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Antioxidant-Angioprotective Actions of Calcium Dobesilate in Diabetic Rats.

The International journal of angiology : official publication of the International College of Angiology, Inc

Brunet J, Farine JC, Garay RP, Hannaert P.
PMID: 10191365
Int J Angiol. 1999;8(5):2-4. doi: 10.1007/BF01619841.

Calcium dobesilate was tested in rats with streptozotocin(STZ)-induced diabetes, for its angioprotective properties against the extravasation of plasma Evans blue towards the peritoneal cavity, induced in situ by the free radical generating agent phenazine methosulfate (PMS). In diabetic rats...

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Brunet J, Farine JC, Garay RP, et al. Antioxidant-Angioprotective Actions of Calcium Dobesilate in Diabetic Rats. Int J Angiol. 1999;8(5):2-4doi: 10.1007/BF01619841.
Brunet, J., Farine, J. C., Garay, R. P., & Hannaert, P. (1999). Antioxidant-Angioprotective Actions of Calcium Dobesilate in Diabetic Rats. The International journal of angiology : official publication of the International College of Angiology, Inc, 8(5), 2-4. https://doi.org/10.1007/BF01619841
Brunet, et al. "Antioxidant-Angioprotective Actions of Calcium Dobesilate in Diabetic Rats." The International journal of angiology : official publication of the International College of Angiology, Inc vol. 8,5 (1999): 2-4. doi: https://doi.org/10.1007/BF01619841
Brunet J, Farine JC, Garay RP, Hannaert P. Antioxidant-Angioprotective Actions of Calcium Dobesilate in Diabetic Rats. Int J Angiol. 1999;8(5):2-4. doi: 10.1007/BF01619841. PMID: 10191365.
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Combined treatment of diabetic nephropathy with alprostadil and calcium dobesilate.

Experimental and therapeutic medicine

Qin L, Qin W, Wang J, Lin L.
PMID: 29201206
Exp Ther Med. 2017 Nov;14(5):5012-5016. doi: 10.3892/etm.2017.5115. Epub 2017 Sep 12.

This study investigated the effects of alprostadil combined with calcium dobesilate on the treatment of diabetic nephropathy. We recruited 80 patients with diabetic nephropathy, who were randomly divided into experimental (n=40) and control (n=40) groups. Patients received high-quality low-protein...

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Qin L, Qin W, Wang J, et al. Combined treatment of diabetic nephropathy with alprostadil and calcium dobesilate. Exp Ther Med. 2017;14(5):5012-5016doi: 10.3892/etm.2017.5115.
Qin, L., Qin, W., Wang, J., & Lin, L. (2017). Combined treatment of diabetic nephropathy with alprostadil and calcium dobesilate. Experimental and therapeutic medicine, 14(5), 5012-5016. https://doi.org/10.3892/etm.2017.5115
Qin, Lili, et al. "Combined treatment of diabetic nephropathy with alprostadil and calcium dobesilate." Experimental and therapeutic medicine vol. 14,5 (2017): 5012-5016. doi: https://doi.org/10.3892/etm.2017.5115
Qin L, Qin W, Wang J, Lin L. Combined treatment of diabetic nephropathy with alprostadil and calcium dobesilate. Exp Ther Med. 2017 Nov;14(5):5012-5016. doi: 10.3892/etm.2017.5115. Epub 2017 Sep 12. PMID: 29201206; PMCID: PMC5704275.
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Calcium Dobesilate (CaD) Attenuates High Glucose and High Lipid-Induced Impairment of Sarcoplasmic Reticulum Calcium Handling in Cardiomyocytes.

Frontiers in cardiovascular medicine

Deng J, Cai X, Hao M, Liu X, Chen Z, Li H, Liu J, Liao Y, Fu H, Chen H, Qin G, Yan D.
PMID: 33604360
Front Cardiovasc Med. 2021 Feb 02;8:637021. doi: 10.3389/fcvm.2021.637021. eCollection 2021.

Calcium dobesilate (CaD) is used effectively in patients with diabetic microvascular disorder, retinopathy, and nephropathy. Here we sought to determine whether it has an effect on cardiomyocytes calcium mishandling that is characteristic of diabetic cardiomyopathy. Cardiomyocytes were sterile isolated...

