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Showing 1 to 12 of 381 entries
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Vasorelaxing and antihypertensive activities of synthesized peptides derived from computer-aided simulation of pepsin hydrolysis of yam dioscorin.

Botanical studies

Lin YS, Lu YL, Wang GJ, Liang HJ, Hou WC.
PMID: 28510941
Bot Stud. 2014 Dec;55(1):49. doi: 10.1186/s40529-014-0049-3. Epub 2014 Jun 07.

BACKGROUND: We reported that yam dioscorin and its peptic hydrolysates exhibited ACE inhibition and antihypertensive effects on SHRs, however, the active peptides are not really isolated until now. Using ACE inhibitory screenings, two penta-peptides, KTCGY and KRIHF, were selected...

[µ-opioid receptors in the central nucleus of the amygdala mediate sodium intake in rats].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University

Yan JB, Hu ZH.
PMID: 28951361
Nan Fang Yi Ke Da Xue Xue Bao. 2017 Sep 20;37(9):1195-1200.

OBJECTIVE: To investigate the opioidergic mechanism of the central nucleus of the amygdala (CeA) for regulating sodium appetite in rats.METHDOS: Using the elaborate invasive cerebral cannulation and brain microinjection method, we observed the effects of bilateral intra-CeA injections of...

Evaluation of the antioxidant properties of the angiotensin-converting enzyme inhibitor, captopril and the nucleotide enhancing agent, acadesine.

Redox report : communications in free radical research

Wasil M, Kelly FJ.
PMID: 27405835
Redox Rep. 1995 Nov;1(5):361-7. doi: 10.1080/13510002.1995.11747012.

The angiotensin-converting enzyme inhibitor, captopril and the nucleotide enhancing agent, acadesine, protect myocardial tissue from ischaemia/reperfusion-induced injury. Although both drugs have well established, independent mechanisms of cardiac protection, they may also have antioxidant activity which could contribute to their...

Pharmacological evidence of α-adrenergic receptors in the hypotensive effect of Chamaemulum nobile L.

Cardiovascular & hematological agents in medicinal chemistry

Hebi M, Ajebli M, Zeggwagh NA, Eddouks M.
PMID: 27052027
Cardiovasc Hematol Agents Med Chem. 2016 Apr 07; Epub 2016 Apr 07.

This study aims to evaluate the underlying mechanism of action involved in the hypotensive effect of Chamaemulum nobile L. (Cn) aqueous extract and in anesthetized Wistar rats. Lyophilized aqueous extract was administered in the jugular vein, arterial blood pressure...

Conceptuation, formulation and evaluation of sustained release floating tablets of captopril compression coated with gastric dispersible hydrochlorothiazide using 2(3) factorial design.

International journal of pharmaceutical investigation

Sirisha PL, Babu GK, Babu PS.
PMID: 25006552
Int J Pharm Investig. 2014 Apr;4(2):77-87. doi: 10.4103/2230-973X.133055.

Ambulatory blood pressure monitoring is regarded as the gold standard for hypertensive therapy in non-dipping hypertension patients. A novel compression coated formulation of captopril and hydrochlorothiazide (HCTZ) was developed in order to improve the efficacy of antihypertensive therapy considering...

Endoplasmic reticulum stress response in spontaneously hypertensive rats is affected by myocardial ischemia reperfusion injury.

Experimental and therapeutic medicine

Guo XF, Yang XJ.
PMID: 25574192
Exp Ther Med. 2015 Feb;9(2):319-326. doi: 10.3892/etm.2014.2094. Epub 2014 Nov 27.

Cell apoptosis induced by endoplasmic reticulum (ER) stress appears to be one of the main causes of myocardial necrosis following myocardial ischemia/reperfusion (MI/R). The C/EBP homologous protein (CHOP) pathway is the main pathway through which apoptosis is induced during...

Autonomic hyperreflexia after spinal cord injury managed successfully with intravenous lidocaine: a case report.

Patient safety in surgery

Leão P, Figueiredo P.
PMID: 26985238
Patient Saf Surg. 2016 Mar 15;10:10. doi: 10.1186/s13037-016-0098-5. eCollection 2016.

BACKGROUND: Some paraplegic patients may wish undergo some surgical procedures, like urological procedures, without anesthesia. However, these patients can develop autonomic hyperreflexia if cystoscopy is performed without anesthesia.CASE PRESENTATION: We present a case of severe autonomic hyperreflexia in a...

Traditional Chinese medicine baoxin decoction improves cardiac fibrosis of rats with dilated cardiomyopathy.

Experimental and therapeutic medicine

Sun R, Wang J, Zheng Y, Li X, Xie T, Li R, Liu M, Cao Y, Lu L, Zhang Q, Zhang P.
PMID: 28565783
Exp Ther Med. 2017 May;13(5):1900-1906. doi: 10.3892/etm.2017.4223. Epub 2017 Mar 10.

We investigated the effect of baoxin decoction (BXD) on myocardial fibrosis and clarified the possible mechanism of action. Dilated myocardiopathy was induced by doxorubicin injected intraperitoneally for 6 weeks. Rats that demonstrated dilated myocardiopathy were randomly divided into five...

Topical captopril as a novel agent against hypertrophic scar formation in new zealand white rabbit skin.

Wounds : a compendium of clinical research and practice

Safaee Ardekani G, Ebrahimi S, Amini M, Sari Aslani F, Handjani F, Ranjbar Omrani G, Safaee Ardekani L, Hamidreza Hosseini Alhashemi S, Kasraee B.
PMID: 25942328
Wounds. 2008 Apr;20(4):101-6.

Collagen constitutes the majority of extracellular matrix in tissues such as bone, cartilage, and especially the skin. Over production and/or decreased degradation of collagen fibers could lead to an abnormal wound healing response resulting in hypertrophic scarring or keloid...

Matrix metalloproteinases in the pathology of natural and bioprosthetic cardiac valves.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology

Simionescu A, Simionescu DT, Deac RF.
PMID: 25851789
Cardiovasc Pathol. 1996 Nov-Dec;5(6):323-32. doi: 10.1016/s1054-8807(96)00043-9.

Degenerative dysfunction of cardiac valves may be accounted for by uncontrolled extracellular matrix degradation processes in which matrix metalloproteinases could play a major role. In this study, 24 pathologic human valves and 26 pericardial-derived bioprostheses were analysed for metalloproteinases...

Effect of sour tea (Lipicom) pill versus captopril on the treatment of hypertension.

Journal of renal injury prevention

Soleimani AR, Akbari H, Soleimani S, Beladi Mousavi SS, Tamadon MR.
PMID: 26468478
J Renal Inj Prev. 2015 Sep 01;4(3):73-9. doi: 10.12861/jrip.2015.15. eCollection 2015.

INTRODUCTION: Herbal medicines are traditionally prescribed to manage blood pressure.OBJECTIVES: We aimed to evaluate effect of sour tea pill containing the herb's extract versus captopril on the treatment of hypertension.PATIENTS AND METHODS: In our crossover clinical trial 20 patients...

Angiotensin receptor blockers in heart failure after the ELITE II trial.

Current controlled trials in cardiovascular medicine

Willenheimer R.
PMID: 11714415
Curr Control Trials Cardiovasc Med. 2000;1(2):79-82. doi: 10.1186/cvm-1-2-079.

Specific blockers of the angiotensin type1 receptor, angiotensin receptor blockers (ARBs), have been introduced as an alternative to angiotensin-converting enzyme inhibitors (ACEi) for the treatment of heart failure. In comparison with ACEi, ARBs are better tolerated and have similar...

Showing 1 to 12 of 381 entries