Advanced Search
Display options
Filter resources
Text Availability
Article type
Publication date
Species
Language
Sex
Age
Showing 1 to 12 of 15 entries
Sorted by: Best Match Show Resources per page
A systems-level analysis of bile acids effects on rat colon epithelial cells.

American journal of physiology. Gastrointestinal and liver physiology

Yde J, Wu Q, Borg JF, Fenton RA, Moeller HB.
PMID: 34643455
Am J Physiol Gastrointest Liver Physiol. 2022 Jan 01;322(1):G34-G48. doi: 10.1152/ajpgi.00178.2021. Epub 2021 Oct 13.

Bile acid diarrhea is a chronic condition caused by increased delivery of bile acids to the colon. The underlying mechanisms remain to be elucidated. To investigate genes involved in bile acid diarrhea, systems-level analyses were used on a rat...

Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury.

Frontiers in pharmacology

Woodhead JL, Yang K, Siler SQ, Watkins PB, Brouwer KL, Barton HA, Howell BA.
PMID: 25426072
Front Pharmacol. 2014 Nov 07;5:240. doi: 10.3389/fphar.2014.00240. eCollection 2014.

Inhibition of the bile salt export pump (BSEP) has been linked to incidence of drug-induced liver injury (DILI), presumably by the accumulation of toxic bile acids in the liver. We have previously constructed and validated a model of bile...

[Intrahepatic cholestasis of pregnancy].

Der Gynakologe

Hagenbeck C, Pecks U, Lammert F, Hütten MAC, Borgmeier F, Fehm T, Schleußner E, Maul H, Kehl S, Hamza A, Keitel V.
PMID: 33896963
Gynakologe. 2021 Apr 20;1-16. doi: 10.1007/s00129-021-04787-4. Epub 2021 Apr 20.

Intrahepatic cholestasis of pregnancy (ICP) is the most frequent pregnancy-specific liver disease. It is characterized by pruritus and an accompanying elevation of serum bile acid concentrations and/or alanine aminotransferase (ALT), which are the key parameters in the diagnosis. Despite...

The Effect of Microbiota on Colon Carcinogenesis.

Journal of cancer prevention

Yoon K, Kim N.
PMID: 30370256
J Cancer Prev. 2018 Sep;23(3):117-125. doi: 10.15430/JCP.2018.23.3.117. Epub 2018 Sep 30.

Although genetic background is known to contribute to colon carcinogenesis, the exact etiology of the disease remains elusive. The organ's extensive interaction with microbes necessitated research on the role of microbiota on development of colon cancer. In this review,...

Relation between bile acids and myocardial damage in obstructive jaundice.

World journal of gastroenterology

Mu YP, Peng SY.
PMID: 27239141
World J Gastroenterol. 1997 Sep 15;3(3):174-6. doi: 10.3748/wjg.v3.i3.174.

AIM: To investigate the morphologic changes of the myocardium and its relationship to serum bile acids in obstructive jaundice.METHODS: Part 1: 35 rats were randomly assigned to three groups: Group I (BDL1, n = 11), the common bile duct...

A systems-level analysis of bile acids effects on rat colon epithelial cells.

American journal of physiology. Gastrointestinal and liver physiology

Yde J, Wu Q, Borg J, Fenton RA, Moeller HB.
PMID: 34643455
Am J Physiol Gastrointest Liver Physiol. 2021 Oct 13; doi: 10.1152/ajpgi.00178.2021. Epub 2021 Oct 13.

Bile acid diarrhoea is a chronic condition caused by increased delivery of bile acids to the colon. The underlying mechanisms remain to be elucidated. To investigate genes involved in bile acid diarrhoea, systems-level analyses were employed on a rat...

A systems-level analysis of bile acids effects on rat colon epithelial cells.

