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Showing 1 to 12 of 221 entries
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Pediatric musculoskeletal tumors: use of dynamic, contrast-enhanced MR imaging to monitor response to chemotherapy.

Radiology

Fletcher BD, Hanna SL, Fairclough DL, Gronemeyer SA.
PMID: 1319075
Radiology. 1992 Jul;184(1):243-8. doi: 10.1148/radiology.184.1.1319075.

The ability of dynamic, gadolinium-enhanced magnetic resonance (MR) imaging to allow prediction of histologic responses to initial chemotherapy was evaluated in 20 patients with osteosarcoma (n = 12), Ewing sarcoma (n = 4), rhabdomyosarcoma (n = 3), or synovial...

Hyperdiploidy and chromosomal rearrangements define the anaplastic variant of Wilms' tumor.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Douglass EC, Look AT, Webber B, Parham D, Wilimas JA, Green AA, Roberson PK.
PMID: 3012007
J Clin Oncol. 1986 Jun;4(6):975-81. doi: 10.1200/JCO.1986.4.6.975.

Flow cytometric measurement of the DNA content of Wilms' tumor cells revealed a striking correspondence with the histologic subtype and treatment outcome. In the 48 cases studied, a hyperdiploid DNA content ranging from 1.7 to 3.2 times the result...

Childhood solid tumors.

Cancer chemotherapy and biological response modifiers

Pratt CB.
PMID: 1327048
Cancer Chemother Biol Response Modif. 1992;13:625-35.

No abstract available.

Ifosfamide/mesna and hematuria.

Cancer treatment reports

Pratt CB, Goren MP.
PMID: 3119210
Cancer Treat Rep. 1987 Nov;71(11):1124-5.

No abstract available.

Phase I study of ICRF-187 in pediatric cancer patients and comparison of its pharmacokinetics in children and adults.

Cancer treatment reports

Holcenberg JS, Tutsch KD, Earhart RH, Ungerleider RS, Kamen BA, Pratt CB, Gribble TJ, Glaubiger DL.
PMID: 3089595
Cancer Treat Rep. 1986 Jun;70(6):703-9.

A phase I study of ICRF-187 as a 2-hour iv infusion daily for 3 days was conducted in 46 evaluable pediatric patients. The maximum tolerated dose was 3500 mg/m2/day X 3 based on changes in hepatic function and coagulation...

Two automated procedures for N-acetyl-beta-D-glucosaminidase determination evaluated for detection of drug-induced tubular nephrotoxicity.

Clinical chemistry

Goren MP, Wright RK, Osborne S.
PMID: 3779949
Clin Chem. 1986 Nov;32(11):2052-5.

We automated two procedures for determination of urinary N-acetyl-beta-D-glucosaminidase (NAG; EC 3.2.1.30) concentrations and evaluated their reliability for detecting drug-induced tubular damage in children receiving cisplatin, methotrexate, or ifosfamide. Results for 174 patient specimens correlated well (r = 0.98),...

Phase I clinical and pharmacokinetic study of bisantrene in refractory pediatric solid tumors.

Investigational new drugs

Pratt CB, Sinkule JA, Etcubanas E, Douglass EC, Crom DB, Choi K, Avery L.
PMID: 3733375
Invest New Drugs. 1986;4(2):149-53. doi: 10.1007/BF00194594.

Fourteen patients with pediatric malignant solid tumors, median age 15 years, received 22 courses of bisantrene in a Phase I study. Dosage escalations ranged from 10 to 120 mg/m2 daily for 5 consecutive days. Toxicity included myelosuppression and phlebitis....

Scheduling of vincristine: drug accumulation and response of xenografts of childhood rhabdomyosarcoma determined by frequency of administration.

Cancer treatment reports

Houghton JA, Meyer WH, Houghton PJ.
PMID: 3607783
Cancer Treat Rep. 1987 Jul-Aug;71(7):717-21.

Vincristine (VCR) is an effective agent in the treatment of childhood rhabdomyosarcoma. Clinically, schedules differ in frequency of administration. To determine the influence of administration frequency, accumulation of VCR in xenografts of human rhabdomyosarcoma has been evaluated following administration...

Amplification of the gli gene in childhood sarcomas.

Cancer research

Roberts WM, Douglass EC, Peiper SC, Houghton PJ, Look AT.
PMID: 2766305
Cancer Res. 1989 Oct 01;49(19):5407-13.
Free Article

The gli gene, originally identified by its amplified copy number in cells from a human malignant glioma, has a predicted translation product that contains five tandem DNA-binding zinc finger motifs related to those of Kr├╝ppel, a developmentally important Drosophila...

Comparison of the conversion of 5-formyltetrahydrofolate and 5-methyltetrahydrofolate to 5,10-methylenetetrahydrofolates and tetrahydrofolates in human colon tumors.

Cancer communications

Houghton JA, Williams LG, de Graaf SS, Cheshire PJ, Wainer IW, Jadaud P, Houghton PJ.
PMID: 2639728
Cancer Commun. 1989;1(3):167-74.

Four hr infusions i.v. of [6RS]5-formyltetrahydrofolate ([6RS]5-CHO-H4PteGlu; 500 mg/m2) and [6RS]5-methyltetrahydrofolate ([6RS]5-CH3-H4PteGlu; 500 mg/m2) were compared for their relative effects on expansion of pools of 5,10-methylenetetrahydrofolates (CH2-H4PteGlun) and tetrahydrofolates (H4PteGlun) in two human colon adenocarcinoma xenografts in mice. Expansion...

Is renal salvage feasible in unilateral Wilms' tumor? Proposed computed tomographic criteria and their relation to surgicopathologic findings.

The American journal of pediatric hematology/oncology

Wilimas JA, Magill L, Parham DM, Jerkins G, Kumar M, Douglass EC.
PMID: 2165744
Am J Pediatr Hematol Oncol. 1990;12(2):164-7.

The ability of computed tomographic (CT) criteria to predict the potential for resection with renal salvage in unilateral Wilms' tumor was evaluated retrospectively in 10 children given preoperative treatment for initially inoperable disease. Criteria were (a) tumor involving only...

Primary Ewing sarcoma: follow-up with Ga-67 scintigraphy.

Radiology

Estes DN, Magill HL, Thompson EI, Hayes FA.
PMID: 2217783
Radiology. 1990 Nov;177(2):449-53. doi: 10.1148/radiology.177.2.2217783.

While avid accumulation of gallium-67 citrate and technetium-99m methylene diphosphonate (MDP) occurs initially in most cases of primary Ewing sarcoma, uptake after therapy is less well defined. Thirty patients with Ewing sarcoma who underwent Ga-67 and bone scintigraphy at...

Showing 1 to 12 of 221 entries