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Deng J, Cai X, Hao M, et al. Calcium Dobesilate (CaD) Attenuates High Glucose and High Lipid-Induced Impairment of Sarcoplasmic Reticulum Calcium Handling in Cardiomyocytes. Front Cardiovasc Med. 2021;8:637021doi: 10.3389/fcvm.2021.637021.
Deng, J., Cai, X., Hao, M., Liu, X., Chen, Z., Li, H., Liu, J., Liao, Y., Fu, H., Chen, H., Qin, G., & Yan, D. (2021). Calcium Dobesilate (CaD) Attenuates High Glucose and High Lipid-Induced Impairment of Sarcoplasmic Reticulum Calcium Handling in Cardiomyocytes. Frontiers in cardiovascular medicine, 8637021. https://doi.org/10.3389/fcvm.2021.637021
Deng, Jianxin, et al. "Calcium Dobesilate (CaD) Attenuates High Glucose and High Lipid-Induced Impairment of Sarcoplasmic Reticulum Calcium Handling in Cardiomyocytes." Frontiers in cardiovascular medicine vol. 8 (2021): 637021. doi: https://doi.org/10.3389/fcvm.2021.637021
Deng J, Cai X, Hao M, Liu X, Chen Z, Li H, Liu J, Liao Y, Fu H, Chen H, Qin G, Yan D. Calcium Dobesilate (CaD) Attenuates High Glucose and High Lipid-Induced Impairment of Sarcoplasmic Reticulum Calcium Handling in Cardiomyocytes. Front Cardiovasc Med. 2021 Feb 02;8:637021. doi: 10.3389/fcvm.2021.637021. eCollection 2021. PMID: 33604360; PMCID: PMC7884338.
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Calcium Dobesilate Modulates PKCδ-NADPH Oxidase- MAPK-NF-κB Signaling Pathway to Reduce .

Antioxidants (Basel, Switzerland)

Njau F, Haller H.
PMID: 34829669
Antioxidants (Basel). 2021 Nov 11;10(11). doi: 10.3390/antiox10111798.

Monocyte-to-macrophage differentiation results in the secretion of various inflammatory mediators and oxidative stress molecules necessary for atherosclerosis pathogenesis. Consequently, this differentiation represents a potential clinical target in atherosclerosis. Calcium dobesilate (CaD), an established vasoactive and angioprotective drug in experimental...

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Njau F, Haller H. Calcium Dobesilate Modulates PKCδ-NADPH Oxidase- MAPK-NF-κB Signaling Pathway to Reduce . Antioxidants (Basel). 2021;10(11)doi: 10.3390/antiox10111798.
Njau, F., & Haller, H. (2021). Calcium Dobesilate Modulates PKCδ-NADPH Oxidase- MAPK-NF-κB Signaling Pathway to Reduce . Antioxidants (Basel, Switzerland), 10(11), . https://doi.org/10.3390/antiox10111798
Njau, Florence, and Haller, Hermann. "Calcium Dobesilate Modulates PKCδ-NADPH Oxidase- MAPK-NF-κB Signaling Pathway to Reduce ." Antioxidants (Basel, Switzerland) vol. 10,11 (2021). doi: https://doi.org/10.3390/antiox10111798
Njau F, Haller H. Calcium Dobesilate Modulates PKCδ-NADPH Oxidase- MAPK-NF-κB Signaling Pathway to Reduce . Antioxidants (Basel). 2021 Nov 11;10(11). doi: 10.3390/antiox10111798. PMID: 34829669; PMCID: PMC8615002.
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Calcium dobesilate alleviates renal dysfunction and inflammation by targeting nuclear factor kappa B (NF-κB) signaling in sepsis-associated acute kidney injury.

Bioengineered

Xie Z, Wei L, Chen J, Chen Z.
PMID: 35038964
Bioengineered. 2022 Feb;13(2):2816-2826. doi: 10.1080/21655979.2021.2024394.

Acute kidney injury (AKI) is a serious complication of sepsis that increases mortality and the risk of progression to chronic kidney disease. Oxidative stress and apoptosis are reported to exert critical function in the pathogenesis of sepsis-associated AKI. Calcium...

