/cvr/cvv278. PMID: 26906921.
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[No title available]

Toxicology reports

Vidyashankar S, Babu UV, Patki PS.
PMID: 28962295
Toxicol Rep. 2014 Sep 04;1:834-842. doi: 10.1016/j.toxrep.2014.08.015. eCollection 2014.

The accumulation of advanced glycation end products (AGE) plays significant role in developing tubular hypertrophy during diabetic nephropathy (DN). Reactive oxygen species and nitric oxide (NO) are directly involved in the progression of DN. We have studied the effect...

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Vidyashankar S, Babu UV, Patki PS. . Toxicol Rep. 2014;1:834-842doi: 10.1016/j.toxrep.2014.08.015.
Vidyashankar, S., Babu, U. V., & Patki, P. S. (2014). . Toxicology reports, 1834-842. https://doi.org/10.1016/j.toxrep.2014.08.015
Vidyashankar, Satyakumar, et al. "." Toxicology reports vol. 1 (2014): 834-842. doi: https://doi.org/10.1016/j.toxrep.2014.08.015
Vidyashankar S, Babu UV, Patki PS. . Toxicol Rep. 2014 Sep 04;1:834-842. doi: 10.1016/j.toxrep.2014.08.015. eCollection 2014. PMID: 28962295; PMCID: PMC5598397.
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Climbing Fibres as a Source of Nitric Oxide in the Cerebellum.

The European journal of neuroscience

Southam E, Garthwaite J.
PMID: 12106196
Eur J Neurosci. 1991;3(4):379-382. doi: 10.1111/j.1460-9568.1991.tb00825.x.

Exposure of adult rat cerebellar slices to a moderately raised K+ concentration (15 mM) caused a large (30-fold) rise in the levels of cyclic GMP. Excitatory amino acid antagonists failed to inhibit this response, nor could it be mimicked...

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Southam E, Garthwaite J. Climbing Fibres as a Source of Nitric Oxide in the Cerebellum. Eur J Neurosci. 1991;3(4):379-382doi: 10.1111/j.1460-9568.1991.tb00825.x.
Southam, E., & Garthwaite, J. (1991). Climbing Fibres as a Source of Nitric Oxide in the Cerebellum. The European journal of neuroscience, 3(4), 379-382. https://doi.org/10.1111/j.1460-9568.1991.tb00825.x
Southam, Eric, and Garthwaite, John. "Climbing Fibres as a Source of Nitric Oxide in the Cerebellum." The European journal of neuroscience vol. 3,4 (1991): 379-382. doi: https://doi.org/10.1111/j.1460-9568.1991.tb00825.x
Southam E, Garthwaite J. Climbing Fibres as a Source of Nitric Oxide in the Cerebellum. Eur J Neurosci. 1991;3(4):379-382. doi: 10.1111/j.1460-9568.1991.tb00825.x. PMID: 12106196.
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Variable acceleration influences cyclic AMP levels in Paramecium biaurelia.

Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology

Hemmersbach R, Wilczek M, Stieber C, Braucker R, Ivanova K.
PMID: 15002574
J Gravit Physiol. 2002 Jul;9(1):P267-8.

Paramecium is used as a model system to analyse the gravity signal transduction pathway, that leads to gravitaxis and gravikinesis. In order to prove whether gravistimulation is coupled with second messenger production (cyclic AMP: hyperpolarization, cyclic GMP: depolarization) Paramecium...

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Hemmersbach R, Wilczek M, Stieber C, et al. Variable acceleration influences cyclic AMP levels in Paramecium biaurelia. J Gravit Physiol. 2002;9(1):P267-8
Hemmersbach, R., Wilczek, M., Stieber, C., Braucker, R., & Ivanova, K. (2002). Variable acceleration influences cyclic AMP levels in Paramecium biaurelia. Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology, 9(1), P267-8.
Hemmersbach, Ruth, et al. "Variable acceleration influences cyclic AMP levels in Paramecium biaurelia." Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology vol. 9,1 (2002): P267-8.
Hemmersbach R, Wilczek M, Stieber C, Braucker R, Ivanova K. Variable acceleration influences cyclic AMP levels in Paramecium biaurelia. J Gravit Physiol. 2002 Jul;9(1):P267-8. PMID: 15002574.
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Calcium induces cyclic GMP formation in Dictyostelium.

FEBS letters

Small NV, Europe-Firmer GN, Newell PC.
PMID: 16926128
FEBS Lett. 1986 Jul 14;203(1):11-4. doi: 10.1016/0014-5793(86)81426-0.

Cyclic GMP is rapidly formed a few seconds after binding of chemotactic signalling molecules to specific receptors on the cell surface of Dictyostelium amoebae. This phenomenon could be mimicked by addition of a pulse of Ca2+ to permeabilised amoebae....

