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Transdifferentiation of cultured human prostate cancer cells to a neuroendocrine cell phenotype in a hormone-depleted medium.

Urologic oncology

Shen R, Dorai T, Szaboles M, Katz AE, Olsson CA, Buttyan R.
PMID: 21227062
Urol Oncol. 1997 Mar-Apr;3(2):67-75. doi: 10.1016/s1078-1439(97)00039-2.

Neuroendocrine (NE) cells are enigmatically found in association with human prostate cancers and their numbers are reported to increase in advanced and hormoneresistant tumors. The origin of this cell type and the reason for their appearance in prostate tumors...

Corrigendum to "Bombesin-like receptor 3 (Brs3) expression in glutamatergic, but not GABAergic, neurons is required for regulation of energy metabolism" [Mol Metabol 6 (2017) 1540-1550].

Molecular metabolism

Xiao C, Piñol RA, Carlin JL, Li C, Deng C, Gavrilova O, Reitman ML.
PMID: 29352726
Mol Metab. 2018 Mar;9:220. doi: 10.1016/j.molmet.2017.12.009. Epub 2017 Dec 27.

No abstract available.

Feeding and the rhodopsin family g-protein coupled receptors in nematodes and arthropods.

Frontiers in endocrinology

Cardoso JC, Félix RC, Fonseca VG, Power DM.
PMID: 23264768
Front Endocrinol (Lausanne). 2012 Dec 18;3:157. doi: 10.3389/fendo.2012.00157. eCollection 2012.

In vertebrates, receptors of the rhodopsin G-protein coupled superfamily (GPCRs) play an important role in the regulation of feeding and energy homeostasis and are activated by peptide hormones produced in the brain-gut axis. These peptides regulate appetite and energy...

Novel dimeric DOTA-coupled peptidic Y1-receptor antagonists for targeting of neuropeptide Y receptor-expressing cancers.

EJNMMI research

Chatenet D, Cescato R, Waser B, Erchegyi J, Rivier JE, Reubi JC.
PMID: 22214201
EJNMMI Res. 2011 Sep 02;1(1):21. doi: 10.1186/2191-219X-1-21.

BACKGROUND: Several peptide hormone receptors were identified that are specifically over-expressed on the cell surface of certain human tumors. For example, high incidence and density of the Y1 subtype of neuropeptide Y (NPY) receptors are found in breast tumors....

Doxorubicin conjugates for selective delivery to tumors.

Topics in current chemistry

Florent JC, Monneret C.
PMID: 23605630
Top Curr Chem. 2008;283:99-140. doi: 10.1007/128_2007_12.

With the aim of improving the therapeutic utility of doxorubicin, numerous conjugates or prodrugshave been prepared to be selectively activated at the tumor site while releasing the cytotoxic drug.Among immuno-conjugates representing a widely studied class of doxorubicin derivatives,the clinical...

F-Labeled GRPR Agonists and Antagonists: A Comparative Study in Prostate Cancer Imaging.


Yang M, Gao H, Zhou Y, Ma Y, Quan Q, Lang L, Chen K, Niu G, Yan Y, Chen X.
PMID: 21544226
Theranostics. 2011;1:220-9. doi: 10.7150/thno/v01p0220.

Radiolabeled bombesin analogs are promising probes for cancer imaging of gastrin-releasing peptide receptor (GRPR). In this study, we developed (18)F-labeled GRPR agonists and antagonists for positron emission tomography (PET) imaging of prostate cancer. GRPR antagonists ATBBN (D-Phe-Gln-Trp-Ala-Val-Gly-His-Leu-NHCH(2)CH(3)) and MATBBN...

Central ventilatory and cardiovascular actions of trout gastrin-releasing peptide (GRP) in the unanesthetized trout.

Biology open

Le Mével JC, Lancien F, Mimassi N, Kermorgant M, Conlon JM.
PMID: 24143283
Biol Open. 2013 Jul 30;2(9):960-7. doi: 10.1242/bio.20135553. eCollection 2013.

Gastrin-releasing peptide (GRP), a neuropeptide initially isolated from porcine stomach, shares sequence similarity with bombesin. GRP and its receptors are present in the brains and peripheral tissues of several species of teleost fish, but little is known about the...

Neuroendocrine regulation of canine gastric secretion, emptying and blood flow.

Journal of neuroendocrinology

Lenz HJ.
PMID: 19210449
J Neuroendocrinol. 1989 Jun 01;1(3):163-7. doi: 10.1111/j.1365-2826.1989.tb00097.x.

Abstract Several peptides have been implicated as central nervous system transmitters regulating various peripheral organ systems. This study examined the central nervous system effects of rat corticotrophin-releasing factor (CRF), salmon calcitonin (CT), beta-endorphin (beta-End), neurotensin (NT), rat calcitonin gene-related...

Resection and survival data from a clinical trial of glioblastoma multiforme-specific IRDye800-BBN fluorescence-guided surgery.

Bioengineering & translational medicine

He K, Chi C, Li D, Zhang J, Niu G, Lv F, Wang J, Che W, Zhang L, Ji N, Zhu Z, Tian J, Chen X.
PMID: 33532584
Bioeng Transl Med. 2020 Aug 31;6(1):e10182. doi: 10.1002/btm2.10182. eCollection 2021 Jan.

Supra-maximum surgical tumor resection without neurological damage is highly valuable for treatment and prognosis of patients with glioblastoma multiforme (GBM). We developed a GBM-specific fluorescence probe using IRDye800CW (peak absorption/emission, 778/795 nm) and bombesin (BBN), which (IRDye800-BBN) targets the...

Clinical significance of elevation in neuroendocrine factors and interleukin-6 in metastatic prostate cancer.

Urologic oncology

Hoosein N, Abdul M, McCabe R, Gero E, Deftos L, Banks M, Hodges S, Finn L, Logothetis C.
PMID: 21224126
Urol Oncol. 1995 Nov-Dec;1(6):246-51. doi: 10.1016/1078-1439(96)00012-9.

Serum biomarkers that reflect the complex pathways of cancer progression have contributed to the clinical understanding of many malignancies. Recent studies have suggested that certain neuroendocrine (NE) elements participate in prostate cancer (PCa) progression. Interleukin-6 (IL-6) may serve as...

Exploiting cancer's phenotypic guise against itself: targeting ectopically expressed peptide G-protein coupled receptors for lung cancer therapy.


Khan M, Huang T, Lin CY, Wu J, Fan BM, Bian ZX.
PMID: 29262666
Oncotarget. 2017 Jun 07;8(61):104615-104637. doi: 10.18632/oncotarget.18403. eCollection 2017 Nov 28.

Lung cancer, claiming millions of lives annually, has the highest mortality rate worldwide. This advocates the development of novel cancer therapies that are highly toxic for cancer cells but negligibly toxic for healthy cells. One of the effective treatments...

Gastrin-releasing peptide regulates fear learning under stressed conditions via activation of the amygdalostriatal transition area.

Molecular psychiatry

Goto F, Kiyama Y, Ogawa I, Okuno H, Ichise T, Ichise H, Anai M, Kodama T, Yoshida N, Bito H, Manabe T.
PMID: 34997193
Mol Psychiatry. 2022 Jan 08; doi: 10.1038/s41380-021-01408-3. Epub 2022 Jan 08.

The amygdala, a critical brain region responsible for emotional behavior, is crucially involved in the regulation of the effects of stress on emotional behavior. In the mammalian forebrain, gastrin-releasing peptide (GRP), a 27-amino-acid mammalian neuropeptide, which is a homolog...

Showing 1 to 12 of 575 entries