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Xie Z, Wei L, Chen J, et al. Calcium dobesilate alleviates renal dysfunction and inflammation by targeting nuclear factor kappa B (NF-κB) signaling in sepsis-associated acute kidney injury. Bioengineered. 2022;13(2):2816-2826doi: 10.1080/21655979.2021.2024394.
Xie, Z., Wei, L., Chen, J., & Chen, Z. (2022). Calcium dobesilate alleviates renal dysfunction and inflammation by targeting nuclear factor kappa B (NF-κB) signaling in sepsis-associated acute kidney injury. Bioengineered, 13(2), 2816-2826. https://doi.org/10.1080/21655979.2021.2024394
Xie, Zhijuan, et al. "Calcium dobesilate alleviates renal dysfunction and inflammation by targeting nuclear factor kappa B (NF-κB) signaling in sepsis-associated acute kidney injury." Bioengineered vol. 13,2 (2022): 2816-2826. doi: https://doi.org/10.1080/21655979.2021.2024394
Xie Z, Wei L, Chen J, Chen Z. Calcium dobesilate alleviates renal dysfunction and inflammation by targeting nuclear factor kappa B (NF-κB) signaling in sepsis-associated acute kidney injury. Bioengineered. 2022 Feb;13(2):2816-2826. doi: 10.1080/21655979.2021.2024394. PMID: 35038964.
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Protective Effect of Calcium Dobesilate on Induced AKI in Severely Burned Mice.

Nephron

Akhter N, Sun H, Machuki JO, Ren HQ.
PMID: 34126619
Nephron. 2021;145(5):553-567. doi: 10.1159/000515420. Epub 2021 Jun 14.

BACKGROUND: Early acute kidney injury (AKI) predicts a high mortality rate in severely burned patients. However, the pathophysiology of early AKI induced by severe burn has not been well-defined. This study was designed to examine the protective effects of...

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Akhter N, Sun H, Machuki JO, et al. Protective Effect of Calcium Dobesilate on Induced AKI in Severely Burned Mice. Nephron. 2021;145(5):553-567doi: 10.1159/000515420.
Akhter, N., Sun, H., Machuki, J. O., & Ren, H. Q. (2021). Protective Effect of Calcium Dobesilate on Induced AKI in Severely Burned Mice. Nephron, 145(5), 553-567. https://doi.org/10.1159/000515420
Akhter, Nazma, et al. "Protective Effect of Calcium Dobesilate on Induced AKI in Severely Burned Mice." Nephron vol. 145,5 (2021): 553-567. doi: https://doi.org/10.1159/000515420
Akhter N, Sun H, Machuki JO, Ren HQ. Protective Effect of Calcium Dobesilate on Induced AKI in Severely Burned Mice. Nephron. 2021;145(5):553-567. doi: 10.1159/000515420. Epub 2021 Jun 14. PMID: 34126619.
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Effects of calcium dobesilate combined with categlicine and valsartan capsules on inflammation and cellular immunity in patients with diabetic nephropathy.

Minerva surgery

Yu M, Liu C, Jiang Y.
PMID: 34523314
Minerva Surg. 2021 Sep 15; doi: 10.23736/S2724-5691.21.09075-4. Epub 2021 Sep 15.

No abstract available.

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Yu M, Liu C, Jiang Y. Effects of calcium dobesilate combined with categlicine and valsartan capsules on inflammation and cellular immunity in patients with diabetic nephropathy. Minerva Surg. 2021;doi: 10.23736/S2724-5691.21.09075-4.
Yu, M., Liu, C., & Jiang, Y. (2021). Effects of calcium dobesilate combined with categlicine and valsartan capsules on inflammation and cellular immunity in patients with diabetic nephropathy. Minerva surgery, . https://doi.org/10.23736/S2724-5691.21.09075-4
Yu, Min, et al. "Effects of calcium dobesilate combined with categlicine and valsartan capsules on inflammation and cellular immunity in patients with diabetic nephropathy." Minerva surgery vol. (2021). doi: https://doi.org/10.23736/S2724-5691.21.09075-4
Yu M, Liu C, Jiang Y. Effects of calcium dobesilate combined with categlicine and valsartan capsules on inflammation and cellular immunity in patients with diabetic nephropathy. Minerva Surg. 2021 Sep 15; doi: 10.23736/S2724-5691.21.09075-4. Epub 2021 Sep 15. PMID: 34523314.
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Venoprotective drugs in pigmented purpuric dermatoses: A case report.