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Small NV, Europe-Firmer GN, Newell PC. Calcium induces cyclic GMP formation in Dictyostelium. FEBS Lett. 1986;203(1):11-4doi: 10.1016/0014-5793(86)81426-0.
Small, N. V., Europe-Firmer, G. N., & Newell, P. C. (1986). Calcium induces cyclic GMP formation in Dictyostelium. FEBS letters, 203(1), 11-4. https://doi.org/10.1016/0014-5793(86)81426-0
Small, N V, et al. "Calcium induces cyclic GMP formation in Dictyostelium." FEBS letters vol. 203,1 (1986): 11-4. doi: https://doi.org/10.1016/0014-5793(86)81426-0
Small NV, Europe-Firmer GN, Newell PC. Calcium induces cyclic GMP formation in Dictyostelium. FEBS Lett. 1986 Jul 14;203(1):11-4. doi: 10.1016/0014-5793(86)81426-0. PMID: 16926128.
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Purification of soluble guanylate cyclase from rat liver.

Proceedings of the National Academy of Sciences of the United States of America

Braughler JM, Mittal CK, Murad F.
PMID: 16592607
Proc Natl Acad Sci U S A. 1979 Jan;76(1):219-22. doi: 10.1073/pnas.76.1.219.

Soluble guanylate cyclase [GTP pyrophosphate-lyase (cyclizing), EC 4.6.1.2] has been purified from rat liver and exhibited a single protein band on polyacrylamide gels coincident with activity and indicative of a molecular weight of 150,000. The apparent specific activity of...

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Braughler JM, Mittal CK, Murad F. Purification of soluble guanylate cyclase from rat liver. Proc Natl Acad Sci U S A. 1979;76(1):219-22doi: 10.1073/pnas.76.1.219.
Braughler, J. M., Mittal, C. K., & Murad, F. (1979). Purification of soluble guanylate cyclase from rat liver. Proceedings of the National Academy of Sciences of the United States of America, 76(1), 219-22. https://doi.org/10.1073/pnas.76.1.219
Braughler, J M, et al. "Purification of soluble guanylate cyclase from rat liver." Proceedings of the National Academy of Sciences of the United States of America vol. 76,1 (1979): 219-22. doi: https://doi.org/10.1073/pnas.76.1.219
Braughler JM, Mittal CK, Murad F. Purification of soluble guanylate cyclase from rat liver. Proc Natl Acad Sci U S A. 1979 Jan;76(1):219-22. doi: 10.1073/pnas.76.1.219. PMID: 16592607; PMCID: PMC382909.
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Retraction. Regulation of FoxO1 transcription factor by nitric oxide and cyclic GMP in cultured rat granulosa cells.

Zoological science

[No authors listed]
PMID: 17551250
Zoolog Sci. 2007 Mar;24(3):281. doi: 10.2108/0289-0003-24.3.281.

No abstract available.

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Retraction. Regulation of FoxO1 transcription factor by nitric oxide and cyclic GMP in cultured rat granulosa cells. Zoolog Sci. 2007;24(3):281doi: 10.2108/0289-0003-24.3.281.
(2007). Retraction. Regulation of FoxO1 transcription factor by nitric oxide and cyclic GMP in cultured rat granulosa cells. Zoological science, 24(3), 281. https://doi.org/10.2108/0289-0003-24.3.281
"Retraction. Regulation of FoxO1 transcription factor by nitric oxide and cyclic GMP in cultured rat granulosa cells." Zoological science vol. 24,3 (2007): 281. doi: https://doi.org/10.2108/0289-0003-24.3.281
Retraction. Regulation of FoxO1 transcription factor by nitric oxide and cyclic GMP in cultured rat granulosa cells. Zoolog Sci. 2007 Mar;24(3):281. doi: 10.2108/0289-0003-24.3.281. PMID: 17551250.
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5-[6-1 -(Cyclohexyl-1 H-tetrazol-5-YL)hexyl]-1,8-naphthyridin-2-(1H)-one, SC-44368, a Potent Anti-aggregatory Agent which Selectively Inhibits Platelet Cyclic AMP Phosphodiesterase.

Platelets

Booth RF, Manley PW, Buckham SP, Hassall DG, Honey AC, Lad N, Lunt DO, Oswald S, Porter RA, Tuffin DP.
PMID: 21043905
Platelets. 1992;3(3):129-36. doi: 10.3109/09537109209013173.

SC-44368 (5-[6-(1-cyclohexyl-1H-tetrazol-5-y)hexyl]-1,8-naphthyridin-2(1H)-one) is a potent and selective competitive inhibitor of platelet cyclic AMP-dependent phosphodiesterase (cAMP-PDE) (Ki: 1.65 μM). For the phosphodiesterase isoenzyms from human platelets SC-44368 shows a 26-fold selectivity (IC50 ratio) for the inhibition of the cAMP-PDE over...

