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Showing 1 to 12 of 38 entries
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Complement System Part I - Molecular Mechanisms of Activation and Regulation.

Frontiers in immunology

Merle NS, Church SE, Fremeaux-Bacchi V, Roumenina LT.
PMID: 26082779
Front Immunol. 2015 Jun 02;6:262. doi: 10.3389/fimmu.2015.00262. eCollection 2015.

Complement is a complex innate immune surveillance system, playing a key role in defense against pathogens and in host homeostasis. The complement system is initiated by conformational changes in recognition molecular complexes upon sensing danger signals. The subsequent cascade...

Platelets and the complement cascade in atherosclerosis.

Frontiers in physiology

Patzelt J, Verschoor A, Langer HF.
PMID: 25784879
Front Physiol. 2015 Mar 02;6:49. doi: 10.3389/fphys.2015.00049. eCollection 2015.

Atherosclerosis and its late sequels are still the number one cause of death in western societies. Platelets are a driving force not only during the genesis of atherosclerosis, but especially in its late stages, as evidenced by complications such...

Soluble mediators regulating immunity in early life.

Frontiers in immunology

Pettengill MA, van Haren SD, Levy O.
PMID: 25309541
Front Immunol. 2014 Sep 24;5:457. doi: 10.3389/fimmu.2014.00457. eCollection 2014.

Soluble factors in blood plasma have a substantial impact on both the innate and adaptive immune responses. The complement system, antibodies, and anti-microbial proteins and peptides can directly interact with potential pathogens, protecting against systemic infection. Levels of these...

Proteome biology of primary colorectal carcinoma and corresponding liver metastases.

Neoplasia (New York, N.Y.)

Fahrner M, Bronsert P, Fichtner-Feigl S, Jud A, Schilling O.
PMID: 34768110
Neoplasia. 2021 Dec;23(12):1240-1251. doi: 10.1016/j.neo.2021.10.005. Epub 2021 Nov 09.

Colorectal adenocarcinomas (CRC) are one of the most commonly diagnosed tumors worldwide. Colorectal adenocarcinomas primarily metastasize into the liver and (less often) into the peritoneum. Patients suffering from CRC-liver metastasis (CRC-LM) typically present with a dismal overall survival compared...

Proteomic Profiling of Gastric Signet Ring Cell Carcinoma Tissues Reveals Characteristic Changes of the Complement Cascade Pathway.

Molecular & cellular proteomics : MCP

Fan Y, Bai B, Liang Y, Ren Y, Liu Y, Zhou F, Lou X, Zi J, Hou G, Chen F, Zhao Q, Liu S.
PMID: 33676000
Mol Cell Proteomics. 2021;20:100068. doi: 10.1016/j.mcpro.2021.100068. Epub 2021 Mar 03.

Signet ring cell carcinoma (SRCC) is a histological subtype of gastric cancer with distinct features in multiple aspects compared with adenocarcinomas (ACs). The lack of a systematic molecular overview of this disease has led to slow progress in its...

The complement system in primary Sjögren's syndrome: the expression of certain cascade and regulatory proteins in labial salivary glands - observational study.

Reumatologia

Legatowicz-Koprowska M, Nitek S, Czerwińska J.
PMID: 33456078
Reumatologia. 2020;58(6):357-366. doi: 10.5114/reum.2020.102000. Epub 2020 Dec 23.

INTRODUCTION: The complement cascade and regulatory proteins are involved in the pathogenesis of the Sjögren's syndrome and other autoimmune diseases. The complement activation via the alternative pathway was recognized as a major pathogenic mechanism in autoimmune conditions. The aim...

Proteomic Profiling of Gastric Signet Ring Cell Carcinoma Tissues Reveals Characteristic Changes of the Complement Cascade Pathway.

Molecular & cellular proteomics : MCP

Fan Y, Bai B, Liang Y, Ren Y, Liu Y, Zhou F, Lou X, Zi J, Hou G, Chen F, Zhao Q, Liu S.
PMID: 33676000
Mol Cell Proteomics. 2021;20:100068. doi: 10.1016/j.mcpro.2021.100068. Epub 2021 Mar 03.

Signet ring cell carcinoma (SRCC) is a histological subtype of gastric cancer with distinct features in multiple aspects compared with adenocarcinomas (ACs). The lack of a systematic molecular overview of this disease has led to slow progress in its...

Age-specific pediatric reference ranges for immunoglobulins and complement proteins on the Optilite.

Journal of clinical laboratory analysis

Garcia-Prat M, Vila-Pijoan G, Martos Gutierrez S, Gala Yerga G, García Guantes E, Martínez-Gallo M, Martín-Nalda A, Soler-Palacín P, Hernández-González M.
PMID: 29603375
J Clin Lab Anal. 2018 Jul;32(6):e22420. doi: 10.1002/jcla.22420. Epub 2018 Mar 30.

BACKGROUND: Measurement of immunoglobulins and complement proteins are frontline tests used in the assessment of immune system integrity, and reference values can vary with age. Their measurement provides an insight into the function of the innate and adaptive immune...

Acute kidney injury in patients with SARS-CoV-2 infection.

Annals of intensive care

Joseph A, Zafrani L, Mabrouki A, Azoulay E, Darmon M.
PMID: 32880774
Ann Intensive Care. 2020 Sep 03;10(1):117. doi: 10.1186/s13613-020-00734-z.

BACKGROUND: Acute Kidney Injury (AKI) is a frequent complication of severe SARS-CoV-2 infection. Multiple mechanisms are involved in COVID-19-associated AKI, from direct viral infection and secondary inflammation to complement activation and microthrombosis. However, data are limited in critically-ill patients....

Complementing Cancer Metastasis.

Frontiers in immunology

Kochanek DM, Ghouse SM, Karbowniczek MM, Markiewski MM.
PMID: 30061895
Front Immunol. 2018 Jul 16;9:1629. doi: 10.3389/fimmu.2018.01629. eCollection 2018.

Complement is an effector of innate immunity and a bridge connecting innate immunity and subsequent adaptive immune responses. It is essential for protection against infections and for orchestrating inflammatory responses. Recent studies have also demonstrated contribution of the complement...

Heparin Mimetics: Their Therapeutic Potential.

Pharmaceuticals (Basel, Switzerland)

Mohamed S, Coombe DR.
PMID: 28974047
Pharmaceuticals (Basel). 2017 Oct 02;10(4). doi: 10.3390/ph10040078.

Heparin mimetics are synthetic and semi-synthetic compounds that are highly sulfated, structurally distinct analogues of glycosaminoglycans. These mimetics are often rationally designed to increase potency and binding selectivity towards specific proteins involved in disease manifestations. Some of the major...

Complement system proteins which interact with C3b or C4b A superfamily of structurally related proteins.

Immunology today

Reid KB, Bentley DR, Campbell RD, Chung LP, Sim RB, Kristensen T, Tack BF.
PMID: 25290405
Immunol Today. 1986 Jul-Aug;7(7):230-4. doi: 10.1016/0167-5699(86)90110-6.

Recent cDNA sequencing data has allowed the prediction of the entire amino acid sequences of complement components factor B and C2, the complement control proteins factor H and C4b-binding protein and a partial sequence for the Cab/C4b receptor CR1....

Showing 1 to 12 of 38 entries