Journal of cosmetic dermatology

Gupta A, Sardana K, Kishan Gautam R.
PMID: 30600593
J Cosmet Dermatol. 2019 Jan 01; doi: 10.1111/jocd.12850. Epub 2019 Jan 01.

Pigmented purpuric dermatoses (PPD) or capillaritis represent a benign condition, presenting with extravasation of erythrocytes in the skin and prominent hemosiderin deposition. The eruption runs a chronic relapsing course and is resistant to therapy. Capillary fragility, cellular immunity, and...

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Gupta A, Sardana K, Kishan Gautam R. Venoprotective drugs in pigmented purpuric dermatoses: A case report. J Cosmet Dermatol. 2019;doi: 10.1111/jocd.12850.
Gupta, A., Sardana, K., & Kishan Gautam, R. (2019). Venoprotective drugs in pigmented purpuric dermatoses: A case report. Journal of cosmetic dermatology, . https://doi.org/10.1111/jocd.12850
Gupta, Aastha, et al. "Venoprotective drugs in pigmented purpuric dermatoses: A case report." Journal of cosmetic dermatology vol. (2019). doi: https://doi.org/10.1111/jocd.12850
Gupta A, Sardana K, Kishan Gautam R. Venoprotective drugs in pigmented purpuric dermatoses: A case report. J Cosmet Dermatol. 2019 Jan 01; doi: 10.1111/jocd.12850. Epub 2019 Jan 01. PMID: 30600593.
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Calcium Dobesilate protects human peripheral blood mononuclear cells from oxidation and apoptosis.

Apoptosis : an international journal on programmed cell death

Graber R, Farine JC, Losa GA.
PMID: 14646517
Apoptosis. 1998;3(1):41-9. doi: 10.1023/a:1009659119635.

The antioxidant effects of Calcium Dobesilate (CD, Doxium) were investigated in relation to the oxidative status, apoptosis and in vitro proliferation of human peripheral blood mononuclear cells (PBMC) isolated from healthy donors. CD alone did not modify cell growth...

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Graber R, Farine JC, Losa GA. Calcium Dobesilate protects human peripheral blood mononuclear cells from oxidation and apoptosis. Apoptosis. 1998;3(1):41-9doi: 10.1023/a:1009659119635.
Graber, R., Farine, J. C., & Losa, G. A. (1998). Calcium Dobesilate protects human peripheral blood mononuclear cells from oxidation and apoptosis. Apoptosis : an international journal on programmed cell death, 3(1), 41-9. https://doi.org/10.1023/a:1009659119635
Graber, R, et al. "Calcium Dobesilate protects human peripheral blood mononuclear cells from oxidation and apoptosis." Apoptosis : an international journal on programmed cell death vol. 3,1 (1998): 41-9. doi: https://doi.org/10.1023/a:1009659119635
Graber R, Farine JC, Losa GA. Calcium Dobesilate protects human peripheral blood mononuclear cells from oxidation and apoptosis. Apoptosis. 1998;3(1):41-9. doi: 10.1023/a:1009659119635. PMID: 14646517.
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An ionic liquid-type carbon paste electrode for electrochemical investigation and determination of calcium dobesilate.

Talanta

Zheng J, Zhang Y, Yang P.
PMID: 19073121
Talanta. 2007 Oct 31;73(5):920-5. doi: 10.1016/j.talanta.2007.05.016. Epub 2007 May 21.

An ionic liquid-type carbon paste electrode (IL-CPE) had been fabricated by replacing non-conductive organic binders with a conductive room temperature ionic liquid, 1-pentyl-3-methylimidazolium hexafluorophosphate (PMIMPF(6)). The electrochemical responses of calcium dobesilate were investigated at the IL-CPE and the traditional...