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Booth RF, Manley PW, Buckham SP, et al. 5-[6-1 -(Cyclohexyl-1 H-tetrazol-5-YL)hexyl]-1,8-naphthyridin-2-(1H)-one, SC-44368, a Potent Anti-aggregatory Agent which Selectively Inhibits Platelet Cyclic AMP Phosphodiesterase. Platelets. 1992;3(3):129-36doi: 10.3109/09537109209013173.
Booth, R. F., Manley, P. W., Buckham, S. P., Hassall, D. G., Honey, A. C., Lad, N., Lunt, D. O., Oswald, S., Porter, R. A., & Tuffin, D. P. (1992). 5-[6-1 -(Cyclohexyl-1 H-tetrazol-5-YL)hexyl]-1,8-naphthyridin-2-(1H)-one, SC-44368, a Potent Anti-aggregatory Agent which Selectively Inhibits Platelet Cyclic AMP Phosphodiesterase. Platelets, 3(3), 129-36. https://doi.org/10.3109/09537109209013173
Booth, R F, et al. "5-[6-1 -(Cyclohexyl-1 H-tetrazol-5-YL)hexyl]-1,8-naphthyridin-2-(1H)-one, SC-44368, a Potent Anti-aggregatory Agent which Selectively Inhibits Platelet Cyclic AMP Phosphodiesterase." Platelets vol. 3,3 (1992): 129-36. doi: https://doi.org/10.3109/09537109209013173
Booth RF, Manley PW, Buckham SP, Hassall DG, Honey AC, Lad N, Lunt DO, Oswald S, Porter RA, Tuffin DP. 5-[6-1 -(Cyclohexyl-1 H-tetrazol-5-YL)hexyl]-1,8-naphthyridin-2-(1H)-one, SC-44368, a Potent Anti-aggregatory Agent which Selectively Inhibits Platelet Cyclic AMP Phosphodiesterase. Platelets. 1992;3(3):129-36. doi: 10.3109/09537109209013173. PMID: 21043905.
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The effect of various drug pretreatments on the convulsions and cerebellar cyclic nucleotide changes induced by the convulsant 4-isopropyl-2,6,7-trioxa-1-phosphatbicyclo(2,2,2)octane-1-oxide(IPTBO).

Neurochemistry international

Blenkinsop IS, Coult DB, Davies WE, Howells DJ.
PMID: 20488040
Neurochem Int. 1984;6(2):211-5. doi: 10.1016/0197-0186(84)90095-0.

The effects of pretreatment of mice with some drugs which modify GABAergic neurotransmission on the convulsions and cerebellar cyclic nucelotide level changes induced by the subsequent intracerebroventricular administration of 4-isopropyl-2,6,7-trioxa-1-phosphabicyclo(2,2,2)octane-1-oxide (IPTBO) have been studied. Muscimol, pentobarbitone and diazepam reduced...

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Blenkinsop IS, Coult DB, Davies WE, et al. The effect of various drug pretreatments on the convulsions and cerebellar cyclic nucleotide changes induced by the convulsant 4-isopropyl-2,6,7-trioxa-1-phosphatbicyclo(2,2,2)octane-1-oxide(IPTBO). Neurochem Int. 1984;6(2):211-5doi: 10.1016/0197-0186(84)90095-0.
Blenkinsop, I. S., Coult, D. B., Davies, W. E., & Howells, D. J. (1984). The effect of various drug pretreatments on the convulsions and cerebellar cyclic nucleotide changes induced by the convulsant 4-isopropyl-2,6,7-trioxa-1-phosphatbicyclo(2,2,2)octane-1-oxide(IPTBO). Neurochemistry international, 6(2), 211-5. https://doi.org/10.1016/0197-0186(84)90095-0
Blenkinsop, I S, et al. "The effect of various drug pretreatments on the convulsions and cerebellar cyclic nucleotide changes induced by the convulsant 4-isopropyl-2,6,7-trioxa-1-phosphatbicyclo(2,2,2)octane-1-oxide(IPTBO)." Neurochemistry international vol. 6,2 (1984): 211-5. doi: https://doi.org/10.1016/0197-0186(84)90095-0
Blenkinsop IS, Coult DB, Davies WE, Howells DJ. The effect of various drug pretreatments on the convulsions and cerebellar cyclic nucleotide changes induced by the convulsant 4-isopropyl-2,6,7-trioxa-1-phosphatbicyclo(2,2,2)octane-1-oxide(IPTBO). Neurochem Int. 1984;6(2):211-5. doi: 10.1016/0197-0186(84)90095-0. PMID: 20488040.
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Showing 1 to 12 of 373 entries