American journal of physiology. Gastrointestinal and liver physiology

Yde J, Wu Q, Borg JF, Fenton RA, Moeller HB.
PMID: 34643455
Am J Physiol Gastrointest Liver Physiol. 2022 Jan 01;322(1):G34-G48. doi: 10.1152/ajpgi.00178.2021. Epub 2021 Oct 13.

Bile acid diarrhea is a chronic condition caused by increased delivery of bile acids to the colon. The underlying mechanisms remain to be elucidated. To investigate genes involved in bile acid diarrhea, systems-level analyses were used on a rat...

Faecal proteomics in the identification of biomarkers to differentiate canine chronic enteropathies.

Journal of proteomics

O'Reilly EL, Horvatić A, Kuleš J, Gelemanović A, Mrljak V, Huang Y, Brady N, Chadwick CC, Eckersall PD, Ridyard A.
PMID: 34958965
J Proteomics. 2021 Dec 24;254:104452. doi: 10.1016/j.jprot.2021.104452. Epub 2021 Dec 24.

Canine chronic enteropathy (CCE) is a collective term used to describe a group of idiopathic enteropathies of dogs that result in a variety of clinical manifestations of intestinal dysfunction. Clinical stratification into food-responsive enteropathy (FRE) or non-food responsive chronic...

Faecal proteomics in the identification of biomarkers to differentiate canine chronic enteropathies.

Journal of proteomics

O'Reilly EL, Horvatić A, Kuleš J, Gelemanović A, Mrljak V, Huang Y, Brady N, Chadwick CC, Eckersall PD, Ridyard A.
PMID: 34958965
J Proteomics. 2021 Dec 24;104452. doi: 10.1016/j.jprot.2021.104452. Epub 2021 Dec 24.

Canine chronic enteropathy (CCE) is a collective term used to describe a group of idiopathic enteropathies of dogs that result in a variety of clinical manifestations of intestinal dysfunction. Clinical stratification into food-responsive enteropathy (FRE) or non-food responsive chronic...

Bile Acid Nuclear Receptor Farnesoid X Receptor: Therapeutic Target for Nonalcoholic Fatty Liver Disease.

Endocrinology and metabolism (Seoul, Korea)

Kim SG, Kim BK, Kim K, Fang S.
PMID: 28029021
Endocrinol Metab (Seoul). 2016 Dec;31(4):500-504. doi: 10.3803/EnM.2016.31.4.500.

Nonalcoholic fatty liver disease (NAFLD) is one of the causes of fatty liver, occurring when fat is accumulated in the liver without alcohol consumption. NAFLD is the most common liver disorder in advanced countries. NAFLD is a spectrum of...

Preventing a Mass Disease: The Case of Gallstones Disease: Role and Competence for Family Physicians.

Korean journal of family medicine

Portincasa P, Di Ciaula A, Grattagliano I.
PMID: 27468338
Korean J Fam Med. 2016 Jul;37(4):205-13. doi: 10.4082/kjfm.2016.37.4.205. Epub 2016 Jul 21.

Gallstone formation is the result of a complex interaction between genetic and nongenetic factors. We searched and reviewed the available literature to define how the primary prevention of gallstones (cholesterol gallstones in particular) could be applied in general practice....

Thyroid Hormone Regulates the mRNA Expression of Small Heterodimer Partner through Liver Receptor Homolog-1.

Endocrinology and metabolism (Seoul, Korea)

Ahn HY, Kim HH, Kim YA, Kim M, Ohn JH, Chung SS, Lee YK, Park DJ, Park KS, Moore DD, Park YJ.
PMID: 26485468
Endocrinol Metab (Seoul). 2015 Dec;30(4):584-92. doi: 10.3803/EnM.2015.30.4.584. Epub 2015 Oct 20.

BACKGROUND: Expression of hepatic cholesterol 7α-hydroxylase (CYP7A1) is negatively regulated by orphan nuclear receptor small heterodimer partner (SHP). In this study, we aimed to find whether thyroid hormone regulates SHP expression by modulating the transcriptional activities of liver receptor...

Showing 1 to 12 of 15 entries