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Zheng J, Zhang Y, Yang P. An ionic liquid-type carbon paste electrode for electrochemical investigation and determination of calcium dobesilate. Talanta. 2007;73(5):920-5doi: 10.1016/j.talanta.2007.05.016.
Zheng, J., Zhang, Y., & Yang, P. (2007). An ionic liquid-type carbon paste electrode for electrochemical investigation and determination of calcium dobesilate. Talanta, 73(5), 920-5. https://doi.org/10.1016/j.talanta.2007.05.016
Zheng, Jianbin, et al. "An ionic liquid-type carbon paste electrode for electrochemical investigation and determination of calcium dobesilate." Talanta vol. 73,5 (2007): 920-5. doi: https://doi.org/10.1016/j.talanta.2007.05.016
Zheng J, Zhang Y, Yang P. An ionic liquid-type carbon paste electrode for electrochemical investigation and determination of calcium dobesilate. Talanta. 2007 Oct 31;73(5):920-5. doi: 10.1016/j.talanta.2007.05.016. Epub 2007 May 21. PMID: 19073121.
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: The Impact of Calcium Dobesilate on Vascular Endothelial Dysfunction.

The International journal of angiology : official publication of the International College of Angiology, Inc

Hachen HJ, Prasad K.
PMID: 10191364
Int J Angiol. 1999;8(5):1. doi: 10.1007/BF01619840.

No abstract available.

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Hachen HJ, Prasad K. : The Impact of Calcium Dobesilate on Vascular Endothelial Dysfunction. Int J Angiol. 1999;8(5):1doi: 10.1007/BF01619840.
Hachen, H. J., & Prasad, K. (1999). : The Impact of Calcium Dobesilate on Vascular Endothelial Dysfunction. The International journal of angiology : official publication of the International College of Angiology, Inc, 8(5), 1. https://doi.org/10.1007/BF01619840
Hachen, and Prasad. ": The Impact of Calcium Dobesilate on Vascular Endothelial Dysfunction." The International journal of angiology : official publication of the International College of Angiology, Inc vol. 8,5 (1999): 1. doi: https://doi.org/10.1007/BF01619840
Hachen HJ, Prasad K. : The Impact of Calcium Dobesilate on Vascular Endothelial Dysfunction. Int J Angiol. 1999;8(5):1. doi: 10.1007/BF01619840. PMID: 10191364.
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Lipolymphedema Associated with Idiopathic Cyclic Edema: A Therapeutic Approach.

Case reports in vascular medicine

Pereira de Godoy JM, Pereira de Godoy HJ, de Sene Souza AA, Budtinger Filho R, de Fatima Guerreiro Godoy M.
PMID: 28913000
Case Rep Vasc Med. 2017;2017:5470909. doi: 10.1155/2017/5470909. Epub 2017 Aug 23.

Idiopathic cyclic edema is a type of generalized edema that mainly affects women. Diagnosis is made by the patient's clinical history and an evaluation of the accumulation of weight during the day. The objective of this study is to...

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Pereira de Godoy JM, Pereira de Godoy HJ, de Sene Souza AA, et al. Lipolymphedema Associated with Idiopathic Cyclic Edema: A Therapeutic Approach. Case Rep Vasc Med. 2017;2017:5470909doi: 10.1155/2017/5470909.
Pereira de Godoy, J. M., Pereira de Godoy, H. J., de Sene Souza, A. A., Budtinger Filho, R., & de Fatima Guerreiro Godoy, M. (2017). Lipolymphedema Associated with Idiopathic Cyclic Edema: A Therapeutic Approach. Case reports in vascular medicine, 20175470909. https://doi.org/10.1155/2017/5470909
Pereira de Godoy, Jose Maria, et al. "Lipolymphedema Associated with Idiopathic Cyclic Edema: A Therapeutic Approach." Case reports in vascular medicine vol. 2017 (2017): 5470909. doi: https://doi.org/10.1155/2017/5470909
Pereira de Godoy JM, Pereira de Godoy HJ, de Sene Souza AA, Budtinger Filho R, de Fatima Guerreiro Godoy M. Lipolymphedema Associated with Idiopathic Cyclic Edema: A Therapeutic Approach. Case Rep Vasc Med. 2017;2017:5470909. doi: 10.1155/2017/5470909. Epub 2017 Aug 23. PMID: 28913000; PMCID: PMC5587928.
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Showing 1 to 12 of 34 entries